Anandamide

Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.

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Introduction

To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Anandamide?

Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Anandamide

MeSH term MeSH ID Detail
Headache Disorders, Secondary D051271 1 associated lipids
Somatosensory Disorders D020886 1 associated lipids
Orthostatic Intolerance D054971 1 associated lipids
Sleep Disorders, Intrinsic D020919 1 associated lipids
Vascular System Injuries D057772 2 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Substance-Related Disorders D019966 2 associated lipids
Ocular Hypotension D015814 2 associated lipids
Bulimia D002032 3 associated lipids
Acute Pain D059787 3 associated lipids
Cardiovirus Infections D018188 3 associated lipids
Schistosomiasis japonica D012554 3 associated lipids
Impotence, Vasculogenic D018783 4 associated lipids
Urinary Incontinence D014549 4 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Fibromyalgia D005356 4 associated lipids
Urinary Bladder Diseases D001745 4 associated lipids
Brain Concussion D001924 5 associated lipids
Muscle Spasticity D009128 5 associated lipids
Sleep Deprivation D012892 5 associated lipids
Pregnancy, Ectopic D011271 5 associated lipids
Intestinal Pseudo-Obstruction D007418 5 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Anorexia D000855 8 associated lipids
Sleep Apnea, Obstructive D020181 9 associated lipids
Morphine Dependence D009021 9 associated lipids
Alveolar Bone Loss D016301 10 associated lipids
Migraine Disorders D008881 11 associated lipids
Learning Disorders D007859 11 associated lipids
Shock, Septic D012772 11 associated lipids
Overweight D050177 11 associated lipids
Hyperkinesis D006948 11 associated lipids
Hepatitis D006505 11 associated lipids
Hypertension, Portal D006975 12 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Bradycardia D001919 13 associated lipids
Neoplasms D009369 13 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Celiac Disease D002446 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Bronchial Spasm D001986 18 associated lipids
Mycoses D009181 18 associated lipids
Cough D003371 19 associated lipids
Hypothermia D007035 19 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Anandamide

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Anandamide?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Anandamide?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Anandamide?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Anandamide?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Anandamide?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Anandamide

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Per page 10 20 50 100 | Total 2222
Authors Title Published Journal PubMed Link
Mechoulam R et al. Endocannabinoids. 1998 Eur. J. Pharmacol. pmid:9831287
Navarro M and Rodríguez de Fonseca F The neurobiology of cannabinoid transmission: from anandamide signaling to higher cerebral functions and disease. 1998 Neurobiol. Dis. pmid:9974172
Di Marzo V and Deutsch DG Biochemistry of the endogenous ligands of cannabinoid receptors. 1998 Neurobiol. Dis. pmid:9974173
Piomelli D et al. Endogenous cannabinoid signaling. 1998 Neurobiol. Dis. pmid:9974178
Barnett-Norris J et al. Exploration of biologically relevant conformations of anandamide, 2-arachidonylglycerol, and their analogues using conformational memories. 1998 J. Med. Chem. pmid:9822555
Maccarrone M et al. Anandamide hydrolysis by human cells in culture and brain. 1998 J. Biol. Chem. pmid:9822713
Chakrabarti A et al. Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice. 1998 Brain Res. Bull. pmid:9434204
Tong W et al. Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis. 1998 J. Med. Chem. pmid:9784095
Richardson JD et al. Antihyperalgesic effects of spinal cannabinoids. 1998 Eur. J. Pharmacol. pmid:9600630
Hampson AJ et al. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. 1998 J. Neurochem. pmid:9453561
Pratt PF et al. N-arachidonylethanolamide relaxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor. 1998 Am. J. Physiol. pmid:9458889
Paria BC et al. Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors. 1998 Biol. Reprod. pmid:9623610
Brăiloiu C et al. [Endothelium-derived hyperpolarizing factor]. 1998 Jul-Dec Rev Med Chir Soc Med Nat Iasi pmid:10756843
Childers SR and Breivogel CS Cannabis and endogenous cannabinoid systems. 1998 Jun-Jul Drug Alcohol Depend pmid:9716939
Zenor BN et al. Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves. 1999 Life Sci. pmid:10416818
Sugiura T et al. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. 1999 J. Biol. Chem. pmid:9915812
Beltramo M and Piomelli D Anandamide transport inhibition by the vanilloid agonist olvanil. 1999 Eur. J. Pharmacol. pmid:9920187
Piomelli D et al. Structural determinants for recognition and translocation by the anandamide transporter. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10318965
Mombouli JV et al. Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells. 1999 Br. J. Pharmacol. pmid:10323591
Watanabe K et al. Pharmacological effects in mice of anandamide and its related fatty acid ethanolamides, and enhancement of cataleptogenic effect of anandamide by phenylmethylsulfonyl fluoride. 1999 Biol. Pharm. Bull. pmid:10328555
Ameri A et al. Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. 1999 Br. J. Pharmacol. pmid:10372827
Self DW Anandamide: a candidate neurotransmitter heads for the big leagues. 1999 Nat. Neurosci. pmid:10204533
Giuffrida A et al. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. 1999 Nat. Neurosci. pmid:10204543
Paria BC et al. Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the periimplantation period. 1999 Biol. Reprod. pmid:10208977
Walker JM et al. Pain modulation by release of the endogenous cannabinoid anandamide. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10518599
Katayama K et al. Equilibrium in the hydrolysis and synthesis of cannabimimetic anandamide demonstrated by a purified enzyme. 1999 Biochim. Biophys. Acta pmid:10521704
Molderings GJ et al. Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship. 1999 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10494885
Leweke FM et al. Elevated endogenous cannabinoids in schizophrenia. 1999 Neuroreport pmid:10501554
Akinshola BE et al. Anandamide inhibition of recombinant AMPA receptor subunits in Xenopus oocytes is increased by forskolin and 8-bromo-cyclic AMP. 1999 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10543424
Di Marzo V et al. Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids. 1999 Curr. Med. Chem. pmid:10469888
Kuwae T et al. Biosynthesis and turnover of anandamide and other N-acylethanolamines in peritoneal macrophages. 1999 FEBS Lett. pmid:10508930
McAllister SD et al. Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system. 1999 J. Pharmacol. Exp. Ther. pmid:10525080
Yousif MH and Oriowo MA Inhibitory effects of cannabinoid receptor ligands on electrically-evoked responses in rat isolated tracheal ring segments. 1999 Pharmacol. Res. pmid:10527656
Zygmunt PM et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. 1999 Nature pmid:10440374
Martin BR et al. Discovery and characterization of endogenous cannabinoids. 1999 Life Sci. pmid:10462059
Khanolkar AD and Makriyannis A Structure-activity relationships of anandamide, an endogenous cannabinoid ligand. 1999 Life Sci. pmid:10462061
Howlett AC et al. Signal transduction of eicosanoid CB1 receptor ligands. 1999 Life Sci. pmid:10462062
Di Marzo V Biosynthesis and inactivation of endocannabinoids: relevance to their proposed role as neuromodulators. 1999 Life Sci. pmid:10462065
Ueda N et al. An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors. 1999 FEBS Lett. pmid:10431820
Fowler CJ et al. Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen. 1999 Arch. Biochem. Biophys. pmid:9989926
Basavarajappa BS and Hungund BL Chronic ethanol increases the cannabinoid receptor agonist anandamide and its precursor N-arachidonoylphosphatidylethanolamine in SK-N-SH cells. 1999 J. Neurochem. pmid:9930723
Wagner JA et al. Mesenteric vasodilation mediated by endothelial anandamide receptors. 1999 Hypertension pmid:9931142
Goparaju SK et al. Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors. 1999 Biochem. Pharmacol. pmid:9933030
Gifford AN et al. Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374). 1999 Eur. J. Pharmacol. pmid:10556675
Melck D et al. Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells. 1999 FEBS Lett. pmid:10606728
Castellano C et al. Strain-dependent effects of anandamide on memory consolidation in mice are antagonized by naltrexone. 1999 Behav Pharmacol pmid:10780251
González S et al. Extrapyramidal and neuroendocrine effects of AM404, an inhibitor of the carrier-mediated transport of anandamide. 1999 Life Sci. pmid:10447218
Melck D et al. Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. 1999 Biochem. Biophys. Res. Commun. pmid:10448105
Lang W et al. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. 1999 J. Med. Chem. pmid:10072686
Bisogno T et al. Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina. 1999 Arch. Biochem. Biophys. pmid:10577359