Capsaicin is a lipid of Fatty Acyls (FA) class. Capsaicin is associated with abnormalities such as Morphologically altered structure. The involved functions are known as inhibitors, Regulation, metaplastic cell transformation, Biochemical Pathway and Uptake. Capsaicin often locates in Tissue fiber, Mucous Membrane, Nerve Endings, group Ia axon and Membrane. The associated genes with Capsaicin are TRPV1 gene, WT-1, MAP1LC3A gene, EIF2S3 gene and SLC33A1 gene. The related experimental models are Transgenic Model.
To understand associated biological information of Capsaicin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Capsaicin is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Capsaicin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Tachycardia | D013610 | 7 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Out-of-Hospital Cardiac Arrest | D058687 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Capsaicin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'In vitro hepatic and skin metabolism of capsaicin.' (Chanda S et al., 2008).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fawley JA et al. | Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission. | 2014 | J. Neurosci. | pmid:24920635 |
| Silva FV et al. | Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents. | 2014 | J Med Food | pmid:24476221 |
| Isensee J et al. | Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. | 2014 | J. Cell. Sci. | pmid:24190886 |
| Langeslag M et al. | Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. | 2014 | Mol Pain | pmid:25431213 |
| Petrov AM et al. | Role of membrane cholesterol in spontaneous exocytosis at frog neuromuscular synapses: reactive oxygen species-calcium interplay. | 2014 | J. Physiol. (Lond.) | pmid:25326454 |
| Chen L et al. | Role of TRPV1 channels in ischemia/reperfusion-induced acute kidney injury. | 2014 | PLoS ONE | pmid:25330307 |
| Eckroth JR et al. | Physiological and behavioural responses to noxious stimuli in the Atlantic cod (Gadus morhua). | 2014 | PLoS ONE | pmid:24936652 |
| Cao Z et al. | Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24305062 |
| Feketa VV et al. | Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. | 2014 | Crit. Care Med. | pmid:24595220 |
| Jiang C et al. | A pseudo three-zone simulated moving bed with solvent gradient for quaternary separations. | 2014 | J Chromatogr A | pmid:24581869 |
| Lu MJ et al. | Hypoxic preconditioning protects rat hearts against ischemia-reperfusion injury via the arachidonate12-lipoxygenase/transient receptor potential vanilloid 1 pathway. | 2014 | Basic Res. Cardiol. | pmid:24816396 |
| Davidson S et al. | Human sensory neurons: Membrane properties and sensitization by inflammatory mediators. | 2014 | Pain | pmid:24973718 |
| Gawande ND et al. | Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking. | 2014 | Bioinformation | pmid:25512683 |
| Usman MG et al. | Capsaicin and dihydrocapsaicin determination in chili pepper genotypes using ultra-fast liquid chromatography. | 2014 | Molecules | pmid:24853712 |
| Zhao JY et al. | Dihydrocapsaicin down-regulates apoM expression through inhibiting Foxa2 expression and enhancing LXRα expression in HepG2 cells. | 2014 | Lipids Health Dis | pmid:24642298 |
| Contri RV et al. | The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids. | 2014 | Int J Nanomedicine | pmid:24611011 |
| Weitlauf C et al. | Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation. | 2014 | J. Neurosci. | pmid:25392504 |
| Kobata K et al. | Formation of long-chain N-vanillyl-acylamides from plant oils. | 2014 | Biosci. Biotechnol. Biochem. | pmid:25229865 |
| Anderson EM et al. | The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device. | 2014 | PLoS ONE | pmid:24558480 |
| Zhang X et al. | Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons. | 2014 | Exp. Neurol. | pmid:24212047 |