Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mayr JA et al. | Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation. | 2011 | Am. J. Hum. Genet. | pmid:22152680 |
| Savrasova EA et al. | Use of the valine biosynthetic pathway to convert glucose into isobutanol. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21161324 |
| Salinthone S et al. | Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms. | 2011 | J. Nutr. Biochem. | pmid:21036588 |
| Madawala SR et al. | Novel Conjugates of 1,3-Diacylglycerol and Lipoic Acid: Synthesis, DPPH Assay, and RP-LC-MS-APCI Analysis. | 2011 | J Lipids | pmid:21966595 |
| Tondo ML et al. | Structural-functional characterization and physiological significance of ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri. | 2011 | PLoS ONE | pmid:22096528 |
| Vazquez A et al. | Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. | 2011 | PLoS ONE | pmid:22073143 |
| Griffin J and Engel PC | An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD-Dependent Glutamate Dehydrogenase. | 2011 | Enzyme Res | pmid:21876794 |
| Patterson S et al. | Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography. | 2011 | J. Med. Chem. | pmid:21851087 |
| Rackham O et al. | Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors. | 2011 | Free Radic. Biol. Med. | pmid:21172426 |
| Shen W et al. | Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. | 2011 | Br. J. Pharmacol. | pmid:21108628 |
| Stobbe MD et al. | Critical assessment of human metabolic pathway databases: a stepping stone for future integration. | 2011 | BMC Syst Biol | pmid:21999653 |
| Diebold AR et al. | Activation of α-keto acid-dependent dioxygenases: application of an {FeNO}7/{FeO2}8 methodology for characterizing the initial steps of O2 activation. | 2011 | J. Am. Chem. Soc. | pmid:21981763 |
| Diedrich M et al. | Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease. | 2011 | Proteome Sci | pmid:21943346 |
| Brunetti-Pierri N et al. | Phenylbutyrate therapy for maple syrup urine disease. | 2011 | Hum. Mol. Genet. | pmid:21098507 |
| Golbidi S et al. | Diabetes and alpha lipoic Acid. | 2011 | Front Pharmacol | pmid:22125537 |
| Mescka C et al. | In vivo neuroprotective effect of L-carnitine against oxidative stress in maple syrup urine disease. | 2011 | Metab Brain Dis | pmid:21380499 |
| Ojano-Dirain C et al. | An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α. | 2010 Oct-Nov | Mol. Genet. Metab. | pmid:20685142 |
| Constantoulakis P et al. | In vivo expression of innate immunity markers in patients with Mycobacterium tuberculosis infection. | 2010 | BMC Infect. Dis. | pmid:20718957 |
| Edes K et al. | JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. | 2010 | PLoS ONE | pmid:20098717 |
| Fioravanti CF and Vandock KP | Transhydrogenase and the anaerobic mitochondrial metabolism of adult Hymenolepis diminuta. | 2010 | Parasitology | pmid:19765334 |
| Seybolt SE | Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia? | 2010 | Med. Hypotheses | pmid:20708342 |
| Schwartz L et al. | A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results. | 2010 | Oncol. Rep. | pmid:20372858 |
| Albers WM et al. | Improved functionality of antibody-colloidal gold conjugates with the aid of lipoamide-grafted N-[tris(hydroxymethyl)methyl]acrylamide polymers. | 2010 | J Colloid Interface Sci | pmid:20416881 |
| Mounsey RB and Teismann P | Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection. | 2010 | Parkinsons Dis | pmid:21234411 |
| Hisahara S and Shimohama S | Toxin-induced and genetic animal models of Parkinson's disease. | 2010 | Parkinsons Dis | pmid:21234368 |
| Joseph SJ et al. | Omega-6 fat supplementation alters lipogenic gene expression in bovine subcutaneous adipose tissue. | 2010 | Gene Regul Syst Bio | pmid:21072324 |
| Moll M et al. | The LabelHash algorithm for substructure matching. | 2010 | BMC Bioinformatics | pmid:21070651 |
| Huang X et al. | Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage. | 2010 | J. Proteome Res. | pmid:20954747 |
| Castro H et al. | Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity. | 2010 | PLoS ONE | pmid:20838623 |
| Kiilerich K et al. | PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20720174 |
| Kusumoto C et al. | Protection by Exogenously Added Coenzyme Q(9) against Free Radical-Induced Injuries in Human Liver Cells. | 2010 | J Clin Biochem Nutr | pmid:20490320 |
| Chen W et al. | Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis. | 2010 | Plant Physiol. | pmid:20488895 |
| Pei Y et al. | Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection. | 2010 | Mol. Microbiol. | pmid:20487290 |
| Rice WL et al. | Two-photon microscopy for non-invasive, quantitative monitoring of stem cell differentiation. | 2010 | PLoS ONE | pmid:20419124 |
| Collins RM et al. | Differential proteomic analysis of Arabidopsis thaliana genotypes exhibiting resistance or susceptibility to the insect herbivore, Plutella xylostella. | 2010 | PLoS ONE | pmid:20386709 |
| Ding F et al. | Neonatal maternal deprivation response and developmental changes in gene expression revealed by hypothalamic gene expression profiling in mice. | 2010 | PLoS ONE | pmid:20195375 |
| Nemeria NS et al. | Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms. | 2010 | J. Biol. Chem. | pmid:20106967 |
| Sun J et al. | Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages. | 2010 | PLoS ONE | pmid:20098737 |
| Komatsu M et al. | Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions. | 2010 | Genes Cells | pmid:20002497 |
| Ortis F et al. | Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. | 2010 | Diabetes | pmid:19934004 |
| Le Bouter S et al. | Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice. | 2010 | PPAR Res | pmid:20953342 |
| Bryk R et al. | Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . | 2010 | Biochemistry | pmid:20078138 |
| McKinlay JB et al. | A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production. | 2010 | BMC Genomics | pmid:21118570 |
| Carleton SM et al. | DNA carrier testing and newborn screening for maple syrup urine disease in Old Order Mennonite communities. | 2010 | Genet Test Mol Biomarkers | pmid:20136525 |
| Vijayakrishnan S et al. | Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. | 2010 | J. Mol. Biol. | pmid:20361979 |
| Bahar M et al. | Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model. | 2010 | Nutr J | pmid:21118526 |
| Wiltafsky MK et al. | The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs. | 2010 | Br. J. Nutr. | pmid:20196890 |
| Matsumoto H et al. | Analysis of branched-chain alpha-keto acid dehydrogenase complex activity in rat tissues using alpha-keto[1-13C]isocaproate as substrate. | 2010 | Anal. Biochem. | pmid:20018161 |
| Wang YH et al. | Regulation of branched-chain amino acid catabolism: glucose limitation enhances the component of isovalerylspiramycin for the bitespiramycin production. | 2010 | Bioprocess Biosyst Eng | pmid:19415340 |
| Chadwick W et al. | Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. | 2010 | Int J Alzheimers Dis | pmid:21151659 |