Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Umathe SN et al. | Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor. | 2012 | Neuropharmacology | pmid:22248639 |
Price TJ et al. | A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons. | 2005 | Neuropharmacology | pmid:15992578 |
Gamber KM et al. | Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. | 2005 | Neuropharmacology | pmid:15949823 |
Schreiber AK et al. | Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats. | 2012 | Neuropharmacology | pmid:22959964 |
Starowicz K et al. | Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. | 2012 | Neuropharmacology | pmid:22178705 |
Sokal DM et al. | Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats. | 2003 | Neuropharmacology | pmid:12871657 |
Liu J et al. | Multiple pathways involved in the biosynthesis of anandamide. | 2008 | Neuropharmacology | pmid:17631919 |
Guindon J and Beaulieu P | Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. | 2006 | Neuropharmacology | pmid:16442133 |
Nader J et al. | Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. | 2014 | Neuropharmacology | pmid:24709540 |
Lisboa SF and Guimarães FS | Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray. | 2012 | Neuropharmacology | pmid:22394688 |
Moreira FA et al. | Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray. | 2007 | Neuropharmacology | pmid:17156799 |
Moreira FA et al. | Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. | 2008 | Neuropharmacology | pmid:17709120 |
Morena M et al. | Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. | 2016 | Neuropharmacology | pmid:27553121 |
Bishay P et al. | Anandamide deficiency and heightened neuropathic pain in aged mice. | 2013 | Neuropharmacology | pmid:23597506 |
Wise LE et al. | Evaluation of fatty acid amides in the carrageenan-induced paw edema model. | 2008 | Neuropharmacology | pmid:17675189 |
Roberts LA et al. | Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. | 2008 | Neuropharmacology | pmid:17631916 |
Rubio M et al. | CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. | 2008 | Neuropharmacology | pmid:18371990 |
Wang W et al. | Enhancement of apamin-sensitive medium afterhyperpolarization current by anandamide and its role in excitability control in cultured hippocampal neurons. | 2011 | Neuropharmacology | pmid:21272594 |
Vela G et al. | Anandamide decreases naloxone-precipitated withdrawal signs in mice chronically treated with morphine. | 1995 | Neuropharmacology | pmid:7566503 |
Suplita RL et al. | Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla. | 2005 | Neuropharmacology | pmid:16129456 |
Lisboa SF et al. | Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats. | 2013 | Neuropharmacology | pmid:23899460 |
Al-Hayani A et al. | The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice. | 2001 | Neuropharmacology | pmid:11747904 |
Poling JS et al. | Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels. | 1996 | Neuropharmacology | pmid:8938728 |
Suplita RL et al. | Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. | 2006 | Neuropharmacology | pmid:16316669 |
Desroches J et al. | Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CBâ‚ and CBâ‚‚ receptors. | 2014 | Neuropharmacology | pmid:24148808 |
Clapper JR et al. | The endocannabinoid system as a target for the treatment of cannabis dependence. | 2009 | Neuropharmacology | pmid:18691603 |
Wilkerson JL et al. | The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. | 2017 | Neuropharmacology | pmid:27890602 |
Piomelli D | More surprises lying ahead. The endocannabinoids keep us guessing. | 2014 | Neuropharmacology | pmid:23954677 |
Piomelli D | The endogenous cannabinoid system and the treatment of marijuana dependence. | 2004 | Neuropharmacology | pmid:15464150 |
Placzek EA et al. | Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. | 2008 | Neuropharmacology | pmid:18760289 |
Scherma M et al. | The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. | 2008 | Neuropharmacology | pmid:17904589 |
Gyires K and Zádori Z | [Analysis of central mechanisms involved in gastric mucosal integrity]. | 2008 | Neuropsychopharmacol Hung | pmid:18956615 |
Mahler SV et al. | Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. | 2007 | Neuropsychopharmacology | pmid:17406653 |
Izumi Y and Zorumski CF | NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. | 2012 | Neuropsychopharmacology | pmid:21993209 |
Gunduz-Cinar O et al. | Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids. | 2016 | Neuropsychopharmacology | pmid:26514583 |
Monteleone P et al. | Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. | 2005 | Neuropsychopharmacology | pmid:15841111 |
Giuffrida A et al. | Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. | 2004 | Neuropsychopharmacology | pmid:15354183 |
Morena M et al. | Neurobiological Interactions Between Stress and the Endocannabinoid System. | 2016 | Neuropsychopharmacology | pmid:26068727 |
Centonze D et al. | A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission. | 2004 | Neuropsychopharmacology | pmid:15100701 |
Pietrzak RH et al. | Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. | 2014 | Neuropsychopharmacology | pmid:24820537 |
Oleson EB et al. | Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. | 2014 | Neuropsychopharmacology | pmid:24345819 |
Falenski KW et al. | FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration. | 2010 | Neuropsychopharmacology | pmid:20357755 |
Varvel SA et al. | Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. | 2007 | Neuropsychopharmacology | pmid:17047668 |
Sarchielli P et al. | Endocannabinoids in chronic migraine: CSF findings suggest a system failure. | 2007 | Neuropsychopharmacology | pmid:17119542 |
Bortolato M et al. | Anxiolytic-like properties of the anandamide transport inhibitor AM404. | 2006 | Neuropsychopharmacology | pmid:16541083 |
Buczynski MW et al. | The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area. | 2013 | Neuropsychopharmacology | pmid:23169348 |
Seillier A et al. | Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CBâ‚ receptors: implications for schizophrenia. | 2013 | Neuropsychopharmacology | pmid:23563893 |
Fernandez-Espejo E et al. | Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function. | 2004 | Neuropsychopharmacology | pmid:15010694 |
Hill MN et al. | Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. | 2009 | Neuropsychopharmacology | pmid:19710634 |
Stein EA et al. | Selective effects of the endogenous cannabinoid arachidonylethanolamide (anandamide) on regional cerebral blood flow in the rat. | 1998 | Neuropsychopharmacology | pmid:9803424 |