Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Sun X et al. | Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. | 2016 | J. Biol. Chem. | pmid:26900150 |
Desarnaud F et al. | Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. | 1995 | J. Biol. Chem. | pmid:7890734 |
Guo Y et al. | N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. | 2005 | J. Biol. Chem. | pmid:15890658 |
Sugiura T et al. | Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. | 1999 | J. Biol. Chem. | pmid:9915812 |
McFarland MJ et al. | A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide. | 2004 | J. Biol. Chem. | pmid:15292270 |
Rueda D et al. | The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. | 2002 | J. Biol. Chem. | pmid:12237305 |
McAllister SD et al. | Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation. | 2004 | J. Biol. Chem. | pmid:15326174 |
Jang Y et al. | Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. | 2012 | J. Biol. Chem. | pmid:22187434 |
Maccarrone M et al. | Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. | 2003 | J. Biol. Chem. | pmid:12799380 |
Laprairie RB et al. | Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. | 2014 | J. Biol. Chem. | pmid:25037227 |
Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
Pucci M et al. | Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. | 2012 | J. Biol. Chem. | pmid:22431736 |
Simon GM and Cravatt BF | Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. | 2008 | J. Biol. Chem. | pmid:18227059 |
Koutek B et al. | Inhibitors of arachidonoyl ethanolamide hydrolysis. | 1994 | J. Biol. Chem. | pmid:8083191 |
Kruszka KK and Gross RW | The ATP- and CoA-independent synthesis of arachidonoylethanolamide. A novel mechanism underlying the synthesis of the endogenous ligand of the cannabinoid receptor. | 1994 | J. Biol. Chem. | pmid:8182035 |
Paradisi A et al. | Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner. | 2008 | J. Biol. Chem. | pmid:18165231 |
Kaczocha M et al. | Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2. | 2010 | J. Biol. Chem. | pmid:19926788 |
Jiang S et al. | Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. | 2010 | J. Biol. Chem. | pmid:20826813 |
Silvestri C et al. | Anandamide-derived prostamide F2α negatively regulates adipogenesis. | 2013 | J. Biol. Chem. | pmid:23801328 |
Jin XH et al. | Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. | 2007 | J. Biol. Chem. | pmid:17158102 |
Wang J et al. | Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. | 2006 | J. Biol. Chem. | pmid:16527816 |
Siegmund SV et al. | Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. | 2006 | J. Biol. Chem. | pmid:16418162 |
Wei BQ et al. | A second fatty acid amide hydrolase with variable distribution among placental mammals. | 2006 | J. Biol. Chem. | pmid:17015445 |
Ueda N et al. | Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide. | 1995 | J. Biol. Chem. | pmid:7559559 |
Deutsch DG et al. | The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. | 2001 | J. Biol. Chem. | pmid:11118429 |
Walter L et al. | Astrocytes in culture produce anandamide and other acylethanolamides. | 2002 | J. Biol. Chem. | pmid:11916961 |
Rajan S et al. | TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor. | 2000 | J. Biol. Chem. | pmid:10747866 |
Matas D et al. | Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. | 2007 | J. Biol. Chem. | pmid:17227767 |
Huang SM et al. | Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. | 2001 | J. Biol. Chem. | pmid:11518719 |
Yu M et al. | Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. | 1997 | J. Biol. Chem. | pmid:9261124 |
Olah Z et al. | Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1. | 2001 | J. Biol. Chem. | pmid:11333266 |
Maccarrone M et al. | Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. | 2000 | J. Biol. Chem. | pmid:10913156 |
Yu S et al. | Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain. | 2014 | J. Biol. Chem. | pmid:24644281 |
Bisogno T et al. | Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes. | 1997 | J. Biol. Chem. | pmid:9013571 |
Brailoiu GC et al. | Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. | 2011 | J. Biol. Chem. | pmid:21719698 |
Movahed P et al. | Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. | 2005 | J. Biol. Chem. | pmid:16081411 |
Bari M et al. | Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis. | 2005 | J. Biol. Chem. | pmid:15657045 |
Boldrup L et al. | A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase. | 2004 | J. Biochem. Biophys. Methods | pmid:15262451 |
Sugiura T and Waku K | Cannabinoid receptors and their endogenous ligands. | 2002 | J. Biochem. | pmid:12097154 |
Oka S et al. | Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes. | 2007 | J. Biochem. | pmid:17339228 |
Kishimoto S et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. | 2004 | J. Biochem. | pmid:15115777 |
Wang J et al. | Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells. | 2008 | J. Biochem. | pmid:18806270 |
Kobayashi Y et al. | Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. | 2001 | J. Biochem. | pmid:11328586 |
Li J et al. | Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel. | 2004 | J. Appl. Physiol. | pmid:15220301 |
Roy A et al. | Anandamide modulates carotid sinus nerve afferent activity via TRPV1 receptors increasing responses to heat. | 2012 | J. Appl. Physiol. | pmid:21903882 |
Lin YS et al. | Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors. | 2009 | J. Appl. Physiol. | pmid:19131477 |
Artegoitia VM et al. | Endocannabinoids concentrations in plasma associated with feed efficiency and carcass composition of beef steers. | 2016 | J. Anim. Sci. | pmid:28046144 |
Koura Y et al. | Anandamide decreases glomerular filtration rate through predominant vasodilation of efferent arterioles in rat kidneys. | 2004 | J. Am. Soc. Nephrol. | pmid:15153559 |
Wagner JA et al. | Endogenous cannabinoids mediate hypotension after experimental myocardial infarction. | 2001 | J. Am. Coll. Cardiol. | pmid:11738314 |
Willibald J et al. | Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells. | 2012 | J. Am. Chem. Soc. | pmid:22812910 |
Kobayashi H et al. | Recent progress in the neurotoxicology of natural drugs associated with dependence or addiction, their endogenous agonists and receptors. | 1999 | J Toxicol Sci | pmid:10073332 |
Canseco-Alba A and RodrÃguez-Manzo G | Anandamide transforms noncopulating rats into sexually active animals. | 2013 | J Sex Med | pmid:22906359 |
Vural IM et al. | Functional characterization of nonadrenergic noncholinergic neurotransmitter release via endocannabinoids: an in vitro study in rabbit corpus cavernosum. | 2009 | J Sex Med | pmid:19175867 |
Li Q et al. | Anandamide enhances expression of heat shock protein 72 to protect against ischemia-reperfusion injury in rat heart. | 2013 | J Physiol Sci | pmid:23007622 |
Placzek EA et al. | Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide). | 2010 | J Pharm Biomed Anal | pmid:20417049 |
Chen L et al. | Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats. | 2009 | J Pain | pmid:19409856 |
Altinsoy A et al. | A cannabinoid ligand, anandamide, exacerbates endotoxin-induced uveitis in rabbits. | 2011 | J Ocul Pharmacol Ther | pmid:21848425 |
Mestre L et al. | Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors. | 2011 | J Neuroinflammation | pmid:21851608 |
Rogers TJ | The molecular basis for neuroimmune receptor signaling. | 2012 | J Neuroimmune Pharmacol | pmid:22935971 |
Sharir H et al. | The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55. | 2012 | J Neuroimmune Pharmacol | pmid:22454039 |
Carney ST et al. | Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. | 2009 | J Neuroimmune Pharmacol | pmid:19365734 |
Koethe D et al. | Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. | 2009 | J Neural Transm | pmid:19137236 |
Kurtuncu M et al. | Effects of cocaine in 5-lipoxygenase-deficient mice. | 2008 | J Neural Transm | pmid:18327533 |
Hill MN et al. | Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. | 2008 | J Neural Transm | pmid:18974922 |
Latek D et al. | Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR. | 2011 | J Mol Model | pmid:21365223 |
Aberturas MR et al. | Anandamide-loaded nanoparticles: preparation and characterization. | 2011 | J Microencapsul | pmid:21425945 |
Sugiura T et al. | N-arachidonoylethanolamine (anandamide), an endogenous cannabinoid receptor ligand, and related lipid molecules in the nervous tissues. | 1996 | J Lipid Mediat Cell Signal | pmid:8906545 |
Ueda N et al. | Enzymes for anandamide biosynthesis and metabolism. | 1996 | J Lipid Mediat Cell Signal | pmid:8906546 |
Berdyshev EV et al. | Anandamide--a new look on fatty acid ethanolamides. | 1996 | J Lipid Mediat Cell Signal | pmid:9029374 |
Kurabayashi M et al. | 2-Arachidonoylglycerol increases in ischemia-reperfusion injury of the rat liver. | 2005 Jan-Feb | J Invest Surg | pmid:15804949 |
Dux M et al. | Endovanilloids are potential activators of the trigeminovascular nocisensor complex. | 2016 | J Headache Pain | pmid:27189587 |
Greco R et al. | Effects of anandamide in migraine: data from an animal model. | 2011 | J Headache Pain | pmid:21331757 |
Camann DE et al. | Acetaminophen, pesticide, and diethylhexyl phthalate metabolites, anandamide, and fatty acids in deciduous molars: potential biomarkers of perinatal exposure. | 2013 | J Expo Sci Environ Epidemiol | pmid:22805989 |
Fowler CJ et al. | Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide. | 2013 | J Enzyme Inhib Med Chem | pmid:22225576 |
Fowler CJ et al. | Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner. | 2003 | J Enzyme Inhib Med Chem | pmid:12751821 |
Fowler CJ et al. | Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin. | 2003 | J Enzyme Inhib Med Chem | pmid:14506913 |
Miyashita K et al. | Anandamide induces matrix metalloproteinase-2 production through cannabinoid-1 receptor and transient receptor potential vanilloid-1 in human dental pulp cells in culture. | 2012 | J Endod | pmid:22595113 |
Stahl SM | Getting stoned without inhaling: anandamide is the brain's natural marijuana. | 1998 | J Clin Psychiatry | pmid:9862600 |
Joshi SR | Endocannabinoid system--a novel target for cardiometabolic risk. | 2007 | J Assoc Physicians India | pmid:17879500 |
Kohro S et al. | Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis. | 2006 | J Anesth | pmid:16421670 |
Hashiguchi T et al. | Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia. | 2008 | J Anesth | pmid:18685926 |
Stefano GB and Salamon EJ | Nitric oxide and anandamide in OMT research. | 2006 | J Am Osteopath Assoc | pmid:17122026 |
Degenhardt BF et al. | Role of osteopathic manipulative treatment in altering pain biomarkers: a pilot study. | 2007 | J Am Osteopath Assoc | pmid:17908831 |
McPartland JM et al. | Cannabimimetic effects of osteopathic manipulative treatment. | 2005 | J Am Osteopath Assoc | pmid:16118355 |
Battista N et al. | The endocannabinoid system in neurodegeneration. | 2006 Sep-Dec | Ital. J. Biochem. | pmid:17274532 |
Laine K et al. | Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356827 |
Nucci C et al. | Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17591864 |
Laine K et al. | Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:11818382 |
Njie YF et al. | N-arachidonylethanolamide-induced increase in aqueous humor outflow facility. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18539938 |
Romano MR and Lograno MD | Evidence for the involvement of cannabinoid CB1 receptors in the bimatoprost-induced contractions on the human isolated ciliary muscle. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17652738 |
Cozzolino R et al. | A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. | 2010 | Invest New Drugs | pmid:19189054 |
Astarita G et al. | Targeted lipidomics as a tool to investigate endocannabinoid function. | 2009 | Int. Rev. Neurobiol. | pmid:19607960 |
Patsos HA et al. | The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. | 2010 | Int. J. Oncol. | pmid:20514410 |
Lisboa SF et al. | Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. | 2015 | Int. J. Neuropsychopharmacol. | pmid:25618404 |
Chauvet C et al. | Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats. | 2014 | Int. J. Neuropsychopharmacol. | pmid:25522382 |
Lisboa SF et al. | Cannabinoid CB1 receptors in the medial prefrontal cortex modulate the expression of contextual fear conditioning. | 2010 | Int. J. Neuropsychopharmacol. | pmid:20587131 |
Giuliano M et al. | Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway. | 2006 | Int. J. Mol. Med. | pmid:16596265 |
Tytgat J et al. | Cannabinoid mimics in chocolate utilized as an argument in court. | 2000 | Int. J. Legal Med. | pmid:10876983 |
Sun LJ et al. | Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication. | 2014 | Int. J. Infect. Dis. | pmid:24704332 |
Stefano GB et al. | Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: endothelial implications. | 1998 | Int. J. Cardiol. | pmid:9687087 |