Lipoamide is a lipid of Fatty Acyls (FA) class. Lipoamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as Phosphorylation, Protonation, Mutagenesis, Site-Directed, Oxidants and Acetylation. Lipoamide often locates in Mitochondria, Mitochondrial matrix, nucleocapsid location and Chloroplasts. The associated genes with lipoamide are Mutant Proteins, Recombinant Proteins, mycothione reductase, alanylproline and Genes, Mitochondrial.
To understand associated biological information of lipoamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lipoamide is suspected in and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with lipoamide
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Hyperglycinemia, Nonketotic | D020158 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hong JK et al. | Growth factor withdrawal in combination with sodium butyrate addition extends culture longevity and enhances antibody production in CHO cells. | 2011 | J. Biotechnol. | pmid:21723342 |
| Ah Mew N et al. | MRI features of 4 female patients with pyruvate dehydrogenase E1 alpha deficiency. | 2011 | Pediatr. Neurol. | pmid:21723463 |
| Ahidjo BA et al. | VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. | 2011 | PLoS ONE | pmid:21738782 |
| pmid:21782792 | ||||
| pmid:21787782 | ||||
| Casteel J et al. | Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis. | 2011 | Plant Physiol. Biochem. | pmid:21798751 |
| pmid:21812000 | ||||
| Park HD et al. | Three Korean patients with maple syrup urine disease: four novel mutations in the BCKDHA gene. | 2011 | Ann. Clin. Lab. Sci. | pmid:21844576 |
| Glushakova LG et al. | Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts. | 2011 | Mol. Genet. Metab. | pmid:21846590 |
| Patterson S et al. | Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography. | 2011 | J. Med. Chem. | pmid:21851087 |
| Griffin J and Engel PC | An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD-Dependent Glutamate Dehydrogenase. | 2011 | Enzyme Res | pmid:21876794 |
| Sharma R et al. | Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency. | 2012 | Dev Med Child Neurol | pmid:21895644 |
| Khan MO | Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design. | 2007 | Drug Target Insights | pmid:21901070 |
| pmid:21914562 | ||||
| Diedrich M et al. | Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease. | 2011 | Proteome Sci | pmid:21943346 |
| Madawala SR et al. | Novel Conjugates of 1,3-Diacylglycerol and Lipoic Acid: Synthesis, DPPH Assay, and RP-LC-MS-APCI Analysis. | 2011 | J Lipids | pmid:21966595 |
| Diebold AR et al. | Activation of α-keto acid-dependent dioxygenases: application of an {FeNO}7/{FeO2}8 methodology for characterizing the initial steps of O2 activation. | 2011 | J. Am. Chem. Soc. | pmid:21981763 |
| Tang H and Goldberg E | A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site. | 2012 | Biol. Reprod. | pmid:21998171 |
| Stobbe MD et al. | Critical assessment of human metabolic pathway databases: a stepping stone for future integration. | 2011 | BMC Syst Biol | pmid:21999653 |
| Vazquez A et al. | Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. | 2011 | PLoS ONE | pmid:22073143 |
| Tondo ML et al. | Structural-functional characterization and physiological significance of ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri. | 2011 | PLoS ONE | pmid:22096528 |
| pmid:22100759 | ||||
| Golbidi S et al. | Diabetes and alpha lipoic Acid. | 2011 | Front Pharmacol | pmid:22125537 |
| Giribaldi G et al. | Intermittent-relapsing pyruvate dehydrogenase complex deficiency: a case with clinical, biochemical, and neuroradiological reversibility. | 2012 | Dev Med Child Neurol | pmid:22142326 |
| Mayr JA et al. | Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation. | 2011 | Am. J. Hum. Genet. | pmid:22152680 |
| Barjaktarovic Z et al. | Radiation-induced signaling results in mitochondrial impairment in mouse heart at 4 weeks after exposure to X-rays. | 2011 | PLoS ONE | pmid:22174747 |
| Marchi S et al. | Mitochondria-ros crosstalk in the control of cell death and aging. | 2012 | J Signal Transduct | pmid:22175013 |
| Reed GH et al. | Radical reactions of thiamin pyrophosphate in 2-oxoacid oxidoreductases. | 2012 | Biochim. Biophys. Acta | pmid:22178227 |
| Chen P et al. | Dietary lipoic acid influences antioxidant capability and oxidative status of broilers. | 2011 | Int J Mol Sci | pmid:22272085 |
| Ferguson LR and Karunasinghe N | Nutrigenetics, nutrigenomics, and selenium. | 2011 | Front Genet | pmid:22303312 |
| Kennedy BW et al. | Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate. | 2012 | J. Am. Chem. Soc. | pmid:22316419 |
| Wang YP et al. | Two novel mutations in the BCKDHB gene (R170H, Q346R) cause the classic form of maple syrup urine disease (MSUD). | 2012 | Gene | pmid:22326532 |
| Adams SH | Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. | 2011 | Adv Nutr | pmid:22332087 |
| pmid:22385680 | ||||
| Eskra L et al. | Differential expression of iron acquisition genes by Brucella melitensis and Brucella canis during macrophage infection. | 2012 | PLoS ONE | pmid:22403618 |
| Brown G | Pyruvate dehydrogenase deficiency and the brain. | 2012 | Dev Med Child Neurol | pmid:22409661 |
| Li Y et al. | Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis. | 2012 | Mar Drugs | pmid:22412803 |
| Ngamskulrungroj P et al. | Differences in nitrogen metabolism between Cryptococcus neoformans and C. gattii, the two etiologic agents of cryptococcosis. | 2012 | PLoS ONE | pmid:22479580 |
| Tam TK et al. | In situ regeneration of NADH via lipoamide dehydrogenase-catalyzed electron transfer reaction evidenced by spectroelectrochemistry. | 2012 | Bioelectrochemistry | pmid:22497727 |
| Pancaldi V et al. | Predicting the fission yeast protein interaction network. | 2012 | G3 (Bethesda) | pmid:22540037 |
| Shaler CR et al. | Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis. | 2012 | Clin. Dev. Immunol. | pmid:22545059 |
| Saylor PJ et al. | Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer. | 2012 | Clin. Cancer Res. | pmid:22589396 |
| Zhou M et al. | Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm). | 2012 | J. Biol. Chem. | pmid:22589535 |
| Knorre DG et al. | Chemical and functional aspects of posttranslational modification of proteins. | 2009 | Acta Naturae | pmid:22649613 |
| Pinheiro A et al. | Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues. | 2012 | PLoS ONE | pmid:22675509 |
| Finnegan PM and Chen W | Arsenic toxicity: the effects on plant metabolism. | 2012 | Front Physiol | pmid:22685440 |
| Lam AK et al. | Quantitative imaging of electron transfer flavoprotein autofluorescence reveals the dynamics of lipid partitioning in living pancreatic islets. | 2012 | Integr Biol (Camb) | pmid:22733276 |
| pmid:22750801 | ||||
| Hessel EV et al. | Mapping an X-linked locus that influences heat-induced febrile seizures in mice. | 2012 | Epilepsia | pmid:22780306 |
| Novarino G et al. | Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. | 2012 | Science | pmid:22956686 |
| da Silva Neto JF et al. | Analysis of the organic hydroperoxide response of Chromobacterium violaceum reveals that OhrR is a cys-based redox sensor regulated by thioredoxin. | 2012 | PLoS ONE | pmid:23071722 |
| Beaudet AL | Neuroscience. Preventable forms of autism? | 2012 | Science | pmid:23087240 |
| McLain AL et al. | Glutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification. | 2013 | Free Radic. Biol. Med. | pmid:23567190 |
| Li Y et al. | Scavenging of blood glutamate for enhancing brain-to-blood glutamate efflux. | 2014 | Mol Med Rep | pmid:24220720 |
| Bryk R et al. | Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. | 2013 | Biochemistry | pmid:24251446 |
| Fussey SP et al. | Characterisation of the reactivity of autoantibodies in primary biliary cirrhosis. | 1989 | FEBS Lett. | pmid:2468528 |
| Flannery GR et al. | Antimitochondrial antibodies in primary biliary cirrhosis recognize both specific peptides and shared epitopes of the M2 family of antigens. | 1989 | Hepatology | pmid:2474482 |
| Mathias RA et al. | Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. | 2014 | Cell | pmid:25525879 |
| Zhao L et al. | Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. | 2015 | PLoS ONE | pmid:26030919 |
| pmid:27671355 | ||||
| Spector A et al. | Thioredoxin fragment 31-36 is reduced by dihydrolipoamide and reduces oxidized protein. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3122752 |
| Said HM et al. | Biotin transport in basolateral membrane vesicles of human intestine. | 1988 | Gastroenterology | pmid:3350285 |
| Kodama S et al. | The effect of a high fat diet on pyruvate decarboxylase deficiency without central nervous system involvement. | 1983 | Brain Dev. | pmid:6416099 |
| Jocelyn PC and Cronshaw AD | The reduction of disulphides by rat liver mitochondria. | 1984 | Biochim. Biophys. Acta | pmid:6421329 |
| Goldstein BN et al. | Principles of symmetrical organization for the pyruvate dehydrogenase complex. | 1995 | FEBS Lett. | pmid:7589478 |
| Sumegi B et al. | Lipoamide influences substrate selection in post-ischaemic perfused rat hearts. | 1994 | Biochem. J. | pmid:7904156 |
| Thijssen HH et al. | Microsomal lipoamide reductase provides vitamin K epoxide reductase with reducing equivalents. | 1994 | Biochem. J. | pmid:8297331 |
| Mattevi A et al. | Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties. | 1993 | J. Mol. Biol. | pmid:8487301 |
| Arnér ES et al. | Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8769129 |
| Pañak KC et al. | Direct determination of glutathione in human blood by micellar electrokinetic chromatography: simultaneous determination of lipoamide and lipoic acid. | 1996 | Electrophoresis | pmid:8957191 |
| Bustamante J et al. | Early redox changes during rat thymocyte apoptosis. | 1997 | Arch. Biochem. Biophys. | pmid:8990276 |
| Sen CK et al. | Regulation of cellular thiols in human lymphocytes by alpha-lipoic acid: a flow cytometric analysis. | 1997 | Free Radic. Biol. Med. | pmid:9098099 |
| Bisby RH and Parker AW | Antioxidant reactions of dihydrolipoic acid and lipoamide with triplet duroquinone. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514912 |