L-octanoylcarnitine

L-octanoylcarnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 311 references associated with L-octanoylcarnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for L-octanoylcarnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with L-octanoylcarnitine

MeSH term MeSH ID Detail
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Metabolic Diseases D008659 12 associated lipids
Starvation D013217 47 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Insulin Resistance D007333 99 associated lipids
Thinness D013851 11 associated lipids
Heart Failure, Systolic D054143 3 associated lipids
Total 7

PubChem Associated disorders and diseases

All references with L-octanoylcarnitine

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Authors Title Published Journal PubMed Link
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Zammit VA The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria. 1980 Biochem. J. pmid:7470052
Jones CT Is there a gloxylate cycle in the liver of the fetal guinea pig? 1980 Biochem. Biophys. Res. Commun. pmid:7417292
Parameswaran M and Arinze IJ Phosphoenolpyruvate synthesis by fetal guinea-pig liver mitochondria. 1981 Biochim. Biophys. Acta pmid:7225415
Nakatani T et al. Changes in predominant energy substrate after hepatectomy. 1981 Life Sci. pmid:7219046
Nakatani T et al. Differences in predominant energy substrate in relation to the resected hepatic mass in the phase immediately after hepatectomy. 1981 J. Lab. Clin. Med. pmid:7229515
Davis-van Thienen W and Davis EJ The effects of energetic steady state, pyruvate concentration, and octanoyl-(--)-carnitine on the relative rates of carboxylation and decarboxylation of pyruvate by rat liver mitochondria. 1981 J. Biol. Chem. pmid:7263658
Nakatani T et al. Effects of (+)-octanoylcarnitine on deoxyribonucleic acid synthesis in regenerating rabbit liver. 1982 Clin. Sci. pmid:7060336
Kim CS et al. L-carnitine: therapeutic strategy for metabolic encephalopathy. 1984 Brain Res. pmid:6478235
Chalmers RA et al. Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine. 1984 Pediatr. Res. pmid:6441143
Millington DS et al. Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry. 1985 Clin. Chim. Acta pmid:3919970
Roe CR et al. Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-coA dehydrogenase deficiency. 1985 Pediatr. Res. pmid:4000772
Duran M et al. Octanoylglucuronide excretion in patients with a defective oxidation of medium-chain fatty acids. 1985 Clin. Chim. Acta pmid:4064333
Roe CR et al. Recognition of medium-chain acyl-CoA dehydrogenase deficiency in asymptomatic siblings of children dying of sudden infant death or Reye-like syndromes. 1986 J. Pediatr. pmid:3944676
Roe CR et al. Post-mortem recognition of inherited metabolic disorders from specific acylcarnitines in tissue in cases of sudden infant death. 1987 Lancet pmid:2881073
DeMaison L et al. Effects of (+)-octanoylcarnitine in intact myocardium. 1988 Jan-Feb Basic Res. Cardiol. pmid:3377743
Brass EP Metabolism of octanoyl- and palmitoylcarnitine by intact rat hepatocytes. 1989 Biochim. Biophys. Acta pmid:2730893
Millington DS and Roe CR Medium-chain acyl-CoA dehydrogenase deficiency. 1989 N. Engl. J. Med. pmid:2710197
Squire RS Synthesis and purification of radioactive fatty acylcarnitines of high specific activity. 1991 Anal. Biochem. pmid:1952050
Muci MR and Gnoni GV Short-term effects of triiodothyronine on exogenous and de novo synthesized fatty acids in rat hepatocytes. 1991 Biochem. Int. pmid:1804101
Marzo A et al. Protein binding of L-carnitine family components. 1991 Eur J Drug Metab Pharmacokinet pmid:1820909
Bhuiyan AK and Pande SV One-step facile synthesis of radioactive acyl-CoA and acylcarnitines using rat liver outer mitochondrial membrane as the enzyme source. 1991 Biochem. Soc. Trans. pmid:1889559
Schmidt-Sommerfeld E et al. Urinary medium-chain acylcarnitines in medium-chain acyl-CoA dehydrogenase deficiency, medium-chain triglyceride feeding and valproic acid therapy: sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method. 1992 Pediatr. Res. pmid:1635814
Farquharson J et al. Direct gas chromatographic assay of urinary medium-chain fatty acylcarnitines by their thermal decomposition. 1992 Clin. Chim. Acta pmid:1576748
Schmidt-Sommerfeld E et al. Detection of inborn errors of fatty acid oxidation from acylcarnitine analysis of plasma and blood spots with the radioisotopic exchange-high-performance liquid chromatographic method. 1993 J. Pediatr. pmid:8496747
Van Hove JL et al. Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood. 1993 Am. J. Hum. Genet. pmid:8488845
Minkler PE and Hoppel CL Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. 1993 Anal. Biochem. pmid:8214594
Ziadeh R et al. Medium chain acyl-CoA dehydrogenase deficiency in Pennsylvania: neonatal screening shows high incidence and unexpected mutation frequencies. 1995 Pediatr. Res. pmid:7603790
Zangar RC and Novak RF Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes. 1997 Arch. Biochem. Biophys. pmid:9016816
Chace DH et al. Rapid diagnosis of MCAD deficiency: quantitative analysis of octanoylcarnitine and other acylcarnitines in newborn blood spots by tandem mass spectrometry. 1997 Clin. Chem. pmid:9365395
Clayton PT et al. Screening for medium chain acyl-CoA dehydrogenase deficiency using electrospray ionisation tandem mass spectrometry. 1998 Arch. Dis. Child. pmid:9797589
Mroczkowska JE et al. Blood-brain barrier controls carnitine level in the brain: a study on a model system with RBE4 cells. 2000 Biochem. Biophys. Res. Commun. pmid:10623637
Pourfarzam M et al. Neonatal screening for medium-chain acyl-CoA dehydrogenase deficiency. 2001 Lancet pmid:11589939
Carpenter K et al. Evaluation of newborn screening for medium chain acyl-CoA dehydrogenase deficiency in 275 000 babies. 2001 Arch. Dis. Child. Fetal Neonatal Ed. pmid:11517203
Chace DH et al. Errors caused by the use of D,L-octanoylcarnitine for blood-spot calibrators. 2001 Clin. Chem. pmid:11274033
Kameoka J et al. A polymeric microfluidic chip for CE/MS determination of small molecules. 2001 Anal. Chem. pmid:11354473
Trumbeckaite S et al. Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function. 2001 Eur. J. Biochem. pmid:11231295
Toleikis A et al. Relevance of fatty acid oxidation in regulation of the outer mitochondrial membrane permeability for ADP. 2001 FEBS Lett. pmid:11741597
Lehotay DC et al. Blood acylcarnitine levels in normal newborns and heterozygotes for medium-chain acyl-CoA dehydrogenase deficiency: a relationship between genotype and biochemical phenotype? 2004 J. Inherit. Metab. Dis. pmid:14970748
Jogl G et al. Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. 2005 J. Biol. Chem. pmid:15492013
Ensenauer R et al. Genotypic differences of MCAD deficiency in the Asian population: novel genotype and clinical symptoms preceding newborn screening notification. 2005 May-Jun Genet. Med. pmid:15915086
de Assis DR et al. Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats. 2006 Exp. Neurol. pmid:16203000
Baumgartner C and Baumgartner D Biomarker discovery, disease classification, and similarity query processing on high-throughput MS/MS data of inborn errors of metabolism. 2006 J Biomol Screen pmid:16314408

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