Lmfa07050031

Lmfa07050031 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Pigment and Polymerization. The related lipids are Propionate.

Cross Reference

Introduction

To understand associated biological information of Lmfa07050031, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lmfa07050031?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lmfa07050031

MeSH term MeSH ID Detail
Medulloblastoma D008527 22 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Loss D015431 56 associated lipids
Myocardial Stunning D017682 10 associated lipids
Cleft Lip D002971 8 associated lipids
Mitochondrial Myopathies D017240 13 associated lipids
Mercury Poisoning D008630 4 associated lipids
Per page 10 20 50 | Total 27

PubChem Associated disorders and diseases

What pathways are associated with Lmfa07050031

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lmfa07050031?

There are no associated biomedical information in the current reference collection.

What functions are associated with Lmfa07050031?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Lmfa07050031?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Lmfa07050031?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Lmfa07050031?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Lmfa07050031

Download all related citations
Per page 10 20 50 100 | Total 787
Authors Title Published Journal PubMed Link
Shafrir E et al. Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. 2002 May-Jun Diabetes Metab. Res. Rev. pmid:12112940
Ghanevati M and Jaworski JG Engineering and mechanistic studies of the Arabidopsis FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS. 2002 Eur. J. Biochem. pmid:12135493
Florova G et al. Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity. 2002 Biochemistry pmid:12173933
Zheng X et al. Substrate binding induces a cooperative conformational change in the 12S subunit of transcarboxylase: Raman crystallographic evidence. 2002 Biochemistry pmid:12196011
Witkowski A et al. Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase. 2002 Biochemistry pmid:12196027
Poirier M et al. Probing the link between citrate and malonyl-CoA in perfused rat hearts. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12234788
Noda M [Mechanism of glucose-induced insulin secretion]. 2002 Nippon Rinsho pmid:12238044
Verhoeyen ME et al. Increasing antioxidant levels in tomatoes through modification of the flavonoid biosynthetic pathway. 2002 J. Exp. Bot. pmid:12324533
Pan Y et al. The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding. 2002 J. Biol. Chem. pmid:12351641
Schwarzer D et al. Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12384573
Laviano A et al. Energy expenditure and treating obesity. 2002 Science pmid:12387285
Onay-Besikci A et al. Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12388233
Dyck JR and Lopaschuk GD Malonyl CoA control of fatty acid oxidation in the ischemic heart. 2002 J. Mol. Cell. Cardiol. pmid:12392882
Ishihara H and Oka Y [Mitochondria as the signal generator in the metabolism-secretion coupling in pancreatic beta cells]. 2002 Nippon Rinsho pmid:12430299
Park SH et al. Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle. 2002 J. Appl. Physiol. pmid:12433937
Steinberg GR et al. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12441311
Tomas E et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12456889
Jensen MD Fatty acid oxidation in human skeletal muscle. 2002 J. Clin. Invest. pmid:12464664
Rasmussen BB et al. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. 2002 J. Clin. Invest. pmid:12464674
Prentki M et al. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. 2002 Diabetes pmid:12475783
Morillas M et al. Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. 2003 J. Biol. Chem. pmid:12499375
Liou GF et al. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. 2003 Biochemistry pmid:12515555
BÃ¥venholm PN et al. Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. 2003 J. Clin. Endocrinol. Metab. pmid:12519834
Wang F et al. Inhibitive effect of zinc ion on fatty acid synthase from chicken liver. 2003 Int. J. Biochem. Cell Biol. pmid:12531252
Treber M et al. Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity. 2003 J. Biol. Chem. pmid:12540837
Ruderman NB et al. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. 2003 Biochem. Soc. Trans. pmid:12546685
Hopkins TA et al. AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart. 2003 Biochem. Soc. Trans. pmid:12546686
Prigge ST et al. The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. 2003 Biochemistry pmid:12549938
Dai J et al. Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity. 2003 Biochem. Biophys. Res. Commun. pmid:12565845
Suzuki H et al. Proposed mechanism and functional amino acid residues of malonyl-CoA:anthocyanin 5-O-glucoside-6'''-O-malonyltransferase from flowers of Salvia splendens, a member of the versatile plant acyltransferase family. 2003 Biochemistry pmid:12578391
Hügler M et al. Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation. 2003 Eur. J. Biochem. pmid:12581213
Cheng YQ et al. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12598647
Sorensen A et al. Localization of messenger RNAs encoding enzymes associated with malonyl-CoA metabolism in mouse brain. 2002 Brain Res. Gene Expr. Patterns pmid:12638127
Lehtihet M et al. Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12684219
Nicholson TP et al. First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination. 2003 Chem. Commun. (Camb.) pmid:12703773
Zhu H et al. Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding. 2003 Arch. Biochem. Biophys. pmid:12706342
Kajikawa M et al. Functional analysis of a beta-ketoacyl-CoA synthase gene, MpFAE2, by gene silencing in the liverwort Marchantia polymorpha L. 2003 Biosci. Biotechnol. Biochem. pmid:12723610
Wortman MD et al. C75 inhibits food intake by increasing CNS glucose metabolism. 2003 Nat. Med. pmid:12724740
Schujman GE et al. FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis. 2003 Dev. Cell pmid:12737802
Boren J et al. The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation. 2003 J. Biol. Chem. pmid:12750369
Gutières S et al. Cloning and tissue distribution of a carnitine palmitoyltransferase I gene in rainbow trout (Oncorhynchus mykiss). 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:12781981
Slade RF et al. Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines. 2003 Mar-Apr Anticancer Res. pmid:12820377
Molnos J et al. A continuous coupled enzyme assay for bacterial malonyl-CoA:acyl carrier protein transacylase (FabD). 2003 Anal. Biochem. pmid:12842120
Harwood HJ et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. 2003 J. Biol. Chem. pmid:12842871
Kiens B and Roepstorff C Utilization of long-chain fatty acids in human skeletal muscle during exercise. 2003 Acta Physiol. Scand. pmid:12864744
Ruderman NB et al. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. 2003 Acta Physiol. Scand. pmid:12864749
Dawe JH et al. A template search reveals mechanistic similarities and differences in beta-ketoacyl synthases (KAS) and related enzymes. 2003 Proteins pmid:12866053
Zhang L et al. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. 2003 J. Biol. Chem. pmid:12882974
Bezaire V et al. Regulation of CPT I activity in intermyofibrillar and subsarcolemmal mitochondria from human and rat skeletal muscle. 2004 Am. J. Physiol. Endocrinol. Metab. pmid:12954596
Focke M et al. Fatty acid biosynthesis in mitochondria of grasses: malonyl-coenzyme A is generated by a mitochondrial-localized acetyl-coenzyme A carboxylase. 2003 Plant Physiol. pmid:12972648
Duan C and Winder WW Nerve stimulation decreases malonyl-CoA in skeletal muscle. 1992 J. Appl. Physiol. pmid:1349012
Kikuchi S and Kolattukudy PE Immobilization of fatty acid synthetase from Mycobacterium smegmatis by radiation-induced polymerization. 1990 Agric. Biol. Chem. pmid:1368562
Spencer JB and Jordan PM Investigation of the mechanism and steric course of the reaction catalyzed by 6-methylsalicylic acid synthase from Penicillium patulum using (R)-[1-13C;2-2H]- and (S)-[1-13C;2-2H]malonates. 1992 Biochemistry pmid:1390697
Chung CH et al. Conferral of malonyl coenzyme A sensitivity to purified rat heart mitochondrial carnitine palmitoyltransferase. 1992 Biochemistry pmid:1390753
Ghadiminejad I and Saggerson D Physiological state and the sensitivity of liver mitochondrial outer membrane carnitine palmitoyltransferase to malonyl-CoA. Correlations with assay temperature, salt concentration and membrane lipid composition. 1992 Int. J. Biochem. pmid:1397505
McGarry JD et al. Insights into the topography of mitochondrial carnitine palmitoyltransferase gained from the use of proteases. 1992 Prog. Clin. Biol. Res. pmid:1438389
Ruderman NB et al. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. 2003 Endocrinology pmid:14500570
Hu Z et al. Hypothalamic malonyl-CoA as a mediator of feeding behavior. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:14532332
Eckermann C et al. Covalent binding of chloroacetamide herbicides to the active site cysteine of plant type III polyketide synthases. 2003 Phytochemistry pmid:14568070
Mazur MT et al. Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. 2003 Biochemistry pmid:14621984
Sleeman MC and Schofield CJ Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis. 2004 J. Biol. Chem. pmid:14625287
Rosa G et al. Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects. 2003 Obes. Res. pmid:14627750
Frayn KN The glucose-fatty acid cycle: a physiological perspective. 2003 Biochem. Soc. Trans. pmid:14641007
Lee GY et al. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. 2004 Biochem. J. pmid:14641110
Guzmán M et al. Pre- and postnatal protein undernutrition increases hepatic carnitine palmitoyltransferase I activity and decreases enzyme sensitivity to inhibitors in the suckling rat. 1992 Horm. Metab. Res. pmid:1464412
Saha AK et al. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. 2004 Biochem. Biophys. Res. Commun. pmid:14733947
Tseng CC et al. Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. 2004 Biochemistry pmid:14744141
Cook GA and Lappi MD Carnitine palmitoyltransferase in the heart is controlled by a different mechanism than the hepatic enzyme. 1992 Mol. Cell. Biochem. pmid:1480153
Traufeller K et al. Different sensitivities of CPT I and CPT II for inhibition by l-aminocarnitine in human skeletal muscle. 2004 Biochim. Biophys. Acta pmid:14871492
Saggerson D et al. Regulation of mitochondrial carnitine palmitoyl transferases from liver and extrahepatic tissues. 1992 Adv. Enzyme Regul. pmid:1496923
Reszko AE et al. Peroxisomal fatty acid oxidation is a substantial source of the acetyl moiety of malonyl-CoA in rat heart. 2004 J. Biol. Chem. pmid:14982940
Abe I et al. The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide. 2004 FEBS Lett. pmid:15044020
Roduit R et al. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. 2004 Diabetes pmid:15047616
Degrace P et al. Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid. 2004 J. Nutr. pmid:15051838
Ruderman N and Prentki M AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. 2004 Nat Rev Drug Discov pmid:15060529
Harwood HJ Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome. 2004 Curr Opin Investig Drugs pmid:15083594
Unger RH The hyperleptinemia of obesity-regulator of caloric surpluses. 2004 Cell pmid:15084251
Weiss DR and Glickman JF Characterization of fatty acid synthase activity using scintillation proximity. 2003 Assay Drug Dev Technol pmid:15090142
Dyck JR et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. 2004 Circ. Res. pmid:15105298
Morita N et al. Synthesis in vitro of very long chain fatty acids in Vibrio sp. strain ABE-1. 1992 Arch. Microbiol. pmid:1510554
Minkler PE et al. Isolation and identification of two isomeric forms of malonyl-coenzyme A in commercial malonyl-coenzyme A. 2004 Anal. Biochem. pmid:15113698
Raharjo TJ et al. Cloning and over-expression of a cDNA encoding a polyketide synthase from Cannabis sativa. 2004 Plant Physiol. Biochem. pmid:15120113
Ghadiminejad I and Saggerson D Use of mitochondrial inner membrane proteins and phospholipids to facilitate disengagement of the catalytic and malonyl-CoA binding components of carnitine palmitoyltransferase from liver mitochondrial outer membranes. 1992 Int. J. Biochem. pmid:1516729
Rodriguez E et al. Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae. 2004 Appl. Microbiol. Biotechnol. pmid:15179529
Reszko AE et al. Regulation of malonyl-CoA concentration and turnover in the normal heart. 2004 J. Biol. Chem. pmid:15181001
Chandler MP et al. Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:15191896
Kerner J et al. Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme. 2004 J. Biol. Chem. pmid:15247243
Onay-Besikci A et al. gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts. 2004 J. Biol. Chem. pmid:15269215
A'Bháird NN and Ramsay RR Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase. 1992 Biochem. J. pmid:1530596
Gande R et al. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. 2004 J. Biol. Chem. pmid:15308633
Yang N et al. C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA. 2005 J. Pharmacol. Exp. Ther. pmid:15356215
Juárez P et al. A microsomal fatty acid synthetase from the integument of Blattella germanica synthesizes methyl-branched fatty acids, precursors to hydrocarbon and contact sex pheromone. 1992 Arch. Biochem. Biophys. pmid:1536569
Yoshida S and Bourre JM Condensation activity for polyunsaturated fatty acids with malonyl-CoA in rat brain microsomes. Characteristics and developmental change. 1992 Biochim. Biophys. Acta pmid:1536871
Roepstorff C et al. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15383373
Sütfeld R et al. Characterization, development and localization of "flavanone synthase" in tulip anthers. 1978 Nov-Dec Z. Naturforsch., C, Biosci. pmid:154221
Relat J et al. Pig muscle carnitine palmitoyltransferase I (CPTI beta), with low Km for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTI alpha) enzyme. 2004 Biochemistry pmid:15449958
Cheng L et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. 2004 Nat. Med. pmid:15475963
Buemann B and Astrup AV [Lipogenesis: does it have a relevance in the obesity research?]. 2004 Ugeskr. Laeg. pmid:15487518
Faye A et al. Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity. 2005 Biochem. J. pmid:15498023
Zhang YQ et al. Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans. 2004 Genetics pmid:15514053