L-octanoylcarnitine is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with L-octanoylcarnitine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Starvation | D013217 | 47 associated lipids |
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Thinness | D013851 | 11 associated lipids |
| Heart Failure, Systolic | D054143 | 3 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Mroczkowska JE et al. | Blood-brain barrier controls carnitine level in the brain: a study on a model system with RBE4 cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623637 |
| Trumbeckaite S et al. | Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function. | 2001 | Eur. J. Biochem. | pmid:11231295 |
| Chace DH et al. | Errors caused by the use of D,L-octanoylcarnitine for blood-spot calibrators. | 2001 | Clin. Chem. | pmid:11274033 |
| Kameoka J et al. | A polymeric microfluidic chip for CE/MS determination of small molecules. | 2001 | Anal. Chem. | pmid:11354473 |
| Carpenter K et al. | Evaluation of newborn screening for medium chain acyl-CoA dehydrogenase deficiency in 275 000 babies. | 2001 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:11517203 |
| Pourfarzam M et al. | Neonatal screening for medium-chain acyl-CoA dehydrogenase deficiency. | 2001 | Lancet | pmid:11589939 |
| Toleikis A et al. | Relevance of fatty acid oxidation in regulation of the outer mitochondrial membrane permeability for ADP. | 2001 | FEBS Lett. | pmid:11741597 |
| Lehotay DC et al. | Blood acylcarnitine levels in normal newborns and heterozygotes for medium-chain acyl-CoA dehydrogenase deficiency: a relationship between genotype and biochemical phenotype? | 2004 | J. Inherit. Metab. Dis. | pmid:14970748 |
| Jogl G et al. | Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. | 2005 | J. Biol. Chem. | pmid:15492013 |
| Farquharson J et al. | Direct gas chromatographic assay of urinary medium-chain fatty acylcarnitines by their thermal decomposition. | 1992 | Clin. Chim. Acta | pmid:1576748 |
| Ensenauer R et al. | Genotypic differences of MCAD deficiency in the Asian population: novel genotype and clinical symptoms preceding newborn screening notification. | 2005 May-Jun | Genet. Med. | pmid:15915086 |
| de Assis DR et al. | Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats. | 2006 | Exp. Neurol. | pmid:16203000 |
| Baumgartner C and Baumgartner D | Biomarker discovery, disease classification, and similarity query processing on high-throughput MS/MS data of inborn errors of metabolism. | 2006 | J Biomol Screen | pmid:16314408 |
| Schmidt-Sommerfeld E et al. | Urinary medium-chain acylcarnitines in medium-chain acyl-CoA dehydrogenase deficiency, medium-chain triglyceride feeding and valproic acid therapy: sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method. | 1992 | Pediatr. Res. | pmid:1635814 |
| Rhead WJ | Newborn screening for medium-chain acyl-CoA dehydrogenase deficiency: a global perspective. | 2006 Apr-Jun | J. Inherit. Metab. Dis. | pmid:16763904 |
| Muci MR and Gnoni GV | Short-term effects of triiodothyronine on exogenous and de novo synthesized fatty acids in rat hepatocytes. | 1991 | Biochem. Int. | pmid:1804101 |
| Marzo A et al. | Protein binding of L-carnitine family components. | 1991 | Eur J Drug Metab Pharmacokinet | pmid:1820909 |
| Hsu HW et al. | Spectrum of medium-chain acyl-CoA dehydrogenase deficiency detected by newborn screening. | 2008 | Pediatrics | pmid:18450854 |
| Bhuiyan AK and Pande SV | One-step facile synthesis of radioactive acyl-CoA and acylcarnitines using rat liver outer mitochondrial membrane as the enzyme source. | 1991 | Biochem. Soc. Trans. | pmid:1889559 |
| Squire RS | Synthesis and purification of radioactive fatty acylcarnitines of high specific activity. | 1991 | Anal. Biochem. | pmid:1952050 |
| Maier EM et al. | Dissection of biochemical borderline phenotypes in carriers and genetic variants of medium-chain acyl-CoA dehyrogenase deficiency: implications for newborn screening [corrected]. | 2009 | Clin. Genet. | pmid:19780764 |
| Arnold GL et al. | Lack of genotype-phenotype correlations and outcome in MCAD deficiency diagnosed by newborn screening in New York State. | 2010 | Mol. Genet. Metab. | pmid:20036593 |
| Schönfeld P et al. | Mitochondrial fatty acid oxidation and oxidative stress: lack of reverse electron transfer-associated production of reactive oxygen species. | 2010 Jun-Jul | Biochim. Biophys. Acta | pmid:20085746 |
| De Jesús VR et al. | Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. | 2010 | Clin. Chim. Acta | pmid:20122909 |
| Khalid JM et al. | Relationship of octanoylcarnitine concentrations to age at sampling in unaffected newborns screened for medium-chain acyl-CoA dehydrogenase deficiency. | 2010 | Clin. Chem. | pmid:20413428 |
| Kraunsøe R et al. | Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. | 2010 | J. Physiol. (Lond.) | pmid:20421291 |
| Smith EH et al. | Allelic diversity in MCAD deficiency: the biochemical classification of 54 variants identified during 5 years of ACADM sequencing. | 2010 | Mol. Genet. Metab. | pmid:20434380 |
| Larsen S et al. | Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. | 2011 | Diabetologia | pmid:21424396 |
| Tonin AM et al. | Disruption of redox homeostasis in cerebral cortex of developing rats by acylcarnitines accumulating in medium-chain acyl-CoA dehydrogenase deficiency. | 2012 | Int. J. Dev. Neurosci. | pmid:22472139 |
| Stride N et al. | Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction. | 2013 | Eur. J. Heart Fail. | pmid:23115323 |
| Meadows JA and Wargo MJ | Characterization of Pseudomonas aeruginosa growth on O-acylcarnitines and identification of a short-chain acylcarnitine hydrolase. | 2013 | Appl. Environ. Microbiol. | pmid:23524670 |
| Alexandre-Gouabau MC et al. | Maternal and cord blood LC-HRMS metabolomics reveal alterations in energy and polyamine metabolism, and oxidative stress in very-low birth weight infants. | 2013 | J. Proteome Res. | pmid:23527880 |
| Naccarato A et al. | Identification and assay of underivatized urinary acylcarnitines by paper spray tandem mass spectrometry. | 2013 | Anal Bioanal Chem | pmid:23907684 |
| Morand R et al. | Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. | 2013 | Anal Bioanal Chem | pmid:23995505 |
| pmid:24845952 | ||||
| pmid:24892382 | ||||
| Donato AJ et al. | The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction. | 2014 | J. Physiol. (Lond.) | pmid:25038241 |
| pmid:25454677 | ||||
| Kim M et al. | Association between arterial stiffness and serum L-octanoylcarnitine and lactosylceramide in overweight middle-aged subjects: 3-year follow-up study. | 2015 | PLoS ONE | pmid:25781947 |
| pmid:26113437 | ||||
| Horscroft JA et al. | Altered Oxygen Utilisation in Rat Left Ventricle and Soleus after 14 Days, but Not 2 Days, of Environmental Hypoxia. | 2015 | PLoS ONE | pmid:26390043 |
| Ojuka E et al. | Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. | 2016 | Am. J. Physiol. Endocrinol. Metab. | pmid:26908505 |
| pmid:26913383 | ||||
| pmid:27055779 | ||||
| Millington DS and Roe CR | Medium-chain acyl-CoA dehydrogenase deficiency. | 1989 | N. Engl. J. Med. | pmid:2710197 |
| Brass EP | Metabolism of octanoyl- and palmitoylcarnitine by intact rat hepatocytes. | 1989 | Biochim. Biophys. Acta | pmid:2730893 |
| pmid:28190699 | ||||
| Roe CR et al. | Post-mortem recognition of inherited metabolic disorders from specific acylcarnitines in tissue in cases of sudden infant death. | 1987 | Lancet | pmid:2881073 |
| DeMaison L et al. | Effects of (+)-octanoylcarnitine in intact myocardium. | 1988 Jan-Feb | Basic Res. Cardiol. | pmid:3377743 |