Lignoceric acid

Lignoceric acid is a lipid of Fatty Acyls (FA) class. Lignoceric acid is associated with abnormalities such as Adrenoleukodystrophy and Peroxisomal Disorders. The involved functions are known as Anabolism, establishment and maintenance of localization, Saturated, Process and long-chain-fatty-acid-CoA ligase activity. Lignoceric acid often locates in Membrane, Microsomes, Plasma membrane, peroxisome and Mitochondria. The associated genes with Lignoceric acid are SLC27A1 gene, CD36 gene, F10 gene, INHA gene and ABCD1 gene. The related lipids are Sphingolipids, Fatty Acids, erucic acid, inositolphosphoceramides and Palmitates.

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Introduction

To understand associated biological information of Lignoceric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lignoceric acid?

Lignoceric acid is suspected in Peroxisomal Disorders, Adrenoleukodystrophy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lignoceric acid

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperthyroidism D006980 12 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Lignoceric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lignoceric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Lignoceric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Lignoceric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Lignoceric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Lignoceric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Lignoceric acid

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Authors Title Published Journal PubMed Link
Lazo O et al. Postnatal development and isolation of peroxisomes from brain. 1991 J. Neurochem. pmid:2002347
Khare G et al. Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis. 2009 PLoS ONE pmid:20027301
Lazo O et al. Effect of ciprofibrate on the activation and oxidation of very long chain fatty acids. 1991 Mol. Cell. Biochem. pmid:2008177
Li H et al. Cytochrome P450 family member CYP704B2 catalyzes the {omega}-hydroxylation of fatty acids and is required for anther cutin biosynthesis and pollen exine formation in rice. 2010 Plant Cell pmid:20086189
Engelen M et al. Lovastatin in X-linked adrenoleukodystrophy. 2010 N. Engl. J. Med. pmid:20089986
Sabale V et al. Comparative evaluation of rice bran wax as an ointment base with standard base. 2009 Indian J Pharm Sci pmid:20177466
Dhaunsi GS et al. FPTIII mitigates peroxisome-mediated oxidative stress in kidneys of spontaneously hypertensive diabetic rats. 2010 Kidney Blood Press. Res. pmid:20197688
Liu CJ et al. [Studies on the chemical constituents of Portulaca oleracea]. 2009 Zhong Yao Cai pmid:20218290
Veerapen N et al. Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. 2010 Bioorg. Med. Chem. Lett. pmid:20462758
Morand O et al. Exogenous [1-(14)C]lignoceric acid uptake by neurons, astrocytes and myelin, as compared to incorporation of [1-(14)C]palmitic and stearic acids. 1981 Neurochem. Int. pmid:20487830
Boiron F et al. Decreased biosynthesis of saturated C20-C24 fatty acids by the trembler mouse sciatic nerve. 1984 Neurochem. Int. pmid:20488028
Shakya R and Bhatla SC A comparative analysis of the distribution and composition of lipidic constituents and associated enzymes in pollen and stigma of sunflower. 2010 Sex. Plant Reprod. pmid:20490969
Mori MA et al. Synthesis of ceramides and cerebrosides in rat brain: comparison with synthesis of lignoceroyl-coenzyme A. 1985 Neurochem. Int. pmid:20492899
Soeda S et al. Long-chain and very long-chain fatty acyl-coa synthetase activity in microsomes of jimpy mouse brain. 1986 Neurochem. Int. pmid:20493149
Reubsaet FA et al. Immunochemical and biochemical studies of fatty acid oxidation in fibroblasts of Zellweger and X-linked adrenoleukodystrophy patients. 1991 Biochim. Biophys. Acta pmid:2049396
Assies J et al. Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study. 2010 PLoS ONE pmid:20498721
Pang CY et al. Comparative proteomics indicates that biosynthesis of pectic precursors is important for cotton fiber and Arabidopsis root hair elongation. 2010 Mol. Cell Proteomics pmid:20525998
Wang HS et al. Infrared band assignments and structure of even-numbered 2-alkyl-7,7, 8, 8-tetracyanoquinodimethane in cast films--two components of the CH2 scissoring vibrations not related to crystal field splitting. 2010 Guang Pu Xue Yu Guang Pu Fen Xi pmid:20545125
Kojima M et al. Structured triacylglycerol containing behenic and oleic acids suppresses triacylglycerol absorption and prevents obesity in rats. 2010 Lipids Health Dis pmid:20653972
Erler F Efficacy of tree trunk coating materials in the control of the apple clearwing, Synanthedon myopaeformis. 2010 J. Insect Sci. pmid:20672979
Hsu WY et al. Screening assay of very long chain fatty acids in human plasma with multiwalled carbon nanotube-based surface-assisted laser desorption/ionization mass spectrometry. 2010 Anal. Chem. pmid:20704371
Zhao Y et al. [Studies on the chemical constituents of Solanum nigrum]. 2010 Zhong Yao Cai pmid:20845784
Abdureyim S et al. Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. 2011 Evid Based Complement Alternat Med pmid:20953388
Guschina I et al. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. 2011 Lipids pmid:20963507
Dhaunsi GS et al. Lipid peroxidation and oxidation of lignoceric acid in kidneys from thioridazine treated rats. 1990 J. Exp. Pathol. pmid:2101135
Elfalleh W et al. Fatty acids from Tunisian and Chinese pomegranate (Punica granatum L.) seeds. 2011 Int J Food Sci Nutr pmid:21118055
Kunwar RM et al. Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. 2010 J Ethnobiol Ethnomed pmid:21144003
Street JM et al. Metabolism of saturated and polyunsaturated very-long-chain fatty acids in fibroblasts from patients with defects in peroxisomal beta-oxidation. 1990 Biochem. J. pmid:2117919
Hoopes MI et al. Bilayer structure and lipid dynamics in a model stratum corneum with oleic acid. 2011 J Phys Chem B pmid:21370846
Cappa M et al. Is subclinical adrenal failure in adrenoleukodystrophy/adrenomyeloneuropathy reversible? 2011 J. Endocrinol. Invest. pmid:21399389
Lazo O et al. Cellular oxidation of lignoceric acid is regulated by the subcellular localization of lignoceroyl-CoA ligases. 1990 J. Lipid Res. pmid:2141053
Sun ZH et al. [Study on the chemical constitutes of submerged cultivation mycelium of Cordyceps jiangxiensis]. 2010 Zhong Yao Cai pmid:21548364
Dan P et al. 2-Hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase. 2011 Lipids Health Dis pmid:21599921
Fabiano A et al. Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results. 2011 J. Matern. Fetal. Neonatal. Med. pmid:21781003
Lenz LS et al. Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet. 2011 J. Biol. Chem. pmid:21808061
Wang XJ et al. [Studies on the chemical constituents of Salsola collina]. 2011 Zhong Yao Cai pmid:21823480
Devera TS et al. Regulation of anthrax toxin-specific antibody titers by natural killer T cell-derived IL-4 and IFNγ. 2011 PLoS ONE pmid:21858226
Patterson AD et al. Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. 2011 Cancer Res. pmid:21900402
Daak AA et al. Hydroxyurea therapy mobilises arachidonic Acid from inner cell membrane aminophospholipids in patients with homozygous sickle cell disease. 2011 J Lipids pmid:21941660
Ní Raghallaigh S et al. The fatty acid profile of the skin surface lipid layer in papulopustular rosacea. 2012 Br. J. Dermatol. pmid:21967555
Yuan C et al. Mychonastes afer HSO-3-1 as a potential new source of biodiesel. 2011 Biotechnol Biofuels pmid:22040677
Qiao X et al. Experimental bone marrow failure in mice ameliorated by OCH via tippling the balance of released cytokines from Th1 to Th2. 2012 Immunopharmacol Immunotoxicol pmid:22124468
Tresch S et al. Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases. 2012 Phytochemistry pmid:22284369
Lv GP et al. Comparison of sterols and fatty acids in two species of Ganoderma. 2012 Chem Cent J pmid:22293530
de Camargo AC et al. Gamma radiation induced oxidation and tocopherols decrease in in-shell, peeled and blanched peanuts. 2012 Int J Mol Sci pmid:22489128
Bourdais A et al. Wood utilization is dependent on catalase activities in the filamentous fungus Podospora anserina. 2012 PLoS ONE pmid:22558065
Blenn B et al. Insect egg deposition induces indirect defense and epicuticular wax changes in Arabidopsis thaliana. 2012 J. Chem. Ecol. pmid:22588570
Lodowska J et al. The chemical composition of endotoxin isolated from intestinal strain of Desulfovibrio desulfuricans. 2012 ScientificWorldJournal pmid:22629175
Lü S et al. Arabidopsis ECERIFERUM9 involvement in cuticle formation and maintenance of plant water status. 2012 Plant Physiol. pmid:22635115
Rozema E et al. Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. 2012 Evid Based Complement Alternat Med pmid:22675394
Matsumori R et al. High levels of very long-chain saturated fatty acid in erythrocytes correlates with atherogenic lipoprotein profiles in subjects with metabolic syndrome. 2013 Diabetes Res. Clin. Pract. pmid:23146370
Bentejac M et al. Time-course of utilization of [stearic or lignoceric acid]sphingomyelin from high-density lipoprotein by rat tissues. 1990 Biochim. Biophys. Acta pmid:2317523
Kim J et al. Arabidopsis 3-ketoacyl-coenzyme a synthase9 is involved in the synthesis of tetracosanoic acids as precursors of cuticular waxes, suberins, sphingolipids, and phospholipids. 2013 Plant Physiol. pmid:23585652
Bourre JM et al. Biosynthesis of lignoceric acid from behenyl0COA in mouse brain microsomes. Comparison between normal and Quaking mutant. 1975 Biochem. Biophys. Res. Commun. pmid:236752
Mojumdar EH et al. Localization of cholesterol and fatty acid in a model lipid membrane: a neutron diffraction approach. 2013 Biophys. J. pmid:23972843
Poulos A et al. Accumulation and defective beta-oxidation of very long chain fatty acids in Zellweger's syndrome, adrenoleukodystrophy and Refsum's disease variants. 1986 Clin. Genet. pmid:2427264
Singh H et al. Beta-oxidation of very-long-chain fatty acids and their coenzyme A derivatives by human skin fibroblasts. 1987 Arch. Biochem. Biophys. pmid:2437859
Wanders RJ et al. Peroxisomal very long-chain fatty acid beta-oxidation in human skin fibroblasts: activity in Zellweger syndrome and other peroxisomal disorders. 1987 Clin. Chim. Acta pmid:2441904
Oguri M et al. The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes. 2014 Biochim. Biophys. Acta pmid:24565794
Yamazaki Y et al. Proportion of nervonic acid in serum lipids is associated with serum plasmalogen levels and metabolic syndrome. 2014 J Oleo Sci pmid:24770479
Fretts AM et al. Plasma phospholipid saturated fatty acids and incident atrial fibrillation: the Cardiovascular Health Study. 2014 J Am Heart Assoc pmid:24970268
El-Shanawany MA et al. Stigmasterol Tetracosanoate, a New Stigmasterol Ester from the Egyptian Blepharis ciliaris. 2015 Drug Res (Stuttg) pmid:24992497
Chang D et al. Serum free fatty acids level in senile cataract. 2014 J Am Coll Nutr pmid:25079310
Školová B et al. Different phase behavior and packing of ceramides with long (C16) and very long (C24) acyls in model membranes: infrared spectroscopy using deuterated lipids. 2014 J Phys Chem B pmid:25122563
Xie JM et al. [Studies on the chemical constituents of Excoecaria cochinchinensis Lour. var. viridis Merr]. 1989 Zhongguo Zhong Yao Za Zhi pmid:2512946
Tanaka K et al. Very long-chain fatty acids in erythrocyte membrane phospholipids in adrenoleukodystrophy. 1989 Acta Paediatr Jpn pmid:2516693
Casadei BR et al. Brij detergents reveal new aspects of membrane microdomain in erythrocytes. 2014 Mol. Membr. Biol. pmid:25222860
Sánchez-Rodríguez P et al. Identification of potential erythrocyte phospholipid fatty acid biomarkers of advanced lung adenocarcinoma, squamous cell lung carcinoma, and small cell lung cancer. 2015 Tumour Biol. pmid:25702090
Singh I et al. Lignoceroyl-CoA ligase activity in rat brain microsomal fraction: topographical localization and effect of detergents and alpha-cyclodextrin. 1985 Arch. Biochem. Biophys. pmid:2578272
Lemaitre RN et al. Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study. 2015 Am. J. Clin. Nutr. pmid:25787996
Stahlberg S et al. Probing the role of the ceramide acyl chain length and sphingosine unsaturation in model skin barrier lipid mixtures by (2)H solid-state NMR spectroscopy. 2015 Langmuir pmid:25870928
Jantzen E et al. Gas chromatography of mycobacterial fatty acids and alcohols: diagnostic applications. 1989 APMIS pmid:2590535
Shivashankar S and Sumathi M Do seed VLCFAs trigger spongy tissue formation in Alphonso mango by inducing germination? 2015 J. Biosci. pmid:25963264
Mojumdar EH et al. Skin lipids: localization of ceramide and fatty acid in the unit cell of the long periodicity phase. 2015 Biophys. J. pmid:26039168
Zarrouk A et al. Impact of C24:0 on actin-microtubule interaction in human neuronal SK-N-BE cells: evaluation by FRET confocal spectral imaging microscopy after dual staining with rhodamine-phalloidin and tubulin tracker green. Funct. Neurol. pmid:26214025
Ramos AP and Lafleur M Chain Length of Free Fatty Acids Influences the Phase Behavior of Stratum Corneum Model Membranes. 2015 Langmuir pmid:26442576
Chung HK et al. Plasma phospholipid arachidonic acid and lignoceric acid are associated with the risk of cardioembolic stroke. 2015 Nutr Res pmid:26452419
Nasrallah F et al. X-linked Adrenoleukodystrophy, The Tunisian Experience. 2015 Clin. Lab. pmid:26642716
Fretts AM et al. Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. 2016 J. Nutr. pmid:26701797
Tel-Çayan G et al. A new fatty acid ester from an edible mushroom Rhizopogon luteolus. 2016 Nat. Prod. Res. pmid:26987031
Lazo O et al. Adrenoleukodystrophy: impaired oxidation of fatty acids due to peroxisomal lignoceroyl-CoA ligase deficiency. 1989 Arch. Biochem. Biophys. pmid:2705786
Bentejac M et al. Utilization of high-density lipoprotein sphingomyelin by the developing and mature brain in the rat. 1989 J. Neurochem. pmid:2709013
Morita M et al. A novel method for determining peroxisomal fatty acid β-oxidation. 2016 J. Inherit. Metab. Dis. pmid:27324171
Singh H et al. Mitochondrial and peroxisomal beta-oxidation of stearic and lignoceric acids by rat brain. 1989 J. Neurochem. pmid:2809586
Bezine M et al. Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. 2017 Chem. Phys. Lipids pmid:28322741
Pullmannová P et al. Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains. 2017 Biophys. Chem. pmid:28363088
Poll-The BT et al. A new peroxisomal disorder with enlarged peroxisomes and a specific deficiency of acyl-CoA oxidase (pseudo-neonatal adrenoleukodystrophy). 1988 Am. J. Hum. Genet. pmid:2894756
Wanders RJ et al. Impaired ability of peroxisomes to activate very-long-chain fatty acids in X-linked adrenoleukodystrophy. 1988 Lancet pmid:2899227
Carneheim C et al. Rare fatty acids in brown fat are substrates for thermogenesis during arousal from hibernation. 1989 Am. J. Physiol. pmid:2912207
Iida N et al. A sulfated glucosylceramide from rat kidney. 1989 J. Biol. Chem. pmid:2925645
Wanders RJ et al. Studies on the peroxisomal oxidation of palmitate and lignocerate in rat liver. 1987 Biochim. Biophys. Acta pmid:2952173
Singh I and Kishimoto Y A novel synthesis of ceramide from lignoceric acid and sphingosine by rat brain preparation; the amide formation requires a pyridine nucleotide. 1978 Biochem. Biophys. Res. Commun. pmid:29620
Singh I et al. Acyl-CoA ligases from rat brain microsomes: an immunochemical study. 1988 Biochim. Biophys. Acta pmid:2973813
Lazo O et al. Peroxisomal lignoceroyl-CoA ligase deficiency in childhood adrenoleukodystrophy and adrenomyeloneuropathy. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3174658
De Lederkremer RM et al. Lipopeptidophosphoglycan from Trypanosoma cruzi. Amide and ester-linked fatty acids. 1977 Eur. J. Biochem. pmid:323009
Sacktor NC et al. Effects of subperineurial injections of very-long-chain and medium-chain fatty acids into rat sciatic nerve. 1986 Neurochem Pathol pmid:3561895
Galloway JH et al. Abnormal myocardial lipid composition in an infant with type II glutaric aciduria. 1987 J. Lipid Res. pmid:3572253
Tanaka K et al. Electronmicroscopic study on biopsied rectal mucosa in adrenoleukodystrophy. 1987 Neurology pmid:3587618
Singh H et al. Very long chain fatty acid beta-oxidation by subcellular fractions of normal and Zellweger syndrome skin fibroblasts. 1987 Arch. Biochem. Biophys. pmid:3662528
Wanders RJ et al. Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. 1987 J. Clin. Invest. pmid:3680527