Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bryk R et al. | Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. | 2002 | Science | pmid:11799204 |
| Nellis MM et al. | Insulin increases branched-chain alpha-ketoacid dehydrogenase kinase expression in Clone 9 rat cells. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12217904 |
| Sutton I and Neuberger J | Primary biliary cirrhosis: seeking the silent partner of autoimmunity. | 2002 | Gut | pmid:12010869 |
| Omelchenko MV et al. | Recurrent intragenomic recombination leading to sequence homogenization during the evolution of the lipoyl-binding domain. | 2002 | FEMS Microbiol. Lett. | pmid:12007814 |
| Fujiki Y et al. | Activation of the promoters of Arabidopsis genes for the branched-chain alpha-keto acid dehydrogenase complex in transgenic tobacco BY-2 cells under sugar starvation. | 2002 | Plant Cell Physiol. | pmid:11917081 |
| Love-Gregory LD et al. | Evidence of common ancestry for the maple syrup urine disease (MSUD) Y438N allele in non-Mennonite MSUD patients. | 2002 | Mol. Genet. Metab. | pmid:11825067 |
| Bunik VI and Sievers C | Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species. | 2002 | Eur. J. Biochem. | pmid:12383259 |
| Naik MT et al. | Folding kinetics of the lipoic acid-bearing domain of human mitochondrial branched chain alpha-ketoacid dehydrogenase complex. | 2002 | FEBS Lett. | pmid:12387880 |
| Argyrou A et al. | The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis. | 2002 | Biochemistry | pmid:12463758 |
| Nemeria N et al. | Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and transketolase. | 2002 | Biochemistry | pmid:12501174 |
| Lynch CJ et al. | Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:12217901 |
| Dallo SF et al. | Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae. | 2002 | Mol. Microbiol. | pmid:12421310 |
| Owen R et al. | Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors. | 2002 | Mol. Ther. | pmid:12231176 |
| Gao H et al. | The E1beta and E2 subunits of the Bacillus subtilis pyruvate dehydrogenase complex are involved in regulation of sporulation. | 2002 | J. Bacteriol. | pmid:11976308 |
| Huang S et al. | Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein. | 2002 | Biophys. J. | pmid:11964266 |
| Cronan JE | Interchangeable enzyme modules. Functional replacement of the essential linker of the biotinylated subunit of acetyl-CoA carboxylase with a linker from the lipoylated subunit of pyruvate dehydrogenase. | 2002 | J. Biol. Chem. | pmid:11956202 |
| Nicholls LI et al. | Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11866475 |
| Richards JG et al. | Glycogen phosphorylase and pyruvate dehydrogenase transformation in white muscle of trout during high-intensity exercise. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11832404 |
| Jacobia SJ et al. | Characterization of a missense mutation at histidine-44 in a pyruvate dehydrogenase-deficient patient. | 2002 | Biochim. Biophys. Acta | pmid:11781147 |
| Gazaryan IG et al. | Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. | 2002 | J. Biol. Chem. | pmid:11744691 |
| Chang CF et al. | Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex. | 2002 | J. Biol. Chem. | pmid:11839747 |
| Bogenhagen DF et al. | Protein components of mitochondrial DNA nucleoids in higher eukaryotes. | 2003 | Mol. Cell Proteomics | pmid:14514796 |
| Bunik VI | 2-Oxo acid dehydrogenase complexes of multicellular organisms. | 2003 | Eur. J. Biochem. | pmid:12631262 |
| Song JL et al. | Encapsulation of an 86-kDa assembly intermediate inside the cavities of GroEL and its single-ring variant SR1 by GroES. | 2003 | J. Biol. Chem. | pmid:12431983 |
| Raj DS et al. | Markers of inflammation, proteolysis, and apoptosis in ESRD. | 2003 | Am. J. Kidney Dis. | pmid:14655193 |
| Fouque F et al. | Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency. | 2003 | Pediatr. Res. | pmid:12621116 |
| Vanacore N | Premorbid weight, body mass, and varsity athletics in ALS. | 2003 | Neurology | pmid:14557595 |
| Henneke M et al. | Identification of twelve novel mutations in patients with classic and variant forms of maple syrup urine disease. | 2003 | Hum. Mutat. | pmid:14517957 |
| Fries M et al. | Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes. | 2003 | Biochemistry | pmid:12795594 |
| Jan W et al. | MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation. | 2003 | Neuroradiology | pmid:12736767 |
| Bunik VI | 2-Oxo acid dehydrogenase complexes in redox regulation. | 2003 | Eur. J. Biochem. | pmid:12631263 |
| Persson HL et al. | Prevention of oxidant-induced cell death by lysosomotropic iron chelators. | 2003 | Free Radic. Biol. Med. | pmid:12726917 |
| Zhao X et al. | Assembly of the covalent linkage between lipoic acid and its cognate enzymes. | 2003 | Chem. Biol. | pmid:14700636 |
| Argyrou A et al. | Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level. | 2003 | Biochemistry | pmid:12590611 |
| Wynn RM et al. | Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site. | 2003 | J. Biol. Chem. | pmid:12902323 |
| Nordman T et al. | Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase. | 2003 | Biofactors | pmid:14695919 |
| Masignani V et al. | NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis. | 2003 | Mol. Microbiol. | pmid:14617161 |
| Fujinoki M et al. | Identification of 36-kDa flagellar phosphoproteins associated with hamster sperm motility. | 2003 | J. Biochem. | pmid:12761172 |
| Bykova NV et al. | Phosphorylation of formate dehydrogenase in potato tuber mitochondria. | 2003 | J. Biol. Chem. | pmid:12714601 |
| Yui R et al. | Antisense inhibition of mitochondrial pyruvate dehydrogenase E1alpha subunit in anther tapetum causes male sterility. | 2003 | Plant J. | pmid:12662309 |
| Ciszak EM et al. | Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. | 2003 | J. Biol. Chem. | pmid:12651851 |
| Miné M et al. | Splicing error in E1alpha pyruvate dehydrogenase mRNA caused by novel intronic mutation responsible for lactic acidosis and mental retardation. | 2003 | J. Biol. Chem. | pmid:12551913 |
| Shilo S et al. | Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection. | 2003 | Biochem. J. | pmid:12423204 |
| Nakai T et al. | Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography. | 2004 | J. Mol. Biol. | pmid:15033367 |
| Sweatt AJ et al. | Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:12965870 |
| Meneses-Lorente G et al. | A proteomic investigation of drug-induced steatosis in rat liver. | 2004 | Chem. Res. Toxicol. | pmid:15144217 |
| Honda T et al. | Effects of liver failure on branched-chain alpha-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure. | 2004 | J. Hepatol. | pmid:15123358 |
| Kasinski A et al. | Leucine toxicity in a neuronal cell model with inhibited branched chain amino acid catabolism. | 2004 | Brain Res. Mol. Brain Res. | pmid:15010210 |
| Self JT et al. | Glutamine synthesis in the developing porcine placenta. | 2004 | Biol. Reprod. | pmid:14736817 |
| Bafunno V et al. | Riboflavin uptake and FAD synthesis in Saccharomyces cerevisiae mitochondria: involvement of the Flx1p carrier in FAD export. | 2004 | J. Biol. Chem. | pmid:14555654 |