Capsaicin is a lipid of Fatty Acyls (FA) class. Capsaicin is associated with abnormalities such as Morphologically altered structure. The involved functions are known as inhibitors, Regulation, metaplastic cell transformation, Biochemical Pathway and Uptake. Capsaicin often locates in Tissue fiber, Mucous Membrane, Nerve Endings, group Ia axon and Membrane. The associated genes with Capsaicin are TRPV1 gene, WT-1, MAP1LC3A gene, EIF2S3 gene and SLC33A1 gene. The related experimental models are Transgenic Model.
To understand associated biological information of Capsaicin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Capsaicin is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Capsaicin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Tachycardia | D013610 | 7 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Out-of-Hospital Cardiac Arrest | D058687 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Capsaicin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'In vitro hepatic and skin metabolism of capsaicin.' (Chanda S et al., 2008).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang XR et al. | Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation. | 2017 | Int J Nanomedicine | pmid:28579775 |
| Elwood RW et al. | Aversive responses by shore crabs to acetic acid but not to capsaicin. | 2017 | Behav. Processes | pmid:28365460 |
| Pitcher MH et al. | Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States. | 2017 | J Pain | pmid:28219667 |
| Dahan S et al. | Dietary factors in rheumatic autoimmune diseases: a recipe for therapy? | 2017 | Nat Rev Rheumatol | pmid:28405001 |
| Pigatto GR et al. | Light-Emitting Diode Phototherapy Reduces Nocifensive Behavior Induced by Thermal and Chemical Noxious Stimuli in Mice: Evidence for the Involvement of Capsaicin-Sensitive Central Afferent Fibers. | 2017 | Mol. Neurobiol. | pmid:27056078 |
| de Lacerda Neto LJ et al. | Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity. | 2017 | Chem. Biol. Interact. | pmid:27871896 |
| Vendrely V et al. | Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model. | 2017 | Cancer Lett. | pmid:28089829 |
| Urbina SL et al. | Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals. | 2017 | Appetite | pmid:28235621 |
| Hochkogler CM et al. | A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects. | 2017 | Mol Nutr Food Res | pmid:28012242 |
| Kurosawa W et al. | Practical large-scale production of dihydrocapsiate, a nonpungent capsaicinoid-like substance. | 2017 | Biosci. Biotechnol. Biochem. | pmid:27838955 |
| Hurley JD et al. | Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers. | 2017 | Cell Adh Migr | pmid:27196129 |
| Schepetkin IA et al. | Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents. | 2016 | J. Agric. Food Chem. | pmid:27586050 |
| Gan X et al. | Potentiation of acid-sensing ion channel activity by peripheral group I metabotropic glutamate receptor signaling. | 2016 | Pharmacol. Res. | pmid:26946972 |
| Sulzberger M et al. | Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A. | 2016 | J Eur Acad Dermatol Venereol | pmid:26805417 |
| Scholl A et al. | Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | 2016 | Oncotarget | pmid:27556861 |
| Belvisi MG et al. | Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies. | 2016 | Am. J. Respir. Crit. Care Med. | pmid:26741046 |
| Malty RH et al. | Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A. | 2016 | J Neuroinflammation | pmid:27400965 |
| Yan L et al. | Design, synthesis and biological evaluation of novel analgesic agents targeting both cyclooxygenase and TRPV1. | 2016 | Bioorg. Med. Chem. | pmid:26795113 |
| Pittman SK et al. | Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons. | 2016 | Exp. Neurol. | pmid:26883566 |
| Åžavk E | Neurologic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578080 |
| Duangjit S et al. | Development, Characterization and Skin Interaction of Capsaicin-Loaded Microemulsion-Based Nonionic Surfactant. | 2016 | Biol. Pharm. Bull. | pmid:27040633 |
| Boros K et al. | Multiple impairments of cutaneous nociceptor function induced by cardiotoxic doses of Adriamycin in the rat. | 2016 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:27342418 |
| Zheng L et al. | Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells. | 2016 | Mol Med Rep | pmid:26648574 |
| Amantini C et al. | Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner. | 2016 | Oncotarget | pmid:27367032 |
| Kim J et al. | Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:27465721 |
| da Silva Brum E et al. | Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice. | 2016 | J Ethnopharmacol | pmid:27321276 |
| Petrosino S et al. | The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. | 2016 | Br. J. Pharmacol. | pmid:25598150 |
| Dux M et al. | Endovanilloids are potential activators of the trigeminovascular nocisensor complex. | 2016 | J Headache Pain | pmid:27189587 |
| Junyun He L et al. | Dihydrocapsaicin-induced hypothermia after asphyxiai cardiac arrest in rats. | 2016 | Conf Proc IEEE Eng Med Biol Soc | pmid:28268688 |
| Xie L et al. | Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+‑mediated mitochondrial pathway. | 2016 | Mol Med Rep | pmid:27748914 |
| Takaishi M et al. | Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8. | 2016 | J Physiol Sci | pmid:26645885 |
| Abaei M et al. | Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. | 2016 | Mol Pain | pmid:27068285 |
| Shima K et al. | The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways. | 2016 | Biol. Pharm. Bull. | pmid:27150146 |
| Wandji BA et al. | Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice. | 2016 | J Ethnopharmacol | pmid:27130641 |
| Hanson SM et al. | Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation. | 2015 | Biophys. J. | pmid:25809255 |
| Spaziano G et al. | Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. | 2015 | Biomed Res Int | pmid:25866824 |
| Maher SA et al. | Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events. | 2015 | Eur. Respir. J. | pmid:25323233 |
| Guo BC et al. | Transient receptor potential vanilloid type 1 is vital for (-)-epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase. | 2015 | Mol Nutr Food Res | pmid:25581901 |
| Swain J and Kumar Mishra A | Location, Partitioning Behavior, and Interaction of Capsaicin with Lipid Bilayer Membrane: Study Using Its Intrinsic Fluorescence. | 2015 | J Phys Chem B | pmid:26302022 |
| Pinho-Ribeiro FA et al. | Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB. | 2015 | Chem. Biol. Interact. | pmid:25617481 |
| Miranda J et al. | Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats. | 2015 | Neuroscience | pmid:25451282 |
| Nam JH and Lee DU | Inhibitory effect of oleanolic acid from the rhizomes of Cyperus rotundus on transient receptor potential vanilloid 1 channel. | 2015 | Planta Med. | pmid:25402944 |
| Torrecillas A et al. | Capsaicin Fluidifies the Membrane and Localizes Itself near the Lipid-Water Interface. | 2015 | ACS Chem Neurosci | pmid:26247812 |
| Borrelli F et al. | Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. | 2015 | Br. J. Pharmacol. | pmid:25205418 |
| Peng X et al. | Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin. | 2015 | Drug Des Devel Ther | pmid:26345516 |
| Silva DF et al. | TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation. | 2015 | PLoS ONE | pmid:26599698 |
| Aicher SA et al. | Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26513503 |
| Nishino A et al. | Accumulation of Paprika Carotenoids in Human Plasma and Erythrocytes. | 2015 | J Oleo Sci | pmid:26369598 |
| Fernández-Blanco JA et al. | Enhanced cough reflex in a model of bleomycin-induced lung fibrosis in guinea pigs. | 2015 | Clin. Sci. | pmid:26275723 |
| Borbiro I et al. | Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. | 2015 | Sci Signal | pmid:25670203 |
| Khan M et al. | Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26514453 |
| Klein AH et al. | Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses. | 2014 | Neuroscience | pmid:24759772 |
| Wu TT et al. | Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression. | 2014 | Cell Calcium | pmid:24889371 |
| Muñoz-Islas E et al. | Spinal 5-HT₅A receptors mediate 5-HT-induced antinociception in several pain models in rats. | 2014 | Pharmacol. Biochem. Behav. | pmid:24517902 |
| Maurer K et al. | Acetylsalicylic acid enhances tachyphylaxis of repetitive capsaicin responses in TRPV1-GFP expressing HEK293 cells. | 2014 | Neurosci. Lett. | pmid:24495935 |
| Diniz DM et al. | Effects of the calcium channel blockers Phα1β and ω-conotoxin MVIIA on capsaicin and acetic acid-induced visceral nociception in mice. | 2014 | Pharmacol. Biochem. Behav. | pmid:25268314 |
| Cai Q et al. | Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons. | 2014 | Brain Res. | pmid:24491633 |
| Fawley JA et al. | Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission. | 2014 | J. Neurosci. | pmid:24920635 |
| Silva FV et al. | Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents. | 2014 | J Med Food | pmid:24476221 |
| Arzuman L et al. | Synergism from combinations of tris(benzimidazole) monochloroplatinum(II) chloride with capsaicin, quercetin, curcumin and cisplatin in human ovarian cancer cell lines. | 2014 | Anticancer Res. | pmid:25275041 |
| Isensee J et al. | Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. | 2014 | PLoS ONE | pmid:25551770 |
| Isensee J et al. | Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. | 2014 | J. Cell. Sci. | pmid:24190886 |
| Langeslag M et al. | Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. | 2014 | Mol Pain | pmid:25431213 |
| Petrov AM et al. | Role of membrane cholesterol in spontaneous exocytosis at frog neuromuscular synapses: reactive oxygen species-calcium interplay. | 2014 | J. Physiol. (Lond.) | pmid:25326454 |
| Chen L et al. | Role of TRPV1 channels in ischemia/reperfusion-induced acute kidney injury. | 2014 | PLoS ONE | pmid:25330307 |
| Fürst R and Zündorf I | Plant-derived anti-inflammatory compounds: hopes and disappointments regarding the translation of preclinical knowledge into clinical progress. | 2014 | Mediators Inflamm. | pmid:24987194 |
| Eckroth JR et al. | Physiological and behavioural responses to noxious stimuli in the Atlantic cod (Gadus morhua). | 2014 | PLoS ONE | pmid:24936652 |
| Mistry S et al. | Prolonged exposure to bradykinin and prostaglandin E2 increases TRPV1 mRNA but does not alter TRPV1 and TRPV1b protein expression in cultured rat primary sensory neurons. | 2014 | Neurosci. Lett. | pmid:24525250 |
| Cao Z et al. | Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24305062 |
| Feketa VV et al. | Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. | 2014 | Crit. Care Med. | pmid:24595220 |
| Jiang C et al. | A pseudo three-zone simulated moving bed with solvent gradient for quaternary separations. | 2014 | J Chromatogr A | pmid:24581869 |
| Lu MJ et al. | Hypoxic preconditioning protects rat hearts against ischemia-reperfusion injury via the arachidonate12-lipoxygenase/transient receptor potential vanilloid 1 pathway. | 2014 | Basic Res. Cardiol. | pmid:24816396 |
| Davidson S et al. | Human sensory neurons: Membrane properties and sensitization by inflammatory mediators. | 2014 | Pain | pmid:24973718 |
| Gawande ND et al. | Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking. | 2014 | Bioinformation | pmid:25512683 |
| Usman MG et al. | Capsaicin and dihydrocapsaicin determination in chili pepper genotypes using ultra-fast liquid chromatography. | 2014 | Molecules | pmid:24853712 |
| Zhao JY et al. | Dihydrocapsaicin down-regulates apoM expression through inhibiting Foxa2 expression and enhancing LXRα expression in HepG2 cells. | 2014 | Lipids Health Dis | pmid:24642298 |
| Contri RV et al. | The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids. | 2014 | Int J Nanomedicine | pmid:24611011 |
| Weitlauf C et al. | Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation. | 2014 | J. Neurosci. | pmid:25392504 |
| Terada Y et al. | Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree. | 2014 | J. Nat. Prod. | pmid:24484240 |
| Kobata K et al. | Formation of long-chain N-vanillyl-acylamides from plant oils. | 2014 | Biosci. Biotechnol. Biochem. | pmid:25229865 |
| Drinovac V et al. | Antinociceptive effect of botulinum toxin type A on experimental abdominal pain. | 2014 | Eur. J. Pharmacol. | pmid:25446429 |
| Anderson EM et al. | The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device. | 2014 | PLoS ONE | pmid:24558480 |
| Zhang X et al. | Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons. | 2014 | Exp. Neurol. | pmid:24212047 |
| Luo YL et al. | Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium. | 2013 | PLoS ONE | pmid:23372735 |
| Ilhan T and Erdost H | Effects of capsaicin on testis ghrelin expression in mice. | 2013 | Biotech Histochem | pmid:23013364 |
| Bazzo KO et al. | Evidence for the analgesic activity of resveratrol in acute models of nociception in mice. | 2013 | J. Nat. Prod. | pmid:23273136 |
| Patel RB et al. | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. | 2013 | Eur. J. Pharmacol. | pmid:23545357 |
| Schwartz L et al. | Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin. | 2013 | Invest New Drugs | pmid:22797854 |
| Rondanelli M et al. | Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects. | 2013 | Endocrine | pmid:23271695 |
| Jansson ET et al. | Effect of cholesterol depletion on the pore dilation of TRPV1. | 2013 | Mol Pain | pmid:23279936 |
| Lindgren CA et al. | Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction. | 2013 | J. Physiol. (Lond.) | pmid:23818695 |
| O'Mullane LM et al. | Co-cultures provide a new tool to probe communication between adult sensory neurons and urothelium. | 2013 | J. Urol. | pmid:23353045 |
| Brandão MS et al. | Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice. | 2013 | J Ethnopharmacol | pmid:23276784 |
| Fogaça MV et al. | Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats. | 2013 | Psychopharmacology (Berl.) | pmid:23183551 |
| Horiguchi N et al. | Involvement of spinal 5-HT1A receptors in isolation rearing-induced hypoalgesia in mice. | 2013 | Psychopharmacology (Berl.) | pmid:23274507 |
| Hu YW et al. | Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet. | 2013 | PLoS ONE | pmid:23840542 |
| Alpizar YA et al. | Lack of correlation between the amplitudes of TRP channel-mediated responses to weak and strong stimuli in intracellular Ca(2+) imaging experiments. | 2013 | Cell Calcium | pmid:24079971 |
| Bouyer PG et al. | Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23139219 |
| Barrière DA et al. | Fatty acid amide hydrolase-dependent generation of antinociceptive drug metabolites acting on TRPV1 in the brain. | 2013 | PLoS ONE | pmid:23940628 |
| Verano J et al. | Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism. | 2013 | Pharmacol. Biochem. Behav. | pmid:23932918 |