Lignoceric acid

Lignoceric acid is a lipid of Fatty Acyls (FA) class. Lignoceric acid is associated with abnormalities such as Adrenoleukodystrophy and Peroxisomal Disorders. The involved functions are known as Anabolism, establishment and maintenance of localization, Saturated, Process and long-chain-fatty-acid-CoA ligase activity. Lignoceric acid often locates in Membrane, Microsomes, Plasma membrane, peroxisome and Mitochondria. The associated genes with Lignoceric acid are SLC27A1 gene, CD36 gene, F10 gene, INHA gene and ABCD1 gene. The related lipids are Sphingolipids, Fatty Acids, erucic acid, inositolphosphoceramides and Palmitates.

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Introduction

To understand associated biological information of Lignoceric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lignoceric acid?

Lignoceric acid is suspected in Peroxisomal Disorders, Adrenoleukodystrophy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lignoceric acid

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Reperfusion Injury D015427 65 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperthyroidism D006980 12 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Lignoceric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lignoceric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Lignoceric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Lignoceric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Lignoceric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Lignoceric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Lignoceric acid

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Authors Title Published Journal PubMed Link
Petroni A et al. Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts. 2000 Neurosci. Lett. pmid:10904139
Tanaka K et al. Electronmicroscopic study on biopsied rectal mucosa in adrenoleukodystrophy. 1987 Neurology pmid:3587618
Burdette DE et al. Late-onset generalized disorder of peroxisomes. 1996 Neurology pmid:8618694
Rizzo WB et al. Adrenoleukodystrophy: very long-chain fatty acid metabolism in fibroblasts. 1984 Neurology pmid:6538003
Shimeno H et al. Alpha-hydroxylation and oxidation of lignoceric acid in brain: the role of heat-stable and heat-labile factors. 1984 Neurochem. Res. pmid:6738789
Singh I et al. Isolation and biochemical characterization of peroxisomes from cultured rat glial cells. 2000 Neurochem. Res. pmid:10786702
Morand O et al. Exogenous [1-(14)C]lignoceric acid uptake by neurons, astrocytes and myelin, as compared to incorporation of [1-(14)C]palmitic and stearic acids. 1981 Neurochem. Int. pmid:20487830
Boiron F et al. Decreased biosynthesis of saturated C20-C24 fatty acids by the trembler mouse sciatic nerve. 1984 Neurochem. Int. pmid:20488028
Mori MA et al. Synthesis of ceramides and cerebrosides in rat brain: comparison with synthesis of lignoceroyl-coenzyme A. 1985 Neurochem. Int. pmid:20492899
Soeda S et al. Long-chain and very long-chain fatty acyl-coa synthetase activity in microsomes of jimpy mouse brain. 1986 Neurochem. Int. pmid:20493149