Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhao L et al. | Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. | 2015 | PLoS ONE | pmid:26030919 |
| Mathias RA et al. | Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. | 2014 | Cell | pmid:25525879 |
| Li Y et al. | Scavenging of blood glutamate for enhancing brain-to-blood glutamate efflux. | 2014 | Mol Med Rep | pmid:24220720 |
| Bryk R et al. | Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. | 2013 | Biochemistry | pmid:24251446 |
| McLain AL et al. | Glutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification. | 2013 | Free Radic. Biol. Med. | pmid:23567190 |
| Giribaldi G et al. | Intermittent-relapsing pyruvate dehydrogenase complex deficiency: a case with clinical, biochemical, and neuroradiological reversibility. | 2012 | Dev Med Child Neurol | pmid:22142326 |
| Tang H and Goldberg E | A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site. | 2012 | Biol. Reprod. | pmid:21998171 |
| Sharma R et al. | Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency. | 2012 | Dev Med Child Neurol | pmid:21895644 |
| Lam AK et al. | Quantitative imaging of electron transfer flavoprotein autofluorescence reveals the dynamics of lipid partitioning in living pancreatic islets. | 2012 | Integr Biol (Camb) | pmid:22733276 |
| Wang YP et al. | Two novel mutations in the BCKDHB gene (R170H, Q346R) cause the classic form of maple syrup urine disease (MSUD). | 2012 | Gene | pmid:22326532 |