Lignoceric acid

Lignoceric acid is a lipid of Fatty Acyls (FA) class. Lignoceric acid is associated with abnormalities such as Adrenoleukodystrophy and Peroxisomal Disorders. The involved functions are known as Anabolism, establishment and maintenance of localization, Saturated, Process and long-chain-fatty-acid-CoA ligase activity. Lignoceric acid often locates in Membrane, Microsomes, Plasma membrane, peroxisome and Mitochondria. The associated genes with Lignoceric acid are SLC27A1 gene, CD36 gene, F10 gene, INHA gene and ABCD1 gene. The related lipids are Sphingolipids, Fatty Acids, erucic acid, inositolphosphoceramides and Palmitates.

Cross Reference

Introduction

To understand associated biological information of Lignoceric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lignoceric acid?

Lignoceric acid is suspected in Peroxisomal Disorders, Adrenoleukodystrophy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lignoceric acid

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperthyroidism D006980 12 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Lignoceric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lignoceric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Lignoceric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Lignoceric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Lignoceric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Lignoceric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Lignoceric acid

Download all related citations
Per page 10 20 50 100 | Total 264
Authors Title Published Journal PubMed Link
pmid:
Rao GX et al. Chemical constituents of Selinum cryptotaenium. J Asian Nat Prod Res pmid:16864434
Zarrouk A et al. Impact of C24:0 on actin-microtubule interaction in human neuronal SK-N-BE cells: evaluation by FRET confocal spectral imaging microscopy after dual staining with rhodamine-phalloidin and tubulin tracker green. Funct. Neurol. pmid:26214025
DUBOS RJ The effect of sphingomyelin on the growth of tubercle bacilli. 1948 J. Exp. Med. pmid:18871879
GATT S and SHAPIRO B Metabolism of 1-14C Lignoceric Acid in the Rat. 1960 Nature pmid:18998246
GRAY GM THE ISOLATION AND PARTIAL CHARACTERIZATION OF THE GLYCOLIPIDS OF BP8/C3H ASCITES-SARCOMA CELLS. 1965 Biochem. J. pmid:14342256
Hoshi M and Kishimoto Y Synthesis of cerebronic acid from lignoceric acid by rat brain preparation. Some properties and distribution of the -hydroxylation system. 1973 J. Biol. Chem. pmid:4145326
Cassagne C and Lessire R Studies on alkane biosynthesis in epidermis of Allium porrum L. leaves. Direct synthesis of tricosane from lignoceric acid. 1974 Arch. Biochem. Biophys. pmid:4441076
Clayton RB et al. Stimulation of erythroblast maturation in vitro by sphingolipids. 1974 J. Lipid Res. pmid:4372286
Bourre JM et al. Biosynthesis of lignoceric acid from behenyl0COA in mouse brain microsomes. Comparison between normal and Quaking mutant. 1975 Biochem. Biophys. Res. Commun. pmid:236752
Murad S and Kishimoto Y Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. 1975 J. Biol. Chem. pmid:1150661
Tatsumi K et al. Mechanism and stereospecificity of alpha-hydroxylation of lignoceric acid in rat brain. 1975 Arch. Biochem. Biophys. pmid:1190799
Zviagintseva IS et al. [Fatty acid makeup of the lipids in soil and epiphytic yeasts]. 1975 Jul-Aug Mikrobiologiia pmid:1177776
Capella P et al. [Saturated fatty acids determination by GLC after TLC separation (author's transl)]. 1975 Jul-Aug S TA NU pmid:1243960
Bourre JM et al. [Comparative biosynthesis of fatty acids, particularly lignoceric acid, in the kidney and brain of normal and "quaking" mice]. 1976 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:817827
Bourre JM et al. [Biosynthesis of lignoceric acid in two organelles (mitochondria and microsomes) during the development of the brain in normal and pathologic (Quaking and Jimpy) mice]. 1976 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:825290
Murad S et al. Alpha-Hydroxylation of lignoceric and nervonic acids in the brain. Effects of altered thyroid function on postnatal development of the hydroxylase activity. 1976 J. Biol. Chem. pmid:956184
De Lederkremer RM et al. Lipopeptidophosphoglycan from Trypanosoma cruzi. Amide and ester-linked fatty acids. 1977 Eur. J. Biochem. pmid:323009
Bourre JM et al. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). 1977 Eur. J. Biochem. pmid:836393
Robert J et al. Glycosphingolipids from cultured astroblasts. 1977 J. Lipid Res. pmid:894142
Ogino T et al. Metabolic studies of adrenoleukodystrophy. 1978 Adv. Exp. Med. Biol. pmid:696482
Singh I and Kishimoto Y A novel synthesis of ceramide from lignoceric acid and sphingosine by rat brain preparation; the amide formation requires a pyridine nucleotide. 1978 Biochem. Biophys. Res. Commun. pmid:29620
Singh I et al. Conversion by rat brain preparation of lignoceric acid to ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids. Effects of compounds which affect sphingolipid metabolism. 1979 J. Biol. Chem. pmid:438163
Akanuma H and Kishimoto Y Synthesis of ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids from lignoceroyl-CoA by rat brain microsomes. 1979 J. Biol. Chem. pmid:762114
Singh I and Kishimoto Y Alpha hydroxylation of lignoceric acid in brain. Subcellular localization of alpha hydroxylation and the requirement for heat-stable and heat-labile factors and sphingosine. 1979 J. Biol. Chem. pmid:38244
Cassagne C et al. [Biochemical aspects of myelinogenesis in the peripheral nervous system]. 1980 C. R. Seances Soc. Biol. Fil. pmid:6449229
Uda M et al. Glutamate formed from lignoceric acid by rat brain preparation in the presence of pyridine nucleotide and cytosolic factors: a brain-specific oxidation of very long chain fatty acids. 1981 Biochemistry pmid:7225329
Kawamura N et al. Very long chain fatty acid oxidation in rat liver. 1981 Biochem. Biophys. Res. Commun. pmid:7259776
Singh I and Kishimoto Y alpha-Hydroxylation of fatty acids in brain: characterization of heat-labile factor. 1981 J. Neurochem. pmid:7264665
Morand O et al. Exogenous [1-(14)C]lignoceric acid uptake by neurons, astrocytes and myelin, as compared to incorporation of [1-(14)C]palmitic and stearic acids. 1981 Neurochem. Int. pmid:20487830
Jaffe R et al. Neonatal adrenoleukodystrophy: clinical, pathologic, and biochemical delineation of a syndrome affecting both males and females. 1982 Am. J. Pathol. pmid:7091298
Uda M et al. Purification of the heat-stable factor required for alpha-hydroxylation and beta-oxidation of very long chain fatty acids in brain. 1982 Arch. Biochem. Biophys. pmid:7103506
Rokukawa C et al. Structural study on gangliosides from rat liver and erythrocytes. 1982 J. Biochem. pmid:7153212
Singh I and Kishimoto Y Brain-specific ceramide synthesis activity: change during brain maturation and in jimpy mouse brain. 1982 Brain Res. pmid:7188035
Shigematsu H et al. Purification and characterization of the heat-stable factors essential for the conversion of lignoceric acid to cerebronic acid and glutamic acid: identification of N-acetyl-L-aspartic acid. 1983 J. Neurochem. pmid:6131106
Shimeno H et al. Further characterization of the heat-stable factor in the alpha-hydroxylation and oxidation of lignoceric acid in brain: effect of acidic amino acids and hexose-phosphates on brain fatty acid metabolism. 1983 Arch. Biochem. Biophys. pmid:6859867
Singh I and Kishimoto Y Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. 1983 J. Lipid Res. pmid:6875391
Singh I Ceramide synthesis from free fatty acids in rat brain: function of NADPH and substrate specificity. 1983 J. Neurochem. pmid:6854321
Shimeno H et al. Alpha-hydroxylation and oxidation of lignoceric acid in brain: the role of heat-stable and heat-labile factors. 1984 Neurochem. Res. pmid:6738789
Rizzo WB et al. Adrenoleukodystrophy: very long-chain fatty acid metabolism in fibroblasts. 1984 Neurology pmid:6538003
Iida H et al. Alterations in erythrocyte membrane lipids in abetalipoproteinemia: phospholipid and fatty acyl composition. 1984 Biochem Med pmid:6497872
Takahashi M et al. Phospholipid and fatty acid composition of erythrocyte membrane from wild Japanese serow (Capricornis crispus). 1984 Comp. Biochem. Physiol., B pmid:6697694
Singh I et al. Lignoceric acid is oxidized in the peroxisome: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy. 1984 Proc. Natl. Acad. Sci. U.S.A. pmid:6588384
Boiron F et al. Decreased biosynthesis of saturated C20-C24 fatty acids by the trembler mouse sciatic nerve. 1984 Neurochem. Int. pmid:20488028
Tsuji S et al. Metabolism of [17,18-3H2]hexacosanoic acid and [15,16-3H2]lignoceric acid in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). 1985 J. Neurol. Sci. pmid:4087029
Mori MA et al. Synthesis of ceramides and cerebrosides in rat brain: comparison with synthesis of lignoceroyl-coenzyme A. 1985 Neurochem. Int. pmid:20492899
Singh I et al. Lignoceroyl-CoA ligase activity in rat brain microsomal fraction: topographical localization and effect of detergents and alpha-cyclodextrin. 1985 Arch. Biochem. Biophys. pmid:2578272
Crook SJ et al. Factors affecting surface expression of glycolipids: influence of lipid environment and ceramide composition on antibody recognition of cerebroside sulfate in liposomes. 1986 Biochemistry pmid:3801428
Sacktor NC et al. Effects of subperineurial injections of very-long-chain and medium-chain fatty acids into rat sciatic nerve. 1986 Neurochem Pathol pmid:3561895
Bhushan A et al. Characterization of rat brain microsomal acyl-coenzyme A ligases: different enzymes for the synthesis of palmitoyl-coenzyme A and lignoceroyl-coenzyme A. 1986 Arch. Biochem. Biophys. pmid:3963826