MeSH term | MeSH ID | Detail |
---|---|---|
Edema | D004487 | 152 associated lipids |
Hypertension | D006973 | 115 associated lipids |
Catalepsy | D002375 | 30 associated lipids |
Hypothermia | D007035 | 19 associated lipids |
Amnesia | D000647 | 12 associated lipids |
Elaidamide is a lipid of Fatty Acyls (FA) class. Elaidamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.
To understand associated biological information of Elaidamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Elaidamide is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Elaidamide
MeSH term | MeSH ID | Detail |
---|---|---|
Edema | D004487 | 152 associated lipids |
Hypertension | D006973 | 115 associated lipids |
Catalepsy | D002375 | 30 associated lipids |
Hypothermia | D007035 | 19 associated lipids |
Amnesia | D000647 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid: | ||||
Boger DL et al. | Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10021942 |
Cheer JF et al. | Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors. | 1999 | Neuropharmacology | pmid:10221757 |
Basile AS et al. | Characterization of the hypnotic properties of oleamide. | 1999 | Neuroreport | pmid:10321465 |
Hanus LO et al. | A gas chromatographic-mass spectral assay for the quantitative determination of oleamide in biological fluids. | 1999 | Anal. Biochem. | pmid:10328778 |
Thomas EA et al. | The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. | 1999 | J. Neurochem. | pmid:10349846 |
Jenkins TC | Lactation performance and fatty acid composition of milk from Holstein cows fed 0 to 5% oleamide. | 1999 | J. Dairy Sci. | pmid:10416167 |
Yang JY et al. | Studies on the sedative and hypnotic effects of oleamide in mice. | 1999 | Arzneimittelforschung | pmid:10483511 |
Hedlund PB et al. | Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. | 1999 | Biochem. Pharmacol. | pmid:10571256 |
Mendelson WB and Basile AS | The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist. | 1999 | Neuroreport | pmid:10574567 |
Gobbi M et al. | Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity. | 1999 | FEBS Lett. | pmid:10606738 |
Ritenour-Rodgers KJ et al. | Induction of peptidylglycine alpha-amidating monooxygenase in N(18)TG(2) cells: a model for studying oleamide biosynthesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10631094 |
Verdon B et al. | Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na(+) channels in vitro: a putative endogenous ligand for depressant drug sites in CNS. | 2000 | Br. J. Pharmacol. | pmid:10694234 |
Quist AP et al. | Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. | 2000 | J. Cell Biol. | pmid:10704454 |
Egertová M et al. | Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide. | 2000 | Neurosci. Lett. | pmid:10713385 |
Jenkins TC | Feeding oleamide to lactating Jersey cows 1. Effects on lactation performance and milk fatty acid composition. | 2000 | J. Dairy Sci. | pmid:10714869 |
DeLuca DD and Jenkins TC | Feeding oleamide to lactating Jersey cows. 2. Effects on nutrient digestibility, plasma fatty acids, and hormones. | 2000 | J. Dairy Sci. | pmid:10750115 |
Boger DL et al. | Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10805767 |
Schweitzer JS et al. | pH Sensitivity of non-synaptic field bursts in the dentate gyrus. | 2000 | J. Neurophysiol. | pmid:10938317 |
Bannerman P et al. | Early migratory rat neural crest cells express functional gap junctions: evidence that neural crest cell survival requires gap junction function. | 2000 | J. Neurosci. Res. | pmid:10972957 |
Jenkins TC et al. | Site of administration and duration of feeding oleamide to cattle on feed intake and ruminal fatty acid concentrations. | 2000 | J. Anim. Sci. | pmid:11048942 |
Nicholson RA et al. | Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain. | 2001 | Anesthesiology | pmid:11135731 |
Huang JK and Jan CR | Linoleamide, a brain lipid that induces sleep, increases cytosolic Ca2+ levels in MDCK renal tubular cells. | 2001 | Life Sci. | pmid:11212875 |
Schiller PC et al. | Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro. | 2001 | J. Biol. Chem. | pmid:11278824 |
Jenkins TC et al. | Direct methylation procedure for converting fatty amides to fatty acid methyl esters in feed and digesta samples. | 2001 | J. Agric. Food Chem. | pmid:11368568 |
Boger DL et al. | alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11412972 |
SiuYi Leung D et al. | Gap junctions modulate survival-promoting effects of fibroblast growth factor-2 on cultured midbrain dopaminergic neurons. | 2001 | Mol. Cell. Neurosci. | pmid:11461152 |
Rami A et al. | Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia. | 2001 | Exp. Neurol. | pmid:11476596 |
Laws D et al. | Fatty acid amides are putative endogenous ligands for anaesthetic recognition sites in mammalian CNS. | 2001 | Br J Anaesth | pmid:11517120 |
Fedorova I et al. | Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11561096 |
Fowler CJ et al. | Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. | 2001 | Biochem. Pharmacol. | pmid:11585048 |
Huitrón-Reséndiz S et al. | Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats. | 2001 | Exp. Neurol. | pmid:11681856 |
Mendelson WB and Basile AS | The hypnotic actions of the fatty acid amide, oleamide. | 2001 | Neuropsychopharmacology | pmid:11682271 |
Murillo-RodrÃguez E et al. | Oleamide modulates memory in rats. | 2001 | Neurosci. Lett. | pmid:11684340 |
Lo YK et al. | Effect of oleamide on Ca(2+) signaling in human bladder cancer cells. | 2001 | Biochem. Pharmacol. | pmid:11709196 |
Alberts GL et al. | Allosteric modulation of the human 5-HT(7A) receptor by lipidic amphipathic compounds. | 2001 | Mol. Pharmacol. | pmid:11723242 |
Laposky AD et al. | Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. | 2001 | Neuroreport | pmid:11742254 |
Bisogno T et al. | Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. | 2002 | Curr. Pharm. Des. | pmid:11945157 |
Coyne L et al. | The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. | 2002 | Br. J. Pharmacol. | pmid:11959801 |
Krutovskikh VA et al. | Gap junction intercellular communication propagates cell death in cancerous cells. | 2002 | Oncogene | pmid:11960371 |
Lichtman AH et al. | Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12065702 |
Yang JY et al. | Oleamide attenuates apoptotic death in cultured rat cerebellar granule neurons. | 2002 | Neurosci. Lett. | pmid:12133580 |
Coleman AM and Sengelaub DR | Patterns of dye coupling in lumbar motor nuclei of the rat. | 2002 | J. Comp. Neurol. | pmid:12410616 |
Burnside AS and Collas P | Induction of Oct-3/4 expression in somatic cells by gap junction-mediated cAMP signaling from blastomeres. | 2002 | Eur. J. Cell Biol. | pmid:12494995 |
Cherezov V et al. | Membrane protein crystallization in meso: lipid type-tailoring of the cubic phase. | 2002 | Biophys. J. | pmid:12496106 |
Hedlund PB et al. | No hypothermic response to serotonin in 5-HT7 receptor knockout mice. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12529502 |
Slotema WF et al. | Economically pertinent continuous amide formation by direct lipase-catalyzed amidation with ammonia. | 2003 | Biotechnol. Bioeng. | pmid:12673765 |
Ransjö M et al. | Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684060 |
Heo HJ et al. | Effects of oleamide on choline acetyltransferase and cognitive activities. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12843655 |
Wu CF et al. | Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. | 2003 | J. Pharm. Pharmacol. | pmid:12956907 |
Uyama N et al. | Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture. | 2003 | J. Hepatol. | pmid:14568257 |
Yang JY et al. | The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14615880 |
Dougalis A et al. | The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. | 2004 | Neuropharmacology | pmid:14654098 |
Fowler CJ | Oleamide: a member of the endocannabinoid family? | 2004 | Br. J. Pharmacol. | pmid:14691053 |
Leggett JD et al. | Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. | 2004 | Br. J. Pharmacol. | pmid:14707029 |
Lees G and Dougalis A | Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. | 2004 | Brain Res. | pmid:14715144 |
Dougalis A et al. | The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model. | 2004 | Neuropharmacology | pmid:14975678 |
Foster AM and Sengelaub DR | Bilateral organization of unilaterally generated activity in lumbar spinal motoneurons of the rat. | 2004 | Brain Res. | pmid:15120587 |
MartÃnez-González D et al. | Oleamide and anandamide effects on food intake and sexual behavior of rats. | 2004 | Neurosci. Lett. | pmid:15193744 |
Ito A et al. | A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells. | 2004 | Carcinogenesis | pmid:15205356 |
Merkler DJ et al. | Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells. | 2004 | Biochemistry | pmid:15449956 |
Huitron-Resendiz S et al. | Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. | 2004 | Sleep | pmid:15453543 |
De Bank PA et al. | A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. | 2005 | Biochem. Pharmacol. | pmid:15794939 |
Hill MN and Gorzalka BB | Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. | 2005 | Eur Neuropsychopharmacol | pmid:15916883 |
Varvel SA et al. | Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16352706 |
Hoi PM and Hiley CR | Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. | 2006 | Br. J. Pharmacol. | pmid:16415907 |
Ehrlich HP et al. | Gap junction communications influence upon fibroblast synthesis of Type I collagen and fibronectin. | 2006 | J. Cell. Biochem. | pmid:16475185 |
Nagasawa K et al. | Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells. | 2006 | J. Cell. Physiol. | pmid:16547974 |
Lee YJ et al. | Enhanced radiosensitization of p53 mutant cells by oleamide. | 2006 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:16580498 |
Garrido-López A et al. | Determination of oleamide and erucamide in polyethylene films by pressurised fluid extraction and gas chromatography. | 2006 | J Chromatogr A | pmid:16716333 |
Grijalvo S et al. | Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. | 2006 | Chem. Phys. Lipids | pmid:16942762 |
Chaturvedi S et al. | In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085322 |
Garrido-López A et al. | Comparison of three gas chromatography methods for the determination of slip agents in polyethylene films. | 2007 | J Chromatogr A | pmid:17161408 |
Tubert-Brohman I et al. | Elucidation of hydrolysis mechanisms for fatty acid amide hydrolase and its Lys142Ala variant via QM/MM simulations. | 2006 | J. Am. Chem. Soc. | pmid:17177441 |
Nichols KK et al. | Identification of fatty acids and fatty acid amides in human meibomian gland secretions. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17197513 |
Romero FA et al. | Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. | 2007 | J. Med. Chem. | pmid:17279740 |
Ohba Y et al. | Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26. | 2007 | Int. J. Cancer | pmid:17290388 |
Hiley CR and Hoi PM | Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? | 2007 | Cardiovasc Drug Rev | pmid:17445087 |
Driscoll WJ et al. | Oleamide synthesizing activity from rat kidney: identification as cytochrome c. | 2007 | J. Biol. Chem. | pmid:17496328 |
Wei XY et al. | Anxiolytic-like effects of oleamide in group-housed and socially isolated mice. | 2007 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:17521793 |
Saito M et al. | The functional interrelationship between gap junctions and fenestrae in endothelial cells of the liver organoid. | 2007 | J. Membr. Biol. | pmid:17568973 |
Leaphart CL et al. | Interferon-gamma inhibits intestinal restitution by preventing gap junction communication between enterocytes. | 2007 | Gastroenterology | pmid:17570214 |
Au K and Ehrlich HP | Does rat granulation tissue maturation involve gap junction communications? | 2007 | Plast. Reconstr. Surg. | pmid:17572550 |
Akanmu MA et al. | Neuropharmacological effects of oleamide in male and female mice. | 2007 | Behav. Brain Res. | pmid:17588682 |
Wise LE et al. | Evaluation of fatty acid amides in the carrageenan-induced paw edema model. | 2008 | Neuropharmacology | pmid:17675189 |
Farrell EK and Merkler DJ | Biosynthesis, degradation and pharmacological importance of the fatty acid amides. | 2008 | Drug Discov. Today | pmid:18598910 |
Nojima H et al. | Oleamide derivatives are prototypical anti-metastasis drugs that act by inhibiting Connexin 26. | 2007 | Curr Drug Saf | pmid:18690969 |
Ciovacco WA et al. | The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. | 2009 | Bone | pmid:18848655 |
McDonald GR et al. | Bioactive contaminants leach from disposable laboratory plasticware. | 2008 | Science | pmid:18988846 |
Solomonia R et al. | Effect of oleamide on pentylenetetrazole-induced seizures in rats. | 2008 | Bull. Exp. Biol. Med. | pmid:19023975 |
Zhang R et al. | One-step formation of straight nanostripes from a mammal lipid-oleamide directly on highly oriented pyrolytic graphite. | 2009 | Langmuir | pmid:19125608 |
Lodola A et al. | Insights into the mechanism and inhibition of fatty acid amide hydrolase from quantum mechanics/molecular mechanics (QM/MM) modelling. | 2009 | Biochem. Soc. Trans. | pmid:19290863 |
Sudhahar V et al. | Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. | 2009 | Eur. J. Pharmacol. | pmid:19326479 |
Mueller GP and Driscoll WJ | Biosynthesis of oleamide. | 2009 | Vitam. Horm. | pmid:19647108 |
Herrera-SolÃs A et al. | Acute and subchronic administration of anandamide or oleamide increases REM sleep in rats. | 2010 | Pharmacol. Biochem. Behav. | pmid:20056119 |
Cheng MC et al. | Chemical synthesis of 9(Z)-octadecenamide and its hypolipidemic effect: a bioactive agent found in the essential oil of mountain celery seeds. | 2010 | J. Agric. Food Chem. | pmid:20078072 |
Oh YT et al. | Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells. | 2010 | Neurosci. Lett. | pmid:20298753 |
Casford MT and Davies PB | The structure of oleamide films at the aluminum/oil interface and aluminum/air interface studied by Sum Frequency Generation (SFG) vibrational spectroscopy and Reflection Absorption Infrared Spectroscopy (RAIRS). | 2009 | ACS Appl Mater Interfaces | pmid:20355782 |
Soria-Gómez E et al. | Oleamide administered into the nucleus accumbens shell regulates feeding behaviour via CB1 and 5-HT2C receptors. | 2010 | Int. J. Neuropsychopharmacol. | pmid:20663269 |
Shim G et al. | Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug. | 2011 | J Control Release | pmid:20971142 |