Elaidamide

Elaidamide is a lipid of Fatty Acyls (FA) class. Elaidamide is associated with abnormalities such as Wiskott-Aldrich Syndrome. The involved functions are known as inhibitors, salivary gland development and branching morphogenesis.

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Introduction

To understand associated biological information of Elaidamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Elaidamide?

Elaidamide is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Elaidamide

PubChem Associated disorders and diseases

What pathways are associated with Elaidamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What functions are associated with Elaidamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What genes are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Elaidamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Elaidamide

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Casford MT and Davies PB The structure of oleamide films at the aluminum/oil interface and aluminum/air interface studied by Sum Frequency Generation (SFG) vibrational spectroscopy and Reflection Absorption Infrared Spectroscopy (RAIRS). 2009 ACS Appl Mater Interfaces pmid:20355782
Méndez-Díaz M et al. The endocannabinoid system modulates the valence of the emotion associated to food ingestion. 2012 Addict Biol pmid:21182571
Desforges B et al. Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity. 2011 Am. J. Physiol., Cell Physiol. pmid:21677260
Hanus LO et al. A gas chromatographic-mass spectral assay for the quantitative determination of oleamide in biological fluids. 1999 Anal. Biochem. pmid:10328778
Yost CS et al. Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. 1998 Anesth. Analg. pmid:9620523
Nicholson RA et al. Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain. 2001 Anesthesiology pmid:11135731
Thomas EA et al. Oleamide-induced modulation of 5-hydroxytryptamine receptor-mediated signaling. 1998 Ann. N. Y. Acad. Sci. pmid:9928256
Yang JY et al. Studies on the sedative and hypnotic effects of oleamide in mice. 1999 Arzneimittelforschung pmid:10483511
Akanmu MA et al. Neuropharmacological effects of oleamide in male and female mice. 2007 Behav. Brain Res. pmid:17588682
Bisogno T et al. The sleep inducing factor oleamide is produced by mouse neuroblastoma cells. 1997 Biochem. Biophys. Res. Commun. pmid:9344854
Ransjö M et al. Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. 2003 Biochem. Biophys. Res. Commun. pmid:12684060
Ritenour-Rodgers KJ et al. Induction of peptidylglycine alpha-amidating monooxygenase in N(18)TG(2) cells: a model for studying oleamide biosynthesis. 2000 Biochem. Biophys. Res. Commun. pmid:10631094
Lo YK et al. Effect of oleamide on Ca(2+) signaling in human bladder cancer cells. 2001 Biochem. Pharmacol. pmid:11709196
Fowler CJ et al. Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. 2001 Biochem. Pharmacol. pmid:11585048
Hedlund PB et al. Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. 1999 Biochem. Pharmacol. pmid:10571256
De Bank PA et al. A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. 2005 Biochem. Pharmacol. pmid:15794939
Lodola A et al. Insights into the mechanism and inhibition of fatty acid amide hydrolase from quantum mechanics/molecular mechanics (QM/MM) modelling. 2009 Biochem. Soc. Trans. pmid:19290863
Merkler DJ et al. Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells. 2004 Biochemistry pmid:15449956
Boger DL et al. Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition. 1999 Bioorg. Med. Chem. Lett. pmid:10021942
Boger DL et al. alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. 2001 Bioorg. Med. Chem. Lett. pmid:11412972
Cherezov V et al. Membrane protein crystallization in meso: lipid type-tailoring of the cubic phase. 2002 Biophys. J. pmid:12496106
Heo HJ et al. Effects of oleamide on choline acetyltransferase and cognitive activities. 2003 Biosci. Biotechnol. Biochem. pmid:12843655
Slotema WF et al. Economically pertinent continuous amide formation by direct lipase-catalyzed amidation with ammonia. 2003 Biotechnol. Bioeng. pmid:12673765
Ciovacco WA et al. The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. 2009 Bone pmid:18848655
Laws D et al. Fatty acid amides are putative endogenous ligands for anaesthetic recognition sites in mammalian CNS. 2001 Br J Anaesth pmid:11517120
Lees G et al. Modulation of GABA(A) receptors and inhibitory synaptic currents by the endogenous CNS sleep regulator cis-9,10-octadecenoamide (cOA). 1998 Br. J. Pharmacol. pmid:9692771
Verdon B et al. Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na(+) channels in vitro: a putative endogenous ligand for depressant drug sites in CNS. 2000 Br. J. Pharmacol. pmid:10694234
Coyne L et al. The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. 2002 Br. J. Pharmacol. pmid:11959801
Leggett JD et al. Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. 2004 Br. J. Pharmacol. pmid:14707029
Fowler CJ Oleamide: a member of the endocannabinoid family? 2004 Br. J. Pharmacol. pmid:14691053
Hoi PM and Hiley CR Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. 2006 Br. J. Pharmacol. pmid:16415907
Foster AM and Sengelaub DR Bilateral organization of unilaterally generated activity in lumbar spinal motoneurons of the rat. 2004 Brain Res. pmid:15120587
Lees G and Dougalis A Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. 2004 Brain Res. pmid:14715144
Solomonia R et al. Effect of oleamide on pentylenetetrazole-induced seizures in rats. 2008 Bull. Exp. Biol. Med. pmid:19023975
Ito A et al. A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells. 2004 Carcinogenesis pmid:15205356
Hiley CR and Hoi PM Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? 2007 Cardiovasc Drug Rev pmid:17445087
Grijalvo S et al. Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. 2006 Chem. Phys. Lipids pmid:16942762