Gamma-butyrolactone

Gamma-butyrolactone is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 14993 references associated with Gamma-butyrolactone in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for Gamma-butyrolactone

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gamma-butyrolactone

MeSH term MeSH ID Detail
Gram-Negative Bacterial Infections D016905 16 associated lipids
Weight Loss D015431 56 associated lipids
Stomach Ulcer D013276 75 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lung Diseases D008171 37 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Ataxia D001259 20 associated lipids
Adenocarcinoma D000230 166 associated lipids
Total 9

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Gamma-butyrolactone

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Authors Title Published Journal PubMed Link
Shaw PD et al. Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9177164
Schaefer AL et al. Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8790360
Lindemann A et al. Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21949379
Chung J et al. Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21730159
Singh L et al. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2153294
Müh U et al. A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17075036
Kato JY et al. Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17277085
Daniels R et al. Quorum signal molecules as biosurfactants affecting swarming in Rhizobium etli. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16990436
Thupari JN et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12060712
Pearson JP et al. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7878006
Hirsch J The search for new ways to treat obesity. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12093927
Menendez JA et al. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15235125
Cha SH et al. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17030788
Gao S and Lane MD Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12724522
Cha SH et al. Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16203972
Zhang HB et al. Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciens. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11930013
Parsek MR and Greenberg EP Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10922036
Ogura H Development of miracle medicines from sialic acids. 2011 Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. pmid:21670567
Jarosz LM et al. Microbial spy games and host response: roles of a Pseudomonas aeruginosa small molecule in communication with other species. 2011 PLoS Pathog. pmid:22114549
Valentine CD et al. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. 2013 PLoS Pathog. pmid:23990788