| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
Anandamide
Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
Cross Reference
Introduction
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Anandamide?
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Anandamide
PubChem Associated disorders and diseases
What pathways are associated with Anandamide
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Anandamide?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Anandamide?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Anandamide?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Anandamide?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Anandamide?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Anandamide
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walker VJ et al. | Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27000802 |
| Porter AC et al. | Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12023533 |
| Darmani NA | The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11752094 |
| Appendino G et al. | Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15356216 |
| Oz M et al. | The endogenous cannabinoid anandamide inhibits alpha7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12766252 |
| Patel S et al. | Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12808005 |
| Lichtman AH et al. | Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15229230 |
| Snider NT et al. | The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18698000 |
| McDougle DR et al. | Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25277139 |
| Oz M et al. | The endogenous cannabinoid anandamide inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17682128 |
| Fride E et al. | Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7853184 |
| Miller LL et al. | Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22514333 |
| Adams IB et al. | Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7791088 |
| Ishioka N and Bukoski RD | A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10087011 |
| Matias I et al. | Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14757851 |
| Akerman S et al. | Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14718591 |
| Trezza V and Vanderschuren LJ | Divergent effects of anandamide transporter inhibitors with different target selectivity on social play behavior in adolescent rats. | 2009 | J. Pharmacol. Exp. Ther. | pmid:18948500 |
| McVey DC et al. | Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). | 2003 | J. Pharmacol. Exp. Ther. | pmid:12538826 |
| McAllister SD et al. | Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10525080 |
| Glaser ST and Kaczocha M | Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20702753 |
| McCollum L et al. | Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17379772 |
| Wang Y et al. | Endocannabinoid regulates blood pressure via activation of the transient receptor potential vanilloid type 1 in Wistar rats fed a high-salt diet. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17308041 |
| Lee M et al. | Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7473135 |
| Fegley D et al. | Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15579492 |
| Lake KD et al. | Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190833 |
| Hillard CJ | Endocannabinoids and vascular function. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871291 |
| Song ZH and Zhong M | CB1 cannabinoid receptor-mediated cell migration. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871313 |
| Di Marzo V et al. | A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11861807 |
| Glaser ST et al. | Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16278311 |
| Adams IB et al. | Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9495885 |
| Brodkin J and Moerschbaecher JM | SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9316868 |
| Li G et al. | Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27189966 |
| Thomas KC et al. | Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17332266 |
| Chiba T et al. | A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. | 2011 | J. Pharm. Pharmacol. | pmid:21492165 |
| Hayase T et al. | Protective effects of cannabinoid receptor agonists against cocaine and other convulsant-induced toxic behavioural symptoms. | 2001 | J. Pharm. Pharmacol. | pmid:11732755 |
| Di Marzo M et al. | Synthesis, conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics. | 2006 | J. Pept. Sci. | pmid:16534762 |
| Gómez R et al. | Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes. | 2014 | J. Orthop. Res. | pmid:24902823 |
| Hutchins-Wiese HL et al. | Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. | 2012 | J. Nutr. Biochem. | pmid:22051448 |
| Battista N et al. | Abnormal anandamide metabolism in celiac disease. | 2012 | J. Nutr. Biochem. | pmid:22209002 |
| Hutchins HL et al. | Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. | 2011 | J. Nutr. Biochem. | pmid:20951563 |
| Mennella I et al. | Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans. | 2015 | J. Nutr. | pmid:26180248 |
| Batetta B et al. | Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. | 2009 | J. Nutr. | pmid:19549757 |
| Thomas EA et al. | Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. | 1997 | J. Neurosci. Res. | pmid:9452020 |
| Bari M et al. | Cholesterol-dependent modulation of type 1 cannabinoid receptors in nerve cells. | 2005 | J. Neurosci. Res. | pmid:15920744 |
| Molina-Holgado F et al. | Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. | 2002 | J. Neurosci. Res. | pmid:11891798 |
| Arias-Carrión O et al. | Biochemical modulation of the sleep-wake cycle: endogenous sleep-inducing factors. | 2011 | J. Neurosci. Res. | pmid:21557294 |
| Bajo M et al. | Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands. | 2009 | J. Neurosci. Res. | pmid:18816788 |
| Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
| Bannerman P et al. | Early migratory rat neural crest cells express functional gap junctions: evidence that neural crest cell survival requires gap junction function. | 2000 | J. Neurosci. Res. | pmid:10972957 |
| Ahern GP et al. | Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. | 2005 | J. Neurosci. | pmid:15917451 |
| Tabatadze N et al. | Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. | 2015 | J. Neurosci. | pmid:26269634 |
| Gómez R et al. | A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. | 2002 | J. Neurosci. | pmid:12417686 |
| Gray JM et al. | Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. | 2015 | J. Neurosci. | pmid:25740517 |
| Wang ZJ et al. | Cannabinoid receptor-mediated regulation of neuronal activity and signaling in glomeruli of the main olfactory bulb. | 2012 | J. Neurosci. | pmid:22723687 |
| Xiong W et al. | A common molecular basis for exogenous and endogenous cannabinoid potentiation of glycine receptors. | 2012 | J. Neurosci. | pmid:22496565 |
| Franklin A et al. | Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. | 2003 | J. Neurosci. | pmid:12944505 |
| Shen Y et al. | A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. | 2009 | J. Neurosci. | pmid:19439586 |
| Derkinderen P et al. | Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. | 2003 | J. Neurosci. | pmid:12657697 |
| Clement AB et al. | Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. | 2003 | J. Neurosci. | pmid:12736361 |
| Marinelli S et al. | Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors. | 2003 | J. Neurosci. | pmid:12716921 |
| Massa F et al. | Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. | 2010 | J. Neurosci. | pmid:20445053 |
| Tognetto M et al. | Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation. | 2001 | J. Neurosci. | pmid:11160380 |
| Cadas H et al. | Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP. | 1996 | J. Neurosci. | pmid:8656287 |
| van der Stelt M et al. | Exogenous anandamide protects rat brain against acute neuronal injury in vivo. | 2001 | J. Neurosci. | pmid:11698588 |
| Beltramo M et al. | Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor. | 2000 | J. Neurosci. | pmid:10777802 |
| Lerner TN et al. | Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. | 2010 | J. Neurosci. | pmid:20147543 |
| Garami A et al. | Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. | 2011 | J. Neurosci. | pmid:21289181 |
| Justinova Z et al. | The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. | 2005 | J. Neurosci. | pmid:15944392 |
| Subbanna S et al. | Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits. | 2013 | J. Neurosci. | pmid:23575834 |
| Dinis P et al. | Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. | 2004 | J. Neurosci. | pmid:15601931 |
| Akerman S et al. | Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine. | 2013 | J. Neurosci. | pmid:24027286 |
| Ade KK and Lovinger DM | Anandamide regulates postnatal development of long-term synaptic plasticity in the rat dorsolateral striatum. | 2007 | J. Neurosci. | pmid:17329438 |
| Khlaifia A et al. | Anandamide, cannabinoid type 1 receptor, and NMDA receptor activation mediate non-Hebbian presynaptically expressed long-term depression at the first central synapse for visceral afferent fibers. | 2013 | J. Neurosci. | pmid:23904599 |
| Kim D and Thayer SA | Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture. | 2001 | J. Neurosci. | pmid:11319244 |
| Khasabova IA et al. | A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain. | 2008 | J. Neurosci. | pmid:18971457 |
| Veldhuis WB et al. | Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. | 2003 | J. Neurosci. | pmid:12764100 |
| Cadas H et al. | Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. | 1997 | J. Neurosci. | pmid:9006968 |
| Khasabova IA et al. | Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy. | 2012 | J. Neurosci. | pmid:22593077 |
| Qin N et al. | TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008 | J. Neurosci. | pmid:18550765 |
| Chemin J et al. | Neuronal T-type alpha 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line. | 2002 | J. Neurosci. | pmid:12177183 |
| Gubellini P et al. | Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. | 2002 | J. Neurosci. | pmid:12177188 |
| Kim SR et al. | Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. | 2005 | J. Neurosci. | pmid:15659603 |
| Ali AB | Presynaptic Inhibition of GABAA receptor-mediated unitary IPSPs by cannabinoid receptors at synapses between CCK-positive interneurons in rat hippocampus. | 2007 | J. Neurophysiol. | pmid:17567776 |
| Fischbach T et al. | Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive drg neurons of rats. | 2007 | J. Neurophysiol. | pmid:17581853 |
| Uhelski ML et al. | Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy. | 2015 | J. Neurophysiol. | pmid:25505113 |
| Fan P | Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons. | 1995 | J. Neurophysiol. | pmid:7760148 |
| Fisyunov A et al. | Cannabinoids modulate the P-type high-voltage-activated calcium currents in purkinje neurons. | 2006 | J. Neurophysiol. | pmid:16738209 |
| De-May CL and Ali AB | Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex. | 2013 | J. Neurophysiol. | pmid:23054605 |
| Morisset V and Urban L | Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord. | 2001 | J. Neurophysiol. | pmid:11431486 |
| Twitchell W et al. | Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. | 1997 | J. Neurophysiol. | pmid:9242259 |
| Contassot E et al. | Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. | 2004 | J. Neuropathol. Exp. Neurol. | pmid:15453094 |
| Jean-Gilles L et al. | Plasma endocannabinoid levels in multiple sclerosis. | 2009 | J. Neurol. Sci. | pmid:19695579 |
| Di Filippo M et al. | Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. | 2008 | J. Neurol. Neurosurg. Psychiatr. | pmid:18535023 |
| Stefano GB | Autoimmunovascular regulation: morphine and anandamide and ancondamide stimulated nitric oxide release. | 1998 | J. Neuroimmunol. | pmid:9610675 |
| Eisenstein TK et al. | Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. | 2007 | J. Neuroimmunol. | pmid:17640739 |
| Schwarz H et al. | Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. | 1994 | J. Neuroimmunol. | pmid:7962480 |
| De Laurentiis A et al. | The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide. | 2010 | J. Neuroimmunol. | pmid:20207018 |
| Hollis JH et al. | The endocannabinoid arachidonylethanolamide attenuates aspects of lipopolysaccharide-induced changes in energy intake, energy expenditure and hypothalamic Fos expression. | 2011 | J. Neuroimmunol. | pmid:21262543 |
| Malfitano AM et al. | Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. | 2006 | J. Neuroimmunol. | pmid:16239036 |
| Bisogno T | Endogenous cannabinoids: structure and metabolism. | 2008 | J. Neuroendocrinol. | pmid:18426492 |