Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid:24671517 | ||||
pmid:24674601 | ||||
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pmid:24687644 | ||||
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pmid:24705535 | ||||
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pmid:24717329 | ||||
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pmid:24747871 | ||||
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pmid:24788457 | ||||
Park SW et al. | Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. | 2015 | Head Neck | pmid:24797795 |
Ravi J et al. | FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway. | 2014 | Oncotarget | pmid:24811863 |
pmid:24813296 | ||||
Scotchie JG et al. | Endocannabinoid regulation in human endometrium across the menstrual cycle. | 2015 | Reprod Sci | pmid:24819878 |
Pietrzak RH et al. | Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. | 2014 | Neuropsychopharmacology | pmid:24820537 |
Jergas B et al. | O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. | 2014 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:24853577 |
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pmid:24911079 | ||||
Pulgar VM et al. | Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. | 2014 | Hypertension | pmid:24935942 |
Dong W et al. | Simulation of Swanson's literature-based discovery: anandamide treatment inhibits growth of gastric cancer cells in vitro and in silico. | 2014 | PLoS ONE | pmid:24949851 |
pmid:24979612 | ||||
pmid:24980781 | ||||
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Cipriano M et al. | The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. | 2014 | BMC Res Notes | pmid:25012825 |
Alpár A et al. | Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. | 2014 | Nat Commun | pmid:25030704 |
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Lau BK et al. | Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. | 2014 | Br. J. Pharmacol. | pmid:25041240 |
Fezza F et al. | Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. | 2014 | Mol. Cell. Neurosci. | pmid:25064144 |
Björklund E et al. | Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study. | 2014 | PLoS ONE | pmid:25078278 |
Yang K et al. | Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. | 2014 | Hippocampus | pmid:25087967 |
pmid:25088244 | ||||
pmid:25098345 | ||||
pmid:25129827 | ||||
Sexton M et al. | Cannabis use by individuals with multiple sclerosis: effects on specific immune parameters. | 2014 | Inflammopharmacology | pmid:25135301 |
Jia J et al. | Anandamide protects HT22 cells exposed to hydrogen peroxide by inhibiting CB1 receptor-mediated type 2 NADPH oxidase. | 2014 | Oxid Med Cell Longev | pmid:25136404 |
pmid:25195527 | ||||
pmid:25204580 | ||||
pmid:25205244 | ||||
pmid:25212838 | ||||
Özdemir B et al. | Endocannabinoids and inflammatory response in periodontal ligament cells. | 2014 | PLoS ONE | pmid:25226300 |
pmid:25229205 | ||||
pmid:25240419 | ||||
De Angelis V et al. | Endocannabinoids control platelet activation and limit aggregate formation under flow. | 2014 | PLoS ONE | pmid:25264625 |
Malek N et al. | Alterations in the anandamide metabolism in the development of neuropathic pain. | 2014 | Biomed Res Int | pmid:25276812 |
McDougle DR et al. | Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25277139 |
Troy-Fioramonti S et al. | Acute activation of cannabinoid receptors by anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice. | 2015 | Diabetes | pmid:25281429 |
Morty RE and Kuebler WM | TRPV4: an exciting new target to promote alveolocapillary barrier function. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25281637 |
pmid:25283614 | ||||
Manna JD et al. | Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. | 2014 | J. Biol. Chem. | pmid:25301951 |
Khasabova IA et al. | JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. | 2014 | Pharmacol. Res. | pmid:25304184 |
pmid:25370126 | ||||
Wang ZY et al. | Attenuation of cystitis and pain sensation in mice lacking fatty acid amide hydrolase. | 2015 | J. Mol. Neurosci. | pmid:25374388 |
pmid:25388290 | ||||
Pacioni G et al. | Truffles contain endocannabinoid metabolic enzymes and anandamide. | 2015 | Phytochemistry | pmid:25433633 |
pmid:25446347 | ||||
Liu J and Pope C | The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. | 2015 | Neurotoxicology | pmid:25447325 |
pmid:25450464 | ||||
pmid:25453774 | ||||
pmid:25456842 | ||||
pmid:25465706 | ||||
Morena M et al. | Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25489086 |
Sticht MA et al. | Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats. | 2015 | Neuroscience | pmid:25499318 |
Ford GK et al. | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | 2015 | Eur J Pain | pmid:25504741 |
Uhelski ML et al. | Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy. | 2015 | J. Neurophysiol. | pmid:25505113 |
Chauvet C et al. | Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats. | 2014 | Int. J. Neuropsychopharmacol. | pmid:25522382 |
pmid:25535694 | ||||
Urquhart P et al. | Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. | 2015 | Biochim. Biophys. Acta | pmid:25543004 |
Aliczki M et al. | Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | 2015 | Psychopharmacology (Berl.) | pmid:25547462 |
Karlsson C et al. | Baseline anandamide levels and body weight impact the weight loss effect of CB1 receptor antagonism in male rats. | 2015 | Endocrinology | pmid:25549047 |
pmid:25557612 | ||||
Sadhasivam S et al. | Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects. | 2015 | Pharmacogenomics J. | pmid:25558980 |
pmid:25581607 | ||||
Kumar S | Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates. | 2015 | BMC Res Notes | pmid:25595103 |
pmid:25601395 | ||||
Orellana-Serradell O et al. | Proapoptotic effect of endocannabinoids in prostate cancer cells. | 2015 | Oncol. Rep. | pmid:25606819 |
Lisboa SF et al. | Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. | 2015 | Int. J. Neuropsychopharmacol. | pmid:25618404 |
pmid:25622579 | ||||
pmid:25637682 | ||||
Gaskari SA et al. | Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids. | 2015 | J. Hepatol. | pmid:25640062 |
Monteleone AM et al. | Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa. | 2015 | Am. J. Clin. Nutr. | pmid:25646322 |
Hind WH et al. | Endocannabinoids modulate human blood-brain barrier permeability in vitro. | 2015 | Br. J. Pharmacol. | pmid:25651941 |
Pisanti S et al. | Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. | 2015 | J. Cell. Physiol. | pmid:25684344 |
Walentiny DM et al. | Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. | 2015 | Neuropharmacology | pmid:25698527 |
pmid:25716652 | ||||
pmid:25719612 | ||||
Gray JM et al. | Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. | 2015 | J. Neurosci. | pmid:25740517 |
pmid:25808995 | ||||
Llorente-Berzal A et al. | 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. | 2015 | Psychopharmacology (Berl.) | pmid:25814137 |
Patsenker E et al. | Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. | 2015 | Int J Mol Sci | pmid:25826533 |
Nicholson J et al. | Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. | 2015 | PLoS ONE | pmid:25835291 |
Woolcott OO et al. | High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets. | 2015 | PLoS ONE | pmid:25855974 |