Gamma-butyrolactone

Gamma-butyrolactone is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 14993 references associated with Gamma-butyrolactone in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Gamma-butyrolactone

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gamma-butyrolactone

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Ataxia D001259 20 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Weight Loss D015431 56 associated lipids
Total 9

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Gamma-butyrolactone

Download all related citations
Per page 10 20 50 100 | Total 3467
Authors Title Published Journal PubMed Link
von Bodman SB et al. A negative regulator mediates quorum-sensing control of exopolysaccharide production in Pantoea stewartii subsp. stewartii. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9636211
Bhatt AP et al. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22752304
Chun CK et al. Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:14970327
Hastings JW Bacterial quorum-sensing signals are inactivated by mammalian cells. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15024108
Yuan ZC et al. The plant signal salicylic acid shuts down expression of the vir regulon and activates quormone-quenching genes in Agrobacterium. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17606909
Chevrot R et al. GABA controls the level of quorum-sensing signal in Agrobacterium tumefaciens. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16645034
Schiff PB and Horwitz SB Taxol stabilizes microtubules in mouse fibroblast cells. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6103535
Hu Z et al. Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15728730
Kaufmann GF et al. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15623555
Lee SE et al. Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25071191
Kumar MV et al. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11854492
Shimokawa T et al. Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11756683
Hu Z et al. Hypothalamic malonyl-CoA as a mediator of feeding behavior. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:14532332
Dong YH et al. AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10716724
Kuhajda FP et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10716717
Surette MG et al. Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9990077
Parsek MR et al. Acyl homoserine-lactone quorum-sensing signal generation. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10200267
Ogura H Development of miracle medicines from sialic acids. 2011 Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. pmid:21670567
Jarosz LM et al. Microbial spy games and host response: roles of a Pseudomonas aeruginosa small molecule in communication with other species. 2011 PLoS Pathog. pmid:22114549
Karlsson T et al. The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration. 2012 PLoS Pathog. pmid:23071436
Simon S et al. Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway. 2015 PLoS Pathog. pmid:26633832
Chu YY et al. A new class of quorum quenching molecules from Staphylococcus species affects communication and growth of gram-negative bacteria. 2013 PLoS Pathog. pmid:24098134
Valentine CD et al. X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. 2013 PLoS Pathog. pmid:23990788
Pérez-Redondo R et al. ArgR of Streptomyces coelicolor is a versatile regulator. 2012 PLoS ONE pmid:22403700
Diaz Z et al. The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF. 2009 PLoS ONE pmid:19714241
Mallegol J et al. Essential roles and regulation of the Legionella pneumophila collagen-like adhesin during biofilm formation. 2012 PLoS ONE pmid:23029523
Pan J et al. Reverting antibiotic tolerance of Pseudomonas aeruginosa PAO1 persister cells by (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one. 2012 PLoS ONE pmid:23029239
Ramli NS et al. The effect of environmental conditions on biofilm formation of Burkholderia pseudomallei clinical isolates. 2012 PLoS ONE pmid:22970167
Webb RL et al. Efficient activation of reconstructed rat embryos by cyclin-dependent kinase inhibitors. 2010 PLoS ONE pmid:20333307
Crépin A et al. Quorum sensing signaling molecules produced by reference and emerging soft-rot bacteria (Dickeya and Pectobacterium spp.). 2012 PLoS ONE pmid:22539957
Xiao L et al. Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages. 2012 PLoS ONE pmid:23226252
Mayer ML et al. The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells. 2011 PLoS ONE pmid:21305014
Verbeurgt C et al. The human bitter taste receptor T2R38 is broadly tuned for bacterial compounds. 2017 PLoS ONE pmid:28902853
Balhouse BN et al. N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro. 2017 PLoS ONE pmid:28692660
Tanui CK et al. Influence of the ferric uptake regulator (Fur) protein on pathogenicity in Pectobacterium carotovorum subsp. brasiliense. 2017 PLoS ONE pmid:28545065
López M et al. Quorum sensing network in clinical strains of A. baumannii: AidA is a new quorum quenching enzyme. 2017 PLoS ONE pmid:28328989
Zhang C et al. S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton. 2009 PLoS ONE pmid:19293927
Zhu Y et al. Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. 2017 PLoS ONE pmid:28152041
Lima DF et al. Seasonal change in main alkaloids of jaborandi (Pilocarpus microphyllus Stapf ex Wardleworth), an economically important species from the Brazilian flora. 2017 PLoS ONE pmid:28151972
Bauer JS et al. The Systematic Investigation of the Quorum Sensing System of the Biocontrol Strain Pseudomonas chlororaphis subsp. aurantiaca PB-St2 Unveils aurI to Be a Biosynthetic Origin for 3-Oxo-Homoserine Lactones. 2016 PLoS ONE pmid:27861617
Zhao LX et al. Differences in Proinflammatory Property of Six Subtypes of Peroxiredoxins and Anti-Inflammatory Effect of Ligustilide in Macrophages. 2016 PLoS ONE pmid:27716839
Galindo P et al. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. 2012 PLoS ONE pmid:22427863
Rochford K et al. Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells. 2016 PLoS ONE pmid:27537375
Mehra S et al. A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor. 2008 PLoS ONE pmid:18628968
Cheema AK et al. Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis. 2016 PLoS ONE pmid:27073845
El Sahili A et al. Natural Guided Genome Engineering Reveals Transcriptional Regulators Controlling Quorum-Sensing Signal Degradation. 2015 PLoS ONE pmid:26554837
Volova T et al. A glucose-utilizing strain, Cupriavidus euthrophus B-10646: growth kinetics, characterization and synthesis of multicomponent PHAs. 2014 PLoS ONE pmid:24586280
Kumar D et al. Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway. 2015 PLoS ONE pmid:26436418
Maisuria VB and Nerurkar AS Interference of Quorum Sensing by Delftia sp. VM4 Depends on the Activity of a Novel N-Acylhomoserine Lactone-Acylase. 2015 PLoS ONE pmid:26384328
Zucca S et al. Multi-Faceted Characterization of a Novel LuxR-Repressible Promoter Library for Escherichia coli. 2015 PLoS ONE pmid:26010244
Chiu CT et al. HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway. 2015 PLoS ONE pmid:25938237
Tominaga M et al. Rapid and liquid-based selection of genetic switches using nucleoside kinase fused with aminoglycoside phosphotransferase. 2015 PLoS ONE pmid:25790096
McFadden JW et al. Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation. 2014 PLoS ONE pmid:25541737
Kumar AS et al. Bacterial quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone causes direct cytotoxicity and reduced cell motility in human pancreatic carcinoma cells. 2014 PLoS ONE pmid:25188245
Kamaeva AA et al. Atomic force microscopy reveals a morphological differentiation of chromobacterium violaceum cells associated with biofilm development and directed by N-hexanoyl-L-homoserine lactone. 2014 PLoS ONE pmid:25111599
O'Grady EP et al. A unique regulator contributes to quorum sensing and virulence in Burkholderia cenocepacia. 2012 PLoS ONE pmid:22624054
De Stefano D et al. Cacospongionolide and scalaradial, two marine sesterterpenoids as potent apoptosis-inducing factors in human carcinoma cell lines. 2012 PLoS ONE pmid:22509253
Gardères J et al. Cellular effects of bacterial N-3-Oxo-dodecanoyl-L-Homoserine lactone on the sponge Suberites domuncula (Olivi, 1792): insights into an intimate inter-kingdom dialogue. 2014 PLoS ONE pmid:24858701
Pellinen J and Szentirmai É The effects of C75, an inhibitor of fatty acid synthase, on sleep and metabolism in mice. 2012 PLoS ONE pmid:22348016
Viswanathan K et al. Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes. 2012 PLoS ONE pmid:22347365
Kim MJ et al. PEP-1-PON1 protein regulates inflammatory response in raw 264.7 macrophages and ameliorates inflammation in a TPA-induced animal model. 2014 PLoS ONE pmid:24465855
Nobels I et al. Toxicity ranking and toxic mode of action evaluation of commonly used agricultural adjuvants on the basis of bacterial gene expression profiles. 2011 PLoS ONE pmid:22125591
Chorna NE et al. Fatty acid synthase as a factor required for exercise-induced cognitive enhancement and dentate gyrus cellular proliferation. 2013 PLoS ONE pmid:24223732
Zhang YF et al. Acute toxicity of the antifouling compound butenolide in non-target organisms. 2011 PLoS ONE pmid:21897857
Rumbo-Feal S et al. Whole transcriptome analysis of Acinetobacter baumannii assessed by RNA-sequencing reveals different mRNA expression profiles in biofilm compared to planktonic cells. 2013 PLoS ONE pmid:24023660
Chatterjee A et al. Convergent transcription in the butyrolactone regulon in Streptomyces coelicolor confers a bistable genetic switch for antibiotic biosynthesis. 2011 PLoS ONE pmid:21765930
Arora S et al. Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. 2011 PLoS ONE pmid:21720559
Véras LM et al. Industrial Scale Isolation, Structural and Spectroscopic Characterization of Epiisopiloturine from Pilocarpus microphyllus Stapf Leaves: A Promising Alkaloid against Schistosomiasis. 2013 PLoS ONE pmid:23840522
Yin J et al. The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells. 2013 PLoS ONE pmid:23805245
Khamviwath V et al. A continuum model of actin waves in Dictyostelium discoideum. 2013 PLoS ONE pmid:23741312
Guimarães MA et al. Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni. 2015 PLoS Negl Trop Dis pmid:25816129
Long T et al. Quantifying the integration of quorum-sensing signals with single-cell resolution. 2009 PLoS Biol. pmid:19320539
Jayachandran R et al. Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling. 2014 PLoS Biol. pmid:24667537
Cunha NL et al. (-)-Hinokinin Induces G2/M Arrest and Contributes to the Antiproliferative Effects of Doxorubicin in Breast Cancer Cells. 2016 Planta Med. pmid:27002393
Zheng YZ et al. Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis. 2010 Planta Med. pmid:19847742
Fall D et al. A new adjacent bis-tetrahydrofuran annonaceous acetogenin from the seeds of Uvaria chamae. 2006 Planta Med. pmid:16868865
Tsai IL et al. Cytotoxic butanolides from the stem bark of Formosan Lindera communis. 2001 Planta Med. pmid:11745027
Gleye C et al. Coronin from roots of Annona muricata, a putative intermediate in acetogenin biosynthesis (1). 2001 Planta Med. pmid:11509986
Waters MT et al. Karrikins force a rethink of strigolactone mode of action. 2012 Plant Signal Behav pmid:22827937
Zorrilla-Fontanesi Y et al. Genetic analysis of strawberry fruit aroma and identification of O-methyltransferase FaOMT as the locus controlling natural variation in mesifurane content. 2012 Plant Physiol. pmid:22474217
Nomura T et al. A novel lactone-forming carboxylesterase: molecular identification of a tuliposide A-converting enzyme in tulip. 2012 Plant Physiol. pmid:22474185
Nelson DC et al. Karrikins discovered in smoke trigger Arabidopsis seed germination by a mechanism requiring gibberellic acid synthesis and light. 2009 Plant Physiol. pmid:19074625
Morquecho-Contreras A et al. Characterization of drr1, an alkamide-resistant mutant of Arabidopsis, reveals an important role for small lipid amides in lateral root development and plant senescence. 2010 Plant Physiol. pmid:20107026
Bai X et al. N-3-oxo-decanoyl-L-homoserine-lactone activates auxin-induced adventitious root formation via hydrogen peroxide- and nitric oxide-dependent cyclic GMP signaling in mung bean. 2012 Plant Physiol. pmid:22138973
Teplitski M et al. Chlamydomonas reinhardtii secretes compounds that mimic bacterial signals and interfere with quorum sensing regulation in bacteria. 2004 Plant Physiol. pmid:14671013
Bayindir U et al. Hinokinin biosynthesis in Linum corymbulosum Reichenb. 2008 Plant J. pmid:18489708
Schuhegger R et al. Induction of systemic resistance in tomato by N-acyl-L-homoserine lactone-producing rhizosphere bacteria. 2006 Plant Cell Environ. pmid:17087474
Wheeler GL et al. Acyl-homoserine lactones modulate the settlement rate of zoospores of the marine alga Ulva intestinalis via a novel chemokinetic mechanism. 2006 Plant Cell Environ. pmid:17080611
Kumrit I et al. Labdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cells. 2010 Phytother Res pmid:19960422
Guzman JD et al. Antimycobacterials from lovage root (Ligusticum officinale Koch). 2013 Phytother Res pmid:22899555
Uto T et al. Anti-inflammatory Activity of Constituents Isolated from Aerial Part of Angelica acutiloba Kitagawa. 2015 Phytother Res pmid:26463105
McClean AE et al. AHL signals induce rubrifacine production in a bruI mutant of Brenneria rubrifaciens. 2012 Phytopathology pmid:22236075
Song Z et al. Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection. 2010 Phytomedicine pmid:20554187
Bucar F et al. Anti-proliferative lichen compounds with inhibitory activity on 12(S)-HETE production in human platelets. 2004 Phytomedicine pmid:15636173
Ammar S et al. Spasmolytic and anti-inflammatory effects of constituents from Hertia cheirifolia. 2009 Phytomedicine pmid:19403291
Su S et al. Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells. 2015 Phytomedicine pmid:25765837
Zhang WL et al. Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications. 2012 Phytomedicine pmid:22902230
Kuehnl S et al. Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase. 2013 Phytomedicine pmid:23867649
Lübken T et al. Hygrophorones A-G: fungicidal cyclopentenones from Hygrophorus species (Basidiomycetes). 2004 Phytochemistry pmid:15110686
Aparicio S and Alcalde R Characterization of two lactones in liquid phase: an experimental and computational approach. 2009 Phys Chem Chem Phys pmid:19809678