Lignoceric acid

Lignoceric acid is a lipid of Fatty Acyls (FA) class. Lignoceric acid is associated with abnormalities such as Adrenoleukodystrophy and Peroxisomal Disorders. The involved functions are known as Anabolism, establishment and maintenance of localization, Saturated, Process and long-chain-fatty-acid-CoA ligase activity. Lignoceric acid often locates in Membrane, Microsomes, Plasma membrane, peroxisome and Mitochondria. The associated genes with Lignoceric acid are SLC27A1 gene, CD36 gene, F10 gene, INHA gene and ABCD1 gene. The related lipids are Sphingolipids, Fatty Acids, erucic acid, inositolphosphoceramides and Palmitates.

Cross Reference

Introduction

To understand associated biological information of Lignoceric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Lignoceric acid?

Lignoceric acid is suspected in Peroxisomal Disorders, Adrenoleukodystrophy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lignoceric acid

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Refsum Disease D012035 19 associated lipids
Hyperthyroidism D006980 12 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Abetalipoproteinemia D000012 7 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Lignoceric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Lignoceric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Lignoceric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Lignoceric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Lignoceric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Lignoceric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Lignoceric acid

Download all related citations
Per page 10 20 50 100 | Total 264
Authors Title Published Journal PubMed Link
Singh I and Kishimoto Y Alpha hydroxylation of lignoceric acid in brain. Subcellular localization of alpha hydroxylation and the requirement for heat-stable and heat-labile factors and sphingosine. 1979 J. Biol. Chem. pmid:38244
Dhaunsi GS and Bitar MS Antioxidants attenuate diabetes-induced activation of peroxisomal functions in the rat kidney. 2004 Sep-Oct J. Biomed. Sci. pmid:15316130
Shivashankar S and Sumathi M Do seed VLCFAs trigger spongy tissue formation in Alphonso mango by inducing germination? 2015 J. Biosci. pmid:25963264
Blenn B et al. Insect egg deposition induces indirect defense and epicuticular wax changes in Arabidopsis thaliana. 2012 J. Chem. Ecol. pmid:22588570
Wanders RJ et al. Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. 1987 J. Clin. Invest. pmid:3680527
Cappa M et al. Is subclinical adrenal failure in adrenoleukodystrophy/adrenomyeloneuropathy reversible? 2011 J. Endocrinol. Invest. pmid:21399389
He XC et al. Molecular cloning, expression profiling, and yeast complementation of 19 beta-tubulin cDNAs from developing cotton ovules. 2008 J. Exp. Bot. pmid:18596112
DUBOS RJ The effect of sphingomyelin on the growth of tubercle bacilli. 1948 J. Exp. Med. pmid:18871879
Dhaunsi GS et al. Lipid peroxidation and oxidation of lignoceric acid in kidneys from thioridazine treated rats. 1990 J. Exp. Pathol. pmid:2101135
Sullivan BA et al. Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. 2010 J. Immunol. pmid:19949076
Morita M et al. A novel method for determining peroxisomal fatty acid β-oxidation. 2016 J. Inherit. Metab. Dis. pmid:27324171
Erler F Efficacy of tree trunk coating materials in the control of the apple clearwing, Synanthedon myopaeformis. 2010 J. Insect Sci. pmid:20672979
Galloway JH et al. Abnormal myocardial lipid composition in an infant with type II glutaric aciduria. 1987 J. Lipid Res. pmid:3572253
Ohta M et al. Novel free ceramides as components of the soldier defense gland of the Formosan subterranean termite (Coptotermes formosanus). 2007 J. Lipid Res. pmid:17164223
Robert J et al. Glycosphingolipids from cultured astroblasts. 1977 J. Lipid Res. pmid:894142
Clayton RB et al. Stimulation of erythroblast maturation in vitro by sphingolipids. 1974 J. Lipid Res. pmid:4372286
Singh I and Kishimoto Y Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. 1983 J. Lipid Res. pmid:6875391
Sandhir R et al. Localization of nervonic acid beta-oxidation in human and rodent peroxisomes: impaired oxidation in Zellweger syndrome and X-linked adrenoleukodystrophy. 1998 J. Lipid Res. pmid:9799802
Alderson NL et al. A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gas chromatography-mass spectrometry. 2005 J. Lipid Res. pmid:15863841
Lazo O et al. Cellular oxidation of lignoceric acid is regulated by the subcellular localization of lignoceroyl-CoA ligases. 1990 J. Lipid Res. pmid:2141053
Fabiano A et al. Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results. 2011 J. Matern. Fetal. Neonatal. Med. pmid:21781003
Kusunoki M et al. Relationship between serum concentrations of saturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus. 2007 J. Med. Invest. pmid:17878672
Razani SH et al. Fatty acid and carotenoid production by Sporobolomyces ruberrimus when using technical glycerol and ammonium sulfate. 2007 J. Microbiol. Biotechnol. pmid:18156773
Harinantenaina L et al. Secondary metabolites of Cinnamosma madagascariensis and their alpha-glucosidase inhibitory properties. 2008 J. Nat. Prod. pmid:18179176
Lazo O et al. Postnatal development and isolation of peroxisomes from brain. 1991 J. Neurochem. pmid:2002347
Shigematsu H et al. Purification and characterization of the heat-stable factors essential for the conversion of lignoceric acid to cerebronic acid and glutamic acid: identification of N-acetyl-L-aspartic acid. 1983 J. Neurochem. pmid:6131106
Singh H et al. Mitochondrial and peroxisomal beta-oxidation of stearic and lignoceric acids by rat brain. 1989 J. Neurochem. pmid:2809586
Singh I and Kishimoto Y alpha-Hydroxylation of fatty acids in brain: characterization of heat-labile factor. 1981 J. Neurochem. pmid:7264665
Yoshida S and Takeshita M Characteristics of synthesis of very-long-chain saturated and tetraenoic fatty acids in swine cerebral microsomes. 1986 J. Neurochem. pmid:3958710
Singh I Ceramide synthesis from free fatty acids in rat brain: function of NADPH and substrate specificity. 1983 J. Neurochem. pmid:6854321
Bentejac M et al. Utilization of high-density lipoprotein sphingomyelin by the developing and mature brain in the rat. 1989 J. Neurochem. pmid:2709013
Tsuji S et al. Metabolism of [17,18-3H2]hexacosanoic acid and [15,16-3H2]lignoceric acid in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). 1985 J. Neurol. Sci. pmid:4087029
Deon M et al. The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy. 2006 J. Neurol. Sci. pmid:16750542
Boles DJ and Rizzo WB Dietary fatty acids temporarily alter liver very long-chain fatty acid composition in mice. 1992 J. Nutr. pmid:1640260
Fretts AM et al. Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. 2016 J. Nutr. pmid:26701797
Ndonye RM et al. Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH. 2005 J. Org. Chem. pmid:16323834
Dhaunsi GS et al. FPTIII mitigates peroxisome-mediated oxidative stress in kidneys of spontaneously hypertensive diabetic rats. 2010 Kidney Blood Press. Res. pmid:20197688
Wanders RJ et al. Impaired ability of peroxisomes to activate very-long-chain fatty acids in X-linked adrenoleukodystrophy. 1988 Lancet pmid:2899227
Ramos AP and Lafleur M Chain Length of Free Fatty Acids Influences the Phase Behavior of Stratum Corneum Model Membranes. 2015 Langmuir pmid:26442576
Stahlberg S et al. Probing the role of the ceramide acyl chain length and sphingosine unsaturation in model skin barrier lipid mixtures by (2)H solid-state NMR spectroscopy. 2015 Langmuir pmid:25870928
Petroni A et al. Effects of the testosterone metabolite dihydrotestosterone and 5 alpha-androstan-3 alpha,17 beta-diol on very long chain fatty acid metabolism in X-adrenoleukodystrophic fibroblasts. 2003 Life Sci. pmid:12865096
Guschina I et al. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. 2011 Lipids pmid:20963507
Bettger WJ and Blackadar CB Dietary very long chain fatty acids directly influence the ratio of tetracosenoic (24:1) to tetracosanoic (24:0) acids of sphingomyelin in rat liver. 1997 Lipids pmid:9075193
Poulos A et al. Metabolism of trideuterated iso-lignoceric acid in rats in vivo and in human fibroblasts in culture. 1999 Lipids pmid:10574659
Nagura M et al. Alterations of fatty acid metabolism and membrane fluidity in peroxisome-defective mutant ZP102 cells. 2004 Lipids pmid:15055234
Yanagisawa N et al. Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. 2008 Lipids Health Dis pmid:19038055
Blomqvist M et al. Uptake of the glycosphingolipid sulfatide in the gastrointestinal tract and pancreas in vivo and in isolated islets of Langerhans. 2006 Lipids Health Dis pmid:17044925
Kojima M et al. Structured triacylglycerol containing behenic and oleic acids suppresses triacylglycerol absorption and prevents obesity in rats. 2010 Lipids Health Dis pmid:20653972
Dan P et al. 2-Hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase. 2011 Lipids Health Dis pmid:21599921
Dhaunsi GS et al. Very-long-chain fatty acids activate lysosomal hydrolases in neonatal human skin tissue. 2005 Med Princ Pract pmid:16103719