Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen W et al. | Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis. | 2010 | Plant Physiol. | pmid:20488895 |
| LeClere S et al. | IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog. | 2004 | Plant Physiol. | pmid:15173569 |
| Casteel J et al. | Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis. | 2011 | Plant Physiol. Biochem. | pmid:21798751 |
| Leichert LI and Jakob U | Protein thiol modifications visualized in vivo. | 2004 | PLoS Biol. | pmid:15502869 |
| Ojha S et al. | Evolution of function in the "two dinucleotide binding domains" flavoproteins. | 2007 | PLoS Comput. Biol. | pmid:17658942 |
| Bury-Moné S et al. | Global analysis of extracytoplasmic stress signaling in Escherichia coli. | 2009 | PLoS Genet. | pmid:19763168 |
| Kuntz AN et al. | Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. | 2007 | PLoS Med. | pmid:17579510 |
| Barjaktarovic Z et al. | Radiation-induced signaling results in mitochondrial impairment in mouse heart at 4 weeks after exposure to X-rays. | 2011 | PLoS ONE | pmid:22174747 |
| Tondo ML et al. | Structural-functional characterization and physiological significance of ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri. | 2011 | PLoS ONE | pmid:22096528 |
| Spalding MD and Prigge ST | The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo. | 2009 | PLoS ONE | pmid:19812687 |