| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oka S et al. | Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes. | 2007 | J. Biochem. | pmid:17339228 |
| D'Argenio G et al. | Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. | 2007 | J. Mol. Med. | pmid:17396241 |
| Holt S et al. | Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. | 2007 | Eur. J. Pharmacol. | pmid:17397826 |
| Mahler SV et al. | Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. | 2007 | Neuropsychopharmacology | pmid:17406653 |
| Kopczyńska B | The contribution of VR1 and CB1 receptors and the role of the afferent vagal pathway in modelling of cardio-respiratory effects of anandamide in rats. | 2007 | Life Sci. | pmid:17379256 |
| Ferrer B et al. | Regulation of brain anandamide by acute administration of ethanol. | 2007 | Biochem. J. | pmid:17302558 |
| Naidu PS et al. | Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. | 2007 | Psychopharmacology (Berl.) | pmid:17279376 |
| Sun Y et al. | Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. | 2007 | Br. J. Pharmacol. | pmid:17906680 |
| Rubio M et al. | Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. | 2007 | Neurosci. Lett. | pmid:17574742 |
| Ryberg E et al. | The orphan receptor GPR55 is a novel cannabinoid receptor. | 2007 | Br. J. Pharmacol. | pmid:17876302 |
| Lam PM et al. | Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death. | 2007 | J. Neurochem. | pmid:17442052 |
| Mulè F et al. | Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon. | 2007 | Pharmacol. Res. | pmid:17574859 |
| Karsak M et al. | Attenuation of allergic contact dermatitis through the endocannabinoid system. | 2007 | Science | pmid:17556587 |
| Köfalvi A et al. | Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. | 2007 | Br. J. Pharmacol. | pmid:17435795 |
| Sharkey KA et al. | Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret. | 2007 | Eur. J. Neurosci. | pmid:17459108 |
| Shivachar AC | Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes. | 2007 | Biochem. Pharmacol. | pmid:17445778 |
| Orliac ML et al. | Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats. | 2007 | Eur. J. Pharmacol. | pmid:17482593 |
| Michalski CW et al. | Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis. | 2007 | Gastroenterology | pmid:17484889 |
| Ghasemi M et al. | Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats. | 2007 | Br. J. Pharmacol. | pmid:17486141 |
| Borsani E et al. | AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain. | 2007 | Brain Res. | pmid:17459353 |
| Sit SY et al. | Novel inhibitors of fatty acid amide hydrolase. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17459705 |
| Lory P and Chemin J | Towards the discovery of novel T-type calcium channel blockers. | 2007 | Expert Opin. Ther. Targets | pmid:17465728 |
| Ryan D et al. | Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. | 2007 | Eur. J. Neurosci. | pmid:17419758 |
| Gonthier MP et al. | Identification of endocannabinoids and related compounds in human fat cells. | 2007 | Obesity (Silver Spring) | pmid:17426318 |
| Raduner S et al. | Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. | 2007 | J. Nat. Prod. | pmid:17497806 |
| Wang Y and Wang DH | Neural control of blood pressure: focusing on capsaicin-sensitive sensory nerves. | 2007 | Cardiovasc Hematol Disord Drug Targets | pmid:17346127 |
| Basavarajappa BS | Critical enzymes involved in endocannabinoid metabolism. | 2007 | Protein Pept. Lett. | pmid:17346227 |
| Lemak MS et al. | Cannabinoid regulation in identified synapse of terrestrial snail. | 2007 | Eur. J. Neurosci. | pmid:18028114 |
| Béquet F et al. | CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus. | 2007 | Eur. J. Neurosci. | pmid:18052990 |
| Rettori V et al. | Endocannabinoids in TNF-alpha and ethanol actions. | 2007 | Neuroimmunomodulation | pmid:18073513 |
| Moreira FA et al. | Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray. | 2007 | Neuropharmacology | pmid:17156799 |
| Jin XH et al. | Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. | 2007 | J. Biol. Chem. | pmid:17158102 |
| Rossi G et al. | Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. | 2007 | Endocrinology | pmid:17110429 |
| Cross-Mellor SK et al. | Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. | 2007 | Psychopharmacology (Berl.) | pmid:17111174 |
| Ronco AM et al. | Anandamide inhibits endothelin-1 production by human cultured endothelial cells: a new vascular action of this endocannabinoid. | 2007 | Pharmacology | pmid:17114903 |
| Ho WS and Randall MD | Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. | 2007 | Br. J. Pharmacol. | pmid:17245358 |
| Russo R et al. | Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. | 2007 | Eur. J. Pharmacol. | pmid:17434479 |
| Wheal AJ et al. | Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro. | 2007 | Br. J. Pharmacol. | pmid:17245361 |
| Bátkai S et al. | Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17434980 |
| Harada N and Okajima K | Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans. | 2007 | Growth Horm. IGF Res. | pmid:17307377 |
| Romero FA et al. | Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. | 2007 | J. Med. Chem. | pmid:17279740 |
| McCollum L et al. | Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17379772 |
| Wang Y et al. | Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17308041 |
| Snider NT et al. | Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17272674 |
| Matta JA et al. | TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. | 2007 | J. Physiol. (Lond.) | pmid:17038422 |
| Solinas M et al. | The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17210800 |
| Matas D et al. | Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. | 2007 | J. Biol. Chem. | pmid:17227767 |
| Wise LE et al. | Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. | 2007 | Eur. J. Pharmacol. | pmid:17217945 |
| Hsu SS et al. | Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. | 2007 | Toxicology | pmid:17222495 |
| Harada N and Okajima K | Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats. | 2007 | Dig. Dis. Sci. | pmid:17211693 |
| Pisanti S et al. | Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy. | 2007 | J. Cell. Physiol. | pmid:17192847 |
| Ekins S et al. | Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. | 2007 | Drug Metab. Dispos. | pmid:17194716 |
| Schreiber D et al. | Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. | 2007 | Anal. Biochem. | pmid:17196922 |
| Kreutz S et al. | Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures. | 2007 | Exp. Neurol. | pmid:17010339 |
| Malfitano AM et al. | Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. | 2007 | Immunol. Lett. | pmid:17360047 |
| Degenhardt BF et al. | Role of osteopathic manipulative treatment in altering pain biomarkers: a pilot study. | 2007 | J Am Osteopath Assoc | pmid:17908831 |
| Thomas KC et al. | Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17332266 |
| Battista N et al. | The endocannabinoid system in neurodegeneration. | 2006 Sep-Dec | Ital. J. Biochem. | pmid:17274532 |
| Lynch DL and Reggio PH | Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer. | 2006 Jul-Aug | J. Comput. Aided Mol. Des. | pmid:17106765 |
| Dickason-Chesterfield AK et al. | Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. | 2006 Jul-Aug | Cell. Mol. Neurobiol. | pmid:16736384 |
| Nilsson O et al. | The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells. | 2006 | Eur. J. Pharmacol. | pmid:16928371 |
| Schuel H | Tuning the oviduct to the anandamide tone. | 2006 | J. Clin. Invest. | pmid:16886056 |
| Kasai HF et al. | Studies on high-energy collision-induced dissociation of endogenous cannabinoids: 2-arachidonoylglycerol and n-arachidonoylethanolamide in FAB-mass spectrometry. | 2006 | Anal Sci | pmid:16837740 |
| Murillo-RodrÃguez E et al. | Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. | 2006 | FEBS Lett. | pmid:16844117 |
| Liu J et al. | A biosynthetic pathway for anandamide. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16938887 |
| Mechoulam R et al. | Endocannabinoids, feeding and suckling--from our perspective. | 2006 | Int J Obes (Lond) | pmid:16570101 |
| Matias I et al. | Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. | 2006 | Int J Obes (Lond) | pmid:16570107 |
| Schiano Moriello A et al. | Development of the first potential covalent inhibitors of anandamide cellular uptake. | 2006 | J. Med. Chem. | pmid:16570928 |
| Kudo R and Hatake K | [Effect of ethanol on anandamide-induced sensory nerve dependent vasorelaxation]. | 2006 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:17313058 |
| Appendino G et al. | Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. | 2006 | J. Med. Chem. | pmid:16570929 |
| Chang L et al. | Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms. | 2006 | Br. J. Pharmacol. | pmid:16501580 |
| Fezza F et al. | Methods to assay anandamide hydrolysis and transport in synaptosomes. | 2006 | Methods Mol. Med. | pmid:16506407 |
| Kaczocha M et al. | Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. | 2006 | J. Biol. Chem. | pmid:16461355 |
| Overton HA et al. | Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. | 2006 | Cell Metab. | pmid:16517404 |
| Matias I et al. | Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011761 |
| Bari M et al. | Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells. | 2006 | J. Immunol. | pmid:17015679 |
| Tan B et al. | Targeted lipidomics: discovery of new fatty acyl amides. | 2006 | AAPS J | pmid:17025263 |
| Guindon J et al. | Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides? | 2006 | Eur. J. Pharmacol. | pmid:17027744 |
| Prestifilippo JP et al. | Inhibition of salivary secretion by activation of cannabinoid receptors. | 2006 | Exp. Biol. Med. (Maywood) | pmid:16946411 |
| Spoto B et al. | Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. | 2006 | Biochimie | pmid:16949718 |
| Vlachou S et al. | Effects of endocannabinoid neurotransmission modulators on brain stimulation reward. | 2006 | Psychopharmacology (Berl.) | pmid:16953388 |
| Mulder AM and Cravatt BF | Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. | 2006 | Biochemistry | pmid:16981687 |
| Hong Z et al. | Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus. | 2006 | Circulation | pmid:16982938 |
| Siegmund SV et al. | Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. | 2006 | J. Biol. Chem. | pmid:16418162 |
| Salo OM et al. | 3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data. | 2006 | J. Med. Chem. | pmid:16420041 |
| Kohro S et al. | Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis. | 2006 | J Anesth | pmid:16421670 |
| Rawls SM et al. | Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats. | 2006 | Pharmacol. Biochem. Behav. | pmid:16647109 |
| Parkkari T et al. | Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide. | 2006 | Bioorg. Med. Chem. | pmid:16644227 |
| McFarland MJ et al. | Detergent-resistant membrane microdomains in the disposition of the lipid signaling molecule anandamide. | 2006 | AAPS J | pmid:16584138 |
| Giuliano M et al. | Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway. | 2006 | Int. J. Mol. Med. | pmid:16596265 |
| Di Marzo M et al. | Synthesis, conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics. | 2006 | J. Pept. Sci. | pmid:16534762 |
| Cobellis G et al. | Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. | 2006 | Biol. Reprod. | pmid:16611862 |
| Solinas M et al. | Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. | 2006 | J. Neurochem. | pmid:16805835 |
| Vinod KY et al. | Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system. | 2006 | Neurochem. Int. | pmid:16822589 |
| Ghasemi M et al. | Effect of anandamide on nonadrenergic noncholinergic-mediated relaxation of rat corpus cavernosum. | 2006 | Eur. J. Pharmacol. | pmid:16824514 |
| Rösch S et al. | R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16330497 |
| Sade H et al. | Activation of large-conductance, Ca2+-activated K+ channels by cannabinoids. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16107501 |
| Wang H et al. | Fatty acid amide hydrolase deficiency limits early pregnancy events. | 2006 | J. Clin. Invest. | pmid:16886060 |
| Tzavara ET et al. | Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications. | 2006 | Biol. Psychiatry | pmid:16199010 |
| Schmidt A et al. | Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography. | 2006 | Biomed. Chromatogr. | pmid:16189813 |