Elaidamide

Elaidamide is a lipid of Fatty Acyls (FA) class. Elaidamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.

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Introduction

To understand associated biological information of Elaidamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Elaidamide?

Elaidamide is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Elaidamide

PubChem Associated disorders and diseases

What pathways are associated with Elaidamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What functions are associated with Elaidamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What genes are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Elaidamide

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Authors Title Published Journal PubMed Link
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Boger DL et al. Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition. 1999 Bioorg. Med. Chem. Lett. pmid:10021942
Cheer JF et al. Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors. 1999 Neuropharmacology pmid:10221757
Basile AS et al. Characterization of the hypnotic properties of oleamide. 1999 Neuroreport pmid:10321465
Hanus LO et al. A gas chromatographic-mass spectral assay for the quantitative determination of oleamide in biological fluids. 1999 Anal. Biochem. pmid:10328778
Thomas EA et al. The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. 1999 J. Neurochem. pmid:10349846
Jenkins TC Lactation performance and fatty acid composition of milk from Holstein cows fed 0 to 5% oleamide. 1999 J. Dairy Sci. pmid:10416167
Yang JY et al. Studies on the sedative and hypnotic effects of oleamide in mice. 1999 Arzneimittelforschung pmid:10483511
Hedlund PB et al. Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. 1999 Biochem. Pharmacol. pmid:10571256
Mendelson WB and Basile AS The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist. 1999 Neuroreport pmid:10574567
Gobbi M et al. Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity. 1999 FEBS Lett. pmid:10606738
Ritenour-Rodgers KJ et al. Induction of peptidylglycine alpha-amidating monooxygenase in N(18)TG(2) cells: a model for studying oleamide biosynthesis. 2000 Biochem. Biophys. Res. Commun. pmid:10631094
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Jenkins TC Feeding oleamide to lactating Jersey cows 1. Effects on lactation performance and milk fatty acid composition. 2000 J. Dairy Sci. pmid:10714869
DeLuca DD and Jenkins TC Feeding oleamide to lactating Jersey cows. 2. Effects on nutrient digestibility, plasma fatty acids, and hormones. 2000 J. Dairy Sci. pmid:10750115
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Nicholson RA et al. Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain. 2001 Anesthesiology pmid:11135731
Huang JK and Jan CR Linoleamide, a brain lipid that induces sleep, increases cytosolic Ca2+ levels in MDCK renal tubular cells. 2001 Life Sci. pmid:11212875
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Fedorova I et al. Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems. 2001 J. Pharmacol. Exp. Ther. pmid:11561096
Fowler CJ et al. Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. 2001 Biochem. Pharmacol. pmid:11585048
Huitrón-Reséndiz S et al. Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats. 2001 Exp. Neurol. pmid:11681856
Mendelson WB and Basile AS The hypnotic actions of the fatty acid amide, oleamide. 2001 Neuropsychopharmacology pmid:11682271
Murillo-Rodríguez E et al. Oleamide modulates memory in rats. 2001 Neurosci. Lett. pmid:11684340
Lo YK et al. Effect of oleamide on Ca(2+) signaling in human bladder cancer cells. 2001 Biochem. Pharmacol. pmid:11709196
Alberts GL et al. Allosteric modulation of the human 5-HT(7A) receptor by lipidic amphipathic compounds. 2001 Mol. Pharmacol. pmid:11723242
Laposky AD et al. Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. 2001 Neuroreport pmid:11742254
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Coyne L et al. The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. 2002 Br. J. Pharmacol. pmid:11959801
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Lichtman AH et al. Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. 2002 J. Pharmacol. Exp. Ther. pmid:12065702
Yang JY et al. Oleamide attenuates apoptotic death in cultured rat cerebellar granule neurons. 2002 Neurosci. Lett. pmid:12133580
Coleman AM and Sengelaub DR Patterns of dye coupling in lumbar motor nuclei of the rat. 2002 J. Comp. Neurol. pmid:12410616
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Hedlund PB et al. No hypothermic response to serotonin in 5-HT7 receptor knockout mice. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12529502
Slotema WF et al. Economically pertinent continuous amide formation by direct lipase-catalyzed amidation with ammonia. 2003 Biotechnol. Bioeng. pmid:12673765
Ransjö M et al. Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. 2003 Biochem. Biophys. Res. Commun. pmid:12684060
Heo HJ et al. Effects of oleamide on choline acetyltransferase and cognitive activities. 2003 Biosci. Biotechnol. Biochem. pmid:12843655
Wu CF et al. Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. 2003 J. Pharm. Pharmacol. pmid:12956907
Uyama N et al. Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture. 2003 J. Hepatol. pmid:14568257
Yang JY et al. The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. 2003 Naunyn Schmiedebergs Arch. Pharmacol. pmid:14615880
Dougalis A et al. The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. 2004 Neuropharmacology pmid:14654098
Fowler CJ Oleamide: a member of the endocannabinoid family? 2004 Br. J. Pharmacol. pmid:14691053
Leggett JD et al. Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. 2004 Br. J. Pharmacol. pmid:14707029
Lees G and Dougalis A Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. 2004 Brain Res. pmid:14715144
Dougalis A et al. The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model. 2004 Neuropharmacology pmid:14975678
Foster AM and Sengelaub DR Bilateral organization of unilaterally generated activity in lumbar spinal motoneurons of the rat. 2004 Brain Res. pmid:15120587
Martínez-González D et al. Oleamide and anandamide effects on food intake and sexual behavior of rats. 2004 Neurosci. Lett. pmid:15193744
Ito A et al. A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells. 2004 Carcinogenesis pmid:15205356
Merkler DJ et al. Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells. 2004 Biochemistry pmid:15449956
Huitron-Resendiz S et al. Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. 2004 Sleep pmid:15453543
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Hill MN and Gorzalka BB Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. 2005 Eur Neuropsychopharmacol pmid:15916883
Varvel SA et al. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. 2006 J. Pharmacol. Exp. Ther. pmid:16352706
Hoi PM and Hiley CR Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. 2006 Br. J. Pharmacol. pmid:16415907
Ehrlich HP et al. Gap junction communications influence upon fibroblast synthesis of Type I collagen and fibronectin. 2006 J. Cell. Biochem. pmid:16475185
Nagasawa K et al. Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells. 2006 J. Cell. Physiol. pmid:16547974
Lee YJ et al. Enhanced radiosensitization of p53 mutant cells by oleamide. 2006 Int. J. Radiat. Oncol. Biol. Phys. pmid:16580498
Garrido-López A et al. Determination of oleamide and erucamide in polyethylene films by pressurised fluid extraction and gas chromatography. 2006 J Chromatogr A pmid:16716333
Grijalvo S et al. Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. 2006 Chem. Phys. Lipids pmid:16942762
Chaturvedi S et al. In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. 2006 Prostaglandins Other Lipid Mediat. pmid:17085322
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Hiley CR and Hoi PM Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? 2007 Cardiovasc Drug Rev pmid:17445087
Driscoll WJ et al. Oleamide synthesizing activity from rat kidney: identification as cytochrome c. 2007 J. Biol. Chem. pmid:17496328
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Farrell EK and Merkler DJ Biosynthesis, degradation and pharmacological importance of the fatty acid amides. 2008 Drug Discov. Today pmid:18598910
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Solomonia R et al. Effect of oleamide on pentylenetetrazole-induced seizures in rats. 2008 Bull. Exp. Biol. Med. pmid:19023975
Zhang R et al. One-step formation of straight nanostripes from a mammal lipid-oleamide directly on highly oriented pyrolytic graphite. 2009 Langmuir pmid:19125608
Lodola A et al. Insights into the mechanism and inhibition of fatty acid amide hydrolase from quantum mechanics/molecular mechanics (QM/MM) modelling. 2009 Biochem. Soc. Trans. pmid:19290863
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Herrera-Solís A et al. Acute and subchronic administration of anandamide or oleamide increases REM sleep in rats. 2010 Pharmacol. Biochem. Behav. pmid:20056119
Cheng MC et al. Chemical synthesis of 9(Z)-octadecenamide and its hypolipidemic effect: a bioactive agent found in the essential oil of mountain celery seeds. 2010 J. Agric. Food Chem. pmid:20078072
Oh YT et al. Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells. 2010 Neurosci. Lett. pmid:20298753
Casford MT and Davies PB The structure of oleamide films at the aluminum/oil interface and aluminum/air interface studied by Sum Frequency Generation (SFG) vibrational spectroscopy and Reflection Absorption Infrared Spectroscopy (RAIRS). 2009 ACS Appl Mater Interfaces pmid:20355782
Soria-Gómez E et al. Oleamide administered into the nucleus accumbens shell regulates feeding behaviour via CB1 and 5-HT2C receptors. 2010 Int. J. Neuropsychopharmacol. pmid:20663269
Shim G et al. Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug. 2011 J Control Release pmid:20971142