Lignoceric acid

Lignoceric acid is a lipid of Fatty Acyls (FA) class. Lignoceric acid is associated with abnormalities such as Adrenoleukodystrophy and Peroxisomal Disorders. The involved functions are known as Anabolism, establishment and maintenance of localization, Saturated, Process and long-chain-fatty-acid-CoA ligase activity. Lignoceric acid often locates in Membrane, Microsomes, Plasma membrane, peroxisome and Mitochondria. The associated genes with Lignoceric acid are SLC27A1 gene, CD36 gene, F10 gene, INHA gene and ABCD1 gene. The related lipids are Sphingolipids, Fatty Acids, erucic acid, inositolphosphoceramides and Palmitates.

Cross Reference

Introduction

To understand associated biological information of Lignoceric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lignoceric acid?

Lignoceric acid is suspected in Peroxisomal Disorders, Adrenoleukodystrophy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lignoceric acid

MeSH term MeSH ID Detail
Sudden Infant Death D013398 3 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Lignoceric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lignoceric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Lignoceric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Lignoceric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Lignoceric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Lignoceric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Lignoceric acid

Download all related citations
Per page 10 20 50 100 | Total 264
Authors Title Published Journal PubMed Link
Jennemann R et al. Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus. 1999 Eur. J. Biochem. pmid:9914511
Sandhir R et al. Localization of nervonic acid beta-oxidation in human and rodent peroxisomes: impaired oxidation in Zellweger syndrome and X-linked adrenoleukodystrophy. 1998 J. Lipid Res. pmid:9799802
Singh I et al. Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy. 1998 FEBS Lett. pmid:9600263
Suzuki Y et al. Biochemical and immunocytochemical properties of peroxisomes and mitochondria in bovine chromaffin cells. 1997 Cell Struct. Funct. pmid:9591053
Murad S et al. Alpha-Hydroxylation of lignoceric and nervonic acids in the brain. Effects of altered thyroid function on postnatal development of the hydroxylase activity. 1976 J. Biol. Chem. pmid:956184
Suzuki Y et al. D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency: a newly identified peroxisomal disorder. 1997 Am. J. Hum. Genet. pmid:9345094
Hayashi H and Hara M 1-Alkenyl group of ethanolamine plasmalogen derives mainly from de novo-synthesized fatty alcohol within peroxisomes, but not extraperoxisomal fatty alcohol or fatty acid. 1997 J. Biochem. pmid:9192743
Bettger WJ and Blackadar CB Dietary very long chain fatty acids directly influence the ratio of tetracosenoic (24:1) to tetracosanoic (24:0) acids of sphingomyelin in rat liver. 1997 Lipids pmid:9075193
Inoue K et al. Carrier identification of X-linked adrenoleukodystrophy by measurement of very long chain fatty acids and lignoceric acid oxidation. 1996 Clin. Genet. pmid:9007322
Dawson G et al. Mitochondrial abnormalities in CLN2 and CLN3 forms of Batten disease. 1996 Oct-Dec Mol. Chem. Neuropathol. pmid:8971698
Robert J et al. Glycosphingolipids from cultured astroblasts. 1977 J. Lipid Res. pmid:894142
ten Grotenhuis E et al. Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers. 1996 Biophys. J. pmid:8874014
Shimozawa N et al. Correction by gene expression of biochemical abnormalities in fibroblasts from Zellweger patients. 1996 Pediatr. Res. pmid:8726233
Kremser K et al. Nitric oxide regulates peroxisomal enzyme activities. 1995 Eur J Clin Chem Clin Biochem pmid:8620052
Burdette DE et al. Late-onset generalized disorder of peroxisomes. 1996 Neurology pmid:8618694
Aveldaño MI and Donnari D Plasma phospholipid fatty acids in X-linked adrenoleukodystrophy. 1996 Clin. Chem. pmid:8598113
Maulik PR and Shipley GG X-ray diffraction and calorimetric study of N-lignoceryl sphingomyelin membranes. 1995 Biophys. J. pmid:8580334
Singh I et al. Phytanic acid alpha-oxidation. Differential subcellular localization in rat and human tissues and its inhibition by nycodenz. 1993 J. Biol. Chem. pmid:8486724
Lu D et al. Effect of glycosphingolipid fatty acid chain length on behavior in unsaturated phosphatidylcholine bilayers: a 2H NMR study. 1993 Biochemistry pmid:8418849
Gulati S et al. Alterations of peroxisomal function in ischemia-reperfusion injury of rat kidney. 1993 Biochim. Biophys. Acta pmid:8399363
Singh I et al. Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain. 1993 Biochim. Biophys. Acta pmid:8399326
Bourre JM et al. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). 1977 Eur. J. Biochem. pmid:836393
Lageweg W and Wanders RJ Studies on the effect of fenoprofen on the activation and oxidation of long chain and very long chain fatty acids in hepatocytes and subcellular fractions from rat liver. 1993 Biochem. Pharmacol. pmid:8347139
Bourre JM et al. [Biosynthesis of lignoceric acid in two organelles (mitochondria and microsomes) during the development of the brain in normal and pathologic (Quaking and Jimpy) mice]. 1976 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:825290
Contreras M et al. The protein coded by the X-adrenoleukodystrophy gene is a peroxisomal integral membrane protein. 1994 FEBS Lett. pmid:8187886
Bourre JM et al. [Comparative biosynthesis of fatty acids, particularly lignoceric acid, in the kidney and brain of normal and "quaking" mice]. 1976 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:817827
Suzuki Y et al. Prenatal diagnosis of peroxisomal disorders. Biochemical and immunocytochemical studies on peroxisomes in human amniocytes. 1994 Jan-Feb Brain Dev. pmid:8059925
Aoyama T et al. Peroxisomal acyl-coenzyme A oxidase is a rate-limiting enzyme in a very-long-chain fatty acid beta-oxidation system. 1994 Biochem. Biophys. Res. Commun. pmid:8024599
Hayashi H and Oohashi M Incorporation of acetyl-CoA generated from peroxisomal beta-oxidation into ethanolamine plasmalogen of rat liver. 1995 Biochim. Biophys. Acta pmid:7857972
Dhaunsi GS et al. Impairment of peroxisomal beta-oxidation system by endotoxin treatment. 1994 Mol. Cell. Biochem. pmid:7838145
Hashimoto F et al. Effect of gemfibrozil on lipid biosynthesis from acetyl-CoA derived from peroxisomal beta-oxidation. 1995 Biochem. Pharmacol. pmid:7763302
Morrow MR et al. Glycosphingolipid acyl chain order profiles: substituent effects. 1995 Biochim. Biophys. Acta pmid:7756331
Akanuma H and Kishimoto Y Synthesis of ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids from lignoceroyl-CoA by rat brain microsomes. 1979 J. Biol. Chem. pmid:762114
Singh I and Kishimoto Y alpha-Hydroxylation of fatty acids in brain: characterization of heat-labile factor. 1981 J. Neurochem. pmid:7264665
Kawamura N et al. Very long chain fatty acid oxidation in rat liver. 1981 Biochem. Biophys. Res. Commun. pmid:7259776
Uda M et al. Glutamate formed from lignoceric acid by rat brain preparation in the presence of pyridine nucleotide and cytosolic factors: a brain-specific oxidation of very long chain fatty acids. 1981 Biochemistry pmid:7225329
Singh I and Kishimoto Y Brain-specific ceramide synthesis activity: change during brain maturation and in jimpy mouse brain. 1982 Brain Res. pmid:7188035
Rokukawa C et al. Structural study on gangliosides from rat liver and erythrocytes. 1982 J. Biochem. pmid:7153212
Uda M et al. Purification of the heat-stable factor required for alpha-hydroxylation and beta-oxidation of very long chain fatty acids in brain. 1982 Arch. Biochem. Biophys. pmid:7103506
Jaffe R et al. Neonatal adrenoleukodystrophy: clinical, pathologic, and biochemical delineation of a syndrome affecting both males and females. 1982 Am. J. Pathol. pmid:7091298
Ogino T et al. Metabolic studies of adrenoleukodystrophy. 1978 Adv. Exp. Med. Biol. pmid:696482
Singh I and Kishimoto Y Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. 1983 J. Lipid Res. pmid:6875391
Shimeno H et al. Further characterization of the heat-stable factor in the alpha-hydroxylation and oxidation of lignoceric acid in brain: effect of acidic amino acids and hexose-phosphates on brain fatty acid metabolism. 1983 Arch. Biochem. Biophys. pmid:6859867
Singh I Ceramide synthesis from free fatty acids in rat brain: function of NADPH and substrate specificity. 1983 J. Neurochem. pmid:6854321
Shimeno H et al. Alpha-hydroxylation and oxidation of lignoceric acid in brain: the role of heat-stable and heat-labile factors. 1984 Neurochem. Res. pmid:6738789
Takahashi M et al. Phospholipid and fatty acid composition of erythrocyte membrane from wild Japanese serow (Capricornis crispus). 1984 Comp. Biochem. Physiol., B pmid:6697694
Singh I et al. Lignoceric acid is oxidized in the peroxisome: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy. 1984 Proc. Natl. Acad. Sci. U.S.A. pmid:6588384
Rizzo WB et al. Adrenoleukodystrophy: very long-chain fatty acid metabolism in fibroblasts. 1984 Neurology pmid:6538003
Iida H et al. Alterations in erythrocyte membrane lipids in abetalipoproteinemia: phospholipid and fatty acyl composition. 1984 Biochem Med pmid:6497872
Cassagne C et al. [Biochemical aspects of myelinogenesis in the peripheral nervous system]. 1980 C. R. Seances Soc. Biol. Fil. pmid:6449229
Shigematsu H et al. Purification and characterization of the heat-stable factors essential for the conversion of lignoceric acid to cerebronic acid and glutamic acid: identification of N-acetyl-L-aspartic acid. 1983 J. Neurochem. pmid:6131106
Cassagne C and Lessire R Studies on alkane biosynthesis in epidermis of Allium porrum L. leaves. Direct synthesis of tricosane from lignoceric acid. 1974 Arch. Biochem. Biophys. pmid:4441076
Singh I et al. Conversion by rat brain preparation of lignoceric acid to ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids. Effects of compounds which affect sphingolipid metabolism. 1979 J. Biol. Chem. pmid:438163
Clayton RB et al. Stimulation of erythroblast maturation in vitro by sphingolipids. 1974 J. Lipid Res. pmid:4372286
Hoshi M and Kishimoto Y Synthesis of cerebronic acid from lignoceric acid by rat brain preparation. Some properties and distribution of the -hydroxylation system. 1973 J. Biol. Chem. pmid:4145326
Tsuji S et al. Metabolism of [17,18-3H2]hexacosanoic acid and [15,16-3H2]lignoceric acid in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). 1985 J. Neurol. Sci. pmid:4087029
Soeda S et al. Immobilization of fatty acyl-CoA synthetase: effect on its stability and substrate specificity. 1986 Biochem. Int. pmid:3964283
Bhushan A et al. Characterization of rat brain microsomal acyl-coenzyme A ligases: different enzymes for the synthesis of palmitoyl-coenzyme A and lignoceroyl-coenzyme A. 1986 Arch. Biochem. Biophys. pmid:3963826
Yoshida S and Takeshita M Characteristics of synthesis of very-long-chain saturated and tetraenoic fatty acids in swine cerebral microsomes. 1986 J. Neurochem. pmid:3958710
Veerkamp JH and van Moerkerk HT Peroxisomal fatty acid oxidation in rat and human tissues. Effect of nutritional state, clofibrate treatment and postnatal development in the rat. 1986 Biochim. Biophys. Acta pmid:3942767
Singh I and Kishimoto Y Alpha hydroxylation of lignoceric acid in brain. Subcellular localization of alpha hydroxylation and the requirement for heat-stable and heat-labile factors and sphingosine. 1979 J. Biol. Chem. pmid:38244
Lacave C et al. [Structural and metabolic study of the mycolic acids of Mycobacterium fortuitum]. 1987 Eur. J. Biochem. pmid:3816811
Crook SJ et al. Factors affecting surface expression of glycolipids: influence of lipid environment and ceramide composition on antibody recognition of cerebroside sulfate in liposomes. 1986 Biochemistry pmid:3801428
Singh H and Poulos A A comparative study of stearic and lignoceric acid oxidation by human skin fibroblasts. 1986 Arch. Biochem. Biophys. pmid:3767370
Wanders RJ et al. Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. 1987 J. Clin. Invest. pmid:3680527
Singh H et al. Very long chain fatty acid beta-oxidation by subcellular fractions of normal and Zellweger syndrome skin fibroblasts. 1987 Arch. Biochem. Biophys. pmid:3662528
Tanaka K et al. Electronmicroscopic study on biopsied rectal mucosa in adrenoleukodystrophy. 1987 Neurology pmid:3587618
Galloway JH et al. Abnormal myocardial lipid composition in an infant with type II glutaric aciduria. 1987 J. Lipid Res. pmid:3572253
Sacktor NC et al. Effects of subperineurial injections of very-long-chain and medium-chain fatty acids into rat sciatic nerve. 1986 Neurochem Pathol pmid:3561895
De Lederkremer RM et al. Lipopeptidophosphoglycan from Trypanosoma cruzi. Amide and ester-linked fatty acids. 1977 Eur. J. Biochem. pmid:323009
Lazo O et al. Peroxisomal lignoceroyl-CoA ligase deficiency in childhood adrenoleukodystrophy and adrenomyeloneuropathy. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3174658
Singh I et al. Acyl-CoA ligases from rat brain microsomes: an immunochemical study. 1988 Biochim. Biophys. Acta pmid:2973813
Singh I and Kishimoto Y A novel synthesis of ceramide from lignoceric acid and sphingosine by rat brain preparation; the amide formation requires a pyridine nucleotide. 1978 Biochem. Biophys. Res. Commun. pmid:29620
Wanders RJ et al. Studies on the peroxisomal oxidation of palmitate and lignocerate in rat liver. 1987 Biochim. Biophys. Acta pmid:2952173
Iida N et al. A sulfated glucosylceramide from rat kidney. 1989 J. Biol. Chem. pmid:2925645
Carneheim C et al. Rare fatty acids in brown fat are substrates for thermogenesis during arousal from hibernation. 1989 Am. J. Physiol. pmid:2912207
Wanders RJ et al. Impaired ability of peroxisomes to activate very-long-chain fatty acids in X-linked adrenoleukodystrophy. 1988 Lancet pmid:2899227
Poll-The BT et al. A new peroxisomal disorder with enlarged peroxisomes and a specific deficiency of acyl-CoA oxidase (pseudo-neonatal adrenoleukodystrophy). 1988 Am. J. Hum. Genet. pmid:2894756
Pullmannová P et al. Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains. 2017 Biophys. Chem. pmid:28363088
Bezine M et al. Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. 2017 Chem. Phys. Lipids pmid:28322741
Singh H et al. Mitochondrial and peroxisomal beta-oxidation of stearic and lignoceric acids by rat brain. 1989 J. Neurochem. pmid:2809586
Morita M et al. A novel method for determining peroxisomal fatty acid β-oxidation. 2016 J. Inherit. Metab. Dis. pmid:27324171
Bentejac M et al. Utilization of high-density lipoprotein sphingomyelin by the developing and mature brain in the rat. 1989 J. Neurochem. pmid:2709013
Lazo O et al. Adrenoleukodystrophy: impaired oxidation of fatty acids due to peroxisomal lignoceroyl-CoA ligase deficiency. 1989 Arch. Biochem. Biophys. pmid:2705786
Tel-Çayan G et al. A new fatty acid ester from an edible mushroom Rhizopogon luteolus. 2016 Nat. Prod. Res. pmid:26987031
Fretts AM et al. Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. 2016 J. Nutr. pmid:26701797
Nasrallah F et al. X-linked Adrenoleukodystrophy, The Tunisian Experience. 2015 Clin. Lab. pmid:26642716
Chung HK et al. Plasma phospholipid arachidonic acid and lignoceric acid are associated with the risk of cardioembolic stroke. 2015 Nutr Res pmid:26452419
Ramos AP and Lafleur M Chain Length of Free Fatty Acids Influences the Phase Behavior of Stratum Corneum Model Membranes. 2015 Langmuir pmid:26442576
Zarrouk A et al. Impact of C24:0 on actin-microtubule interaction in human neuronal SK-N-BE cells: evaluation by FRET confocal spectral imaging microscopy after dual staining with rhodamine-phalloidin and tubulin tracker green. Funct. Neurol. pmid:26214025
Mojumdar EH et al. Skin lipids: localization of ceramide and fatty acid in the unit cell of the long periodicity phase. 2015 Biophys. J. pmid:26039168
Shivashankar S and Sumathi M Do seed VLCFAs trigger spongy tissue formation in Alphonso mango by inducing germination? 2015 J. Biosci. pmid:25963264
Jantzen E et al. Gas chromatography of mycobacterial fatty acids and alcohols: diagnostic applications. 1989 APMIS pmid:2590535
Stahlberg S et al. Probing the role of the ceramide acyl chain length and sphingosine unsaturation in model skin barrier lipid mixtures by (2)H solid-state NMR spectroscopy. 2015 Langmuir pmid:25870928
Lemaitre RN et al. Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study. 2015 Am. J. Clin. Nutr. pmid:25787996
Singh I et al. Lignoceroyl-CoA ligase activity in rat brain microsomal fraction: topographical localization and effect of detergents and alpha-cyclodextrin. 1985 Arch. Biochem. Biophys. pmid:2578272
Sánchez-Rodríguez P et al. Identification of potential erythrocyte phospholipid fatty acid biomarkers of advanced lung adenocarcinoma, squamous cell lung carcinoma, and small cell lung cancer. 2015 Tumour Biol. pmid:25702090
Casadei BR et al. Brij detergents reveal new aspects of membrane microdomain in erythrocytes. 2014 Mol. Membr. Biol. pmid:25222860
Tanaka K et al. Very long-chain fatty acids in erythrocyte membrane phospholipids in adrenoleukodystrophy. 1989 Acta Paediatr Jpn pmid:2516693
Xie JM et al. [Studies on the chemical constituents of Excoecaria cochinchinensis Lour. var. viridis Merr]. 1989 Zhongguo Zhong Yao Za Zhi pmid:2512946