Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Sordelli MS et al. | The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. | 2011 | PLoS ONE | pmid:21559512 |
Liao YS et al. | [Anandamide inhibits the growth of colorectal cancer cells through CB1 and lipid rafts]. | 2011 | Zhonghua Zhong Liu Za Zhi | pmid:21575494 |
McHugh D et al. | Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. | 2012 | Br. J. Pharmacol. | pmid:21595653 |
Shekhar C | Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. | 2011 | Chem. Biol. | pmid:21609833 |
Khanna IK and Alexander CW | Fatty acid amide hydrolase inhibitors--progress and potential. | 2011 | CNS Neurol Disord Drug Targets | pmid:21631410 |
Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
Whyte LS et al. | Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. | 2012 | Br. J. Pharmacol. | pmid:21649637 |
Pamplona FA and Takahashi RN | Psychopharmacology of the endocannabinoids: far beyond anandamide. | 2012 | J. Psychopharmacol. (Oxford) | pmid:21652605 |
Romani R et al. | Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? | 2011 | Biochimie | pmid:21664223 |
Warzecha Z et al. | Role of sensory nerves in gastroprotective effect of anandamide in rats. | 2011 | J. Physiol. Pharmacol. | pmid:21673369 |
MartÃn-Couce L et al. | Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. | 2011 | J. Med. Chem. | pmid:21675776 |
Busquets-Garcia A et al. | Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. | 2011 | Biol. Psychiatry | pmid:21684528 |
Zoerner AA et al. | Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma. | 2011 | Clin. Pharmacol. Ther. | pmid:21716266 |
Brailoiu GC et al. | Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. | 2011 | J. Biol. Chem. | pmid:21719698 |
Catanzaro G et al. | Effect of capacitation on the endocannabinoid system of mouse sperm. | 2011 | Mol. Cell. Endocrinol. | pmid:21723369 |
Zoerner AA et al. | Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21752730 |
Kopczyńska B et al. | Anandamide enhances expression of heat shock proteins Hsp70 and Hsp25 in rat lungs. | 2011 | Eur. J. Pharmacol. | pmid:21756900 |
Hayase T | Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors. | 2011 | BMC Pharmacol. | pmid:21767384 |
Goonawardena AV et al. | Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus. | 2011 Oct-Nov | Neuropharmacology | pmid:21767554 |
Theile JW and Cummins TR | Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide. | 2011 | Mol. Pharmacol. | pmid:21788423 |
Lin QS et al. | Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formation. | 2011 | Brain Res. Bull. | pmid:21801815 |
Tsuboi K et al. | Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. | 2011 | Biochim. Biophys. Acta | pmid:21801852 |
Chianese R et al. | Anandamide modulates the expression of GnRH-II and GnRHRs in frog, Rana esculenta, diencephalon. | 2011 | Gen. Comp. Endocrinol. | pmid:21802420 |
Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
Kim HY et al. | A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21810478 |
Palermo G et al. | Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. | 2011 | J. Med. Chem. | pmid:21830831 |
Gatta-Cherifi B et al. | Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity. | 2012 | Int J Obes (Lond) | pmid:21844878 |
Altinsoy A et al. | A cannabinoid ligand, anandamide, exacerbates endotoxin-induced uveitis in rabbits. | 2011 | J Ocul Pharmacol Ther | pmid:21848425 |
Mestre L et al. | Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptors. | 2011 | J Neuroinflammation | pmid:21851608 |
Clugston RD et al. | Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. | 2011 | J. Lipid Res. | pmid:21856784 |
Dollery C | Investigative clinical pharmacology. | 2011 | Clin. Pharmacol. Ther. | pmid:21862965 |
Weller K et al. | TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release. | 2011 | Neuropeptides | pmid:21868092 |
Ndong C et al. | Cloning and pharmacological characterization of the dog cannabinoid CBâ‚‚receptor. | 2011 | Eur. J. Pharmacol. | pmid:21871882 |
Romero TR et al. | The neuronal NO synthase participation in the peripheral antinociception mechanism induced by several analgesic drugs. | 2011 | Nitric Oxide | pmid:21875681 |
Feledziak M et al. | SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process. | 2011 | J. Med. Chem. | pmid:21899370 |
Roy A et al. | Anandamide modulates carotid sinus nerve afferent activity via TRPV1 receptors increasing responses to heat. | 2012 | J. Appl. Physiol. | pmid:21903882 |
Butler RK et al. | Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase. | 2012 | J. Psychopharmacol. (Oxford) | pmid:21926424 |
Dean C | Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat. | 2011 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:21940402 |
Thomas KC et al. | Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21949157 |
Alenmyr L et al. | TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo. | 2011 | Clin Physiol Funct Imaging | pmid:21981454 |
Izumi Y and Zorumski CF | NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. | 2012 | Neuropsychopharmacology | pmid:21993209 |
Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
Haas MJ et al. | Inhibition of apolipoprotein A-I gene expression by obesity-associated endocannabinoids. | 2012 | Obesity (Silver Spring) | pmid:22016100 |
Malinowska B et al. | Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? | 2012 | Br. J. Pharmacol. | pmid:22022923 |
Ito T et al. | Propofol protects against anandamide-induced injury in human umbilical vein endothelial cells. | 2011 | Kurume Med J | pmid:22027193 |
Heyman E et al. | Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. | 2012 | Psychoneuroendocrinology | pmid:22029953 |
Brizzi A et al. | Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. | 2011 | J. Med. Chem. | pmid:22044209 |
Hamtiaux L et al. | Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. | 2011 | PLoS ONE | pmid:22046372 |
Hutchins-Wiese HL et al. | Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. | 2012 | J. Nutr. Biochem. | pmid:22051448 |
Fu J et al. | A catalytically silent FAAH-1 variant drives anandamide transport in neurons. | 2012 | Nat. Neurosci. | pmid:22101642 |
Feuerecker M et al. | Effects of exercise stress on the endocannabinoid system in humans under field conditions. | 2012 | Eur. J. Appl. Physiol. | pmid:22101870 |
Taylor AH et al. | Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones. | 2011 | Reprod. Biol. Endocrinol. | pmid:22126420 |
Reyes-Cabello C et al. | Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration. | 2012 | Pharmacol. Biochem. Behav. | pmid:22133635 |
Cippitelli A et al. | Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. | 2011 | PLoS ONE | pmid:22140525 |
Wheal AJ et al. | Hydrogen peroxide as a mediator of vasorelaxation evoked by N-oleoylethanolamine and anandamide in rat small mesenteric arteries. | 2012 | Eur. J. Pharmacol. | pmid:22154756 |
Li Q et al. | Effects of anandamide on potassium channels in rat ventricular myocytes: a suppression of I(to) and augmentation of K(ATP) channels. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22173869 |
Wu X et al. | Alteration of endocannabinoid system in human gliomas. | 2012 | J. Neurochem. | pmid:22176552 |
Starowicz K et al. | Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. | 2012 | Neuropharmacology | pmid:22178705 |
Jang Y et al. | Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. | 2012 | J. Biol. Chem. | pmid:22187434 |
Marsicano G and Chaouloff F | Moving bliss: a new anandamide transporter. | 2012 | Nat. Neurosci. | pmid:22193249 |
Battista N et al. | Abnormal anandamide metabolism in celiac disease. | 2012 | J. Nutr. Biochem. | pmid:22209002 |
Schulte K et al. | Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. | 2012 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:22215206 |
Fowler CJ et al. | Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide. | 2013 | J Enzyme Inhib Med Chem | pmid:22225576 |
Harvey BS et al. | Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. | 2012 | Neurotoxicology | pmid:22233683 |
Jarzimski C et al. | Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol? | 2012 | Br J Clin Pharmacol | pmid:22242687 |
Umathe SN et al. | Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor. | 2012 | Neuropharmacology | pmid:22248639 |
Feuerecker M et al. | Effect of an acute consumption of a moderate amount of ethanol on plasma endocannabinoid levels in humans. | 2012 May-Jun | Alcohol Alcohol. | pmid:22278319 |
Czikora à et al. | Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation. | 2012 | Life Sci. | pmid:22285599 |
Alger BE | Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know. | 2012 | J. Physiol. (Lond.) | pmid:22289914 |
Sun Y et al. | Cannabinoid receptor activation disrupts the internal structure of hippocampal sharp wave-ripple complexes. | 2012 | J. Pharmacol. Sci. | pmid:22293299 |
Fowler CJ | Anandamide uptake explained? | 2012 | Trends Pharmacol. Sci. | pmid:22297258 |
Izzo AA et al. | Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. | 2012 | Br. J. Pharmacol. | pmid:22300105 |
Battista N et al. | The role of endocannabinoids in gonadal function and fertility along the evolutionary axis. | 2012 | Mol. Cell. Endocrinol. | pmid:22305972 |
Liu J et al. | Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. | 2012 | Gastroenterology | pmid:22307032 |
Psychoyos D et al. | Cannabinoid receptor 1 signaling in embryo neurodevelopment. | 2012 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:22311661 |
Rajesh M et al. | Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. | 2012 | Diabetes | pmid:22315315 |
Shi RZ et al. | Decreased anandamide transporter activity and calcitonin gene-related peptide production in spontaneously hypertensive rats: role of angiotensin II. | 2012 | Eur. J. Pharmacol. | pmid:22318155 |
McLaughlin RJ et al. | Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. | 2012 | Eur Neuropsychopharmacol | pmid:22325231 |
Newberry EP et al. | Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. | 2012 | J. Lipid Res. | pmid:22327204 |
Zhang X et al. | Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives. | 2012 | Mol. Pharmacol. | pmid:22328719 |
Alvheim AR et al. | Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. | 2012 | Obesity (Silver Spring) | pmid:22334255 |
Osycka-Salut C et al. | Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. | 2012 | PLoS ONE | pmid:22363468 |
Gatta L et al. | Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability. | 2012 | PLoS ONE | pmid:22363560 |
Manna SS and Umathe SN | Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. | 2012 | Epilepsy Res. | pmid:22386872 |
Fogaça MV et al. | Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters. | 2012 | Braz. J. Med. Biol. Res. | pmid:22392189 |
Lisboa SF and Guimarães FS | Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric oxide in the dorsolateral periaqueductal gray. | 2012 | Neuropharmacology | pmid:22394688 |
Romano MR and Lograno MD | Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery. | 2012 | Eur. J. Pharmacol. | pmid:22429572 |
Pucci M et al. | Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. | 2012 | J. Biol. Chem. | pmid:22431736 |
Dubreucq S et al. | Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. | 2012 | Neuropsychopharmacology | pmid:22434220 |
Monteleone P et al. | Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22442280 |
Andrianova EL et al. | In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. | 2011 | Bull. Exp. Biol. Med. | pmid:22442796 |
Kenessey I et al. | Revisiting CB1 receptor as drug target in human melanoma. | 2012 | Pathol. Oncol. Res. | pmid:22447182 |
Petrovszki Z et al. | The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level. | 2012 | Anesth. Analg. | pmid:22451592 |
Sharir H et al. | The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55. | 2012 | J Neuroimmune Pharmacol | pmid:22454039 |
Simpson CD et al. | A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance. | 2012 | Apoptosis | pmid:22488300 |
Xiong W et al. | A common molecular basis for exogenous and endogenous cannabinoid potentiation of glycine receptors. | 2012 | J. Neurosci. | pmid:22496565 |
Tamaki C et al. | Anandamide induces endothelium-dependent vasoconstriction and CGRPergic nerve-mediated vasodilatation in the rat mesenteric vascular bed. | 2012 | J. Pharmacol. Sci. | pmid:22510966 |
Czifra G et al. | Endocannabinoids regulate growth and survival of human eccrine sweat gland-derived epithelial cells. | 2012 | J. Invest. Dermatol. | pmid:22513781 |
Miller LL et al. | Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22514333 |
Caprioli A et al. | The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22514334 |