MeSH term | MeSH ID | Detail |
---|---|---|
Edema | D004487 | 152 associated lipids |
Hypertension | D006973 | 115 associated lipids |
Catalepsy | D002375 | 30 associated lipids |
Hypothermia | D007035 | 19 associated lipids |
Amnesia | D000647 | 12 associated lipids |
Elaidamide is a lipid of Fatty Acyls (FA) class. Elaidamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.
To understand associated biological information of Elaidamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Elaidamide is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Elaidamide
MeSH term | MeSH ID | Detail |
---|---|---|
Edema | D004487 | 152 associated lipids |
Hypertension | D006973 | 115 associated lipids |
Catalepsy | D002375 | 30 associated lipids |
Hypothermia | D007035 | 19 associated lipids |
Amnesia | D000647 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Chen J et al. | Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca/Mn-transport ATPase (SPCA1a). | 2017 | J. Biol. Chem. | pmid:28264934 |
Roy A et al. | Identification and characterization of PPARα ligands in the hippocampus. | 2016 | Nat. Chem. Biol. | pmid:27748752 |
Kruk-Slomka M et al. | The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801. | 2016 | Neurotox Res | pmid:27577742 |
Yamada A et al. | Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation. | 2016 | J. Biol. Chem. | pmid:26565022 |
Togashi K et al. | Dysfunction in gap junction intercellular communication induces aberrant behavior of the inner cell mass and frequent collapses of expanded blastocysts in mouse embryos. | 2015 | J. Assist. Reprod. Genet. | pmid:25917498 |
Ano Y et al. | Preventive effects of a fermented dairy product against Alzheimer's disease and identification of a novel oleamide with enhanced microglial phagocytosis and anti-inflammatory activity. | 2015 | PLoS ONE | pmid:25760987 |
Yang Y et al. | Connexin-dependent gap junction enhancement is involved in the synergistic effect of sorafenib and all-trans retinoic acid on HCC growth inhibition. | 2014 | Oncol. Rep. | pmid:24317203 |
Zhang L et al. | Fabrication of microspheres via solvent volatization induced aggregation of self-assembled nanomicellar structures and their use as a pH-dependent drug release system. | 2013 | Langmuir | pmid:23215353 |
Riquelme MA et al. | The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels. | 2013 | Neuropharmacology | pmid:23583931 |
Méndez-DÃaz M et al. | The endocannabinoid system modulates the valence of the emotion associated to food ingestion. | 2012 | Addict Biol | pmid:21182571 |
Farrell EK et al. | Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells. | 2012 | J. Lipid Res. | pmid:22095832 |
Dionisi M et al. | Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) in vitro. | 2012 | Lipids Health Dis | pmid:22584002 |
Reyes Prieto NM et al. | Oleamide restores sleep in adult rats that were subjected to maternal separation. | 2012 | Pharmacol. Biochem. Behav. | pmid:22975223 |
Hei Z et al. | Lipopolysaccharide effects on the proliferation of NRK52E cells via alternations in gap-junction function. | 2012 | J Trauma Acute Care Surg | pmid:22743374 |
Hopps JJ et al. | Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension. | 2012 | Eur. J. Pharmacol. | pmid:22465182 |
Yang J et al. | Connexin 32 and its derived homotypic gap junctional intercellular communication inhibit the migration and invasion of transfected HeLa cells via enhancement of intercellular adhesion. | 2011 Sep-Oct | Mol Med Rep | pmid:21687945 |
Desforges B et al. | Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21677260 |
Yoshitani K et al. | Low concentrations of alendronate increase the local invasive potential of osteoblastic sarcoma cell lines via connexin 43 activation. | 2011 | Pathol. Res. Pract. | pmid:21665377 |
Liu B et al. | Berberine potentizes apoptosis induced by X-rays irradiation probably through modulation of gap junctions. | 2011 | Chin. Med. J. | pmid:21543001 |
Shim G et al. | Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug. | 2011 | J Control Release | pmid:20971142 |
Walentiny DM et al. | The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice. | 2011 | Eur. J. Pharmacol. | pmid:21300050 |
Munigunti R et al. | Identification of oleamide in Guatteria recurvisepala by LC/MS-based Plasmodium falciparum thioredoxin reductase ligand binding method. | 2011 | Planta Med. | pmid:21567357 |
Adriano E et al. | A novel hypothesis about mechanisms affecting conduction velocity of central myelinated fibers. | 2011 | Neurochem. Res. | pmid:21553257 |
Kim SJ et al. | Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats. | 2011 | Urology | pmid:21820587 |
Oh YT et al. | Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells. | 2010 | Neurosci. Lett. | pmid:20298753 |
Soria-Gómez E et al. | Oleamide administered into the nucleus accumbens shell regulates feeding behaviour via CB1 and 5-HT2C receptors. | 2010 | Int. J. Neuropsychopharmacol. | pmid:20663269 |
Herrera-SolÃs A et al. | Acute and subchronic administration of anandamide or oleamide increases REM sleep in rats. | 2010 | Pharmacol. Biochem. Behav. | pmid:20056119 |
Cheng MC et al. | Chemical synthesis of 9(Z)-octadecenamide and its hypolipidemic effect: a bioactive agent found in the essential oil of mountain celery seeds. | 2010 | J. Agric. Food Chem. | pmid:20078072 |
Ciovacco WA et al. | The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. | 2009 | Bone | pmid:18848655 |
Sudhahar V et al. | Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. | 2009 | Eur. J. Pharmacol. | pmid:19326479 |
Lodola A et al. | Insights into the mechanism and inhibition of fatty acid amide hydrolase from quantum mechanics/molecular mechanics (QM/MM) modelling. | 2009 | Biochem. Soc. Trans. | pmid:19290863 |
Zhang R et al. | One-step formation of straight nanostripes from a mammal lipid-oleamide directly on highly oriented pyrolytic graphite. | 2009 | Langmuir | pmid:19125608 |
Mueller GP and Driscoll WJ | Biosynthesis of oleamide. | 2009 | Vitam. Horm. | pmid:19647108 |
Casford MT and Davies PB | The structure of oleamide films at the aluminum/oil interface and aluminum/air interface studied by Sum Frequency Generation (SFG) vibrational spectroscopy and Reflection Absorption Infrared Spectroscopy (RAIRS). | 2009 | ACS Appl Mater Interfaces | pmid:20355782 |
McDonald GR et al. | Bioactive contaminants leach from disposable laboratory plasticware. | 2008 | Science | pmid:18988846 |
Solomonia R et al. | Effect of oleamide on pentylenetetrazole-induced seizures in rats. | 2008 | Bull. Exp. Biol. Med. | pmid:19023975 |
Wise LE et al. | Evaluation of fatty acid amides in the carrageenan-induced paw edema model. | 2008 | Neuropharmacology | pmid:17675189 |
Farrell EK and Merkler DJ | Biosynthesis, degradation and pharmacological importance of the fatty acid amides. | 2008 | Drug Discov. Today | pmid:18598910 |
Nichols KK et al. | Identification of fatty acids and fatty acid amides in human meibomian gland secretions. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17197513 |
Ohba Y et al. | Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26. | 2007 | Int. J. Cancer | pmid:17290388 |
Romero FA et al. | Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. | 2007 | J. Med. Chem. | pmid:17279740 |
Wei XY et al. | Anxiolytic-like effects of oleamide in group-housed and socially isolated mice. | 2007 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:17521793 |
Saito M et al. | The functional interrelationship between gap junctions and fenestrae in endothelial cells of the liver organoid. | 2007 | J. Membr. Biol. | pmid:17568973 |
Leaphart CL et al. | Interferon-gamma inhibits intestinal restitution by preventing gap junction communication between enterocytes. | 2007 | Gastroenterology | pmid:17570214 |
Akanmu MA et al. | Neuropharmacological effects of oleamide in male and female mice. | 2007 | Behav. Brain Res. | pmid:17588682 |
Hiley CR and Hoi PM | Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? | 2007 | Cardiovasc Drug Rev | pmid:17445087 |
Driscoll WJ et al. | Oleamide synthesizing activity from rat kidney: identification as cytochrome c. | 2007 | J. Biol. Chem. | pmid:17496328 |
Garrido-López A et al. | Comparison of three gas chromatography methods for the determination of slip agents in polyethylene films. | 2007 | J Chromatogr A | pmid:17161408 |
Nojima H et al. | Oleamide derivatives are prototypical anti-metastasis drugs that act by inhibiting Connexin 26. | 2007 | Curr Drug Saf | pmid:18690969 |
Au K and Ehrlich HP | Does rat granulation tissue maturation involve gap junction communications? | 2007 | Plast. Reconstr. Surg. | pmid:17572550 |
Varvel SA et al. | Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16352706 |
Grijalvo S et al. | Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. | 2006 | Chem. Phys. Lipids | pmid:16942762 |
Ehrlich HP et al. | Gap junction communications influence upon fibroblast synthesis of Type I collagen and fibronectin. | 2006 | J. Cell. Biochem. | pmid:16475185 |
Chaturvedi S et al. | In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085322 |
Nagasawa K et al. | Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells. | 2006 | J. Cell. Physiol. | pmid:16547974 |
Hoi PM and Hiley CR | Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. | 2006 | Br. J. Pharmacol. | pmid:16415907 |
Garrido-López A et al. | Determination of oleamide and erucamide in polyethylene films by pressurised fluid extraction and gas chromatography. | 2006 | J Chromatogr A | pmid:16716333 |
Lee YJ et al. | Enhanced radiosensitization of p53 mutant cells by oleamide. | 2006 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:16580498 |
Tubert-Brohman I et al. | Elucidation of hydrolysis mechanisms for fatty acid amide hydrolase and its Lys142Ala variant via QM/MM simulations. | 2006 | J. Am. Chem. Soc. | pmid:17177441 |
De Bank PA et al. | A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. | 2005 | Biochem. Pharmacol. | pmid:15794939 |
Hill MN and Gorzalka BB | Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. | 2005 | Eur Neuropsychopharmacol | pmid:15916883 |
Dougalis A et al. | The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. | 2004 | Neuropharmacology | pmid:14654098 |
Ito A et al. | A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells. | 2004 | Carcinogenesis | pmid:15205356 |
MartÃnez-González D et al. | Oleamide and anandamide effects on food intake and sexual behavior of rats. | 2004 | Neurosci. Lett. | pmid:15193744 |
Foster AM and Sengelaub DR | Bilateral organization of unilaterally generated activity in lumbar spinal motoneurons of the rat. | 2004 | Brain Res. | pmid:15120587 |
Leggett JD et al. | Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. | 2004 | Br. J. Pharmacol. | pmid:14707029 |
Fowler CJ | Oleamide: a member of the endocannabinoid family? | 2004 | Br. J. Pharmacol. | pmid:14691053 |
Lees G and Dougalis A | Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. | 2004 | Brain Res. | pmid:14715144 |
Merkler DJ et al. | Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells. | 2004 | Biochemistry | pmid:15449956 |
Huitron-Resendiz S et al. | Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. | 2004 | Sleep | pmid:15453543 |
Dougalis A et al. | The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model. | 2004 | Neuropharmacology | pmid:14975678 |
Wu CF et al. | Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. | 2003 | J. Pharm. Pharmacol. | pmid:12956907 |
Slotema WF et al. | Economically pertinent continuous amide formation by direct lipase-catalyzed amidation with ammonia. | 2003 | Biotechnol. Bioeng. | pmid:12673765 |
Ransjö M et al. | Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684060 |
Hedlund PB et al. | No hypothermic response to serotonin in 5-HT7 receptor knockout mice. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12529502 |
Heo HJ et al. | Effects of oleamide on choline acetyltransferase and cognitive activities. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12843655 |
Yang JY et al. | The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14615880 |
Uyama N et al. | Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture. | 2003 | J. Hepatol. | pmid:14568257 |
Yang JY et al. | Oleamide attenuates apoptotic death in cultured rat cerebellar granule neurons. | 2002 | Neurosci. Lett. | pmid:12133580 |
Bisogno T et al. | Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. | 2002 | Curr. Pharm. Des. | pmid:11945157 |
Krutovskikh VA et al. | Gap junction intercellular communication propagates cell death in cancerous cells. | 2002 | Oncogene | pmid:11960371 |
Lichtman AH et al. | Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12065702 |
Coleman AM and Sengelaub DR | Patterns of dye coupling in lumbar motor nuclei of the rat. | 2002 | J. Comp. Neurol. | pmid:12410616 |
Cherezov V et al. | Membrane protein crystallization in meso: lipid type-tailoring of the cubic phase. | 2002 | Biophys. J. | pmid:12496106 |
Coyne L et al. | The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. | 2002 | Br. J. Pharmacol. | pmid:11959801 |
Burnside AS and Collas P | Induction of Oct-3/4 expression in somatic cells by gap junction-mediated cAMP signaling from blastomeres. | 2002 | Eur. J. Cell Biol. | pmid:12494995 |
Huang JK and Jan CR | Linoleamide, a brain lipid that induces sleep, increases cytosolic Ca2+ levels in MDCK renal tubular cells. | 2001 | Life Sci. | pmid:11212875 |
Huitrón-Reséndiz S et al. | Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats. | 2001 | Exp. Neurol. | pmid:11681856 |
Alberts GL et al. | Allosteric modulation of the human 5-HT(7A) receptor by lipidic amphipathic compounds. | 2001 | Mol. Pharmacol. | pmid:11723242 |
Lo YK et al. | Effect of oleamide on Ca(2+) signaling in human bladder cancer cells. | 2001 | Biochem. Pharmacol. | pmid:11709196 |
Fowler CJ et al. | Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. | 2001 | Biochem. Pharmacol. | pmid:11585048 |
Fedorova I et al. | Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11561096 |
SiuYi Leung D et al. | Gap junctions modulate survival-promoting effects of fibroblast growth factor-2 on cultured midbrain dopaminergic neurons. | 2001 | Mol. Cell. Neurosci. | pmid:11461152 |
Laws D et al. | Fatty acid amides are putative endogenous ligands for anaesthetic recognition sites in mammalian CNS. | 2001 | Br J Anaesth | pmid:11517120 |
Rami A et al. | Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia. | 2001 | Exp. Neurol. | pmid:11476596 |
Laposky AD et al. | Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. | 2001 | Neuroreport | pmid:11742254 |
Murillo-RodrÃguez E et al. | Oleamide modulates memory in rats. | 2001 | Neurosci. Lett. | pmid:11684340 |
Jenkins TC et al. | Direct methylation procedure for converting fatty amides to fatty acid methyl esters in feed and digesta samples. | 2001 | J. Agric. Food Chem. | pmid:11368568 |
Boger DL et al. | alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11412972 |
Mendelson WB and Basile AS | The hypnotic actions of the fatty acid amide, oleamide. | 2001 | Neuropsychopharmacology | pmid:11682271 |