MeSH term | MeSH ID | Detail |
---|---|---|
Edema | D004487 | 152 associated lipids |
Hypertension | D006973 | 115 associated lipids |
Catalepsy | D002375 | 30 associated lipids |
Hypothermia | D007035 | 19 associated lipids |
Amnesia | D000647 | 12 associated lipids |
Elaidamide is a lipid of Fatty Acyls (FA) class. Elaidamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.
To understand associated biological information of Elaidamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Elaidamide is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Elaidamide
MeSH term | MeSH ID | Detail |
---|---|---|
Edema | D004487 | 152 associated lipids |
Hypertension | D006973 | 115 associated lipids |
Catalepsy | D002375 | 30 associated lipids |
Hypothermia | D007035 | 19 associated lipids |
Amnesia | D000647 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid:28340410 | ||||
pmid:27595606 | ||||
pmid:27152459 | ||||
pmid:27087645 | ||||
pmid:27049283 | ||||
pmid:26711911 | ||||
pmid:26547872 | ||||
pmid:26408695 | ||||
pmid:25660201 | ||||
pmid:25652184 | ||||
pmid:25641667 | ||||
pmid:25171777 | ||||
pmid: | ||||
Osmundsen PE | Contact urticaria from nickel and plastic additives (butylhydroxytoluene, oleylamide). | 1980 | Contact Derm. | pmid:7214887 |
Cravatt BF et al. | Chemical characterization of a family of brain lipids that induce sleep. | 1995 | Science | pmid:7770779 |
Huidobro-Toro JP and Harris RA | Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8755606 |
Langstein J et al. | cis-9,10-octadecenoamide, an endogenous sleep-inducing CNS compound, inhibits lymphocyte proliferation. | 1996 Jul-Aug | Res. Immunol. | pmid:8903105 |
Thomas EA et al. | Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. | 1997 | J. Neurosci. Res. | pmid:9452020 |
Bisogno T et al. | The sleep inducing factor oleamide is produced by mouse neuroblastoma cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9344854 |
Lerner RA | A hypothesis about the endogenous analogue of general anesthesia. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9391028 |
Thomas EA et al. | Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9391162 |
Mechoulam R et al. | Anandamide may mediate sleep induction. | 1997 | Nature | pmid:9288961 |
Guan X et al. | The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. | 1997 | J. Cell Biol. | pmid:9412472 |
Jenkins TC | Fatty acid composition of milk from Holstein cows fed oleamide or canola oil. | 1998 | J. Dairy Sci. | pmid:9565883 |
Boger DL et al. | Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539697 |
Boger DL et al. | Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9560184 |
Huang GY et al. | Gap junction-mediated cell-cell communication modulates mouse neural crest migration. | 1998 | J. Cell Biol. | pmid:9852163 |
Bisogno T et al. | Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells--implications for cell proliferation and differentiation. | 1998 | Eur. J. Biochem. | pmid:9688276 |
Lees G et al. | Modulation of GABA(A) receptors and inhibitory synaptic currents by the endogenous CNS sleep regulator cis-9,10-octadecenoamide (cOA). | 1998 | Br. J. Pharmacol. | pmid:9692771 |
Yost CS et al. | Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. | 1998 | Anesth. Analg. | pmid:9620523 |
Thomas EA et al. | Oleamide-induced modulation of 5-hydroxytryptamine receptor-mediated signaling. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9928256 |
Basile AS et al. | Characterization of the hypnotic properties of oleamide. | 1999 | Neuroreport | pmid:10321465 |
Hanus LO et al. | A gas chromatographic-mass spectral assay for the quantitative determination of oleamide in biological fluids. | 1999 | Anal. Biochem. | pmid:10328778 |
Jenkins TC | Lactation performance and fatty acid composition of milk from Holstein cows fed 0 to 5% oleamide. | 1999 | J. Dairy Sci. | pmid:10416167 |
Boger DL et al. | Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10021942 |
Yang JY et al. | Studies on the sedative and hypnotic effects of oleamide in mice. | 1999 | Arzneimittelforschung | pmid:10483511 |
Thomas EA et al. | The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. | 1999 | J. Neurochem. | pmid:10349846 |
Mendelson WB and Basile AS | The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist. | 1999 | Neuroreport | pmid:10574567 |
Gobbi M et al. | Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity. | 1999 | FEBS Lett. | pmid:10606738 |
Hedlund PB et al. | Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. | 1999 | Biochem. Pharmacol. | pmid:10571256 |
Cheer JF et al. | Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors. | 1999 | Neuropharmacology | pmid:10221757 |
Boger DL et al. | Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10805767 |
DeLuca DD and Jenkins TC | Feeding oleamide to lactating Jersey cows. 2. Effects on nutrient digestibility, plasma fatty acids, and hormones. | 2000 | J. Dairy Sci. | pmid:10750115 |
Jenkins TC et al. | Site of administration and duration of feeding oleamide to cattle on feed intake and ruminal fatty acid concentrations. | 2000 | J. Anim. Sci. | pmid:11048942 |
Quist AP et al. | Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. | 2000 | J. Cell Biol. | pmid:10704454 |
Egertová M et al. | Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide. | 2000 | Neurosci. Lett. | pmid:10713385 |
Verdon B et al. | Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na(+) channels in vitro: a putative endogenous ligand for depressant drug sites in CNS. | 2000 | Br. J. Pharmacol. | pmid:10694234 |
Ritenour-Rodgers KJ et al. | Induction of peptidylglycine alpha-amidating monooxygenase in N(18)TG(2) cells: a model for studying oleamide biosynthesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10631094 |
Jenkins TC | Feeding oleamide to lactating Jersey cows 1. Effects on lactation performance and milk fatty acid composition. | 2000 | J. Dairy Sci. | pmid:10714869 |
Schweitzer JS et al. | pH Sensitivity of non-synaptic field bursts in the dentate gyrus. | 2000 | J. Neurophysiol. | pmid:10938317 |
Bannerman P et al. | Early migratory rat neural crest cells express functional gap junctions: evidence that neural crest cell survival requires gap junction function. | 2000 | J. Neurosci. Res. | pmid:10972957 |
Nicholson RA et al. | Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain. | 2001 | Anesthesiology | pmid:11135731 |
Huang JK and Jan CR | Linoleamide, a brain lipid that induces sleep, increases cytosolic Ca2+ levels in MDCK renal tubular cells. | 2001 | Life Sci. | pmid:11212875 |
Huitrón-Reséndiz S et al. | Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats. | 2001 | Exp. Neurol. | pmid:11681856 |
Alberts GL et al. | Allosteric modulation of the human 5-HT(7A) receptor by lipidic amphipathic compounds. | 2001 | Mol. Pharmacol. | pmid:11723242 |
Lo YK et al. | Effect of oleamide on Ca(2+) signaling in human bladder cancer cells. | 2001 | Biochem. Pharmacol. | pmid:11709196 |
Fowler CJ et al. | Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. | 2001 | Biochem. Pharmacol. | pmid:11585048 |
Fedorova I et al. | Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11561096 |
SiuYi Leung D et al. | Gap junctions modulate survival-promoting effects of fibroblast growth factor-2 on cultured midbrain dopaminergic neurons. | 2001 | Mol. Cell. Neurosci. | pmid:11461152 |
Laws D et al. | Fatty acid amides are putative endogenous ligands for anaesthetic recognition sites in mammalian CNS. | 2001 | Br J Anaesth | pmid:11517120 |
Rami A et al. | Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia. | 2001 | Exp. Neurol. | pmid:11476596 |
Laposky AD et al. | Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. | 2001 | Neuroreport | pmid:11742254 |
Murillo-RodrÃguez E et al. | Oleamide modulates memory in rats. | 2001 | Neurosci. Lett. | pmid:11684340 |
Jenkins TC et al. | Direct methylation procedure for converting fatty amides to fatty acid methyl esters in feed and digesta samples. | 2001 | J. Agric. Food Chem. | pmid:11368568 |
Boger DL et al. | alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11412972 |
Schiller PC et al. | Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro. | 2001 | J. Biol. Chem. | pmid:11278824 |
Mendelson WB and Basile AS | The hypnotic actions of the fatty acid amide, oleamide. | 2001 | Neuropsychopharmacology | pmid:11682271 |
Yang JY et al. | Oleamide attenuates apoptotic death in cultured rat cerebellar granule neurons. | 2002 | Neurosci. Lett. | pmid:12133580 |
Bisogno T et al. | Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. | 2002 | Curr. Pharm. Des. | pmid:11945157 |
Krutovskikh VA et al. | Gap junction intercellular communication propagates cell death in cancerous cells. | 2002 | Oncogene | pmid:11960371 |
Lichtman AH et al. | Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12065702 |
Coleman AM and Sengelaub DR | Patterns of dye coupling in lumbar motor nuclei of the rat. | 2002 | J. Comp. Neurol. | pmid:12410616 |
Cherezov V et al. | Membrane protein crystallization in meso: lipid type-tailoring of the cubic phase. | 2002 | Biophys. J. | pmid:12496106 |
Coyne L et al. | The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. | 2002 | Br. J. Pharmacol. | pmid:11959801 |
Burnside AS and Collas P | Induction of Oct-3/4 expression in somatic cells by gap junction-mediated cAMP signaling from blastomeres. | 2002 | Eur. J. Cell Biol. | pmid:12494995 |
Wu CF et al. | Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. | 2003 | J. Pharm. Pharmacol. | pmid:12956907 |
Slotema WF et al. | Economically pertinent continuous amide formation by direct lipase-catalyzed amidation with ammonia. | 2003 | Biotechnol. Bioeng. | pmid:12673765 |
Ransjö M et al. | Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684060 |
Hedlund PB et al. | No hypothermic response to serotonin in 5-HT7 receptor knockout mice. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12529502 |
Heo HJ et al. | Effects of oleamide on choline acetyltransferase and cognitive activities. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12843655 |
Yang JY et al. | The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14615880 |
Uyama N et al. | Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture. | 2003 | J. Hepatol. | pmid:14568257 |
Dougalis A et al. | The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. | 2004 | Neuropharmacology | pmid:14654098 |
Ito A et al. | A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells. | 2004 | Carcinogenesis | pmid:15205356 |
MartÃnez-González D et al. | Oleamide and anandamide effects on food intake and sexual behavior of rats. | 2004 | Neurosci. Lett. | pmid:15193744 |
Foster AM and Sengelaub DR | Bilateral organization of unilaterally generated activity in lumbar spinal motoneurons of the rat. | 2004 | Brain Res. | pmid:15120587 |
Leggett JD et al. | Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. | 2004 | Br. J. Pharmacol. | pmid:14707029 |
Fowler CJ | Oleamide: a member of the endocannabinoid family? | 2004 | Br. J. Pharmacol. | pmid:14691053 |
Lees G and Dougalis A | Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. | 2004 | Brain Res. | pmid:14715144 |
Merkler DJ et al. | Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells. | 2004 | Biochemistry | pmid:15449956 |
Huitron-Resendiz S et al. | Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. | 2004 | Sleep | pmid:15453543 |
Dougalis A et al. | The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model. | 2004 | Neuropharmacology | pmid:14975678 |
De Bank PA et al. | A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. | 2005 | Biochem. Pharmacol. | pmid:15794939 |
Hill MN and Gorzalka BB | Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. | 2005 | Eur Neuropsychopharmacol | pmid:15916883 |
Varvel SA et al. | Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16352706 |
Grijalvo S et al. | Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. | 2006 | Chem. Phys. Lipids | pmid:16942762 |
Chaturvedi S et al. | In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085322 |
Hoi PM and Hiley CR | Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. | 2006 | Br. J. Pharmacol. | pmid:16415907 |
Garrido-López A et al. | Determination of oleamide and erucamide in polyethylene films by pressurised fluid extraction and gas chromatography. | 2006 | J Chromatogr A | pmid:16716333 |
Tubert-Brohman I et al. | Elucidation of hydrolysis mechanisms for fatty acid amide hydrolase and its Lys142Ala variant via QM/MM simulations. | 2006 | J. Am. Chem. Soc. | pmid:17177441 |