Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Guilhaudis L et al. | Investigation of the local structure and dynamics of the H subunit of the mitochondrial glycine decarboxylase using heteronuclear NMR spectroscopy. | 1999 | Biochemistry | pmid:10387079 |
| Aevarsson A et al. | Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. | 1999 | Nat. Struct. Biol. | pmid:10426958 |
| Szabados E et al. | Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart. | 1999 | Free Radic. Biol. Med. | pmid:10569643 |
| Neuburger M et al. | Interaction between the lipoamide-containing H-protein and the lipoamide dehydrogenase (L-protein) of the glycine decarboxylase multienzyme system. 1. Biochemical studies. | 2000 | Eur. J. Biochem. | pmid:10806385 |
| Cabiscol E et al. | Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae. | 2000 | J. Biol. Chem. | pmid:10852912 |
| Self WT et al. | Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11050172 |
| Wynn RM et al. | Roles of active site and novel K+ ion-binding site residues in human mitochondrial branched-chain alpha-ketoacid decarboxylase/dehydrogenase. | 2001 | J. Biol. Chem. | pmid:11069910 |
| Nellis MM and Danner DJ | Gene preference in maple syrup urine disease. | 2001 | Am. J. Hum. Genet. | pmid:11112664 |
| Domingo GJ et al. | Multiple display of peptides and proteins on a macromolecular scaffold derived from a multienzyme complex. | 2001 | J. Mol. Biol. | pmid:11124904 |
| Ono K et al. | cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase. | 2001 | Eur. J. Biochem. | pmid:11168412 |
| pmid:11170645 | ||||
| Obayashi M et al. | Regulation of the activity of branched-chain 2-oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase. | 2001 | FEBS Lett. | pmid:11226417 |
| Xia L et al. | Reduction of ubiquinone by lipoamide dehydrogenase. An antioxidant regenerating pathway. | 2001 | Eur. J. Biochem. | pmid:11231302 |
| Guo Q et al. | Inhibitory effect of alpha-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages. | 2001 | Biochem. Pharmacol. | pmid:11239497 |
| pmid:11243735 | ||||
| Wang X et al. | Acidification and glucocorticoids independently regulate branched-chain alpha-ketoacid dehydrogenase subunit genes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11287331 |
| Holecek M | Effect of starvation on branched-chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle. | 2001 | Physiol Res | pmid:11300223 |
| Korotchkina LG et al. | Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal. | 2001 | Free Radic. Biol. Med. | pmid:11316579 |
| Liu S et al. | Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates. | 2001 | Arch. Biochem. Biophys. | pmid:11368334 |
| Harris EE and Hey J | Human populations show reduced DNA sequence variation at the factor IX locus. | 2001 | Curr. Biol. | pmid:11378388 |
| Eicher I and Schmidt HL | Electrocatalytic reduction of lipoic acid and electroenzymatic reduction of NAD(P)(+) for integrated dehydrogenase biosensors. | 2001 | Biosens Bioelectron | pmid:11390211 |
| pmid:11391973 | ||||
| Huang X et al. | Channeling of substrates and intermediates in enzyme-catalyzed reactions. | 2001 | Annu. Rev. Biochem. | pmid:11395405 |
| Fujiki Y et al. | Leucine and its keto acid enhance the coordinated expression of genes for branched-chain amino acid catabolism in Arabidopsis under sugar starvation. | 2001 | FEBS Lett. | pmid:11418132 |
| Wynn RM et al. | Biochemical basis of type IB (E1beta ) mutations in maple syrup urine disease. A prevalent allele in patients from the Druze kindred in Israel. | 2001 | J. Biol. Chem. | pmid:11448970 |
| Mori T et al. | Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo acid dehydrogenase complex. | 2001 | J. Hepatol. | pmid:11451161 |
| Reed LJ | A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. | 2001 | J. Biol. Chem. | pmid:11477096 |
| Love-Gregory LD et al. | Carrier detection and rapid newborn diagnostic test for the common Y393N maple syrup urine disease allele by PCR-RFLP: culturally permissible testing in the Mennonite community. | 2001 | J. Inherit. Metab. Dis. | pmid:11486905 |
| pmid:11495999 | ||||
| Song JL and Chuang DT | Natural osmolyte trimethylamine N-oxide corrects assembly defects of mutant branched-chain alpha-ketoacid decarboxylase in maple syrup urine disease. | 2001 | J. Biol. Chem. | pmid:11507102 |
| Edelmann L et al. | Maple syrup urine disease: identification and carrier-frequency determination of a novel founder mutation in the Ashkenazi Jewish population. | 2001 | Am. J. Hum. Genet. | pmid:11509994 |
| pmid:11527545 | ||||
| pmid:11560483 | ||||
| Shimomura Y et al. | Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain alpha-keto acid dehydrogenase kinase. | 2001 | Curr Opin Clin Nutr Metab Care | pmid:11568504 |
| pmid:11575725 | ||||
| Lutziger I and Oliver DJ | Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis. | 2001 | Plant Physiol. | pmid:11598235 |
| pmid:11603835 | ||||
| pmid:11606230 | ||||
| Kloesz JL et al. | Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats. | 2001 | Pediatr. Res. | pmid:11641455 |
| pmid:11673873 | ||||
| pmid:11702081 | ||||
| pmid:11708858 | ||||
| pmid:11713642 | ||||
| pmid:11724561 | ||||
| Gazaryan IG et al. | Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. | 2002 | J. Biol. Chem. | pmid:11744691 |
| pmid:11757583 | ||||
| Persson HL et al. | Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. | 2001 | Redox Rep. | pmid:11778851 |
| Jacobia SJ et al. | Characterization of a missense mutation at histidine-44 in a pyruvate dehydrogenase-deficient patient. | 2002 | Biochim. Biophys. Acta | pmid:11781147 |
| Patel MS and Korotchkina LG | Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. | 2001 | Exp. Mol. Med. | pmid:11795479 |