Mevalonolactone is a lipid of Fatty Acyls (FA) class. Mevalonolactone is associated with abnormalities such as Degenerative disorder. The involved functions are known as Regulation, cholesterol biosynthetic process, Mutation, Apoptosis and Anabolism. The associated genes with Mevalonolactone are STN gene, Candidate Disease Gene, Locus, PSAT1 gene and SPEN gene. The related lipids are Hydroxycholesterols, Sterols, 25-hydroxycholesterol, 22-hydroxycholesterol and Total cholesterol.
To understand associated biological information of Mevalonolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Mevalonolactone is suspected in Degenerative disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Mevalonolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Feitosa AO et al. | Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). | 2016 Jul - Sep | Rev. Argent. Microbiol. | pmid:27567521 |
| Surup F et al. | Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471. | 2015 | J. Nat. Prod. | pmid:25871540 |
| Matsuo S et al. | Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension. | 2015 | J. Thorac. Cardiovasc. Surg. | pmid:25454916 |
| Smith R et al. | Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. | 2014 | PLoS ONE | pmid:24416446 |
| Liu YP et al. | Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. | 2014 | J. Clin. Invest. | pmid:24691443 |
| Citron CA and Dickschat JS | The stereochemical course of tricho-acorenol biosynthesis. | 2013 | Org. Biomol. Chem. | pmid:24084795 |
| Fuhrmeister J et al. | Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells. | 2012 | Toxicol. Lett. | pmid:23092657 |
| Wang H et al. | Production and characterization of antifungal compounds produced by Lactobacillus plantarum IMAU10014. | 2012 | PLoS ONE | pmid:22276116 |
| Zhang B et al. | Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. | 2012 | Eur. J. Pharmacol. | pmid:22796672 |
| Katuru R et al. | Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21540247 |
| Waldron J and Webster C | Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. | 2011 | Ann. Clin. Biochem. | pmid:21355014 |
| Brock NL et al. | Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi. | 2011 | Chembiochem | pmid:21990128 |
| Engelson EJ et al. | An essential farnesylated kinesin in Trypanosoma brucei. | 2011 | PLoS ONE | pmid:22073170 |
| Vallianou I et al. | Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. | 2011 | PLoS ONE | pmid:22073134 |
| Morrone D et al. | Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19777230 |
| Bouvier-Navé P et al. | Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. | 2010 | Plant Physiol. | pmid:19923239 |
| Fujisawa M et al. | Cloning and characterization of a novel gene that encodes (S)-beta-bisabolene synthase from ginger, Zingiber officinale. | 2010 | Planta | pmid:20229191 |
| Qi XF et al. | Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells. | 2010 | Toxicol. Lett. | pmid:20883752 |
| Martin DM et al. | Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. | 2010 | BMC Plant Biol. | pmid:20964856 |
| Lorenzen W et al. | Isoprenoids are essential for fruiting body formation in Myxococcus xanthus. | 2009 | J. Bacteriol. | pmid:19617362 |
| Schwartz YSh et al. | Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages. | 2009 | Bull. Exp. Biol. Med. | pmid:20396700 |
| Zhao S et al. | Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. | 2009 | Bioorg. Med. Chem. | pmid:19879766 |
| Suzuki M et al. | Complete blockage of the mevalonate pathway results in male gametophyte lethality. | 2009 | J. Exp. Bot. | pmid:19363204 |
| Okada K et al. | Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. | 2008 | Plant Cell Physiol. | pmid:18303110 |
| Lüdke SM et al. | Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2008 | J. Lipid Res. | pmid:18669481 |
| Burke LP and Kukoly CA | Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. | 2008 | Leuk. Lymphoma | pmid:18231920 |
| Yoshida T et al. | Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. | 2008 | Anal Chem Insights | pmid:19609389 |
| Paintlia AS et al. | Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. | 2008 | Mol. Pharmacol. | pmid:18239032 |
| Nishimoto T et al. | Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17599378 |
| Honda A et al. | Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. | 2007 | J. Lipid Res. | pmid:17272831 |
| Sarrabayrouse G et al. | Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. | 2007 | Neoplasia | pmid:18084615 |
| Seto SW et al. | Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. | 2007 | Br. J. Pharmacol. | pmid:17558433 |
| Kanellis J et al. | Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. | 2006 | Immunol. Cell Biol. | pmid:16405649 |
| Polo MP and de Bravo MG | Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | 2006 | Biochem. Cell Biol. | pmid:16462894 |
| Hampel D et al. | Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. | 2006 | J. Agric. Food Chem. | pmid:16478276 |
| Saini GS et al. | Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. | 2006 | J. Lipid Res. | pmid:16861623 |
| Treiblmayr K et al. | Juvenile hormone titer versus juvenile hormone synthesis in female nymphs and adults of the German cockroach, Blattella germanica. | 2006 | J. Insect Sci. | pmid:20233097 |
| Kim J et al. | 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. | 2005 | J. Chem. Ecol. | pmid:16222778 |
| Huang Y et al. | Prenylation-defective human connexin32 mutants are normally localized and function equivalently to wild-type connexin32 in myelinating Schwann cells. | 2005 | J. Neurosci. | pmid:16079393 |
| Harry R et al. | Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. | 2005 | J. Immunol. | pmid:15699169 |
| Dubuc G et al. | Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15178557 |
| Rasouli M et al. | Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes. | 2004 | Biochim. Biophys. Acta | pmid:15158760 |
| Gerber R et al. | Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. | 2004 | Anal. Biochem. | pmid:15136164 |
| Sauane M et al. | Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14706631 |
| Berger A et al. | Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. | 2004 | Lipids Health Dis | pmid:14969592 |
| Yoshida S et al. | Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines. | 2003 | Steroids | pmid:12475725 |
| Awad AB et al. | Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. | 2003 | J. Nutr. Biochem. | pmid:12667603 |
| Kreck M et al. | Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols. | 2003 | J. Agric. Food Chem. | pmid:12517111 |
| Wang CZ and Miziorko HM | Methodology for synthesis and isolation of 5-phosphomevalonic acid. | 2003 | Anal. Biochem. | pmid:14511696 |
| Barkawi LS et al. | Frontalin: De novo biosynthesis of an aggregation pheromone component by Dendroctonus spp. bark beetles (Coleoptera: Scolytidae). | 2003 | Insect Biochem. Mol. Biol. | pmid:12878224 |
| Greenwood J et al. | Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. | 2003 | FASEB J. | pmid:12626426 |
| Hiyoshi H et al. | Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. | 2003 | J. Lipid Res. | pmid:12518031 |
| Vamvakopoulos JE and Green C | HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. | 2003 | BMC Cardiovasc Disord | pmid:12871602 |
| Miggin SM et al. | Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. | 2002 | Eur. J. Biochem. | pmid:11895442 |
| Gubina E et al. | CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. | 2002 | Blood | pmid:11895788 |
| Kumar B et al. | Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. | 2002 | J. Neurosci. Res. | pmid:12111853 |
| Alla S et al. | [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)]. | 2002 | C. R. Biol. | pmid:12481687 |
| Zeidler J and Lichtenthaler HK | Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. | 2001 | Planta | pmid:11469599 |
| Park EJ et al. | Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11339276 |
| Archelas A and Furstoss R | Synthetic applications of epoxide hydrolases. | 2001 | Curr Opin Chem Biol | pmid:11282336 |
| Kojima K et al. | Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein. | 2001 | Biochim. Biophys. Acta | pmid:11470238 |
| Vanhorebeek I et al. | Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model. | 2001 | Biochim. Biophys. Acta | pmid:11420171 |
| Funatsu T et al. | Prolonged inhibition of cholesterol synthesis by atorvastatin inhibits apo B-100 and triglyceride secretion from HepG2 cells. | 2001 | Atherosclerosis | pmid:11427209 |
| Zhou Q et al. | An excess concentration of oxysterols in the plasma is cytotoxic to cultured endothelial cells. | 2000 | Atherosclerosis | pmid:10704631 |
| Cenedella RJ et al. | Lens epithelia contain a high-affinity, membrane steroid hormone-binding protein. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10359327 |
| Girgert R et al. | Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms. | 1999 | Cancer Lett. | pmid:10374838 |
| Niku-Paavola ML et al. | New types of antimicrobial compounds produced by Lactobacillus plantarum. | 1999 | J. Appl. Microbiol. | pmid:10200070 |
| Lambert M and Bui ND | Dexamethasone-induced decrease in HMG-CoA reductase and protein-farnesyl transferase activities does not impair ras processing in AR 4-2J cells. | 1999 | Mol. Cell. Biochem. | pmid:10706000 |
| Kwiterovich PO and Motevalli M | Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9445257 |
| Cenedella RJ and Sexton PS | Probing cataractogenesis associated with mevalonic aciduria. | 1998 | Curr. Eye Res. | pmid:9523093 |
| Natarajan R et al. | Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9480812 |
| Coxon FP et al. | Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs. | 1998 | Mol. Pharmacol. | pmid:9765505 |
| Aspbury RA et al. | Isoprenylation of polypeptides in the nematode Caenorhabditis elegans. | 1998 | Biochim. Biophys. Acta | pmid:9630668 |
| Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
| Ren Z and Gould MN | Modulation of small G protein isoprenylation by anticancer monoterpenes in in situ mammary gland epithelial cells. | 1998 | Carcinogenesis | pmid:9635870 |
| Kitahara M et al. | NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery. | 1998 | Jpn. J. Pharmacol. | pmid:9681568 |
| Ren Z et al. | Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells. | 1997 | Biochem. Pharmacol. | pmid:9296357 |
| Spencer TA et al. | Feasibility of an immunoassay for mevalonolactone. | 1997 | Bioorg. Med. Chem. | pmid:9208099 |
| Komori A et al. | Anti-tumor promoting activity of canventol and its synthetic analogs through inhibition of protein isoprenylation. | 1996 | Jpn. J. Cancer Res. | pmid:8878447 |
| Honda A et al. | Effect of YM 9429, a potent teratogen, on cholesterol biosynthesis in cultured cells and rat liver microsomes. | 1996 | Steroids | pmid:8883221 |
| Field H et al. | Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei. | 1996 | Mol. Biochem. Parasitol. | pmid:8943151 |
| MartÃn D et al. | Inhibition of vitellogenin production by allatostatin in the German cockroach. | 1996 | Mol. Cell. Endocrinol. | pmid:8892320 |
| McTaggart F et al. | Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines. | 1996 | Biochem. Pharmacol. | pmid:8630089 |
| Keller RK et al. | Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. | 1996 | Arch. Biochem. Biophys. | pmid:8645011 |
| Nantais DE et al. | Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. | 1996 | J. Leukoc. Biol. | pmid:8830800 |
| Reimann FM et al. | Reduced cholesterol esterification in CaCo-2 cells by indirect action of pravastatin. | 1996 | Atherosclerosis | pmid:8831928 |
| Rea TJ et al. | Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells. | 1996 | Biochim. Biophys. Acta | pmid:8555254 |
| Doerner KC et al. | Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. | 1995 | J. Lipid Res. | pmid:7665995 |
| Latruffe N et al. | Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7503722 |
| Aspbury RA et al. | Lipid modification of signal-transducing polypeptides in the free-living nematode Caenorhabditis elegans. | 1995 | Biochem. Soc. Trans. | pmid:7758740 |
| Herold G et al. | Influence of cholesterol supply on cell growth and differentiation in cultured enterocytes (CaCo-2). | 1995 | Digestion | pmid:7895934 |
| Masters BA et al. | In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7878672 |
| Crick DC et al. | Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7794274 |
| Inglese J | Prenylation-dependent targeting of G-protein-coupled receptor kinases. | 1995 | Meth. Enzymol. | pmid:7651147 |
| Kikuchi A et al. | Purification and properties of Rab3A. | 1995 | Meth. Enzymol. | pmid:8583939 |
| Crick DC et al. | Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. | 1995 | J. Neurochem. | pmid:7643114 |
| Rogler G et al. | Effects of fluvastatin on growth of porcine and human vascular smooth muscle cells in vitro. | 1995 | Am. J. Cardiol. | pmid:7604784 |
| Kwiterovich PO and Motevalli M | Inhibition of protein tyrosine kinase alters the effect of serum basic protein I on triacylglycerols and cholesterol differently in normal and hyperapoB fibroblasts. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7627714 |
| Schroeder WA and Johnson EA | Singlet oxygen and peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodozyma. | 1995 | J. Biol. Chem. | pmid:7629161 |
| Ness GC et al. | Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. | 1994 | Arch. Biochem. Biophys. | pmid:7911291 |