Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mersey BD et al. | Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell. | 2005 | Hum. Mol. Genet. | pmid:16203741 |
| Günther S et al. | Plasmodium falciparum possesses organelle-specific alpha-keto acid dehydrogenase complexes and lipoylation pathways. | 2005 | Biochem. Soc. Trans. | pmid:16246025 |
| Nemeria N et al. | Glutamate 636 of the Escherichia coli pyruvate dehydrogenase-E1 participates in active center communication and behaves as an engineered acetolactate synthase with unusual stereoselectivity. | 2005 | J. Biol. Chem. | pmid:15802265 |
| Gass N et al. | Pyruvate decarboxylase provides growing pollen tubes with a competitive advantage in petunia. | 2005 | Plant Cell | pmid:15994907 |
| Nakai T et al. | Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography. | 2004 | J. Mol. Biol. | pmid:15033367 |
| Wynn RM et al. | Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation. | 2004 | Structure | pmid:15576032 |
| Sweatt AJ et al. | Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:12965870 |
| Tajima G et al. | A simple and rapid enzymatic assay for the branched-chain alpha-ketoacid dehydrogenase complex using high-performance liquid chromatography. | 2004 | J. Inherit. Metab. Dis. | pmid:15669679 |
| Meneses-Lorente G et al. | A proteomic investigation of drug-induced steatosis in rat liver. | 2004 | Chem. Res. Toxicol. | pmid:15144217 |
| Honda T et al. | Effects of liver failure on branched-chain alpha-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure. | 2004 | J. Hepatol. | pmid:15123358 |
| Kasinski A et al. | Leucine toxicity in a neuronal cell model with inhibited branched chain amino acid catabolism. | 2004 | Brain Res. Mol. Brain Res. | pmid:15010210 |
| Self JT et al. | Glutamine synthesis in the developing porcine placenta. | 2004 | Biol. Reprod. | pmid:14736817 |
| Harris RA et al. | Mechanisms responsible for regulation of branched-chain amino acid catabolism. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14684174 |
| Taylor NL et al. | Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. | 2004 | Plant Physiol. | pmid:14764908 |
| Shimomura Y et al. | Effects of liver failure on the enzymes in the branched-chain amino acid catabolic pathway. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14684172 |
| Smit BA et al. | Diversity of L-leucine catabolism in various microorganisms involved in dairy fermentations, and identification of the rate-controlling step in the formation of the potent flavour component 3-methylbutanal. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14624315 |
| Park YH et al. | Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit. | 2004 | Biochemistry | pmid:15518552 |
| Marracci GH et al. | Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis. | 2004 | J. Neurosci. Res. | pmid:15389837 |
| Lee HH et al. | Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia. | 2004 | J. Biol. Chem. | pmid:15355973 |
| Li J et al. | Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase. | 2004 | J. Biol. Chem. | pmid:15166214 |
| Frank RA et al. | A molecular switch and proton wire synchronize the active sites in thiamine enzymes. | 2004 | Science | pmid:15514159 |
| Leichert LI and Jakob U | Protein thiol modifications visualized in vivo. | 2004 | PLoS Biol. | pmid:15502869 |
| Head RA et al. | Pyruvate dehydrogenase deficiency presenting as dystonia in childhood. | 2004 | Dev Med Child Neurol | pmid:15473177 |
| Argyrou A et al. | Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis. | 2004 | J. Biol. Chem. | pmid:15456792 |
| Igamberdiev AU et al. | Dihydrolipoamide dehydrogenase from porcine heart catalyzes NADH-dependent scavenging of nitric oxide. | 2004 | FEBS Lett. | pmid:15196936 |
| LeClere S et al. | IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog. | 2004 | Plant Physiol. | pmid:15173569 |
| Rocheleau JV et al. | Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response. | 2004 | J. Biol. Chem. | pmid:15148320 |
| Hiromasa Y et al. | Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components. | 2004 | J. Biol. Chem. | pmid:14638692 |
| Bafunno V et al. | Riboflavin uptake and FAD synthesis in Saccharomyces cerevisiae mitochondria: involvement of the Flx1p carrier in FAD export. | 2004 | J. Biol. Chem. | pmid:14555654 |
| Naik MT and Huang TH | Conformational stability and thermodynamic characterization of the lipoic acid bearing domain of human mitochondrial branched chain alpha-ketoacid dehydrogenase. | 2004 | Protein Sci. | pmid:15322287 |
| Bogenhagen DF et al. | Protein components of mitochondrial DNA nucleoids in higher eukaryotes. | 2003 | Mol. Cell Proteomics | pmid:14514796 |
| Bunik VI | 2-Oxo acid dehydrogenase complexes of multicellular organisms. | 2003 | Eur. J. Biochem. | pmid:12631262 |
| Song JL et al. | Encapsulation of an 86-kDa assembly intermediate inside the cavities of GroEL and its single-ring variant SR1 by GroES. | 2003 | J. Biol. Chem. | pmid:12431983 |
| Raj DS et al. | Markers of inflammation, proteolysis, and apoptosis in ESRD. | 2003 | Am. J. Kidney Dis. | pmid:14655193 |
| Fouque F et al. | Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency. | 2003 | Pediatr. Res. | pmid:12621116 |
| Fries M et al. | Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes. | 2003 | Biochemistry | pmid:12795594 |
| Jan W et al. | MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation. | 2003 | Neuroradiology | pmid:12736767 |
| Bunik VI | 2-Oxo acid dehydrogenase complexes in redox regulation. | 2003 | Eur. J. Biochem. | pmid:12631263 |
| Persson HL et al. | Prevention of oxidant-induced cell death by lysosomotropic iron chelators. | 2003 | Free Radic. Biol. Med. | pmid:12726917 |
| Zhao X et al. | Assembly of the covalent linkage between lipoic acid and its cognate enzymes. | 2003 | Chem. Biol. | pmid:14700636 |
| Argyrou A et al. | Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level. | 2003 | Biochemistry | pmid:12590611 |
| Wynn RM et al. | Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site. | 2003 | J. Biol. Chem. | pmid:12902323 |
| Nordman T et al. | Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase. | 2003 | Biofactors | pmid:14695919 |
| Masignani V et al. | NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis. | 2003 | Mol. Microbiol. | pmid:14617161 |
| Fujinoki M et al. | Identification of 36-kDa flagellar phosphoproteins associated with hamster sperm motility. | 2003 | J. Biochem. | pmid:12761172 |
| Bykova NV et al. | Phosphorylation of formate dehydrogenase in potato tuber mitochondria. | 2003 | J. Biol. Chem. | pmid:12714601 |
| Yui R et al. | Antisense inhibition of mitochondrial pyruvate dehydrogenase E1alpha subunit in anther tapetum causes male sterility. | 2003 | Plant J. | pmid:12662309 |
| Ciszak EM et al. | Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. | 2003 | J. Biol. Chem. | pmid:12651851 |
| Miné M et al. | Splicing error in E1alpha pyruvate dehydrogenase mRNA caused by novel intronic mutation responsible for lactic acidosis and mental retardation. | 2003 | J. Biol. Chem. | pmid:12551913 |
| Shilo S et al. | Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection. | 2003 | Biochem. J. | pmid:12423204 |