Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Melanoma D008545 69 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Hawkins V and Butt A TASK-1 channels in oligodendrocytes: a role in ischemia mediated disruption. 2013 Neurobiol. Dis. pmid:23567653
Starowicz K et al. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. 2013 PLoS ONE pmid:23573230
Subbanna S et al. Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits. 2013 J. Neurosci. pmid:23575834
Descalzi F et al. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. 2013 Tissue Eng Part A pmid:23578218
Morgan CJ et al. Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. 2013 Br J Psychiatry pmid:23580381
Roy A et al. Stress peptide PACAP engages multiple signaling pathways within the carotid body to initiate excitatory responses in respiratory and sympathetic chemosensory afferents. 2013 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:23594614
Bishay P et al. Anandamide deficiency and heightened neuropathic pain in aged mice. 2013 Neuropharmacology pmid:23597506
Zhang J et al. Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits. 2013 Sheng Li Xue Bao pmid:23598867
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Pryce G et al. Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors. 2013 Mult. Scler. pmid:23625705
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
Khasabova IA et al. Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain. 2013 Neurobiol. Dis. pmid:23644187
Marco EM et al. Emotional, endocrine and brain anandamide response to social challenge in infant male rats. 2013 Psychoneuroendocrinology pmid:23660109
Li Q et al. Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes. 2013 PLoS ONE pmid:23667607
Lobato NS et al. Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. 2013 PLoS ONE pmid:23667622
Neumeister A et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. 2013 Mol. Psychiatry pmid:23670490
Ohsaka Y and Nishino H 3T3-L1 adipocytes possess anandamide- and epinephrine-responsive machinery for MDM2 distribution to the plasma membrane. 2013 Gen. Physiol. Biophys. pmid:23682023
Amoako AA et al. Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia. 2013 Hum. Reprod. pmid:23697839
Berge K et al. Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men. 2013 Lipids Health Dis pmid:23706001
Harvey BS et al. Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. 2013 Cytokine pmid:23706402
Andrag E and Curtis MJ Feasibility of targeting ischaemia-related ventricular arrhythmias by mimicry of endogenous protection by endocannabinoids. 2013 Br. J. Pharmacol. pmid:23713981
Haller J et al. The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats. 2013 Psychopharmacology (Berl.) pmid:23743650
Carr RL et al. Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. 2013 Toxicol. Sci. pmid:23761300
Brantl SA et al. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. 2014 Platelets pmid:23789792
Silvestri C et al. Anandamide-derived prostamide F2α negatively regulates adipogenesis. 2013 J. Biol. Chem. pmid:23801328
Iannotti FA et al. Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23830028
Citraro R et al. CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. 2013 Epilepsy Res. pmid:23860329
Ruginsk SG et al. Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion. 2013 Clin. Exp. Pharmacol. Physiol. pmid:23875874
Coppola M and Mondola R Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. 2013 Med. Hypotheses pmid:23896215
Lisboa SF et al. Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats. 2013 Neuropharmacology pmid:23899460
Ilayan E et al. Do cannabinoids exhibit a tyramine-like effect? 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23900610
Khlaifia A et al. Anandamide, cannabinoid type 1 receptor, and NMDA receptor activation mediate non-Hebbian presynaptically expressed long-term depression at the first central synapse for visceral afferent fibers. 2013 J. Neurosci. pmid:23904599
Maione S et al. Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics. 2013 Pharmacol. Res. pmid:23911581
Derbenev AV and Smith BN Dexamethasone rapidly increases GABA release in the dorsal motor nucleus of the vagus via retrograde messenger-mediated enhancement of TRPV1 activity. 2013 PLoS ONE pmid:23936221
Krumbholz A et al. Diagnostic value of concentration profiles of glucocorticosteroids and endocannabinoids in hair. 2013 Ther Drug Monit pmid:23942543
pmid:23948212
Piomelli D More surprises lying ahead. The endocannabinoids keep us guessing. 2014 Neuropharmacology pmid:23954677
Jourdan T et al. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. 2013 Nat. Med. pmid:23955712
Gervasi MG et al. Anandamide levels fluctuate in the bovine oviduct during the oestrous cycle. 2013 PLoS ONE pmid:23977311
O'Brien LD et al. Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus). 2013 Br. J. Pharmacol. pmid:23991698
Brocato B et al. Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. 2013 Placenta pmid:24008071
Akerman S et al. Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine. 2013 J. Neurosci. pmid:24027286
Hill MN et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. 2013 Psychoneuroendocrinology pmid:24035186
pmid:24037493
Adinolfi B et al. Anticancer activity of anandamide in human cutaneous melanoma cells. 2013 Eur. J. Pharmacol. pmid:24041928
Limebeer CL et al. Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. 2014 Psychopharmacology (Berl.) pmid:24043345
Fonseca BM et al. The endocannabinoid anandamide induces apoptosis of rat decidual cells through a mechanism involving ceramide synthesis and p38 MAPK activation. 2013 Apoptosis pmid:24048885
Marichal-Cancino BA et al. Analysis of anandamide- and lysophosphatidylinositol-induced inhibition of the vasopressor responses produced by sympathetic stimulation or noradrenaline in pithed rats. 2013 Eur. J. Pharmacol. pmid:24076186
Alvheim AR et al. Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. 2014 Lipids pmid:24081493
Malenczyk K et al. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. 2013 J. Biol. Chem. pmid:24089517