King KL et al. |
Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power. |
2005 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:15821035
|
Oikawa S |
[Is hyperfattyacidemia related to the occurrence of diabetes?]. |
2005 |
Nippon Rinsho |
pmid:15779455
|
Jeong JC et al. |
Exploiting the reaction flexibility of a type III polyketide synthase through in vitro pathway manipulation. |
2005 |
J. Am. Chem. Soc. |
pmid:15631450
|
Raney MA et al. |
AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction. |
2005 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:15547141
|
Bian F et al. |
Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. |
2005 |
J. Biol. Chem. |
pmid:15611129
|
Liu H et al. |
Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. |
2005 |
J. Biol. Chem. |
pmid:15579906
|
Taylor EB et al. |
Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25. |
2005 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:15644453
|
Koves TR et al. |
Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism. |
2005 |
Am. J. Physiol., Cell Physiol. |
pmid:15647392
|
Lane MD et al. |
Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure. |
2005 |
Biochem. Soc. Trans. |
pmid:16246046
|
Kelley DE |
Pulling in more fat. |
2005 |
Cell Metab. |
pmid:16271525
|
Hu Z et al. |
A role for hypothalamic malonyl-CoA in the control of food intake. |
2005 |
J. Biol. Chem. |
pmid:16219771
|
Abu-Elheiga L et al. |
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16103361
|
Mizuarai S et al. |
Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. |
2005 |
J. Biol. Chem. |
pmid:16027120
|
Funa N et al. |
A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides. |
2005 |
J. Biol. Chem. |
pmid:15701630
|
Rendina AR and Cheng D |
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates. |
2005 |
Biochem. J. |
pmid:15715522
|
Oh W et al. |
Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:15677334
|
Herrero L et al. |
Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion. |
2005 |
Diabetes |
pmid:15677504
|
Abe I et al. |
A plant type III polyketide synthase that produces pentaketide chromone. |
2005 |
J. Am. Chem. Soc. |
pmid:15686354
|
Giordano A et al. |
tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1. |
2005 |
Cell Death Differ. |
pmid:15846373
|
Dowell P et al. |
Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. |
2005 |
Annu. Rev. Biochem. |
pmid:15952896
|
Mingrone G et al. |
Leptin pulsatility in formerly obese women. |
2005 |
FASEB J. |
pmid:15955844
|
Assifi MM et al. |
AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. |
2005 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:15956049
|
Lelliott CJ et al. |
Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. |
2005 |
FASEB J. |
pmid:15985534
|
Cha SH et al. |
Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:16203972
|
Spiteller D et al. |
A method for trapping intermediates of polyketide biosynthesis with a nonhydrolyzable malonyl-coenzyme A analogue. |
2005 |
Angew. Chem. Int. Ed. Engl. |
pmid:16208728
|
Roepstorff C et al. |
Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. |
2005 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:15383373
|
Yang N et al. |
C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA. |
2005 |
J. Pharmacol. Exp. Ther. |
pmid:15356215
|
Götz T and Böger P |
The very-long-chain fatty acid synthase is inhibited by chloroacetamides. |
2004 Jul-Aug |
Z. Naturforsch., C, J. Biosci. |
pmid:15813378
|
Griffin MJ and Sul HS |
Insulin regulation of fatty acid synthase gene transcription: roles of USF and SREBP-1c. |
2004 |
IUBMB Life |
pmid:15814457
|
Shirai Y et al. |
Metabolic regulation of leptin production in adipocytes: a role of fatty acid synthesis intermediates. |
2004 |
J. Nutr. Biochem. |
pmid:15590268
|
Foster DW |
The role of the carnitine system in human metabolism. |
2004 |
Ann. N. Y. Acad. Sci. |
pmid:15590999
|
Dulloo AG et al. |
Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity. |
2004 |
Int. J. Obes. Relat. Metab. Disord. |
pmid:15592483
|
Yu X et al. |
Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. |
2004 |
Diabetologia |
pmid:15578153
|
Reszko AE et al. |
Peroxisomal fatty acid oxidation is a substantial source of the acetyl moiety of malonyl-CoA in rat heart. |
2004 |
J. Biol. Chem. |
pmid:14982940
|
Abe I et al. |
The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide. |
2004 |
FEBS Lett. |
pmid:15044020
|
Roduit R et al. |
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. |
2004 |
Diabetes |
pmid:15047616
|
Degrace P et al. |
Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid. |
2004 |
J. Nutr. |
pmid:15051838
|
Sleeman MC and Schofield CJ |
Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis. |
2004 |
J. Biol. Chem. |
pmid:14625287
|
Buemann B and Astrup AV |
[Lipogenesis: does it have a relevance in the obesity research?]. |
2004 |
Ugeskr. Laeg. |
pmid:15487518
|
Oguro S et al. |
Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:15530429
|
Nicot C et al. |
C75 activates malonyl-CoA sensitive and insensitive components of the CPT system. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:15541339
|
Zhang YQ et al. |
Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans. |
2004 |
Genetics |
pmid:15514053
|
Cheng L et al. |
Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. |
2004 |
Nat. Med. |
pmid:15475963
|
Bezaire V et al. |
Regulation of CPT I activity in intermyofibrillar and subsarcolemmal mitochondria from human and rat skeletal muscle. |
2004 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:12954596
|
Traufeller K et al. |
Different sensitivities of CPT I and CPT II for inhibition by l-aminocarnitine in human skeletal muscle. |
2004 |
Biochim. Biophys. Acta |
pmid:14871492
|
Chandler MP et al. |
Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation. |
2004 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:15191896
|
Lee GY et al. |
Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. |
2004 |
Biochem. J. |
pmid:14641110
|
Gande R et al. |
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. |
2004 |
J. Biol. Chem. |
pmid:15308633
|
Kerner J et al. |
Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme. |
2004 |
J. Biol. Chem. |
pmid:15247243
|
Onay-Besikci A et al. |
gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts. |
2004 |
J. Biol. Chem. |
pmid:15269215
|
Rodriguez E et al. |
Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae. |
2004 |
Appl. Microbiol. Biotechnol. |
pmid:15179529
|
Reszko AE et al. |
Regulation of malonyl-CoA concentration and turnover in the normal heart. |
2004 |
J. Biol. Chem. |
pmid:15181001
|
Harwood HJ |
Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome. |
2004 |
Curr Opin Investig Drugs |
pmid:15083594
|
Unger RH |
The hyperleptinemia of obesity-regulator of caloric surpluses. |
2004 |
Cell |
pmid:15084251
|
Dyck JR et al. |
Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. |
2004 |
Circ. Res. |
pmid:15105298
|
Ruderman N and Prentki M |
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. |
2004 |
Nat Rev Drug Discov |
pmid:15060529
|
Raharjo TJ et al. |
Cloning and over-expression of a cDNA encoding a polyketide synthase from Cannabis sativa. |
2004 |
Plant Physiol. Biochem. |
pmid:15120113
|
Minkler PE et al. |
Isolation and identification of two isomeric forms of malonyl-coenzyme A in commercial malonyl-coenzyme A. |
2004 |
Anal. Biochem. |
pmid:15113698
|
Saha AK et al. |
Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:14733947
|
Tseng CC et al. |
Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. |
2004 |
Biochemistry |
pmid:14744141
|
Relat J et al. |
Pig muscle carnitine palmitoyltransferase I (CPTI beta), with low Km for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTI alpha) enzyme. |
2004 |
Biochemistry |
pmid:15449958
|
Slade RF et al. |
Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines. |
2003 Mar-Apr |
Anticancer Res. |
pmid:12820377
|
Rosa G et al. |
Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects. |
2003 |
Obes. Res. |
pmid:14627750
|
Onay-Besikci A et al. |
Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart. |
2003 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:12388233
|
Gutières S et al. |
Cloning and tissue distribution of a carnitine palmitoyltransferase I gene in rainbow trout (Oncorhynchus mykiss). |
2003 |
Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |
pmid:12781981
|
Focke M et al. |
Fatty acid biosynthesis in mitochondria of grasses: malonyl-coenzyme A is generated by a mitochondrial-localized acetyl-coenzyme A carboxylase. |
2003 |
Plant Physiol. |
pmid:12972648
|
Boren J et al. |
The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation. |
2003 |
J. Biol. Chem. |
pmid:12750369
|
Nicholson TP et al. |
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination. |
2003 |
Chem. Commun. (Camb.) |
pmid:12703773
|
Zhu H et al. |
Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding. |
2003 |
Arch. Biochem. Biophys. |
pmid:12706342
|
Kajikawa M et al. |
Functional analysis of a beta-ketoacyl-CoA synthase gene, MpFAE2, by gene silencing in the liverwort Marchantia polymorpha L. |
2003 |
Biosci. Biotechnol. Biochem. |
pmid:12723610
|
Wortman MD et al. |
C75 inhibits food intake by increasing CNS glucose metabolism. |
2003 |
Nat. Med. |
pmid:12724740
|
Lehtihet M et al. |
Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis. |
2003 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:12684219
|
Schujman GE et al. |
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis. |
2003 |
Dev. Cell |
pmid:12737802
|
Treber M et al. |
Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity. |
2003 |
J. Biol. Chem. |
pmid:12540837
|
Ruderman NB et al. |
Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. |
2003 |
Biochem. Soc. Trans. |
pmid:12546685
|
Hopkins TA et al. |
AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart. |
2003 |
Biochem. Soc. Trans. |
pmid:12546686
|
Suzuki H et al. |
Proposed mechanism and functional amino acid residues of malonyl-CoA:anthocyanin 5-O-glucoside-6'''-O-malonyltransferase from flowers of Salvia splendens, a member of the versatile plant acyltransferase family. |
2003 |
Biochemistry |
pmid:12578391
|
Hügler M et al. |
Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation. |
2003 |
Eur. J. Biochem. |
pmid:12581213
|
Cheng YQ et al. |
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12598647
|
Prigge ST et al. |
The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. |
2003 |
Biochemistry |
pmid:12549938
|
Wang F et al. |
Inhibitive effect of zinc ion on fatty acid synthase from chicken liver. |
2003 |
Int. J. Biochem. Cell Biol. |
pmid:12531252
|
Dai J et al. |
Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity. |
2003 |
Biochem. Biophys. Res. Commun. |
pmid:12565845
|
Liou GF et al. |
Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. |
2003 |
Biochemistry |
pmid:12515555
|
Steinberg GR et al. |
AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. |
2003 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:12441311
|
BÃ¥venholm PN et al. |
Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. |
2003 |
J. Clin. Endocrinol. Metab. |
pmid:12519834
|
Morillas M et al. |
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. |
2003 |
J. Biol. Chem. |
pmid:12499375
|
Zhang L et al. |
Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. |
2003 |
J. Biol. Chem. |
pmid:12882974
|
Kiens B and Roepstorff C |
Utilization of long-chain fatty acids in human skeletal muscle during exercise. |
2003 |
Acta Physiol. Scand. |
pmid:12864744
|
Ruderman NB et al. |
AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. |
2003 |
Acta Physiol. Scand. |
pmid:12864749
|
Dawe JH et al. |
A template search reveals mechanistic similarities and differences in beta-ketoacyl synthases (KAS) and related enzymes. |
2003 |
Proteins |
pmid:12866053
|
Molnos J et al. |
A continuous coupled enzyme assay for bacterial malonyl-CoA:acyl carrier protein transacylase (FabD). |
2003 |
Anal. Biochem. |
pmid:12842120
|
Harwood HJ et al. |
Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. |
2003 |
J. Biol. Chem. |
pmid:12842871
|
Ruderman NB et al. |
Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. |
2003 |
Endocrinology |
pmid:14500570
|
Mazur MT et al. |
Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. |
2003 |
Biochemistry |
pmid:14621984
|
Eckermann C et al. |
Covalent binding of chloroacetamide herbicides to the active site cysteine of plant type III polyketide synthases. |
2003 |
Phytochemistry |
pmid:14568070
|
Frayn KN |
The glucose-fatty acid cycle: a physiological perspective. |
2003 |
Biochem. Soc. Trans. |
pmid:14641007
|
Hu Z et al. |
Hypothalamic malonyl-CoA as a mediator of feeding behavior. |
2003 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:14532332
|
Weiss DR and Glickman JF |
Characterization of fatty acid synthase activity using scintillation proximity. |
2003 |
Assay Drug Dev Technol |
pmid:15090142
|
Shafrir E et al. |
Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. |
2002 May-Jun |
Diabetes Metab. Res. Rev. |
pmid:12112940
|
Takahashi H et al. |
Inhibition of very-long-chain fatty acid formation by indanofan, 2-[2-(3-chlorophenyl)oxiran-2-ylmethyl]-2-ethylindan-1,3-dione, and its relatives. |
2002 Jan-Feb |
Z. Naturforsch., C, J. Biosci. |
pmid:11926546
|