Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ronowska A et al. | Effects of zinc on SN56 cholinergic neuroblastoma cells. | 2007 | J. Neurochem. | pmid:17662047 |
| Blombach B et al. | RamB is an activator of the pyruvate dehydrogenase complex subunit E1p gene in Corynebacterium glutamicum. | 2009 | J. Mol. Microbiol. Biotechnol. | pmid:17890844 |
| Nakai T et al. | Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography. | 2004 | J. Mol. Biol. | pmid:15033367 |
| Domingo GJ et al. | Multiple display of peptides and proteins on a macromolecular scaffold derived from a multienzyme complex. | 2001 | J. Mol. Biol. | pmid:11124904 |
| Mattevi A et al. | Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties. | 1993 | J. Mol. Biol. | pmid:8487301 |
| Vijayakrishnan S et al. | Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. | 2010 | J. Mol. Biol. | pmid:20361979 |
| Patterson S et al. | Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography. | 2011 | J. Med. Chem. | pmid:21851087 |
| Lee EH et al. | A Korean female patient with thiamine-responsive pyruvate dehydrogenase complex deficiency due to a novel point mutation (Y161C)in the PDHA1 gene. | 2006 | J. Korean Med. Sci. | pmid:17043409 |
| Neidig ML et al. | Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases. | 2006 | J. Inorg. Biochem. | pmid:17070917 |
| Flaschker N et al. | Description of the mutations in 15 subjects with variant forms of maple syrup urine disease. | 2007 | J. Inherit. Metab. Dis. | pmid:17922217 |