Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Aevarsson A et al. | Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. | 1999 | Nat. Struct. Biol. | pmid:10426958 |
| Szabados E et al. | Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart. | 1999 | Free Radic. Biol. Med. | pmid:10569643 |
| Neuburger M et al. | Interaction between the lipoamide-containing H-protein and the lipoamide dehydrogenase (L-protein) of the glycine decarboxylase multienzyme system. 1. Biochemical studies. | 2000 | Eur. J. Biochem. | pmid:10806385 |
| Cabiscol E et al. | Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae. | 2000 | J. Biol. Chem. | pmid:10852912 |
| Self WT et al. | Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11050172 |
| Wynn RM et al. | Roles of active site and novel K+ ion-binding site residues in human mitochondrial branched-chain alpha-ketoacid decarboxylase/dehydrogenase. | 2001 | J. Biol. Chem. | pmid:11069910 |
| Nellis MM and Danner DJ | Gene preference in maple syrup urine disease. | 2001 | Am. J. Hum. Genet. | pmid:11112664 |
| Domingo GJ et al. | Multiple display of peptides and proteins on a macromolecular scaffold derived from a multienzyme complex. | 2001 | J. Mol. Biol. | pmid:11124904 |
| Ono K et al. | cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase. | 2001 | Eur. J. Biochem. | pmid:11168412 |
| pmid:11170645 | ||||
| Obayashi M et al. | Regulation of the activity of branched-chain 2-oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase. | 2001 | FEBS Lett. | pmid:11226417 |
| Xia L et al. | Reduction of ubiquinone by lipoamide dehydrogenase. An antioxidant regenerating pathway. | 2001 | Eur. J. Biochem. | pmid:11231302 |
| Guo Q et al. | Inhibitory effect of alpha-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages. | 2001 | Biochem. Pharmacol. | pmid:11239497 |
| pmid:11243735 | ||||
| Wang X et al. | Acidification and glucocorticoids independently regulate branched-chain alpha-ketoacid dehydrogenase subunit genes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11287331 |
| Holecek M | Effect of starvation on branched-chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle. | 2001 | Physiol Res | pmid:11300223 |
| Korotchkina LG et al. | Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal. | 2001 | Free Radic. Biol. Med. | pmid:11316579 |
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| Harris EE and Hey J | Human populations show reduced DNA sequence variation at the factor IX locus. | 2001 | Curr. Biol. | pmid:11378388 |
| Eicher I and Schmidt HL | Electrocatalytic reduction of lipoic acid and electroenzymatic reduction of NAD(P)(+) for integrated dehydrogenase biosensors. | 2001 | Biosens Bioelectron | pmid:11390211 |
| pmid:11391973 | ||||
| Huang X et al. | Channeling of substrates and intermediates in enzyme-catalyzed reactions. | 2001 | Annu. Rev. Biochem. | pmid:11395405 |
| Fujiki Y et al. | Leucine and its keto acid enhance the coordinated expression of genes for branched-chain amino acid catabolism in Arabidopsis under sugar starvation. | 2001 | FEBS Lett. | pmid:11418132 |
| Wynn RM et al. | Biochemical basis of type IB (E1beta ) mutations in maple syrup urine disease. A prevalent allele in patients from the Druze kindred in Israel. | 2001 | J. Biol. Chem. | pmid:11448970 |
| Mori T et al. | Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo acid dehydrogenase complex. | 2001 | J. Hepatol. | pmid:11451161 |
| Reed LJ | A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. | 2001 | J. Biol. Chem. | pmid:11477096 |
| Love-Gregory LD et al. | Carrier detection and rapid newborn diagnostic test for the common Y393N maple syrup urine disease allele by PCR-RFLP: culturally permissible testing in the Mennonite community. | 2001 | J. Inherit. Metab. Dis. | pmid:11486905 |
| pmid:11495999 | ||||
| Song JL and Chuang DT | Natural osmolyte trimethylamine N-oxide corrects assembly defects of mutant branched-chain alpha-ketoacid decarboxylase in maple syrup urine disease. | 2001 | J. Biol. Chem. | pmid:11507102 |
| Edelmann L et al. | Maple syrup urine disease: identification and carrier-frequency determination of a novel founder mutation in the Ashkenazi Jewish population. | 2001 | Am. J. Hum. Genet. | pmid:11509994 |
| pmid:11527545 | ||||
| pmid:11560483 | ||||
| Shimomura Y et al. | Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain alpha-keto acid dehydrogenase kinase. | 2001 | Curr Opin Clin Nutr Metab Care | pmid:11568504 |
| pmid:11575725 | ||||
| Lutziger I and Oliver DJ | Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis. | 2001 | Plant Physiol. | pmid:11598235 |
| pmid:11603835 | ||||
| pmid:11606230 | ||||
| Kloesz JL et al. | Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats. | 2001 | Pediatr. Res. | pmid:11641455 |
| pmid:11673873 | ||||
| pmid:11702081 | ||||
| pmid:11708858 | ||||
| pmid:11713642 | ||||
| pmid:11724561 | ||||
| Gazaryan IG et al. | Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. | 2002 | J. Biol. Chem. | pmid:11744691 |
| pmid:11757583 | ||||
| Persson HL et al. | Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. | 2001 | Redox Rep. | pmid:11778851 |
| Jacobia SJ et al. | Characterization of a missense mutation at histidine-44 in a pyruvate dehydrogenase-deficient patient. | 2002 | Biochim. Biophys. Acta | pmid:11781147 |
| Patel MS and Korotchkina LG | Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. | 2001 | Exp. Mol. Med. | pmid:11795479 |
| Bryk R et al. | Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. | 2002 | Science | pmid:11799204 |
| Owen KQ et al. | Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine. | 2001 | J. Anim. Sci. | pmid:11811466 |
| Love-Gregory LD et al. | Evidence of common ancestry for the maple syrup urine disease (MSUD) Y438N allele in non-Mennonite MSUD patients. | 2002 | Mol. Genet. Metab. | pmid:11825067 |
| Richards JG et al. | Glycogen phosphorylase and pyruvate dehydrogenase transformation in white muscle of trout during high-intensity exercise. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11832404 |
| pmid:11837719 | ||||
| Chang CF et al. | Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex. | 2002 | J. Biol. Chem. | pmid:11839747 |
| Nicholls LI et al. | Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11866475 |
| pmid:11870584 | ||||
| pmid:11882887 | ||||
| Fujiki Y et al. | Activation of the promoters of Arabidopsis genes for the branched-chain alpha-keto acid dehydrogenase complex in transgenic tobacco BY-2 cells under sugar starvation. | 2002 | Plant Cell Physiol. | pmid:11917081 |
| Nishio A et al. | Primary biliary cirrhosis: lessons learned from an organ-specific disease. | 2001 | Clin. Exp. Med. | pmid:11918275 |
| pmid:11935326 | ||||
| Hengeveld AF and de Kok A | Structural basis of the dysfunctioning of human 2-oxo acid dehydrogenase complexes. | 2002 | Curr. Med. Chem. | pmid:11945122 |
| Cronan JE | Interchangeable enzyme modules. Functional replacement of the essential linker of the biotinylated subunit of acetyl-CoA carboxylase with a linker from the lipoylated subunit of pyruvate dehydrogenase. | 2002 | J. Biol. Chem. | pmid:11956202 |
| Huang S et al. | Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein. | 2002 | Biophys. J. | pmid:11964266 |
| Gao H et al. | The E1beta and E2 subunits of the Bacillus subtilis pyruvate dehydrogenase complex are involved in regulation of sporulation. | 2002 | J. Bacteriol. | pmid:11976308 |
| Omelchenko MV et al. | Recurrent intragenomic recombination leading to sequence homogenization during the evolution of the lipoyl-binding domain. | 2002 | FEMS Microbiol. Lett. | pmid:12007814 |
| Sutton I and Neuberger J | Primary biliary cirrhosis: seeking the silent partner of autoimmunity. | 2002 | Gut | pmid:12010869 |
| Perham RN et al. | Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes. | 2002 | Biochem. Soc. Trans. | pmid:12023822 |
| Morton DH et al. | Diagnosis and treatment of maple syrup disease: a study of 36 patients. | 2002 | Pediatrics | pmid:12042535 |
| pmid:12070266 | ||||
| pmid:12075488 | ||||
| Dursun A et al. | Maple syrup urine disease: mutation analysis in Turkish patients. | 2002 | J. Inherit. Metab. Dis. | pmid:12118532 |
| Porras P et al. | Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12135599 |
| pmid:12163191 | ||||
| Lynch CJ et al. | Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12217901 |
| Nellis MM et al. | Insulin increases branched-chain alpha-ketoacid dehydrogenase kinase expression in Clone 9 rat cells. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12217904 |
| Mooney BP et al. | The complex fate of alpha-ketoacids. | 2002 | Annu Rev Plant Biol | pmid:12221980 |
| pmid:12227466 | ||||
| Owen R et al. | Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors. | 2002 | Mol. Ther. | pmid:12231176 |
| Bunik VI and Sievers C | Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species. | 2002 | Eur. J. Biochem. | pmid:12383259 |
| Naik MT et al. | Folding kinetics of the lipoic acid-bearing domain of human mitochondrial branched chain alpha-ketoacid dehydrogenase complex. | 2002 | FEBS Lett. | pmid:12387880 |
| Kobayashi R et al. | Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms. | 2002 | Arch. Biochem. Biophys. | pmid:12413496 |
| Dallo SF et al. | Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae. | 2002 | Mol. Microbiol. | pmid:12421310 |
| Shilo S et al. | Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection. | 2003 | Biochem. J. | pmid:12423204 |
| Song JL et al. | Encapsulation of an 86-kDa assembly intermediate inside the cavities of GroEL and its single-ring variant SR1 by GroES. | 2003 | J. Biol. Chem. | pmid:12431983 |
| Argyrou A et al. | The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis. | 2002 | Biochemistry | pmid:12463758 |
| Nemeria N et al. | Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and transketolase. | 2002 | Biochemistry | pmid:12501174 |
| Miné M et al. | Splicing error in E1alpha pyruvate dehydrogenase mRNA caused by novel intronic mutation responsible for lactic acidosis and mental retardation. | 2003 | J. Biol. Chem. | pmid:12551913 |
| pmid:12557299 | ||||
| Argyrou A et al. | Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level. | 2003 | Biochemistry | pmid:12590611 |
| Fouque F et al. | Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency. | 2003 | Pediatr. Res. | pmid:12621116 |
| Bunik VI | 2-Oxo acid dehydrogenase complexes of multicellular organisms. | 2003 | Eur. J. Biochem. | pmid:12631262 |
| Bunik VI | 2-Oxo acid dehydrogenase complexes in redox regulation. | 2003 | Eur. J. Biochem. | pmid:12631263 |
| Ciszak EM et al. | Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. | 2003 | J. Biol. Chem. | pmid:12651851 |
| Yui R et al. | Antisense inhibition of mitochondrial pyruvate dehydrogenase E1alpha subunit in anther tapetum causes male sterility. | 2003 | Plant J. | pmid:12662309 |
| Bykova NV et al. | Phosphorylation of formate dehydrogenase in potato tuber mitochondria. | 2003 | J. Biol. Chem. | pmid:12714601 |
| Persson HL et al. | Prevention of oxidant-induced cell death by lysosomotropic iron chelators. | 2003 | Free Radic. Biol. Med. | pmid:12726917 |
| Jan W et al. | MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation. | 2003 | Neuroradiology | pmid:12736767 |
| Fujinoki M et al. | Identification of 36-kDa flagellar phosphoproteins associated with hamster sperm motility. | 2003 | J. Biochem. | pmid:12761172 |