Elaidamide

Elaidamide is a lipid of Fatty Acyls (FA) class. Elaidamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.

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Introduction

To understand associated biological information of Elaidamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Elaidamide?

Elaidamide is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Elaidamide

PubChem Associated disorders and diseases

What pathways are associated with Elaidamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What functions are associated with Elaidamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What genes are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Elaidamide

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Authors Title Published Journal PubMed Link
Wu CF et al. Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. 2003 J. Pharm. Pharmacol. pmid:12956907
Fedorova I et al. Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems. 2001 J. Pharmacol. Exp. Ther. pmid:11561096
Lichtman AH et al. Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. 2002 J. Pharmacol. Exp. Ther. pmid:12065702
Varvel SA et al. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. 2006 J. Pharmacol. Exp. Ther. pmid:16352706
Zhang R et al. One-step formation of straight nanostripes from a mammal lipid-oleamide directly on highly oriented pyrolytic graphite. 2009 Langmuir pmid:19125608
Zhang L et al. Fabrication of microspheres via solvent volatization induced aggregation of self-assembled nanomicellar structures and their use as a pH-dependent drug release system. 2013 Langmuir pmid:23215353
Huang JK and Jan CR Linoleamide, a brain lipid that induces sleep, increases cytosolic Ca2+ levels in MDCK renal tubular cells. 2001 Life Sci. pmid:11212875
Dionisi M et al. Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) in vitro. 2012 Lipids Health Dis pmid:22584002
Yang J et al. Connexin 32 and its derived homotypic gap junctional intercellular communication inhibit the migration and invasion of transfected HeLa cells via enhancement of intercellular adhesion. 2011 Sep-Oct Mol Med Rep pmid:21687945
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Alberts GL et al. Allosteric modulation of the human 5-HT(7A) receptor by lipidic amphipathic compounds. 2001 Mol. Pharmacol. pmid:11723242
Roy A et al. Identification and characterization of PPARα ligands in the hippocampus. 2016 Nat. Chem. Biol. pmid:27748752
Mechoulam R et al. Anandamide may mediate sleep induction. 1997 Nature pmid:9288961
Yang JY et al. The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. 2003 Naunyn Schmiedebergs Arch. Pharmacol. pmid:14615880
Adriano E et al. A novel hypothesis about mechanisms affecting conduction velocity of central myelinated fibers. 2011 Neurochem. Res. pmid:21553257
Cheer JF et al. Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors. 1999 Neuropharmacology pmid:10221757
Dougalis A et al. The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. 2004 Neuropharmacology pmid:14654098
Wise LE et al. Evaluation of fatty acid amides in the carrageenan-induced paw edema model. 2008 Neuropharmacology pmid:17675189
Dougalis A et al. The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model. 2004 Neuropharmacology pmid:14975678
Riquelme MA et al. The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels. 2013 Neuropharmacology pmid:23583931
Mendelson WB and Basile AS The hypnotic actions of the fatty acid amide, oleamide. 2001 Neuropsychopharmacology pmid:11682271
Basile AS et al. Characterization of the hypnotic properties of oleamide. 1999 Neuroreport pmid:10321465
Laposky AD et al. Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. 2001 Neuroreport pmid:11742254
Mendelson WB and Basile AS The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist. 1999 Neuroreport pmid:10574567
Murillo-Rodríguez E et al. Oleamide modulates memory in rats. 2001 Neurosci. Lett. pmid:11684340
Yang JY et al. Oleamide attenuates apoptotic death in cultured rat cerebellar granule neurons. 2002 Neurosci. Lett. pmid:12133580
Egertová M et al. Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide. 2000 Neurosci. Lett. pmid:10713385
Martínez-González D et al. Oleamide and anandamide effects on food intake and sexual behavior of rats. 2004 Neurosci. Lett. pmid:15193744
Oh YT et al. Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells. 2010 Neurosci. Lett. pmid:20298753
Kruk-Slomka M et al. The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801. 2016 Neurotox Res pmid:27577742
Krutovskikh VA et al. Gap junction intercellular communication propagates cell death in cancerous cells. 2002 Oncogene pmid:11960371
Yang Y et al. Connexin-dependent gap junction enhancement is involved in the synergistic effect of sorafenib and all-trans retinoic acid on HCC growth inhibition. 2014 Oncol. Rep. pmid:24317203
Yoshitani K et al. Low concentrations of alendronate increase the local invasive potential of osteoblastic sarcoma cell lines via connexin 43 activation. 2011 Pathol. Res. Pract. pmid:21665377
Herrera-Solís A et al. Acute and subchronic administration of anandamide or oleamide increases REM sleep in rats. 2010 Pharmacol. Biochem. Behav. pmid:20056119
Reyes Prieto NM et al. Oleamide restores sleep in adult rats that were subjected to maternal separation. 2012 Pharmacol. Biochem. Behav. pmid:22975223
Munigunti R et al. Identification of oleamide in Guatteria recurvisepala by LC/MS-based Plasmodium falciparum thioredoxin reductase ligand binding method. 2011 Planta Med. pmid:21567357
Au K and Ehrlich HP Does rat granulation tissue maturation involve gap junction communications? 2007 Plast. Reconstr. Surg. pmid:17572550
Ano Y et al. Preventive effects of a fermented dairy product against Alzheimer's disease and identification of a novel oleamide with enhanced microglial phagocytosis and anti-inflammatory activity. 2015 PLoS ONE pmid:25760987
Lerner RA A hypothesis about the endogenous analogue of general anesthesia. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9391028
Thomas EA et al. Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9391162
Boger DL et al. Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9539697
Boger DL et al. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9560184
Hedlund PB et al. No hypothermic response to serotonin in 5-HT7 receptor knockout mice. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12529502
Boger DL et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10805767
Huidobro-Toro JP and Harris RA Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8755606
Wei XY et al. Anxiolytic-like effects of oleamide in group-housed and socially isolated mice. 2007 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:17521793
Chaturvedi S et al. In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. 2006 Prostaglandins Other Lipid Mediat. pmid:17085322
Langstein J et al. cis-9,10-octadecenoamide, an endogenous sleep-inducing CNS compound, inhibits lymphocyte proliferation. 1996 Jul-Aug Res. Immunol. pmid:8903105
Cravatt BF et al. Chemical characterization of a family of brain lipids that induce sleep. 1995 Science pmid:7770779
McDonald GR et al. Bioactive contaminants leach from disposable laboratory plasticware. 2008 Science pmid:18988846