Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
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Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| del Carmen GarcÃa M et al. | Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:14504685 |
| Barinaga M | Pot, heroin unlock new areas for neuroscience. | 1992 | Science | pmid:1335165 |
| Hillard CJ and Jarrahian A | Cellular accumulation of anandamide: consensus and controversy. | 2003 | Br. J. Pharmacol. | pmid:12970089 |
| Segall Y et al. | Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12951114 |
| Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
| Fowler CJ et al. | Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. | 2003 | Biochem. Pharmacol. | pmid:12948856 |
| Franklin A et al. | Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. | 2003 | J. Neurosci. | pmid:12944505 |
| Helyes Z et al. | Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat. | 2003 | Life Sci. | pmid:12941436 |
| Cravatt BF and Lichtman AH | Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system. | 2003 | Curr Opin Chem Biol | pmid:12941421 |
| Maccarrone M and Finazzi-Agró A | The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. | 2003 | Cell Death Differ. | pmid:12934069 |
| Fasia L et al. | Uptake and metabolism of [3H]anandamide by rabbit platelets. Lack of transporter? | 2003 | Eur. J. Biochem. | pmid:12919314 |
| Dogulu FH et al. | Intra-arterial simultaneous administration of anandamide attenuates endothelin-1 induced vasospasm in rabbit basilar arteries. | 2003 | Acta Neurochir (Wien) | pmid:12910401 |
| Storr M et al. | Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12893627 |
| Kozak KR et al. | Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide. | 2003 | Biochemistry | pmid:12885237 |
| Watanabe H et al. | Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. | 2003 | Nature | pmid:12879072 |
| Sokal DM et al. | Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats. | 2003 | Neuropharmacology | pmid:12871657 |
| Sarker KP and Maruyama I | Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. | 2003 | Cell. Mol. Life Sci. | pmid:12861385 |
| González S et al. | Region-dependent changes in endocannabinoid transmission in the brain of morphine-dependent rats. | 2003 | Addict Biol | pmid:12850774 |
| Patel S et al. | The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. | 2003 | Br. J. Pharmacol. | pmid:12839875 |
| Bojesen IN and Hansen HS | Binding of anandamide to bovine serum albumin. | 2003 | J. Lipid Res. | pmid:12837852 |
| Nicholson RA et al. | Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. | 2003 | Brain Res. | pmid:12834914 |
| Obata T et al. | Simultaneous determination of endocannabinoids (arachidonylethanolamide and 2-arachidonylglycerol) and isoprostane (8-epiprostaglandin F2alpha) by gas chromatography-mass spectrometry-selected ion monitoring for medical samples. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12829006 |
| Ahluwalia J et al. | Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. | 2003 | Eur. J. Neurosci. | pmid:12823468 |
| Maccarrone M et al. | The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. | 2003 | J. Biol. Chem. | pmid:12815050 |
| Wilson SJ et al. | A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase. | 2003 | Anal. Biochem. | pmid:12814631 |
| Klegeris A et al. | Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. | 2003 | Br. J. Pharmacol. | pmid:12813001 |
| Shiraishi T et al. | The presence of ceramidase activity in liver nuclear membrane. | 2003 | Biol. Pharm. Bull. | pmid:12808285 |
| Patel S et al. | Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12808005 |
| Han J et al. | Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate. | 2003 | J. Physiol. (Lond.) | pmid:12807991 |
| Maccarrone M et al. | Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. | 2003 | J. Biol. Chem. | pmid:12799380 |
| El Fangour S et al. | Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12781177 |
| Vásquez C et al. | Effects of cannabinoids on endogenous K+ and Ca2+ currents in HEK293 cells. | 2003 | Can. J. Physiol. Pharmacol. | pmid:12774849 |
| Tarzia G et al. | Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. | 2003 | J. Med. Chem. | pmid:12773040 |
| Oz M et al. | The endogenous cannabinoid anandamide inhibits alpha7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12766252 |
| Veldhuis WB et al. | Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. | 2003 | J. Neurosci. | pmid:12764100 |
| Ahern GP | Activation of TRPV1 by the satiety factor oleoylethanolamide. | 2003 | J. Biol. Chem. | pmid:12761211 |
| Tóth A et al. | Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. | 2003 | Life Sci. | pmid:12759142 |
| Fowler CJ et al. | Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner. | 2003 | J Enzyme Inhib Med Chem | pmid:12751821 |
| López-RodrÃguez ML et al. | Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. | 2003 | Eur J Med Chem | pmid:12750028 |
| Mimeault M et al. | Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. | 2003 | Prostate | pmid:12746841 |
| Hermann H et al. | Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. | 2003 | Cell. Mol. Life Sci. | pmid:12737320 |
| Clement AB et al. | Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. | 2003 | J. Neurosci. | pmid:12736361 |
| Ortar G et al. | Novel selective and metabolically stable inhibitors of anandamide cellular uptake. | 2003 | Biochem. Pharmacol. | pmid:12732359 |
| Juntunen J et al. | Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide. | 2003 | Eur J Pharm Sci | pmid:12729860 |
| Yamaji K et al. | Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications. | 2003 | Thromb. Haemost. | pmid:12719786 |
| Maccarrone M | The blissful state of endothelium. | 2003 | Thromb. Haemost. | pmid:12719771 |
| Marinelli S et al. | Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors. | 2003 | J. Neurosci. | pmid:12716921 |
| Maccarrone M et al. | Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. | 2003 | J. Neurochem. | pmid:12716433 |
| Jonsson KO et al. | AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. | 2003 | Arch. Toxicol. | pmid:12698235 |
| Basavarajappa BS et al. | Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons. | 2003 | Eur. J. Pharmacol. | pmid:12679143 |