Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Acute Pain D059787 3 associated lipids
Vascular System Injuries D057772 2 associated lipids
Orthostatic Intolerance D054971 1 associated lipids
Headache Disorders, Secondary D051271 1 associated lipids
Overweight D050177 11 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Sleep Disorders, Intrinsic D020919 1 associated lipids
Somatosensory Disorders D020886 1 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Sleep Apnea, Obstructive D020181 9 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Endotoxemia D019446 27 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Impotence, Vasculogenic D018783 4 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Authors Title Published Journal PubMed Link
El-Talatini MR et al. The relationship between plasma levels of the endocannabinoid, anandamide, sex steroids, and gonadotrophins during the menstrual cycle. 2010 Fertil. Steril. pmid:19200965
Navarrete CM et al. Opposite effects of anandamide and N-arachidonoyl dopamine in the regulation of prostaglandin E and 8-iso-PGF formation in primary glial cells. 2009 J. Neurochem. pmid:19200337
Mallat A and Lotersztajn S Cannabinoid receptors as novel therapeutic targets for the management of non-alcoholic steatohepatitis. 2008 Diabetes Metab. pmid:19195630
Ribeiro ML et al. 17beta-oestradiol and progesterone regulate anandamide synthesis in the rat uterus. 2009 Reprod. Biomed. Online pmid:19192341
Lissoni P et al. The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation. 2008 Nov-Dec Anticancer Res. pmid:19189659
Cozzolino R et al. A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. 2010 Invest New Drugs pmid:19189054
Tang B et al. Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells. 2009 Am. J. Respir. Cell Mol. Biol. pmid:19188660
Schlosburg JE et al. Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation. 2009 AAPS J pmid:19184452
Vural IM et al. Functional characterization of nonadrenergic noncholinergic neurotransmitter release via endocannabinoids: an in vitro study in rabbit corpus cavernosum. 2009 J Sex Med pmid:19175867
Snider NT et al. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. 2009 Mol. Pharmacol. pmid:19171674
Balas L et al. Total synthesis of photoactivatable or fluorescent anandamide probes: novel bioactive compounds with angiogenic activity. 2009 J. Med. Chem. pmid:19161308
Escartín-Pérez RE et al. Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. 2009 Physiol. Behav. pmid:19150453
Van Dross RT Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes. 2009 Mol. Carcinog. pmid:19148897
Prieto D Editorial comment on: localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity. 2010 Eur. Urol. pmid:19147273
Gratzke C et al. Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity. 2010 Eur. Urol. pmid:19147270
Araújo JR et al. Effect of cannabinoids upon the uptake of folic acid by BeWo cells. 2009 Pharmacology pmid:19145103
Koethe D et al. Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. 2009 J Neural Transm pmid:19137236
Doroshenko P and Renaud LP Acid-sensitive TASK-like K+ conductances contribute to resting membrane potential and to orexin-induced membrane depolarization in rat thalamic paraventricular nucleus neurons. 2009 Neuroscience pmid:19135504
Ho WS and Gardiner SM Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats. 2009 Br. J. Pharmacol. pmid:19133994
Marco EM et al. Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas. 2009 Brain Res. pmid:19133243
Lin YS et al. Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors. 2009 J. Appl. Physiol. pmid:19131477
Hydock DS et al. Anandamide preserves cardiac function and geometry in an acute doxorubicin cardiotoxicity rat model. 2009 J. Cardiovasc. Pharmacol. Ther. pmid:19129423
Wang J and Ueda N Biology of endocannabinoid synthesis system. 2009 Prostaglandins Other Lipid Mediat. pmid:19126434
Adermark L et al. Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity. 2009 Eur. J. Neurosci. pmid:19120438
Ferreira SG et al. N-acyldopamines control striatal input terminals via novel ligand-gated cation channels. 2009 Neuropharmacology pmid:19101577
Wheal AJ and Randall MD Effects of hypertension on vasorelaxation to endocannabinoids in vitro. 2009 Eur. J. Pharmacol. pmid:19100733
Acone G et al. Low type I cannabinoid receptor levels characterize placental villous in labouring delivery. 2009 Placenta pmid:19097644
Karbarz MJ et al. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. 2009 Anesth. Analg. pmid:19095868
Eckardt K et al. Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. 2009 Diabetologia pmid:19089403
Jiang LS et al. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. 2009 Cardiovasc. Res. pmid:19074161
Rossi F et al. The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. 2009 Bone pmid:19059369
Wyffels L et al. Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. 2009 Bioorg. Med. Chem. pmid:19054678
Gervasi MG et al. The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. 2009 Reproduction pmid:19042982
Lehtonen M et al. Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. 2008 Chem. Biodivers. pmid:19035572
Vignali M et al. The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. 2009 Glia pmid:19031444
Long JZ et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. 2009 Nat. Chem. Biol. pmid:19029917
Pelorosso FG et al. The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. 2009 Eur. J. Pharmacol. pmid:19022239
Tuboly G et al. Antinociceptive interactions between anandamide and endomorphin-1 at the spinal level. 2009 Clin. Exp. Pharmacol. Physiol. pmid:19018802
De Petrocellis L et al. Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide. 2009 J. Lipid Res. pmid:19017617
Panlilio LV et al. Anandamide-induced behavioral disruption through a vanilloid-dependent mechanism in rats. 2009 Psychopharmacology (Berl.) pmid:19015836
Aneetha H et al. Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals. 2009 Bioorg. Med. Chem. Lett. pmid:19013794
Butler RK et al. Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates. 2008 Pain pmid:19004548
Schacht JP et al. Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. 2009 Psychopharmacology (Berl.) pmid:19002671
Sun X et al. Genetic loss of Faah compromises male fertility in mice. 2009 Biol. Reprod. pmid:18987328
Hill MN et al. Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. 2008 J Neural Transm pmid:18974922
Khasabova IA et al. A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain. 2008 J. Neurosci. pmid:18971457
Gyires K and Zádori Z [Analysis of central mechanisms involved in gastric mucosal integrity]. 2008 Neuropsychopharmacol Hung pmid:18956615
Trezza V and Vanderschuren LJ Divergent effects of anandamide transporter inhibitors with different target selectivity on social play behavior in adolescent rats. 2009 J. Pharmacol. Exp. Ther. pmid:18948500
Kase Y et al. Removal of 2-arachidonylglycerol by direct hemoperfusion therapy with polymyxin B immobilized fibers benefits patients with septic shock. 2008 Ther Apher Dial pmid:18937720
Hong S et al. Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat. 2009 Gut pmid:18936104
Meuth SG et al. The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice. 2009 Neurobiol. Dis. pmid:18930826
Musella A et al. TRPV1 channels facilitate glutamate transmission in the striatum. 2009 Mol. Cell. Neurosci. pmid:18930149
Garcia-Ovejero D et al. The endocannabinoid system is modulated in response to spinal cord injury in rats. 2009 Neurobiol. Dis. pmid:18930143
Bambico FR and Gobbi G The cannabinoid CB1 receptor and the endocannabinoid anandamide: possible antidepressant targets. 2008 Expert Opin. Ther. Targets pmid:18851692
Correa F et al. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. 2009 Biochem. Pharmacol. pmid:18848818
Malvindi MA et al. Rod-shaped nanocrystals elicit neuronal activity in vivo. 2008 Small pmid:18844306
DeMorrow S et al. The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18832445
Kurjak M et al. Differential stimulatory effects of cannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum. 2008 Oct-Dec Neuropeptides pmid:18829105
Woo DH et al. Direct activation of transient receptor potential vanilloid 1(TRPV1) by diacylglycerol (DAG). 2008 Mol Pain pmid:18826653
Marczylo TH et al. A solid-phase method for the extraction and measurement of anandamide from multiple human biomatrices. 2009 Anal. Biochem. pmid:18823934
Murillo-Rodríguez E et al. The anandamide membrane transporter inhibitor, VDM-11, modulates sleep and c-Fos expression in the rat brain. 2008 Neuroscience pmid:18822353
Catani MV et al. Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. 2009 J. Mol. Med. pmid:18820887
Bajo M et al. Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands. 2009 J. Neurosci. Res. pmid:18816788
Justinova Z et al. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. 2008 Biol. Psychiatry pmid:18814866
Mato S et al. CB1 cannabinoid receptor-dependent and -independent inhibition of depolarization-induced calcium influx in oligodendrocytes. 2009 Glia pmid:18814177
Wang J et al. Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells. 2008 J. Biochem. pmid:18806270
Ferreri C et al. Synthesis of all-trans anandamide: a substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation. 2008 Bioorg. Med. Chem. pmid:18782671
McPartland JM et al. Cannabimimetic effects modulated by cholinergic compounds. 2008 Addict Biol pmid:18782385
Fowler CJ "The tools of the trade"--an overview of the pharmacology of the endocannabinoid system. 2008 Curr. Pharm. Des. pmid:18781976
Placzek EA et al. Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. 2008 J. Neurochem. pmid:18778304
Neelands TR et al. Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons. 2008 Inflamm. Res. pmid:18777111
Rácz I et al. Anandamide effects on 5-HT(3) receptors in vivo. 2008 Eur. J. Pharmacol. pmid:18775693
Haller VL et al. Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase. 2008 Eur. J. Pharmacol. pmid:18762181
Tuboly G et al. The antinociceptive interaction of anandamide and adenosine at the spinal level. 2009 Pharmacol. Biochem. Behav. pmid:18760296
Placzek EA et al. Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. 2008 Neuropharmacology pmid:18760289
da Veiga MA et al. Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. 2008 J. Endocrinol. pmid:18755884
Yang Z et al. Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. 2008 Biochem. Pharmacol. pmid:18755158
Scherma M et al. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. 2008 J. Pharmacol. Exp. Ther. pmid:18725543
Yao F et al. Development of novel tail-modified anandamide analogs. 2008 Bioorg. Med. Chem. Lett. pmid:18723350
Moezi L et al. Endocannabinoids and liver disease. V. endocannabinoids as mediators of vascular and cardiac abnormalities in cirrhosis. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18703639
Williams JL et al. K+ channel inhibition modulates the biochemical and morphological differentiation of human placental cytotrophoblast cells in vitro. 2008 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:18703414
Woodward DF et al. The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products. 2008 Pharmacol. Ther. pmid:18700152
Snider NT et al. The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. 2008 J. Pharmacol. Exp. Ther. pmid:18698000
Ho WS et al. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. 2008 Br. J. Pharmacol. pmid:18695637
Currie S et al. IP(3)R-mediated Ca(2+) release is modulated by anandamide in isolated cardiac nuclei. 2008 J. Mol. Cell. Cardiol. pmid:18692061
Clapper JR et al. The endocannabinoid system as a target for the treatment of cannabis dependence. 2009 Neuropharmacology pmid:18691603
Lisboa SF et al. Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test. 2008 Eur. J. Pharmacol. pmid:18691568
Hashiguchi T et al. Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia. 2008 J Anesth pmid:18685926
Fowler CJ and Ghafouri N Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? 2008 Pharmacol. Res. pmid:18675915
Ellgren M et al. Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. 2008 Eur Neuropsychopharmacol pmid:18674887
Maione S et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. 2008 Br. J. Pharmacol. pmid:18660824
Kudo R and Hatake K [Effect of ethanol on anandamide-induced sensory nerve dependent vasorelaxation (the second report)]. 2008 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:18646646
Hill MN et al. Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. 2008 J. Neurochem. pmid:18643796
Maccarrone M Anandamide as a marker of human disease. 2008 JAMA pmid:18632539
Turco MY et al. High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation. 2008 Hum. Reprod. pmid:18614613
Habayeb OM et al. Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation. 2008 Endocrinology pmid:18599552
Farrell EK and Merkler DJ Biosynthesis, degradation and pharmacological importance of the fatty acid amides. 2008 Drug Discov. Today pmid:18598910
Dembiński A et al. Dual, time-dependent deleterious and protective effect of anandamide on the course of cerulein-induced acute pancreatitis. Role of sensory nerves. 2008 Eur. J. Pharmacol. pmid:18593574
McMahon LR Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol. 2009 Psychopharmacology (Berl.) pmid:18592221
Liu HY et al. [Effects of anandamide on the activation and proliferation of hepatic stellate cells through cannabinoid-2 receptors]. 2008 Zhonghua Gan Zang Bing Za Zhi pmid:18578993