Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

Cross Reference

Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Melanoma D008545 69 associated lipids
Per page 10 20 50 100 | Total 105

PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

Download all related citations
Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
pmid:26126926
pmid:26119821
Palermo G et al. Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets. 2015 PLoS Comput. Biol. pmid:26111155
Malek N et al. Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. 2015 Neural Plast. pmid:26090232
Mecha M et al. Endocannabinoids drive the acquisition of an alternative phenotype in microglia. 2015 Brain Behav. Immun. pmid:26086345
Grzeda E et al. Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus. 2015 J. Physiol. Pharmacol. pmid:26084216
pmid:26072692
Morena M et al. Neurobiological Interactions Between Stress and the Endocannabinoid System. 2016 Neuropsychopharmacology pmid:26068727
pmid:26061461
pmid:25989217
Qin M et al. Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. 2015 Behav. Brain Res. pmid:25979787
pmid:25960165
Krishnan G and Chatterjee N Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected]. 2015 Sci Rep pmid:25943894
Juan CC et al. Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. 2015 Fertil. Steril. pmid:25935491
Vilela LR et al. Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity. 2015 Toxicol. Appl. Pharmacol. pmid:25933444
Vázquez C et al. Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. 2015 Neurobiol. Dis. pmid:25917763
Jokisch V et al. Endocannabinoid Levels in Newborns in Relation to the Mode of Delivery. 2015 Am J Perinatol pmid:25915139
Manduca A et al. Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. 2015 Eur Neuropsychopharmacol pmid:25914159
pmid:25910421
Turcotte C et al. Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. 2015 J. Leukoc. Biol. pmid:25877930
Spaziano G et al. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. 2015 Biomed Res Int pmid:25866824
Subbanna S et al. Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol lipase does not cause neurodegeneration in neonatal mice. 2015 J. Neurochem. pmid:25857698
Woolcott OO et al. High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets. 2015 PLoS ONE pmid:25855974
Nicholson J et al. Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. 2015 PLoS ONE pmid:25835291
Patsenker E et al. Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. 2015 Int J Mol Sci pmid:25826533
Llorente-Berzal A et al. 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. 2015 Psychopharmacology (Berl.) pmid:25814137
pmid:25808995
Gray JM et al. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. 2015 J. Neurosci. pmid:25740517
pmid:25719612
pmid:25716652
Walentiny DM et al. Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. 2015 Neuropharmacology pmid:25698527
Pisanti S et al. Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. 2015 J. Cell. Physiol. pmid:25684344
Hind WH et al. Endocannabinoids modulate human blood-brain barrier permeability in vitro. 2015 Br. J. Pharmacol. pmid:25651941
Monteleone AM et al. Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa. 2015 Am. J. Clin. Nutr. pmid:25646322
Gaskari SA et al. Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids. 2015 J. Hepatol. pmid:25640062
pmid:25637682
pmid:25622579
Lisboa SF et al. Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. 2015 Int. J. Neuropsychopharmacol. pmid:25618404
Orellana-Serradell O et al. Proapoptotic effect of endocannabinoids in prostate cancer cells. 2015 Oncol. Rep. pmid:25606819
pmid:25601395
Kumar S Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates. 2015 BMC Res Notes pmid:25595103
pmid:25581607
Sadhasivam S et al. Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects. 2015 Pharmacogenomics J. pmid:25558980
pmid:25557612
Karlsson C et al. Baseline anandamide levels and body weight impact the weight loss effect of CB1 receptor antagonism in male rats. 2015 Endocrinology pmid:25549047
Aliczki M et al. Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. 2015 Psychopharmacology (Berl.) pmid:25547462
Urquhart P et al. Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. 2015 Biochim. Biophys. Acta pmid:25543004
pmid:25535694
Chauvet C et al. Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats. 2014 Int. J. Neuropsychopharmacol. pmid:25522382
Uhelski ML et al. Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy. 2015 J. Neurophysiol. pmid:25505113
Ford GK et al. Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. 2015 Eur J Pain pmid:25504741
Sticht MA et al. Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats. 2015 Neuroscience pmid:25499318
Morena M et al. Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25489086
pmid:25465706
pmid:25456842
pmid:25453774
pmid:25450464
Liu J and Pope C The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. 2015 Neurotoxicology pmid:25447325
pmid:25446347
Pacioni G et al. Truffles contain endocannabinoid metabolic enzymes and anandamide. 2015 Phytochemistry pmid:25433633
pmid:25388290
Wang ZY et al. Attenuation of cystitis and pain sensation in mice lacking fatty acid amide hydrolase. 2015 J. Mol. Neurosci. pmid:25374388
pmid:25370126
Khasabova IA et al. JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. 2014 Pharmacol. Res. pmid:25304184
Manna JD et al. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. 2014 J. Biol. Chem. pmid:25301951
pmid:25283614
Morty RE and Kuebler WM TRPV4: an exciting new target to promote alveolocapillary barrier function. 2014 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25281637
Troy-Fioramonti S et al. Acute activation of cannabinoid receptors by anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice. 2015 Diabetes pmid:25281429
McDougle DR et al. Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. 2014 J. Pharmacol. Exp. Ther. pmid:25277139
Malek N et al. Alterations in the anandamide metabolism in the development of neuropathic pain. 2014 Biomed Res Int pmid:25276812
De Angelis V et al. Endocannabinoids control platelet activation and limit aggregate formation under flow. 2014 PLoS ONE pmid:25264625
pmid:25240419
pmid:25229205
Özdemir B et al. Endocannabinoids and inflammatory response in periodontal ligament cells. 2014 PLoS ONE pmid:25226300
pmid:25212838
pmid:25205244
pmid:25204580
pmid:25195527
Jia J et al. Anandamide protects HT22 cells exposed to hydrogen peroxide by inhibiting CB1 receptor-mediated type 2 NADPH oxidase. 2014 Oxid Med Cell Longev pmid:25136404
Sexton M et al. Cannabis use by individuals with multiple sclerosis: effects on specific immune parameters. 2014 Inflammopharmacology pmid:25135301
pmid:25129827
pmid:25098345
pmid:25088244
Yang K et al. Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. 2014 Hippocampus pmid:25087967
Björklund E et al. Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study. 2014 PLoS ONE pmid:25078278
Fezza F et al. Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. 2014 Mol. Cell. Neurosci. pmid:25064144
Lau BK et al. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. 2014 Br. J. Pharmacol. pmid:25041240
Laprairie RB et al. Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. 2014 J. Biol. Chem. pmid:25037227
Alpár A et al. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. 2014 Nat Commun pmid:25030704
Cipriano M et al. The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. 2014 BMC Res Notes pmid:25012825
Bluett RJ et al. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. 2014 Transl Psychiatry pmid:25004388
pmid:24980781
pmid:24979612
Dong W et al. Simulation of Swanson's literature-based discovery: anandamide treatment inhibits growth of gastric cancer cells in vitro and in silico. 2014 PLoS ONE pmid:24949851
Pulgar VM et al. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. 2014 Hypertension pmid:24935942
pmid:24911079
Gómez R et al. Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes. 2014 J. Orthop. Res. pmid:24902823
Lu W et al. Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons. 2014 Mol Brain pmid:24886791
Navarria A et al. The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. 2014 Pharmacol. Res. pmid:24861565
Wiley JL et al. Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. 2014 Eur. J. Pharmacol. pmid:24858366