Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Orthostatic Intolerance D054971 1 associated lipids
Sleep Disorders, Intrinsic D020919 1 associated lipids
Headache Disorders, Secondary D051271 1 associated lipids
Somatosensory Disorders D020886 1 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Ocular Hypotension D015814 2 associated lipids
Vascular System Injuries D057772 2 associated lipids
Schistosomiasis japonica D012554 3 associated lipids
Bulimia D002032 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Rubio M et al. Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. 2007 Neurosci. Lett. pmid:17574742
Jaggar SI et al. The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder. 1998 Neurosci. Lett. pmid:9774165
Milton NG Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. 2002 Neurosci. Lett. pmid:12384227
Abalo R et al. Evaluation of the effect of age on cannabinoid receptor functionality and expression in guinea-pig ileum longitudinal muscle-myenteric plexus preparations. 2005 Jul 22-29 Neurosci. Lett. pmid:15936532
Sinor AD et al. Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats. 2000 Neurosci. Lett. pmid:10653017
Martínez-González D et al. Oleamide and anandamide effects on food intake and sexual behavior of rats. 2004 Neurosci. Lett. pmid:15193744
Abalo R et al. Postnatal maturation of the gastrointestinal tract: a functional and immunohistochemical study in the guinea-pig ileum at weaning. 2009 Neurosci. Lett. pmid:19819299
Németh J et al. Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae. 2003 Neurosci. Lett. pmid:12499047
Rueda-Orozco PE et al. Intrahippocampal administration of anandamide increases REM sleep. 2010 Neurosci. Lett. pmid:20188142
Pamplona FA et al. Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice. 2010 Neurosci. Lett. pmid:20036315
Luo C et al. Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin. 2002 Neurosci. Lett. pmid:11872246
Leweke FM et al. Elevated endogenous cannabinoids in schizophrenia. 1999 Neuroreport pmid:10501554
Beltramo M and Piomelli D Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. 2000 Neuroreport pmid:10817598
Harris J et al. Spinal anandamide inhibits nociceptive transmission via cannabinoid receptor activation in vivo. 2000 Neuroreport pmid:10976969
Szöke E et al. Interacting effects of capsaicin and anandamide on intracellular calcium in sensory neurones. 2000 Neuroreport pmid:10884049
Molina-Holgado F et al. Anandamide suppresses nitric oxide and TNF-alpha responses to Theiler's virus or endotoxin in astrocytes. 1997 Neuroreport pmid:9223079
Cottone E et al. Goldfish CB1 mRNA expression is affected by fasting and anandamide administration. 2009 Neuroreport pmid:19293731
Sparling PB et al. Exercise activates the endocannabinoid system. 2003 Neuroreport pmid:14625449
Murillo-Rodríguez E et al. Anandamide-induced sleep is blocked by SR141716A, a CB1 receptor antagonist and by U73122, a phospholipase C inhibitor. 2001 Neuroreport pmid:11447321
Shinohara Y et al. Cannabinoid in the nucleus accumbens enhances the intake of palatable solution. 2009 Neuroreport pmid:19734811
Ishii I and Chun J Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. 2002 Neuroreport pmid:11973452
Mahler SV et al. Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. 2007 Neuropsychopharmacology pmid:17406653
Izumi Y and Zorumski CF NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. 2012 Neuropsychopharmacology pmid:21993209
Gunduz-Cinar O et al. Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids. 2016 Neuropsychopharmacology pmid:26514583
Monteleone P et al. Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. 2005 Neuropsychopharmacology pmid:15841111
Giuffrida A et al. Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. 2004 Neuropsychopharmacology pmid:15354183
Morena M et al. Neurobiological Interactions Between Stress and the Endocannabinoid System. 2016 Neuropsychopharmacology pmid:26068727
Centonze D et al. A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission. 2004 Neuropsychopharmacology pmid:15100701
Pietrzak RH et al. Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. 2014 Neuropsychopharmacology pmid:24820537
Dubreucq S et al. Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. 2012 Neuropsychopharmacology pmid:22434220
Oleson EB et al. Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. 2014 Neuropsychopharmacology pmid:24345819
Falenski KW et al. FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration. 2010 Neuropsychopharmacology pmid:20357755
Varvel SA et al. Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. 2007 Neuropsychopharmacology pmid:17047668
Sarchielli P et al. Endocannabinoids in chronic migraine: CSF findings suggest a system failure. 2007 Neuropsychopharmacology pmid:17119542
Bortolato M et al. Anxiolytic-like properties of the anandamide transport inhibitor AM404. 2006 Neuropsychopharmacology pmid:16541083
Buczynski MW et al. The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area. 2013 Neuropsychopharmacology pmid:23169348
Seillier A et al. Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia. 2013 Neuropsychopharmacology pmid:23563893
Fernandez-Espejo E et al. Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function. 2004 Neuropsychopharmacology pmid:15010694
Hill MN et al. Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. 2009 Neuropsychopharmacology pmid:19710634
Stein EA et al. Selective effects of the endogenous cannabinoid arachidonylethanolamide (anandamide) on regional cerebral blood flow in the rat. 1998 Neuropsychopharmacology pmid:9803424
Gyires K and Zádori Z [Analysis of central mechanisms involved in gastric mucosal integrity]. 2008 Neuropsychopharmacol Hung pmid:18956615
Umathe SN et al. Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor. 2012 Neuropharmacology pmid:22248639
Starowicz K et al. Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. 2012 Neuropharmacology pmid:22178705
Liu J et al. Multiple pathways involved in the biosynthesis of anandamide. 2008 Neuropharmacology pmid:17631919
Lisboa SF and Guimarães FS Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray. 2012 Neuropharmacology pmid:22394688
Roberts LA et al. Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. 2008 Neuropharmacology pmid:17631916
Poling JS et al. Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels. 1996 Neuropharmacology pmid:8938728
Desroches J et al. Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB₁ and CB₂ receptors. 2014 Neuropharmacology pmid:24148808
Piomelli D More surprises lying ahead. The endocannabinoids keep us guessing. 2014 Neuropharmacology pmid:23954677
Placzek EA et al. Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. 2008 Neuropharmacology pmid:18760289