Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Debray FG et al. | Pyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia. | 2008 | Neuropediatrics | pmid:18504677 |
| Jan W et al. | MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation. | 2003 | Neuroradiology | pmid:12736767 |
| Bahar M et al. | Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model. | 2010 | Nutr J | pmid:21118526 |
| Tarnopolsky M | Protein requirements for endurance athletes. | Nutrition | pmid:15212749 | |
| Schwartz L et al. | A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results. | 2010 | Oncol. Rep. | pmid:20372858 |
| Fioravanti CF and Vandock KP | Transhydrogenase and the anaerobic mitochondrial metabolism of adult Hymenolepis diminuta. | 2010 | Parasitology | pmid:19765334 |
| Mounsey RB and Teismann P | Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection. | 2010 | Parkinsons Dis | pmid:21234411 |
| Hisahara S and Shimohama S | Toxin-induced and genetic animal models of Parkinson's disease. | 2010 | Parkinsons Dis | pmid:21234368 |
| Ah Mew N et al. | MRI features of 4 female patients with pyruvate dehydrogenase E1 alpha deficiency. | 2011 | Pediatr. Neurol. | pmid:21723463 |
| Fouque F et al. | Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency. | 2003 | Pediatr. Res. | pmid:12621116 |
| Kloesz JL et al. | Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats. | 2001 | Pediatr. Res. | pmid:11641455 |
| Morton DH et al. | Diagnosis and treatment of maple syrup disease: a study of 36 patients. | 2002 | Pediatrics | pmid:12042535 |
| Holmquist L et al. | Lipoic acid as a novel treatment for Alzheimer's disease and related dementias. | 2007 | Pharmacol. Ther. | pmid:16989905 |
| Miura T et al. | Lipid peroxidation of erythrocyte membrane induced by lipoamide dehydrogenase in the presence of ADP-Fe3+. | 1992 | Pharmacol. Toxicol. | pmid:1454754 |
| Holecek M | Effect of starvation on branched-chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle. | 2001 | Physiol Res | pmid:11300223 |
| Gass N et al. | Pyruvate decarboxylase provides growing pollen tubes with a competitive advantage in petunia. | 2005 | Plant Cell | pmid:15994907 |
| Fujiki Y et al. | Activation of the promoters of Arabidopsis genes for the branched-chain alpha-keto acid dehydrogenase complex in transgenic tobacco BY-2 cells under sugar starvation. | 2002 | Plant Cell Physiol. | pmid:11917081 |
| Yui R et al. | Antisense inhibition of mitochondrial pyruvate dehydrogenase E1alpha subunit in anther tapetum causes male sterility. | 2003 | Plant J. | pmid:12662309 |
| Taylor NL et al. | Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. | 2004 | Plant Physiol. | pmid:14764908 |
| Chen W et al. | Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis. | 2010 | Plant Physiol. | pmid:20488895 |
| LeClere S et al. | IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog. | 2004 | Plant Physiol. | pmid:15173569 |
| Lutziger I and Oliver DJ | Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis. | 2001 | Plant Physiol. | pmid:11598235 |
| Casteel J et al. | Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis. | 2011 | Plant Physiol. Biochem. | pmid:21798751 |
| Leichert LI and Jakob U | Protein thiol modifications visualized in vivo. | 2004 | PLoS Biol. | pmid:15502869 |
| Ojha S et al. | Evolution of function in the "two dinucleotide binding domains" flavoproteins. | 2007 | PLoS Comput. Biol. | pmid:17658942 |
| Bury-Moné S et al. | Global analysis of extracytoplasmic stress signaling in Escherichia coli. | 2009 | PLoS Genet. | pmid:19763168 |
| Kuntz AN et al. | Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. | 2007 | PLoS Med. | pmid:17579510 |
| Olvera L et al. | Transcription analysis of central metabolism genes in Escherichia coli. Possible roles of sigma38 in their expression, as a response to carbon limitation. | 2009 | PLoS ONE | pmid:19838295 |
| Edes K et al. | JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. | 2010 | PLoS ONE | pmid:20098717 |
| Zhao L et al. | Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. | 2015 | PLoS ONE | pmid:26030919 |
| Chen Z et al. | Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. | 2009 | PLoS ONE | pmid:19440339 |
| Zheng H et al. | Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv. | 2008 | PLoS ONE | pmid:18584054 |
| Günther S et al. | Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival. | 2009 | PLoS ONE | pmid:19434237 |
| Buchholz K et al. | Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite. | 2008 | PLoS ONE | pmid:18575607 |
| Anestål K et al. | Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. | 2008 | PLoS ONE | pmid:18382651 |
| da Silva Neto JF et al. | Analysis of the organic hydroperoxide response of Chromobacterium violaceum reveals that OhrR is a cys-based redox sensor regulated by thioredoxin. | 2012 | PLoS ONE | pmid:23071722 |
| Pinheiro A et al. | Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues. | 2012 | PLoS ONE | pmid:22675509 |
| Ngamskulrungroj P et al. | Differences in nitrogen metabolism between Cryptococcus neoformans and C. gattii, the two etiologic agents of cryptococcosis. | 2012 | PLoS ONE | pmid:22479580 |
| Eskra L et al. | Differential expression of iron acquisition genes by Brucella melitensis and Brucella canis during macrophage infection. | 2012 | PLoS ONE | pmid:22403618 |
| Barjaktarovic Z et al. | Radiation-induced signaling results in mitochondrial impairment in mouse heart at 4 weeks after exposure to X-rays. | 2011 | PLoS ONE | pmid:22174747 |
| Tondo ML et al. | Structural-functional characterization and physiological significance of ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri. | 2011 | PLoS ONE | pmid:22096528 |
| Vazquez A et al. | Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. | 2011 | PLoS ONE | pmid:22073143 |
| Ahidjo BA et al. | VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. | 2011 | PLoS ONE | pmid:21738782 |
| Sandegren L et al. | Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden. | 2011 | PLoS ONE | pmid:21304944 |
| Castro H et al. | Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity. | 2010 | PLoS ONE | pmid:20838623 |
| Burnside K et al. | Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase. | 2010 | PLoS ONE | pmid:20552019 |
| Rice WL et al. | Two-photon microscopy for non-invasive, quantitative monitoring of stem cell differentiation. | 2010 | PLoS ONE | pmid:20419124 |
| Collins RM et al. | Differential proteomic analysis of Arabidopsis thaliana genotypes exhibiting resistance or susceptibility to the insect herbivore, Plutella xylostella. | 2010 | PLoS ONE | pmid:20386709 |
| Ding F et al. | Neonatal maternal deprivation response and developmental changes in gene expression revealed by hypothalamic gene expression profiling in mice. | 2010 | PLoS ONE | pmid:20195375 |
| Sun J et al. | Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages. | 2010 | PLoS ONE | pmid:20098737 |
| Prieto JH et al. | Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment. | 2008 | PLoS ONE | pmid:19116658 |
| Goedhart J et al. | Sensitive detection of p65 homodimers using red-shifted and fluorescent protein-based FRET couples. | 2007 | PLoS ONE | pmid:17925859 |
| Spalding MD and Prigge ST | The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo. | 2009 | PLoS ONE | pmid:19812687 |
| Baughn AD et al. | An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. | 2009 | PLoS Pathog. | pmid:19936047 |
| Le Bouter S et al. | Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice. | 2010 | PPAR Res | pmid:20953342 |
| Kikuchi G et al. | Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia. | 2008 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:18941301 |
| Self WT et al. | Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11050172 |
| Naik MT and Huang TH | Conformational stability and thermodynamic characterization of the lipoic acid bearing domain of human mitochondrial branched chain alpha-ketoacid dehydrogenase. | 2004 | Protein Sci. | pmid:15322287 |
| Bunik VI and Degtyarev D | Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. | 2008 | Proteins | pmid:18004749 |
| Diedrich M et al. | Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease. | 2011 | Proteome Sci | pmid:21943346 |
| Persson HL et al. | Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. | 2001 | Redox Rep. | pmid:11778851 |
| Gabr AA et al. | Alterations in cytoskeletal and immune function-related proteome profiles in whole rat lung following intratracheal instillation of heparin. | 2007 | Respir. Res. | pmid:17488504 |
| Blanco-Barca O et al. | [Pyruvate dehydrogenase deficit associated to the C515T mutation in exon 6 of the E1alpha gene]. | 2006 Sep 16-30 | Rev Neurol | pmid:16981164 |
| Bryk R et al. | Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. | 2002 | Science | pmid:11799204 |
| Beaudet AL | Neuroscience. Preventable forms of autism? | 2012 | Science | pmid:23087240 |
| Novarino G et al. | Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. | 2012 | Science | pmid:22956686 |
| Frank RA et al. | A molecular switch and proton wire synchronize the active sites in thiamine enzymes. | 2004 | Science | pmid:15514159 |
| Wynn RM et al. | Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation. | 2004 | Structure | pmid:15576032 |
| Kato M et al. | Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. | 2008 | Structure | pmid:19081061 |
| Pei XY et al. | Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multienzyme complex. | 2008 | Structure | pmid:19081062 |
| Machius M et al. | A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. | 2006 | Structure | pmid:16472748 |
| Kurakin A | The self-organizing fractal theory as a universal discovery method: the phenomenon of life. | 2011 | Theor Biol Med Model | pmid:21447162 |
| Knapik-Czajka M et al. | Adverse effect of fenofibrate on branched-chain alpha-ketoacid dehydrogenase complex in rat's liver. | 2009 | Toxicology | pmid:19819289 |