Lmfa07050031

Lmfa07050031 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Pigment and Polymerization. The related lipids are Propionate.

Cross Reference

Introduction

To understand associated biological information of Lmfa07050031, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lmfa07050031?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lmfa07050031

MeSH term MeSH ID Detail
Hyperinsulinism D006946 27 associated lipids
Hypertension D006973 115 associated lipids
Hypoglycemia D007003 13 associated lipids
Hypothyroidism D007037 32 associated lipids
Insulin Resistance D007333 99 associated lipids
Ketosis D007662 13 associated lipids
Medulloblastoma D008527 22 associated lipids
Mercury Poisoning D008630 4 associated lipids
Placental Insufficiency D010927 6 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Per page 10 20 50 | Total 27

PubChem Associated disorders and diseases

What pathways are associated with Lmfa07050031

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lmfa07050031?

There are no associated biomedical information in the current reference collection.

What functions are associated with Lmfa07050031?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Lmfa07050031?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Lmfa07050031?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Lmfa07050031?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Lmfa07050031

Download all related citations
Per page 10 20 50 100 | Total 787
Authors Title Published Journal PubMed Link
McGarry JD et al. Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay. 1978 J. Biol. Chem. pmid:711752
Rangan VS et al. Fatty acid synthase dimers containing catalytically active beta-ketoacyl synthase or malonyl/acetyltransferase domains in only one subunit can support fatty acid synthesis at the acyl carrier protein domains of both subunits. 1998 J. Biol. Chem. pmid:9857025
Antinozzi PA et al. Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis. 1998 J. Biol. Chem. pmid:9632669
Velasco G et al. Malonyl-CoA-independent acute control of hepatic carnitine palmitoyltransferase I activity. Role of Ca2+/calmodulin-dependent protein kinase II and cytoskeletal components. 1998 J. Biol. Chem. pmid:9705278
Hoppel CL et al. The malonyl-CoA-sensitive form of carnitine palmitoyltransferase is not localized exclusively in the outer membrane of rat liver mitochondria. 1998 J. Biol. Chem. pmid:9722587
Kim YS and Kolattukudy PE Stereospecificity of malonyl-CoA decarboxylase, acetyl-CoA carboxylase, and fatty acid synthetase from the uropygial gland of goose. 1980 J. Biol. Chem. pmid:6101330
Price NT et al. Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues. 2010 J. Biol. Chem. pmid:20061394
Cook GA The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase. 1987 J. Biol. Chem. pmid:3104327
Saddik M et al. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. 1993 J. Biol. Chem. pmid:7902355
Guay C et al. A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion. 2007 J. Biol. Chem. pmid:17928289
Li S et al. Molecular analysis of the role of tyrosine 224 in the active site of Streptomyces coelicolor RppA, a bacterial type III polyketide synthase. 2007 J. Biol. Chem. pmid:17331946
Campbell FM et al. A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. 2002 J. Biol. Chem. pmid:11734553
Morillas M et al. Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity. 2001 J. Biol. Chem. pmid:11553629
López-Viñas E et al. Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A. 2007 J. Biol. Chem. pmid:17452323
Kerner J et al. Characterization of the malonyl-CoA-sensitive carnitine palmitoyltransferase (CPTo) of a rat heart mitochondrial particle. Evidence that the catalytic unit is CPTi. 1994 J. Biol. Chem. pmid:8132545
Cook GA et al. Yonetani-Theorell analysis of hepatic carnitine palmitoyltransferase-I inhibition indicates two distinct inhibitory binding sites. 1994 J. Biol. Chem. pmid:8132614
Nicot C et al. Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity. 2002 J. Biol. Chem. pmid:11790778
Morillas M et al. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. 2002 J. Biol. Chem. pmid:11790793
Esser V et al. Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function. 1993 J. Biol. Chem. pmid:8449948
Funabashi M et al. Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus. 2008 J. Biol. Chem. pmid:18364359
Thampy KG Formation of malonyl coenzyme A in rat heart. Identification and purification of an isozyme of A carboxylase from rat heart. 1989 J. Biol. Chem. pmid:2572585
Jackowski S et al. Acetoacetyl-acyl carrier protein synthase. A target for the antibiotic thiolactomycin. 1989 J. Biol. Chem. pmid:2651445
Heath RJ and Rock CO Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli. 1996 J. Biol. Chem. pmid:8567624
Bian F et al. Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. 2005 J. Biol. Chem. pmid:15611129
Liu H et al. Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. 2005 J. Biol. Chem. pmid:15579906
Atkinson LL et al. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. 2002 J. Biol. Chem. pmid:12058043
Pan Y et al. The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding. 2002 J. Biol. Chem. pmid:12351641
Lopaschuk GD et al. Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. 1994 J. Biol. Chem. pmid:7929291
Hu Z et al. A role for hypothalamic malonyl-CoA in the control of food intake. 2005 J. Biol. Chem. pmid:16219771
Brown NF et al. Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast establishes that catalytic activity and malonyl-CoA sensitivity reside in a single polypeptide. 1994 J. Biol. Chem. pmid:7929364
Mizuarai S et al. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. 2005 J. Biol. Chem. pmid:16027120
Decaux JF et al. Decreased hepatic fatty acid oxidation at weaning in the rat is not linked to a variation of malonyl-CoA concentration. 1988 J. Biol. Chem. pmid:2893801
Funa N et al. A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides. 2005 J. Biol. Chem. pmid:15701630
Cook GA and Gamble MS Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA. 1987 J. Biol. Chem. pmid:2950085
Boren J et al. The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation. 2003 J. Biol. Chem. pmid:12750369
Treber M et al. Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity. 2003 J. Biol. Chem. pmid:12540837
Wolfgang MJ and Lane MD The role of hypothalamic malonyl-CoA in energy homeostasis. 2006 J. Biol. Chem. pmid:17018521
Harwood HJ et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. 2003 J. Biol. Chem. pmid:12842871
Mulder H et al. Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells. 2001 J. Biol. Chem. pmid:11113153
Roduit R et al. Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. 2000 J. Biol. Chem. pmid:10967113
Jackson VN et al. Identification of positive and negative determinants of malonyl-CoA sensitivity and carnitine affinity within the amino termini of rat liver- and muscle-type carnitine palmitoyltransferase I. 2000 J. Biol. Chem. pmid:10969089
Declercq PE et al. Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors. 1987 J. Biol. Chem. pmid:3597441
Kudo N et al. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. 1995 J. Biol. Chem. pmid:7615556
Cook GA Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values. 1984 J. Biol. Chem. pmid:6480597
Soulié JM et al. Transient kinetic studies of fatty acid synthetase. A kinetic self-editing mechanism for the loading of acetyl and malonyl residues and the role of coenzyme A. 1984 J. Biol. Chem. pmid:6706923
Gokulan K et al. Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. 2013 J. Biol. Chem. pmid:23615910
Gande R et al. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. 2004 J. Biol. Chem. pmid:15308633
Rangan VS and Smith S Expression in Escherichia coli and refolding of the malonyl-/acetyltransferase domain of the multifunctional animal fatty acid synthase. 1996 J. Biol. Chem. pmid:8940200
Rangan VS and Smith S Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue. 1997 J. Biol. Chem. pmid:9115261
McGarry JD et al. Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA. 1978 J. Biol. Chem. pmid:659409