Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhao L et al. | Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. | 2015 | PLoS ONE | pmid:26030919 |
| Mathias RA et al. | Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. | 2014 | Cell | pmid:25525879 |
| Li Y et al. | Scavenging of blood glutamate for enhancing brain-to-blood glutamate efflux. | 2014 | Mol Med Rep | pmid:24220720 |
| Bryk R et al. | Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. | 2013 | Biochemistry | pmid:24251446 |
| McLain AL et al. | Glutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification. | 2013 | Free Radic. Biol. Med. | pmid:23567190 |
| Saylor PJ et al. | Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer. | 2012 | Clin. Cancer Res. | pmid:22589396 |
| da Silva Neto JF et al. | Analysis of the organic hydroperoxide response of Chromobacterium violaceum reveals that OhrR is a cys-based redox sensor regulated by thioredoxin. | 2012 | PLoS ONE | pmid:23071722 |
| Hessel EV et al. | Mapping an X-linked locus that influences heat-induced febrile seizures in mice. | 2012 | Epilepsia | pmid:22780306 |
| Pinheiro A et al. | Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues. | 2012 | PLoS ONE | pmid:22675509 |
| Shaler CR et al. | Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis. | 2012 | Clin. Dev. Immunol. | pmid:22545059 |
| Pancaldi V et al. | Predicting the fission yeast protein interaction network. | 2012 | G3 (Bethesda) | pmid:22540037 |
| Tam TK et al. | In situ regeneration of NADH via lipoamide dehydrogenase-catalyzed electron transfer reaction evidenced by spectroelectrochemistry. | 2012 | Bioelectrochemistry | pmid:22497727 |
| Ngamskulrungroj P et al. | Differences in nitrogen metabolism between Cryptococcus neoformans and C. gattii, the two etiologic agents of cryptococcosis. | 2012 | PLoS ONE | pmid:22479580 |
| Brown G | Pyruvate dehydrogenase deficiency and the brain. | 2012 | Dev Med Child Neurol | pmid:22409661 |
| Eskra L et al. | Differential expression of iron acquisition genes by Brucella melitensis and Brucella canis during macrophage infection. | 2012 | PLoS ONE | pmid:22403618 |
| Kennedy BW et al. | Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate. | 2012 | J. Am. Chem. Soc. | pmid:22316419 |
| Reed GH et al. | Radical reactions of thiamin pyrophosphate in 2-oxoacid oxidoreductases. | 2012 | Biochim. Biophys. Acta | pmid:22178227 |
| Marchi S et al. | Mitochondria-ros crosstalk in the control of cell death and aging. | 2012 | J Signal Transduct | pmid:22175013 |
| Giribaldi G et al. | Intermittent-relapsing pyruvate dehydrogenase complex deficiency: a case with clinical, biochemical, and neuroradiological reversibility. | 2012 | Dev Med Child Neurol | pmid:22142326 |
| Tang H and Goldberg E | A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site. | 2012 | Biol. Reprod. | pmid:21998171 |
| Koga Y et al. | Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene. | 2012 | Brain Dev. | pmid:21454027 |
| Beaudet AL | Neuroscience. Preventable forms of autism? | 2012 | Science | pmid:23087240 |
| Novarino G et al. | Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. | 2012 | Science | pmid:22956686 |
| Zhou M et al. | Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm). | 2012 | J. Biol. Chem. | pmid:22589535 |
| Li Y et al. | Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis. | 2012 | Mar Drugs | pmid:22412803 |
| Finnegan PM and Chen W | Arsenic toxicity: the effects on plant metabolism. | 2012 | Front Physiol | pmid:22685440 |
| Sharma R et al. | Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency. | 2012 | Dev Med Child Neurol | pmid:21895644 |
| Lam AK et al. | Quantitative imaging of electron transfer flavoprotein autofluorescence reveals the dynamics of lipid partitioning in living pancreatic islets. | 2012 | Integr Biol (Camb) | pmid:22733276 |
| Wang YP et al. | Two novel mutations in the BCKDHB gene (R170H, Q346R) cause the classic form of maple syrup urine disease (MSUD). | 2012 | Gene | pmid:22326532 |
| Chen P et al. | Dietary lipoic acid influences antioxidant capability and oxidative status of broilers. | 2011 | Int J Mol Sci | pmid:22272085 |
| Mayr JA et al. | Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation. | 2011 | Am. J. Hum. Genet. | pmid:22152680 |
| Savrasova EA et al. | Use of the valine biosynthetic pathway to convert glucose into isobutanol. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21161324 |
| Salinthone S et al. | Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms. | 2011 | J. Nutr. Biochem. | pmid:21036588 |
| Madawala SR et al. | Novel Conjugates of 1,3-Diacylglycerol and Lipoic Acid: Synthesis, DPPH Assay, and RP-LC-MS-APCI Analysis. | 2011 | J Lipids | pmid:21966595 |
| Kurakin A | The self-organizing fractal theory as a universal discovery method: the phenomenon of life. | 2011 | Theor Biol Med Model | pmid:21447162 |
| Hong JK et al. | Growth factor withdrawal in combination with sodium butyrate addition extends culture longevity and enhances antibody production in CHO cells. | 2011 | J. Biotechnol. | pmid:21723342 |
| Ferguson LR and Karunasinghe N | Nutrigenetics, nutrigenomics, and selenium. | 2011 | Front Genet | pmid:22303312 |
| Barjaktarovic Z et al. | Radiation-induced signaling results in mitochondrial impairment in mouse heart at 4 weeks after exposure to X-rays. | 2011 | PLoS ONE | pmid:22174747 |
| Tondo ML et al. | Structural-functional characterization and physiological significance of ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri. | 2011 | PLoS ONE | pmid:22096528 |
| Vazquez A et al. | Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. | 2011 | PLoS ONE | pmid:22073143 |
| Griffin J and Engel PC | An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD-Dependent Glutamate Dehydrogenase. | 2011 | Enzyme Res | pmid:21876794 |
| Patterson S et al. | Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography. | 2011 | J. Med. Chem. | pmid:21851087 |
| Glushakova LG et al. | Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts. | 2011 | Mol. Genet. Metab. | pmid:21846590 |
| Ahidjo BA et al. | VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. | 2011 | PLoS ONE | pmid:21738782 |
| Ah Mew N et al. | MRI features of 4 female patients with pyruvate dehydrogenase E1 alpha deficiency. | 2011 | Pediatr. Neurol. | pmid:21723463 |
| Taccola L et al. | Zinc oxide nanoparticles as selective killers of proliferating cells. | 2011 | Int J Nanomedicine | pmid:21698081 |
| Kiilerich K et al. | Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. | 2011 | J. Appl. Physiol. | pmid:21680880 |
| Roldán A et al. | Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei. | 2011 | Mol. Microbiol. | pmid:21631607 |
| Fedorov VB et al. | Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus). | 2011 | BMC Genomics | pmid:21453527 |
| Sandegren L et al. | Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden. | 2011 | PLoS ONE | pmid:21304944 |
| SimonÄiÄ M et al. | Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle. | 2011 | BMC Genomics | pmid:21291556 |
| Christophersen OA and Haug A | Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. | 2011 | Lipids Health Dis | pmid:21247506 |
| Venugopal A et al. | Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. | 2011 | Cell Host Microbe | pmid:21238944 |
| Packer L and Cadenas E | Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. | 2011 | J Clin Biochem Nutr | pmid:21297908 |
| Boyle KE et al. | A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21190973 |
| Rackham O et al. | Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors. | 2011 | Free Radic. Biol. Med. | pmid:21172426 |
| Shen W et al. | Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. | 2011 | Br. J. Pharmacol. | pmid:21108628 |
| Adams SH | Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. | 2011 | Adv Nutr | pmid:22332087 |
| Stobbe MD et al. | Critical assessment of human metabolic pathway databases: a stepping stone for future integration. | 2011 | BMC Syst Biol | pmid:21999653 |
| Diebold AR et al. | Activation of α-keto acid-dependent dioxygenases: application of an {FeNO}7/{FeO2}8 methodology for characterizing the initial steps of O2 activation. | 2011 | J. Am. Chem. Soc. | pmid:21981763 |
| Diedrich M et al. | Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease. | 2011 | Proteome Sci | pmid:21943346 |
| Brunetti-Pierri N et al. | Phenylbutyrate therapy for maple syrup urine disease. | 2011 | Hum. Mol. Genet. | pmid:21098507 |
| Golbidi S et al. | Diabetes and alpha lipoic Acid. | 2011 | Front Pharmacol | pmid:22125537 |
| Park HD et al. | Three Korean patients with maple syrup urine disease: four novel mutations in the BCKDHA gene. | 2011 | Ann. Clin. Lab. Sci. | pmid:21844576 |
| Mescka C et al. | In vivo neuroprotective effect of L-carnitine against oxidative stress in maple syrup urine disease. | 2011 | Metab Brain Dis | pmid:21380499 |
| Casteel J et al. | Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis. | 2011 | Plant Physiol. Biochem. | pmid:21798751 |
| Ojano-Dirain C et al. | An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α. | 2010 Oct-Nov | Mol. Genet. Metab. | pmid:20685142 |
| Constantoulakis P et al. | In vivo expression of innate immunity markers in patients with Mycobacterium tuberculosis infection. | 2010 | BMC Infect. Dis. | pmid:20718957 |
| Edes K et al. | JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. | 2010 | PLoS ONE | pmid:20098717 |
| Fioravanti CF and Vandock KP | Transhydrogenase and the anaerobic mitochondrial metabolism of adult Hymenolepis diminuta. | 2010 | Parasitology | pmid:19765334 |
| Seybolt SE | Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia? | 2010 | Med. Hypotheses | pmid:20708342 |
| Schwartz L et al. | A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results. | 2010 | Oncol. Rep. | pmid:20372858 |
| Albers WM et al. | Improved functionality of antibody-colloidal gold conjugates with the aid of lipoamide-grafted N-[tris(hydroxymethyl)methyl]acrylamide polymers. | 2010 | J Colloid Interface Sci | pmid:20416881 |
| Mounsey RB and Teismann P | Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection. | 2010 | Parkinsons Dis | pmid:21234411 |
| Hisahara S and Shimohama S | Toxin-induced and genetic animal models of Parkinson's disease. | 2010 | Parkinsons Dis | pmid:21234368 |
| Joseph SJ et al. | Omega-6 fat supplementation alters lipogenic gene expression in bovine subcutaneous adipose tissue. | 2010 | Gene Regul Syst Bio | pmid:21072324 |
| Moll M et al. | The LabelHash algorithm for substructure matching. | 2010 | BMC Bioinformatics | pmid:21070651 |
| Huang X et al. | Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage. | 2010 | J. Proteome Res. | pmid:20954747 |
| Ji X et al. | A stable and controllable Prussian blue layer electrodeposited on self-assembled monolayers for constructing highly sensitive glucose biosensor. | 2010 | Analyst | pmid:20517545 |
| Castro H et al. | Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity. | 2010 | PLoS ONE | pmid:20838623 |
| Kiilerich K et al. | PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20720174 |
| Michelizzi VN et al. | Water buffalo genome science comes of age. | 2010 | Int. J. Biol. Sci. | pmid:20582226 |
| Burnside K et al. | Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase. | 2010 | PLoS ONE | pmid:20552019 |
| Kusumoto C et al. | Protection by Exogenously Added Coenzyme Q(9) against Free Radical-Induced Injuries in Human Liver Cells. | 2010 | J Clin Biochem Nutr | pmid:20490320 |
| Chen W et al. | Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis. | 2010 | Plant Physiol. | pmid:20488895 |
| Pei Y et al. | Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection. | 2010 | Mol. Microbiol. | pmid:20487290 |
| Rice WL et al. | Two-photon microscopy for non-invasive, quantitative monitoring of stem cell differentiation. | 2010 | PLoS ONE | pmid:20419124 |
| Collins RM et al. | Differential proteomic analysis of Arabidopsis thaliana genotypes exhibiting resistance or susceptibility to the insect herbivore, Plutella xylostella. | 2010 | PLoS ONE | pmid:20386709 |
| Ding F et al. | Neonatal maternal deprivation response and developmental changes in gene expression revealed by hypothalamic gene expression profiling in mice. | 2010 | PLoS ONE | pmid:20195375 |
| Nemeria NS et al. | Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms. | 2010 | J. Biol. Chem. | pmid:20106967 |
| Sun J et al. | Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages. | 2010 | PLoS ONE | pmid:20098737 |
| Komatsu M et al. | Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions. | 2010 | Genes Cells | pmid:20002497 |
| Ortis F et al. | Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. | 2010 | Diabetes | pmid:19934004 |
| Le Bouter S et al. | Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice. | 2010 | PPAR Res | pmid:20953342 |
| Bryk R et al. | Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . | 2010 | Biochemistry | pmid:20078138 |
| Carleton SM et al. | DNA carrier testing and newborn screening for maple syrup urine disease in Old Order Mennonite communities. | 2010 | Genet Test Mol Biomarkers | pmid:20136525 |
| Vijayakrishnan S et al. | Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. | 2010 | J. Mol. Biol. | pmid:20361979 |
| Wiltafsky MK et al. | The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs. | 2010 | Br. J. Nutr. | pmid:20196890 |
| Matsumoto H et al. | Analysis of branched-chain alpha-keto acid dehydrogenase complex activity in rat tissues using alpha-keto[1-13C]isocaproate as substrate. | 2010 | Anal. Biochem. | pmid:20018161 |
| Wang YH et al. | Regulation of branched-chain amino acid catabolism: glucose limitation enhances the component of isovalerylspiramycin for the bitespiramycin production. | 2010 | Bioprocess Biosyst Eng | pmid:19415340 |