| MeSH term | MeSH ID | Detail |
|---|---|---|
| Sudden Infant Death | D013398 | 3 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Chondrodysplasia Punctata | D002806 | 8 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Polycystic Kidney Diseases | D007690 | 12 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
Lignoceric acid
Lignoceric acid is a lipid of Fatty Acyls (FA) class. Lignoceric acid is associated with abnormalities such as Adrenoleukodystrophy and Peroxisomal Disorders. The involved functions are known as Anabolism, establishment and maintenance of localization, Saturated, Process and long-chain-fatty-acid-CoA ligase activity. Lignoceric acid often locates in Membrane, Microsomes, Plasma membrane, peroxisome and Mitochondria. The associated genes with Lignoceric acid are SLC27A1 gene, CD36 gene, F10 gene, INHA gene and ABCD1 gene. The related lipids are Sphingolipids, Fatty Acids, erucic acid, inositolphosphoceramides and Palmitates.
Cross Reference
Introduction
To understand associated biological information of Lignoceric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lignoceric acid?
Lignoceric acid is suspected in Peroxisomal Disorders, Adrenoleukodystrophy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lignoceric acid
PubChem Associated disorders and diseases
What pathways are associated with Lignoceric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lignoceric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Lignoceric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Lignoceric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Lignoceric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Lignoceric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Lignoceric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sacktor NC et al. | Effects of subperineurial injections of very-long-chain and medium-chain fatty acids into rat sciatic nerve. | 1986 | Neurochem Pathol | pmid:3561895 |
| GATT S and SHAPIRO B | Metabolism of 1-14C Lignoceric Acid in the Rat. | 1960 | Nature | pmid:18998246 |
| Tel-Çayan G et al. | A new fatty acid ester from an edible mushroom Rhizopogon luteolus. | 2016 | Nat. Prod. Res. | pmid:26987031 |
| Engelen M et al. | Lovastatin in X-linked adrenoleukodystrophy. | 2010 | N. Engl. J. Med. | pmid:20089986 |
| Wilkins A et al. | Very long chain fatty acid levels in patients diagnosed with multiple sclerosis. | 2009 | Mult. Scler. | pmid:19965514 |
| Atherton HJ et al. | Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. | 2009 | Mol. Syst. Biol. | pmid:19357638 |
| Casadei BR et al. | Brij detergents reveal new aspects of membrane microdomain in erythrocytes. | 2014 | Mol. Membr. Biol. | pmid:25222860 |
| Dawson G et al. | Mitochondrial abnormalities in CLN2 and CLN3 forms of Batten disease. | 1996 Oct-Dec | Mol. Chem. Neuropathol. | pmid:8971698 |
| Dhaunsi GS et al. | Impairment of peroxisomal beta-oxidation system by endotoxin treatment. | 1994 | Mol. Cell. Biochem. | pmid:7838145 |
| Lazo O et al. | Effect of ciprofibrate on the activation and oxidation of very long chain fatty acids. | 1991 | Mol. Cell. Biochem. | pmid:2008177 |
| Pang CY et al. | Comparative proteomics indicates that biosynthesis of pectic precursors is important for cotton fiber and Arabidopsis root hair elongation. | 2010 | Mol. Cell Proteomics | pmid:20525998 |
| Zviagintseva IS et al. | [Fatty acid makeup of the lipids in soil and epiphytic yeasts]. | 1975 Jul-Aug | Mikrobiologiia | pmid:1177776 |
| Singh I | Peroxisomal fatty acid oxidation and cellular redox. | 2002 | Meth. Enzymol. | pmid:12125363 |
| Di Marino L et al. | Is the erythrocyte membrane fatty acid composition a valid index of skeletal muscle membrane fatty acid composition? | 2000 | Metab. Clin. Exp. | pmid:11016898 |
| Dhaunsi GS et al. | Very-long-chain fatty acids activate lysosomal hydrolases in neonatal human skin tissue. | 2005 | Med Princ Pract | pmid:16103719 |
| Yanagisawa N et al. | Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. | 2008 | Lipids Health Dis | pmid:19038055 |
| Blomqvist M et al. | Uptake of the glycosphingolipid sulfatide in the gastrointestinal tract and pancreas in vivo and in isolated islets of Langerhans. | 2006 | Lipids Health Dis | pmid:17044925 |
| Kojima M et al. | Structured triacylglycerol containing behenic and oleic acids suppresses triacylglycerol absorption and prevents obesity in rats. | 2010 | Lipids Health Dis | pmid:20653972 |
| Dan P et al. | 2-Hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase. | 2011 | Lipids Health Dis | pmid:21599921 |
| Guschina I et al. | Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. | 2011 | Lipids | pmid:20963507 |
| Bettger WJ and Blackadar CB | Dietary very long chain fatty acids directly influence the ratio of tetracosenoic (24:1) to tetracosanoic (24:0) acids of sphingomyelin in rat liver. | 1997 | Lipids | pmid:9075193 |
| Poulos A et al. | Metabolism of trideuterated iso-lignoceric acid in rats in vivo and in human fibroblasts in culture. | 1999 | Lipids | pmid:10574659 |
| Nagura M et al. | Alterations of fatty acid metabolism and membrane fluidity in peroxisome-defective mutant ZP102 cells. | 2004 | Lipids | pmid:15055234 |
| Petroni A et al. | Effects of the testosterone metabolite dihydrotestosterone and 5 alpha-androstan-3 alpha,17 beta-diol on very long chain fatty acid metabolism in X-adrenoleukodystrophic fibroblasts. | 2003 | Life Sci. | pmid:12865096 |
| Ramos AP and Lafleur M | Chain Length of Free Fatty Acids Influences the Phase Behavior of Stratum Corneum Model Membranes. | 2015 | Langmuir | pmid:26442576 |
| Stahlberg S et al. | Probing the role of the ceramide acyl chain length and sphingosine unsaturation in model skin barrier lipid mixtures by (2)H solid-state NMR spectroscopy. | 2015 | Langmuir | pmid:25870928 |
| Wanders RJ et al. | Impaired ability of peroxisomes to activate very-long-chain fatty acids in X-linked adrenoleukodystrophy. | 1988 | Lancet | pmid:2899227 |
| Dhaunsi GS et al. | FPTIII mitigates peroxisome-mediated oxidative stress in kidneys of spontaneously hypertensive diabetic rats. | 2010 | Kidney Blood Press. Res. | pmid:20197688 |
| Ndonye RM et al. | Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH. | 2005 | J. Org. Chem. | pmid:16323834 |
| Boles DJ and Rizzo WB | Dietary fatty acids temporarily alter liver very long-chain fatty acid composition in mice. | 1992 | J. Nutr. | pmid:1640260 |
| Fretts AM et al. | Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. | 2016 | J. Nutr. | pmid:26701797 |
| Tsuji S et al. | Metabolism of [17,18-3H2]hexacosanoic acid and [15,16-3H2]lignoceric acid in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). | 1985 | J. Neurol. Sci. | pmid:4087029 |
| Deon M et al. | The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy. | 2006 | J. Neurol. Sci. | pmid:16750542 |
| Lazo O et al. | Postnatal development and isolation of peroxisomes from brain. | 1991 | J. Neurochem. | pmid:2002347 |
| Shigematsu H et al. | Purification and characterization of the heat-stable factors essential for the conversion of lignoceric acid to cerebronic acid and glutamic acid: identification of N-acetyl-L-aspartic acid. | 1983 | J. Neurochem. | pmid:6131106 |
| Singh H et al. | Mitochondrial and peroxisomal beta-oxidation of stearic and lignoceric acids by rat brain. | 1989 | J. Neurochem. | pmid:2809586 |
| Singh I and Kishimoto Y | alpha-Hydroxylation of fatty acids in brain: characterization of heat-labile factor. | 1981 | J. Neurochem. | pmid:7264665 |
| Yoshida S and Takeshita M | Characteristics of synthesis of very-long-chain saturated and tetraenoic fatty acids in swine cerebral microsomes. | 1986 | J. Neurochem. | pmid:3958710 |
| Singh I | Ceramide synthesis from free fatty acids in rat brain: function of NADPH and substrate specificity. | 1983 | J. Neurochem. | pmid:6854321 |
| Bentejac M et al. | Utilization of high-density lipoprotein sphingomyelin by the developing and mature brain in the rat. | 1989 | J. Neurochem. | pmid:2709013 |
| Harinantenaina L et al. | Secondary metabolites of Cinnamosma madagascariensis and their alpha-glucosidase inhibitory properties. | 2008 | J. Nat. Prod. | pmid:18179176 |
| Razani SH et al. | Fatty acid and carotenoid production by Sporobolomyces ruberrimus when using technical glycerol and ammonium sulfate. | 2007 | J. Microbiol. Biotechnol. | pmid:18156773 |
| Kusunoki M et al. | Relationship between serum concentrations of saturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus. | 2007 | J. Med. Invest. | pmid:17878672 |
| Fabiano A et al. | Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:21781003 |
| Galloway JH et al. | Abnormal myocardial lipid composition in an infant with type II glutaric aciduria. | 1987 | J. Lipid Res. | pmid:3572253 |
| Ohta M et al. | Novel free ceramides as components of the soldier defense gland of the Formosan subterranean termite (Coptotermes formosanus). | 2007 | J. Lipid Res. | pmid:17164223 |
| Clayton RB et al. | Stimulation of erythroblast maturation in vitro by sphingolipids. | 1974 | J. Lipid Res. | pmid:4372286 |
| Singh I and Kishimoto Y | Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. | 1983 | J. Lipid Res. | pmid:6875391 |
| Alderson NL et al. | A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gas chromatography-mass spectrometry. | 2005 | J. Lipid Res. | pmid:15863841 |
| Lazo O et al. | Cellular oxidation of lignoceric acid is regulated by the subcellular localization of lignoceroyl-CoA ligases. | 1990 | J. Lipid Res. | pmid:2141053 |