Anandamide is a lipid of Fatty Acyls (FA) class. Anandamide is associated with abnormalities such as Dehydration. The involved functions are known as Process, Phenomenon, Phosphorylation, Catabolic Process and Gene Expression. Anandamide often locates in Nuchal region, Microglial and Hepatic. The associated genes with Anandamide are SGPL1 gene, SPTLC1 gene, RPSA gene, KDSR gene and SMPD1 gene. The related lipids are Sphingolipids, Lipopolysaccharides, Lysophospholipids, LYSO-PC and lysophosphatidylethanolamine.
To understand associated biological information of Anandamide, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Anandamide is suspected in Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Anandamide
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kollarik M and Undem BJ | Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1-/- mice. | 2004 | J. Physiol. (Lond.) | pmid:14634201 |
Alger BE | Endocannabinoids: getting the message across. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15173576 |
Koura Y et al. | Anandamide decreases glomerular filtration rate through predominant vasodilation of efferent arterioles in rat kidneys. | 2004 | J. Am. Soc. Nephrol. | pmid:15153559 |
Lichtman AH et al. | Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. | 2004 | Pain | pmid:15157693 |
Mendiguren A and Pineda J | Cannabinoids enhance N-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices. | 2004 | Neurosci. Lett. | pmid:15157983 |
Karlsson M et al. | Reversible, temperature-dependent, and AM404-inhibitable adsorption of anandamide to cell culture wells as a confounding factor in release experiments. | 2004 | Eur J Pharm Sci | pmid:15158903 |
Lin GC et al. | Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells. | 2004 | J. Cell. Sci. | pmid:14762115 |
Lees G and Dougalis A | Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. | 2004 | Brain Res. | pmid:14715144 |
Ruiz-Llorente L et al. | Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. | 2004 | Br. J. Pharmacol. | pmid:14718261 |
Akerman S et al. | Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14718591 |
Maccarrone M | Inhibition of anandamide hydrolysis: cells also know how to do it. | 2004 | Trends Mol Med | pmid:14720580 |
Bátkai S et al. | Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. | 2004 | Circulation | pmid:15451779 |
Braun M and Kietzmann M | Ischaemia-reperfusion injury in the isolated haemoperfused bovine uterus: an in vitro model of acute inflammation. | 2004 | Altern Lab Anim | pmid:15601235 |
Dinis P et al. | Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. | 2004 | J. Neurosci. | pmid:15601931 |
Motobe T et al. | Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. | 2004 | Shock | pmid:14676677 |
RodrÃguez de Fonseca F | [The endocannabinoid system and food intake control]. | 2004 Apr-Jun | Rev Med Univ Navarra | pmid:15382609 |
Mechoulam R | The promise of advances in the field of endocannabinoids. | 2004 Feb-Apr | Neuro Endocrinol. Lett. | pmid:15159675 |
Fride E | The endocannabinoid-CB receptor system: Importance for development and in pediatric disease. | 2004 Feb-Apr | Neuro Endocrinol. Lett. | pmid:15159678 |
Russo EB | Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? | 2004 Feb-Apr | Neuro Endocrinol. Lett. | pmid:15159679 |
Lam PM et al. | Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids. | 2005 | Br J Anaesth | pmid:15722382 |
Oddi S et al. | Confocal microscopy and biochemical analysis reveal spatial and functional separation between anandamide uptake and hydrolysis in human keratinocytes. | 2005 | Cell. Mol. Life Sci. | pmid:15723173 |
Rodella LF et al. | AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation. | 2005 | Eur. J. Pharmacol. | pmid:15680264 |
Oz M et al. | Additive effects of endogenous cannabinoid anandamide and ethanol on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus Oocytes. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15687372 |
Mbvundula EC et al. | Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage. | 2005 | Biochem. Pharmacol. | pmid:15670582 |
Ashton CH et al. | Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential. | 2005 | J. Psychopharmacol. (Oxford) | pmid:15888515 |
Guo Y et al. | N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. | 2005 | J. Biol. Chem. | pmid:15890658 |
Fowler CJ and Tiger G | Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. | 2005 | Biochem. Pharmacol. | pmid:15794945 |
Kaplan BL et al. | Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2'-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15893538 |
van der Stelt M et al. | A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease. | 2005 | FASEB J. | pmid:15894565 |
Vandevoorde S and Fowler CJ | Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate. | 2005 | Br. J. Pharmacol. | pmid:15895107 |
Hillard CJ and Jarrahian A | Accumulation of anandamide: evidence for cellular diversity. | 2005 | Neuropharmacology | pmid:15910883 |
Jia Y et al. | TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence. | 2005 | Drug News Perspect. | pmid:15915217 |
Ahern GP et al. | Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. | 2005 | J. Neurosci. | pmid:15917451 |
Glass M et al. | Misidentification of prostamides as prostaglandins. | 2005 | J. Lipid Res. | pmid:15863842 |
Lambert DM and Fowler CJ | The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. | 2005 | J. Med. Chem. | pmid:16078824 |
Osei-Hyiaman D et al. | Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. | 2005 | J. Clin. Invest. | pmid:15864349 |
Siegmund SV et al. | Anandamide induces necrosis in primary hepatic stellate cells. | 2005 | Hepatology | pmid:15841466 |
Hayase T et al. | Persistent anxiogenic effects of a single or repeated doses of cocaine and methamphetamine: interactions with endogenous cannabinoid receptor ligands. | 2005 | Behav Pharmacol | pmid:16148444 |
Gavva NR et al. | AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15615864 |
Appendino G et al. | Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15356216 |
O'Sullivan SE et al. | Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. | 2005 | Eur. J. Pharmacol. | pmid:15659311 |
Sancho R et al. | Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. | 2005 | J. Immunol. | pmid:16148147 |
Ueda N et al. | N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: a novel enzyme of the beta-lactamase fold family releasing anandamide and other N-acylethanolamines. | 2005 | Life Sci. | pmid:15949819 |
Gamber KM et al. | Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. | 2005 | Neuropharmacology | pmid:15949823 |
Karava V et al. | Anandamide metabolism by Tetrahymena pyriformis in vitro. Characterization and identification of a 66 kDa fatty acid amidohydrolase. | 2005 | Biochimie | pmid:15951097 |
Kwolek G et al. | [Influence of anandamide, the endogenous agonist of cannabinoid receptors on the circulatory system]. | 2005 | Postepy Hig Med Dosw (Online) | pmid:15928605 |
Bojesen IN and Hansen HS | Membrane transport of anandamide through resealed human red blood cell membranes. | 2005 | J. Lipid Res. | pmid:15930521 |
Fowler CJ et al. | The endocannabinoid signaling system: pharmacological and therapeutic aspects. | 2005 | Pharmacol. Biochem. Behav. | pmid:15935456 |
De Petrocellis L and Di Marzo V | Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels. | 2005 | Life Sci. | pmid:15936040 |
Balas L et al. | Synthesis of a photoactivatable probe of the anandamide re-uptake. | 2005 | Nat. Prod. Res. | pmid:15938150 |
Bouaboula M et al. | Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. | 2005 | Eur. J. Pharmacol. | pmid:15987634 |
Fezza F et al. | Radiochromatographic assay of N-acyl-phosphatidylethanolamine-specific phospholipase D activity. | 2005 | Anal. Biochem. | pmid:15766717 |
Ueda N and Tsuboi K | [Enzymes involved in the biosynthesis and degradation of anandamide]. | 2005 | Seikagaku | pmid:16440755 |
De Bank PA et al. | A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. | 2005 | Biochem. Pharmacol. | pmid:15794939 |
Tóth A et al. | Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. | 2005 | Life Sci. | pmid:15820503 |
Kraft B and Kress HG | Indirect CB2 receptor and mediator-dependent stimulation of human whole-blood neutrophils by exogenous and endogenous cannabinoids. | 2005 | J. Pharmacol. Exp. Ther. | pmid:16055676 |
Pacher P et al. | Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15821037 |
Poblete IM et al. | Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. | 2005 | J. Physiol. (Lond.) | pmid:16081483 |
O'Sullivan SE et al. | The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. | 2005 | Br. J. Pharmacol. | pmid:15821751 |
Chen J et al. | Finding of endocannabinoids in human eye tissues: implications for glaucoma. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15823551 |
Chen JZ et al. | Preferred conformations of endogenous cannabinoid ligand anandamide. | 2005 | Life Sci. | pmid:15826873 |
Zhang N et al. | A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15764707 |
Kvasnicka T | [Endocannabinoids--the new option in the treatment of metabolic syndrome and in smoking cessation]. | 2005 | Cas. Lek. Cesk. | pmid:15807291 |
Minowa S et al. | Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. | 2005 | Brain Res. | pmid:15781048 |
Justinova Z et al. | The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. | 2005 | J. Neurosci. | pmid:15944392 |
Sandberg A and Fowler CJ | Measurement of saturable and non-saturable components of anandamide uptake into P19 embryonic carcinoma cells in the presence of fatty acid-free bovine serum albumin. | 2005 | Chem. Phys. Lipids | pmid:15784231 |
Maccarrone M et al. | Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction. | 2005 | J. Cell. Sci. | pmid:16144868 |
Chen P et al. | Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium. | 2005 | Microvasc. Res. | pmid:15797258 |
Randall MD | The cardiovascular actions of anandamide: more targets? | 2005 | Br. J. Pharmacol. | pmid:15834438 |
Yang W et al. | Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2. | 2005 | J. Lipid Res. | pmid:16150817 |
Kwolek G et al. | Central and peripheral components of the pressor effect of anandamide in urethane-anaesthetized rats. | 2005 | Br. J. Pharmacol. | pmid:15834445 |
Gasperi V et al. | Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells. | 2005 | Neurotoxicology | pmid:16154199 |
Mestre L et al. | Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis. | 2005 | J. Neurochem. | pmid:15748152 |
Sun YX et al. | Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. | 2005 | Biochim. Biophys. Acta | pmid:16154384 |
Domenicali M et al. | Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors. | 2005 | Gut | pmid:15753538 |
Barun S et al. | Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16173925 |
Bazinet RP et al. | Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain. | 2005 | Neurochem. Res. | pmid:16176062 |
Oz M et al. | Effects of saturated long-chain N-acylethanolamines on voltage-dependent Ca2+ fluxes in rabbit T-tubule membranes. | 2005 | Arch. Biochem. Biophys. | pmid:15639235 |
Straiker A and Mackie K | Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. | 2005 | J. Physiol. (Lond.) | pmid:16179366 |
Engeli S et al. | Activation of the peripheral endocannabinoid system in human obesity. | 2005 | Diabetes | pmid:16186383 |
Underdown NJ et al. | Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. | 2005 | Br. J. Pharmacol. | pmid:16158067 |
Maccarrone M et al. | Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. | 2005 | Mol. Hum. Reprod. | pmid:15563449 |
Wang Y et al. | VR1-mediated depressor effects during high-salt intake: role of anandamide. | 2005 | Hypertension | pmid:16144988 |
Voets T et al. | Sensing with TRP channels. | 2005 | Nat. Chem. Biol. | pmid:16408004 |
Siegmund SV and Brenner DA | Molecular pathogenesis of alcohol-induced hepatic fibrosis. | 2005 | Alcohol. Clin. Exp. Res. | pmid:16344593 |
Gobbi G et al. | Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16352709 |
Jiang W et al. | Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. | 2005 | J. Clin. Invest. | pmid:16224541 |
Di S et al. | Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. | 2005 | J. Physiol. (Lond.) | pmid:16239276 |
Kim HI et al. | Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. | 2005 | Brain Res. | pmid:16256960 |
Kadoi Y et al. | Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. | 2005 | Crit. Care Med. | pmid:16276190 |
Brizzi A et al. | Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors. | 2005 | J. Med. Chem. | pmid:16279794 |
Singh Tahim A et al. | Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons. | 2005 | Neuroscience | pmid:16198486 |
Cabranes A et al. | Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis. | 2005 | Neurobiol. Dis. | pmid:16242629 |
Lee MG et al. | Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung. | 2005 | Br. J. Pharmacol. | pmid:16056239 |
Movahed P et al. | Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. | 2005 | Br. J. Pharmacol. | pmid:15997233 |
Movahed P et al. | Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. | 2005 | J. Biol. Chem. | pmid:16081411 |
Awumey EM et al. | Is there a role for anandamide in cardiovascular regulation? Insights from studies of endocannabinoid metabolism. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16014613 |
Wahn H et al. | The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16055511 |
Bari M et al. | Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis. | 2005 | J. Biol. Chem. | pmid:15657045 |
Kim SR et al. | Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. | 2005 | J. Neurosci. | pmid:15659603 |