Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Pilegaard H et al. | PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion. | 2006 | Diabetes | pmid:17065338 |
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| Prachayasittikul V et al. | NAD(H) recycling activity of an engineered bifunctional enzyme galactose dehydrogenase/lactate dehydrogenase. | 2006 | Int. J. Biol. Sci. | pmid:16585948 |
| Vergauwen B et al. | Hydrogen peroxide scavenging is not a virulence determinant in the pathogenesis of Haemophilus influenzae type b strain Eagan. | 2006 | BMC Microbiol. | pmid:16430767 |
| Stellingwerff T et al. | Hyperoxia decreases muscle glycogenolysis, lactate production, and lactate efflux during steady-state exercise. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16403777 |
| Onder O et al. | Modifications of the lipoamide-containing mitochondrial subproteome in a yeast mutant defective in cysteine desulfurase. | 2006 | Mol. Cell Proteomics | pmid:16684766 |
| Li M et al. | Effect of lpdA gene knockout on the metabolism in Escherichia coli based on enzyme activities, intracellular metabolite concentrations and metabolic flux analysis by 13C-labeling experiments. | 2006 | J. Biotechnol. | pmid:16310273 |
| Hutson SM | The case for regulating indispensable amino acid metabolism: the branched-chain alpha-keto acid dehydrogenase kinase-knockout mouse. | 2006 | Biochem. J. | pmid:17061958 |
| Joshi MA et al. | Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. | 2006 | Biochem. J. | pmid:16875466 |
| Chang CF et al. | Structure of the subunit binding domain and dynamics of the di-domain region from the core of human branched chain alpha-ketoacid dehydrogenase complex. | 2006 | J. Biol. Chem. | pmid:16861235 |
| Knoechel TR et al. | Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. | 2006 | Biochemistry | pmid:16401071 |
| Machius M et al. | A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. | 2006 | Structure | pmid:16472748 |
| Kouza M et al. | Folding of the protein domain hbSBD. | 2005 | Biophys. J. | pmid:16126825 |
| McMillan PJ et al. | The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases. | 2005 | Mol. Microbiol. | pmid:15612914 |
| Mersey BD et al. | Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell. | 2005 | Hum. Mol. Genet. | pmid:16203741 |
| Odièvre MH et al. | A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency. | 2005 | Hum. Mutat. | pmid:15712224 |
| Shiraki M et al. | Activation of hepatic branched-chain alpha-keto acid dehydrogenase complex by tumor necrosis factor-alpha in rats. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15707973 |
| Günther S et al. | Plasmodium falciparum possesses organelle-specific alpha-keto acid dehydrogenase complexes and lipoylation pathways. | 2005 | Biochem. Soc. Trans. | pmid:16246025 |
| Nemeria N et al. | Glutamate 636 of the Escherichia coli pyruvate dehydrogenase-E1 participates in active center communication and behaves as an engineered acetolactate synthase with unusual stereoselectivity. | 2005 | J. Biol. Chem. | pmid:15802265 |
| Zhu K et al. | Precursor and temperature modulation of fatty acid composition and growth of Listeria monocytogenes cold-sensitive mutants with transposon-interrupted branched-chain alpha-keto acid dehydrogenase. | 2005 | Microbiology (Reading, Engl.) | pmid:15699210 |
| Lin W and Kang UJ | Neuroprotective therapy in Parkinson's disease: current status and new directions from experimental and genetic clues. | 2005 | J Clin Neurol | pmid:20396458 |
| Rajashankar KR et al. | Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. | 2005 | J. Biol. Chem. | pmid:16093239 |
| Modlich O et al. | Predictors of primary breast cancers responsiveness to preoperative epirubicin/cyclophosphamide-based chemotherapy: translation of microarray data into clinically useful predictive signatures. | 2005 | J Transl Med | pmid:16091131 |
| Nakai T et al. | Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia. | 2005 | EMBO J. | pmid:15791207 |
| Tian J et al. | Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. | 2005 | Mol. Microbiol. | pmid:16045627 |
| Gass N et al. | Pyruvate decarboxylase provides growing pollen tubes with a competitive advantage in petunia. | 2005 | Plant Cell | pmid:15994907 |
| Nogusa Y et al. | Short-term feeding of fish oil down-regulates the expression of pyruvate dehydrogenase E1 alpha subunit mRNA in mouse brain. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15725654 |
| Klyachko NL et al. | pH-dependent substrate preference of pig heart lipoamide dehydrogenase varies with oligomeric state: response to mitochondrial matrix acidification. | 2005 | J. Biol. Chem. | pmid:15710613 |
| Nakai T et al. | Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography. | 2004 | J. Mol. Biol. | pmid:15033367 |
| Wynn RM et al. | Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation. | 2004 | Structure | pmid:15576032 |
| Sweatt AJ et al. | Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:12965870 |
| Tajima G et al. | A simple and rapid enzymatic assay for the branched-chain alpha-ketoacid dehydrogenase complex using high-performance liquid chromatography. | 2004 | J. Inherit. Metab. Dis. | pmid:15669679 |
| Meneses-Lorente G et al. | A proteomic investigation of drug-induced steatosis in rat liver. | 2004 | Chem. Res. Toxicol. | pmid:15144217 |
| Honda T et al. | Effects of liver failure on branched-chain alpha-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure. | 2004 | J. Hepatol. | pmid:15123358 |
| Kasinski A et al. | Leucine toxicity in a neuronal cell model with inhibited branched chain amino acid catabolism. | 2004 | Brain Res. Mol. Brain Res. | pmid:15010210 |
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| Harris RA et al. | Mechanisms responsible for regulation of branched-chain amino acid catabolism. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14684174 |
| Taylor NL et al. | Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. | 2004 | Plant Physiol. | pmid:14764908 |
| Shimomura Y et al. | Effects of liver failure on the enzymes in the branched-chain amino acid catabolic pathway. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14684172 |
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| Park YH et al. | Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit. | 2004 | Biochemistry | pmid:15518552 |
| Marracci GH et al. | Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis. | 2004 | J. Neurosci. Res. | pmid:15389837 |
| Lee HH et al. | Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia. | 2004 | J. Biol. Chem. | pmid:15355973 |
| Li J et al. | Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase. | 2004 | J. Biol. Chem. | pmid:15166214 |
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| Head RA et al. | Pyruvate dehydrogenase deficiency presenting as dystonia in childhood. | 2004 | Dev Med Child Neurol | pmid:15473177 |
| Argyrou A et al. | Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis. | 2004 | J. Biol. Chem. | pmid:15456792 |
| Igamberdiev AU et al. | Dihydrolipoamide dehydrogenase from porcine heart catalyzes NADH-dependent scavenging of nitric oxide. | 2004 | FEBS Lett. | pmid:15196936 |
| LeClere S et al. | IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog. | 2004 | Plant Physiol. | pmid:15173569 |
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| Hiromasa Y et al. | Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components. | 2004 | J. Biol. Chem. | pmid:14638692 |
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| Song JL et al. | Encapsulation of an 86-kDa assembly intermediate inside the cavities of GroEL and its single-ring variant SR1 by GroES. | 2003 | J. Biol. Chem. | pmid:12431983 |
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| Jan W et al. | MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation. | 2003 | Neuroradiology | pmid:12736767 |
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| Persson HL et al. | Prevention of oxidant-induced cell death by lysosomotropic iron chelators. | 2003 | Free Radic. Biol. Med. | pmid:12726917 |
| Zhao X et al. | Assembly of the covalent linkage between lipoic acid and its cognate enzymes. | 2003 | Chem. Biol. | pmid:14700636 |
| Argyrou A et al. | Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level. | 2003 | Biochemistry | pmid:12590611 |
| Wynn RM et al. | Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site. | 2003 | J. Biol. Chem. | pmid:12902323 |
| Masignani V et al. | NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis. | 2003 | Mol. Microbiol. | pmid:14617161 |
| Fujinoki M et al. | Identification of 36-kDa flagellar phosphoproteins associated with hamster sperm motility. | 2003 | J. Biochem. | pmid:12761172 |
| Bykova NV et al. | Phosphorylation of formate dehydrogenase in potato tuber mitochondria. | 2003 | J. Biol. Chem. | pmid:12714601 |
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| Ciszak EM et al. | Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. | 2003 | J. Biol. Chem. | pmid:12651851 |
| Miné M et al. | Splicing error in E1alpha pyruvate dehydrogenase mRNA caused by novel intronic mutation responsible for lactic acidosis and mental retardation. | 2003 | J. Biol. Chem. | pmid:12551913 |
| Shilo S et al. | Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection. | 2003 | Biochem. J. | pmid:12423204 |