Capsaicin is a lipid of Fatty Acyls (FA) class. Capsaicin is associated with abnormalities such as Morphologically altered structure. The involved functions are known as inhibitors, Regulation, metaplastic cell transformation, Biochemical Pathway and Uptake. Capsaicin often locates in Tissue fiber, Mucous Membrane, Nerve Endings, group Ia axon and Membrane. The associated genes with Capsaicin are TRPV1 gene, WT-1, MAP1LC3A gene, EIF2S3 gene and SLC33A1 gene. The related experimental models are Transgenic Model.
To understand associated biological information of Capsaicin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Capsaicin is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Capsaicin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Tachycardia | D013610 | 7 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Out-of-Hospital Cardiac Arrest | D058687 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Capsaicin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'In vitro hepatic and skin metabolism of capsaicin.' (Chanda S et al., 2008).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang XR et al. | Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation. | 2017 | Int J Nanomedicine | pmid:28579775 |
| Elwood RW et al. | Aversive responses by shore crabs to acetic acid but not to capsaicin. | 2017 | Behav. Processes | pmid:28365460 |
| Pitcher MH et al. | Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States. | 2017 | J Pain | pmid:28219667 |
| Dahan S et al. | Dietary factors in rheumatic autoimmune diseases: a recipe for therapy? | 2017 | Nat Rev Rheumatol | pmid:28405001 |
| Pigatto GR et al. | Light-Emitting Diode Phototherapy Reduces Nocifensive Behavior Induced by Thermal and Chemical Noxious Stimuli in Mice: Evidence for the Involvement of Capsaicin-Sensitive Central Afferent Fibers. | 2017 | Mol. Neurobiol. | pmid:27056078 |
| de Lacerda Neto LJ et al. | Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity. | 2017 | Chem. Biol. Interact. | pmid:27871896 |
| Vendrely V et al. | Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model. | 2017 | Cancer Lett. | pmid:28089829 |
| Urbina SL et al. | Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals. | 2017 | Appetite | pmid:28235621 |
| Hochkogler CM et al. | A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects. | 2017 | Mol Nutr Food Res | pmid:28012242 |
| Kurosawa W et al. | Practical large-scale production of dihydrocapsiate, a nonpungent capsaicinoid-like substance. | 2017 | Biosci. Biotechnol. Biochem. | pmid:27838955 |
| Hurley JD et al. | Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers. | 2017 | Cell Adh Migr | pmid:27196129 |
| Schepetkin IA et al. | Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents. | 2016 | J. Agric. Food Chem. | pmid:27586050 |
| Gan X et al. | Potentiation of acid-sensing ion channel activity by peripheral group I metabotropic glutamate receptor signaling. | 2016 | Pharmacol. Res. | pmid:26946972 |
| Sulzberger M et al. | Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A. | 2016 | J Eur Acad Dermatol Venereol | pmid:26805417 |
| Scholl A et al. | Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | 2016 | Oncotarget | pmid:27556861 |
| Belvisi MG et al. | Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies. | 2016 | Am. J. Respir. Crit. Care Med. | pmid:26741046 |
| Malty RH et al. | Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A. | 2016 | J Neuroinflammation | pmid:27400965 |
| Yan L et al. | Design, synthesis and biological evaluation of novel analgesic agents targeting both cyclooxygenase and TRPV1. | 2016 | Bioorg. Med. Chem. | pmid:26795113 |
| Pittman SK et al. | Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons. | 2016 | Exp. Neurol. | pmid:26883566 |
| Åžavk E | Neurologic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578080 |
| Duangjit S et al. | Development, Characterization and Skin Interaction of Capsaicin-Loaded Microemulsion-Based Nonionic Surfactant. | 2016 | Biol. Pharm. Bull. | pmid:27040633 |
| Boros K et al. | Multiple impairments of cutaneous nociceptor function induced by cardiotoxic doses of Adriamycin in the rat. | 2016 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:27342418 |
| Zheng L et al. | Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells. | 2016 | Mol Med Rep | pmid:26648574 |
| Amantini C et al. | Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner. | 2016 | Oncotarget | pmid:27367032 |
| Kim J et al. | Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:27465721 |
| da Silva Brum E et al. | Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice. | 2016 | J Ethnopharmacol | pmid:27321276 |
| Petrosino S et al. | The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. | 2016 | Br. J. Pharmacol. | pmid:25598150 |
| Dux M et al. | Endovanilloids are potential activators of the trigeminovascular nocisensor complex. | 2016 | J Headache Pain | pmid:27189587 |
| Junyun He L et al. | Dihydrocapsaicin-induced hypothermia after asphyxiai cardiac arrest in rats. | 2016 | Conf Proc IEEE Eng Med Biol Soc | pmid:28268688 |
| Xie L et al. | Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+‑mediated mitochondrial pathway. | 2016 | Mol Med Rep | pmid:27748914 |
| Takaishi M et al. | Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8. | 2016 | J Physiol Sci | pmid:26645885 |
| Abaei M et al. | Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. | 2016 | Mol Pain | pmid:27068285 |
| Shima K et al. | The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways. | 2016 | Biol. Pharm. Bull. | pmid:27150146 |
| Wandji BA et al. | Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice. | 2016 | J Ethnopharmacol | pmid:27130641 |
| Hanson SM et al. | Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation. | 2015 | Biophys. J. | pmid:25809255 |
| Maher SA et al. | Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events. | 2015 | Eur. Respir. J. | pmid:25323233 |
| Guo BC et al. | Transient receptor potential vanilloid type 1 is vital for (-)-epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase. | 2015 | Mol Nutr Food Res | pmid:25581901 |
| Swain J and Kumar Mishra A | Location, Partitioning Behavior, and Interaction of Capsaicin with Lipid Bilayer Membrane: Study Using Its Intrinsic Fluorescence. | 2015 | J Phys Chem B | pmid:26302022 |
| Pinho-Ribeiro FA et al. | Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB. | 2015 | Chem. Biol. Interact. | pmid:25617481 |
| Miranda J et al. | Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats. | 2015 | Neuroscience | pmid:25451282 |
| Nam JH and Lee DU | Inhibitory effect of oleanolic acid from the rhizomes of Cyperus rotundus on transient receptor potential vanilloid 1 channel. | 2015 | Planta Med. | pmid:25402944 |
| Torrecillas A et al. | Capsaicin Fluidifies the Membrane and Localizes Itself near the Lipid-Water Interface. | 2015 | ACS Chem Neurosci | pmid:26247812 |
| Borrelli F et al. | Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. | 2015 | Br. J. Pharmacol. | pmid:25205418 |
| Peng X et al. | Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin. | 2015 | Drug Des Devel Ther | pmid:26345516 |
| Silva DF et al. | TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation. | 2015 | PLoS ONE | pmid:26599698 |
| Aicher SA et al. | Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26513503 |
| Nishino A et al. | Accumulation of Paprika Carotenoids in Human Plasma and Erythrocytes. | 2015 | J Oleo Sci | pmid:26369598 |
| Fernández-Blanco JA et al. | Enhanced cough reflex in a model of bleomycin-induced lung fibrosis in guinea pigs. | 2015 | Clin. Sci. | pmid:26275723 |
| Borbiro I et al. | Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. | 2015 | Sci Signal | pmid:25670203 |
| Khan M et al. | Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26514453 |