Mevalonolactone is a lipid of Fatty Acyls (FA) class. Mevalonolactone is associated with abnormalities such as Degenerative disorder. The involved functions are known as Regulation, cholesterol biosynthetic process, Mutation, Apoptosis and Anabolism. The associated genes with Mevalonolactone are STN gene, Candidate Disease Gene, Locus, PSAT1 gene and SPEN gene. The related lipids are Hydroxycholesterols, Sterols, 25-hydroxycholesterol, 22-hydroxycholesterol and Total cholesterol.
To understand associated biological information of Mevalonolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Mevalonolactone is suspected in Degenerative disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Mevalonolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Surup F et al. | Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. | 2015 | J. Nat. Prod. | pmid:25871540 |
| Matsuo S et al. | Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension. | 2015 | J. Thorac. Cardiovasc. Surg. | pmid:25454916 |
| Smith R et al. | Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. | 2014 | PLoS ONE | pmid:24416446 |
| Liu YP et al. | Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. | 2014 | J. Clin. Invest. | pmid:24691443 |
| Citron CA and Dickschat JS | The stereochemical course of tricho-acorenol biosynthesis. | 2013 | Org. Biomol. Chem. | pmid:24084795 |
| Fuhrmeister J et al. | Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells. | 2012 | Toxicol. Lett. | pmid:23092657 |
| Wang H et al. | Production and characterization of antifungal compounds produced by Lactobacillus plantarum IMAU10014. | 2012 | PLoS ONE | pmid:22276116 |
| Zhang B et al. | Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. | 2012 | Eur. J. Pharmacol. | pmid:22796672 |
| Waldron J and Webster C | Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. | 2011 | Ann. Clin. Biochem. | pmid:21355014 |