Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
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Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen P et al. | Metabolism of anandamide in cerebral microvascular endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165032 |
| Breivogel CS et al. | Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids. | 2004 | Neuropharmacology | pmid:15165836 |
| Kim J and Alger BE | Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. | 2004 | Nat. Neurosci. | pmid:15184902 |
| McAllister SD et al. | Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation. | 2004 | J. Biol. Chem. | pmid:15326174 |
| Di Marzo V et al. | The anandamide membrane transporter. Structure-activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region. | 2004 | Bioorg. Med. Chem. | pmid:15351399 |
| Valenti M et al. | Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain. | 2004 | Cell. Mol. Life Sci. | pmid:15095014 |
| Kishimoto S et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. | 2004 | J. Biochem. | pmid:15115777 |
| Steffens M et al. | Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex. | 2004 | Br. J. Pharmacol. | pmid:14993102 |
| Sun YX et al. | Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D. | 2004 | Biochem. J. | pmid:14998370 |
| Holt S et al. | Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase. | 2004 | Life Sci. | pmid:15530507 |
| Habayeb OM et al. | Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor? | 2004 | J. Clin. Endocrinol. Metab. | pmid:15531501 |
| Muthian S et al. | Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. | 2004 | Neuroscience | pmid:15541895 |
| Nilsson O et al. | Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures. | 2003 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:14659458 |
| Ross RA | Anandamide and vanilloid TRPV1 receptors. | 2003 | Br. J. Pharmacol. | pmid:14517174 |
| McAllister SD et al. | An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region. | 2003 | J. Med. Chem. | pmid:14613317 |
| Han B et al. | Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. | 2003 | J. Nat. Prod. | pmid:14575438 |
| Chen N et al. | Inhibition by arachidonic acid and other fatty acids of dopamine uptake at the human dopamine transporter. | 2003 | Eur. J. Pharmacol. | pmid:14575792 |
| Farquhar-Smith WP and Rice AS | A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia. | 2003 | Anesthesiology | pmid:14639155 |
| Jones S and Howl J | Cannabinoid receptor systems: therapeutic targets for tumour intervention. | 2003 | Expert Opin. Ther. Targets | pmid:14640910 |
| Zoratti C et al. | Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. | 2003 | Br. J. Pharmacol. | pmid:14645143 |
| Wang H et al. | Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14645706 |
| Gurney AM et al. | Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells. | 2003 | Circ. Res. | pmid:14551239 |
| Biswas KK et al. | Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. | 2003 | Hepatology | pmid:14578855 |
| Vandevoorde S et al. | Esters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine-selective acid amidase. | 2003 | J. Med. Chem. | pmid:14521402 |
| Oz M et al. | The endogenous cannabinoid anandamide inhibits alpha7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12766252 |
| Campanucci VA et al. | A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance. | 2003 | J. Physiol. (Lond.) | pmid:12640017 |
| Sarker KP et al. | ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death. | 2003 | J. Neurochem. | pmid:12641726 |
| Li J et al. | Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor. | 2003 | Hypertension | pmid:12623992 |
| Holt S and Fowler CJ | Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:12644895 |
| Vásquez C et al. | Effects of cannabinoids on endogenous K+ and Ca2+ currents in HEK293 cells. | 2003 | Can. J. Physiol. Pharmacol. | pmid:12774849 |
| Han J et al. | Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate. | 2003 | J. Physiol. (Lond.) | pmid:12807991 |
| Fowler CJ et al. | Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. | 2003 | Biochem. Pharmacol. | pmid:12948856 |
| Patel S et al. | Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12808005 |
| Shiraishi T et al. | The presence of ceramidase activity in liver nuclear membrane. | 2003 | Biol. Pharm. Bull. | pmid:12808285 |
| Klegeris A et al. | Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. | 2003 | Br. J. Pharmacol. | pmid:12813001 |
| Juntunen J et al. | Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide. | 2003 | Eur J Pharm Sci | pmid:12729860 |
| Wilson SJ et al. | A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase. | 2003 | Anal. Biochem. | pmid:12814631 |
| Maccarrone M et al. | The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. | 2003 | J. Biol. Chem. | pmid:12815050 |
| Obata T et al. | Simultaneous determination of endocannabinoids (arachidonylethanolamide and 2-arachidonylglycerol) and isoprostane (8-epiprostaglandin F2alpha) by gas chromatography-mass spectrometry-selected ion monitoring for medical samples. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12829006 |
| Nicholson RA et al. | Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. | 2003 | Brain Res. | pmid:12834914 |
| Pearlman RJ et al. | Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. | 2003 | J. Neurochem. | pmid:12558979 |
| Perrier JF et al. | 5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle. | 2003 | J. Physiol. (Lond.) | pmid:12626670 |
| Maccarrone M et al. | Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. | 2003 | J. Biol. Chem. | pmid:12799380 |
| Ahluwalia J et al. | Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. | 2003 | Eur. J. Neurosci. | pmid:12823468 |
| El Fangour S et al. | Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12781177 |
| Tarzia G et al. | Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. | 2003 | J. Med. Chem. | pmid:12773040 |
| Sokal DM et al. | Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats. | 2003 | Neuropharmacology | pmid:12871657 |
| Hillard CJ and Jarrahian A | Cellular accumulation of anandamide: consensus and controversy. | 2003 | Br. J. Pharmacol. | pmid:12970089 |
| Cravatt BF and Lichtman AH | Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system. | 2003 | Curr Opin Chem Biol | pmid:12941421 |
| del Carmen GarcÃa M et al. | Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14504685 |
| Derkinderen P et al. | Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. | 2003 | J. Neurosci. | pmid:12657697 |
| Jonsson KO et al. | AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. | 2003 | Arch. Toxicol. | pmid:12698235 |
| López-RodrÃguez ML et al. | Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. | 2003 | J. Med. Chem. | pmid:12672252 |
| Maccarrone M | The blissful state of endothelium. | 2003 | Thromb. Haemost. | pmid:12719771 |
| Murillo-Rodriguez E et al. | Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. | 2003 | Sleep | pmid:14746372 |
| Yamaji K et al. | Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications. | 2003 | Thromb. Haemost. | pmid:12719786 |
| Basavarajappa BS et al. | Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons. | 2003 | Eur. J. Pharmacol. | pmid:12679143 |
| Ortar G et al. | Novel selective and metabolically stable inhibitors of anandamide cellular uptake. | 2003 | Biochem. Pharmacol. | pmid:12732359 |
| Clement AB et al. | Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. | 2003 | J. Neurosci. | pmid:12736361 |
| Hermann H et al. | Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. | 2003 | Cell. Mol. Life Sci. | pmid:12737320 |
| Fowler CJ et al. | Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner. | 2003 | J Enzyme Inhib Med Chem | pmid:12751821 |
| Kasai HF et al. | Analyses of anandamide and endocannabinoid-like compounds using collision-induced dissociation in fast atom bombardment ionization-mass spectrometry and gas chromatography/chemical ionization-mass spectrometry. | 2003 | Anal Sci | pmid:14696920 |
| Gaetani S et al. | Anandamide hydrolysis: a new target for anti-anxiety drugs? | 2003 | Trends Mol Med | pmid:14604824 |
| Ahern GP | Activation of TRPV1 by the satiety factor oleoylethanolamide. | 2003 | J. Biol. Chem. | pmid:12761211 |
| Maccarrone M et al. | Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. | 2003 | J. Neurochem. | pmid:12716433 |
| Marinelli S et al. | Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors. | 2003 | J. Neurosci. | pmid:12716921 |
| McVey DC et al. | Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). | 2003 | J. Pharmacol. Exp. Ther. | pmid:12538826 |
| Scorticati C et al. | The effect of anandamide on prolactin secretion is modulated by estrogen. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12578974 |
| Ahluwalia J et al. | Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. | 2003 | J. Neurochem. | pmid:12558978 |
| Sancho R et al. | Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway. | 2003 | Mol. Pharmacol. | pmid:12527815 |
| Jennings EA et al. | The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. | 2003 | J. Physiol. (Lond.) | pmid:12562891 |
| Randall MD | A new endothelial target for cannabinoids. | 2003 | Mol. Pharmacol. | pmid:12606752 |
| Wisnoskey BJ et al. | Activation of vanilloid receptor type I in the endoplasmic reticulum fails to activate store-operated Ca2+ entry. | 2003 | Biochem. J. | pmid:12608892 |
| Vandevoorde S et al. | N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity. | 2003 | Bioorg. Med. Chem. | pmid:12614867 |
| Lau AH and Chow SS | Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cells. | 2003 | Eur. J. Pharmacol. | pmid:12620517 |
| Maccarrone M et al. | Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells. | 2003 | Endocrinology | pmid:12488326 |
| Orliac ML et al. | Potentiation of anandamide effects in mesenteric beds isolated from endotoxemic rats. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12490589 |
| Schelegle ES | Functional morphology and physiology of slowly adapting pulmonary stretch receptors. | 2003 | Anat Rec A Discov Mol Cell Evol Biol | pmid:12494485 |
| Németh J et al. | Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae. | 2003 | Neurosci. Lett. | pmid:12499047 |
| Maccarrone M and Finazzi-Agró A | The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. | 2003 | Cell Death Differ. | pmid:12934069 |
| González S et al. | Region-dependent changes in endocannabinoid transmission in the brain of morphine-dependent rats. | 2003 | Addict Biol | pmid:12850774 |
| Dogulu FH et al. | Intra-arterial simultaneous administration of anandamide attenuates endothelin-1 induced vasospasm in rabbit basilar arteries. | 2003 | Acta Neurochir (Wien) | pmid:12910401 |
| Fasia L et al. | Uptake and metabolism of [3H]anandamide by rabbit platelets. Lack of transporter? | 2003 | Eur. J. Biochem. | pmid:12919314 |
| Sarker KP and Maruyama I | Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. | 2003 | Cell. Mol. Life Sci. | pmid:12861385 |
| Bojesen IN and Hansen HS | Binding of anandamide to bovine serum albumin. | 2003 | J. Lipid Res. | pmid:12837852 |
| Patel S et al. | The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. | 2003 | Br. J. Pharmacol. | pmid:12839875 |
| Liu YC and Wu SN | Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | 2003 | Eur. J. Pharmacol. | pmid:12498905 |
| Watanabe H et al. | Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. | 2003 | Nature | pmid:12879072 |
| Kozak KR et al. | Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide. | 2003 | Biochemistry | pmid:12885237 |
| Sparling PB et al. | Exercise activates the endocannabinoid system. | 2003 | Neuroreport | pmid:14625449 |
| Mechoulam R and Lichtman AH | Neuroscience. Stout guards of the central nervous system. | 2003 | Science | pmid:14526067 |
| Marsicano G et al. | CB1 cannabinoid receptors and on-demand defense against excitotoxicity. | 2003 | Science | pmid:14526074 |
| Veldhuis WB et al. | Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. | 2003 | J. Neurosci. | pmid:12764100 |
| Glaser ST et al. | Evidence against the presence of an anandamide transporter. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12655057 |
| Lo YK et al. | Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells. | 2003 | Biochem. Pharmacol. | pmid:12566085 |
| Steffens M et al. | Quantitative measurement of depolarization-induced anandamide release in human and rat neocortex. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14566450 |
| Vandevoorde S et al. | Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide. | 2003 | J. Med. Chem. | pmid:12672243 |
| Wenger T et al. | The endogenous cannabinoid, anandamide, activates the hypothalamo-pituitary-adrenal axis in CB1 cannabinoid receptor knockout mice. | 2003 | Neuroendocrinology | pmid:14688442 |
| Tóth A et al. | Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. | 2003 | Life Sci. | pmid:12759142 |
| Chu CJ et al. | N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. | 2003 | J. Biol. Chem. | pmid:12569099 |